(R)-S-lactoylglutathione

Three steps

• CHEBI:15699Reach from here →
  1. (R)-S-Lactoylglutathione hydrolase
  2. cystine to cysteine conversion
  3. transport of cysteine and homoserine (cytosol to extracellular)

  Catalysed by HAGH, HAGHL, SLC7A5cytosol, extracellular spaceOne of 3 routes

• formateReach from here →
  1. (R)-S-Lactoylglutathione hydrolase
  2. alcohol dehydrogenase (formaldehyde)
  3. S-formylglutathione + H2O = formate + glutathione + H(+)

  Catalysed by HAGH, HAGHL, ADH1C, ADH1A and 5 morecytosol

• CHEBI:15971Reach from here →
  1. (R)-S-Lactoylglutathione hydrolase
  2. cystine to cysteine conversion
  3. transport of cysteine and histidine (cytosol to extracellular)

  Catalysed by HAGH, HAGHL, SLC7A6cytosol, extracellular spaceOne of 2 routes

• ferricytochrome cReach from here →
  1. (R)-S-Lactoylglutathione hydrolase
  2. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  3. 13(S)-HPODE to 13-oxy-radical-octadecadienoate conversion

  Catalysed by HAGH, HAGHL, LDHDcytosol, mitochondrial matrixOne of 4 routes

• methanethiolReach from here →
  1. (R)-S-lactoylglutathione + H2O = (R)-lactate + glutathione + H(+)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. methanethiol + O2 + H2O = hydrogen sulfide + formaldehyde + H2O2 + H(+)

  Catalysed by HAGH, TSTD1, SELENBP1

• sulfateReach from here →
  1. (R)-S-Lactoylglutathione hydrolase
  2. transport of GSH and sulfoglycolithocholate (cytosol to extracellular)
  3. steroid sulfatase (sulfoglycolithocholate)

  Catalysed by HAGH, HAGHL, SLCO1A2, SLCO1B3 and 1 morecytosol, extracellular spaceOne of 7 routes

• ureaReach from here →
  1. (R)-S-lactoylglutathione + H2O = (R)-lactate + glutathione + H(+)
  2. urate(out) + glutathione(in) = urate(in) + glutathione(out)
  3. Peroxidase

  Catalysed by HAGH, SLC22A13, MPOinner side of the membrane, outer side of the membrane, nucleusOne of 3 routes

• dimethylarsinateReach from here →
  1. (R)-S-lactoylglutathione + H2O = (R)-lactate + glutathione + H(+)
  2. methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O
  3. methylarsonous acid + S-adenosyl-L-methionine = dimethylarsinate + S-adenosyl-L-homocysteine + 2 H(+)

  Catalysed by HAGH, GSTO1, GSTO2, HEMK2

• 2-methyl-3-oxopropanoic acidReach from here →
  1. (R)-S-Lactoylglutathione hydrolase
  2. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by HAGH, HAGHL, LDHD, AGXT2cytosol, mitochondrial matrix

• L-cystineReach from here →
  1. (R)-S-Lactoylglutathione hydrolase
  2. Glutathione: 5-HPETE oxidoreductase
  3. cystine to cysteine conversion

  Catalysed by HAGH, HAGHL, GPX5, GPX1 and 7 morecytosolOne of 5 routes

• L-citrullineReach from here →
  1. (R)-S-Lactoylglutathione hydrolase
  2. cystine to cysteine conversion
  3. transport of citrulline and cysteine (cytosol to extracellular)

  Catalysed by HAGH, HAGHL, SLC7A6cytosol, extracellular spaceOne of 2 routes

• iodideReach from here →
  1. (R)-S-Lactoylglutathione hydrolase
  2. transport of GSH and thyroxine (cytosol to extracellular)
  3. 3,3',5-triiodo-L-thyronine,iodide:acceptor oxidoreductase (iodinating)

  Catalysed by HAGH, HAGHL, SLCO1A2, SLCO1B3 and 2 morecytosol, extracellular spaceOne of 9 routes

• L-valineReach from here →
  1. (R)-S-Lactoylglutathione hydrolase
  2. cystine to cysteine conversion
  3. transport of cysteine and valine (cytosol to extracellular)

  Catalysed by HAGH, HAGHL, SLC7A5cytosol, extracellular spaceOne of 3 routes

• oxaloacetateReach from here →
  1. (R)-S-Lactoylglutathione hydrolase
  2. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  3. Pyruvate:carbon-dioxide ligase (ADP-forming)

  Catalysed by HAGH, HAGHL, LDHD, PCcytosol, mitochondrial matrixOne of 3 routes

• L-arginineReach from here →
  1. (R)-S-Lactoylglutathione hydrolase
  2. cystine to cysteine conversion
  3. transport of arginine and cysteine (cytosol to extracellular)

  Catalysed by HAGH, HAGHL, SLC7A6cytosol, extracellular spaceOne of 5 routes

• protein polypeptide chainReach from here →
  1. (R)-S-Lactoylglutathione hydrolase
  2. cystine to cysteine conversion
  3. PROTEIN_BS

  Catalysed by HAGH, HAGHLcytosol

• (S)-lactateReach from here →
  1. (R)-S-Lactoylglutathione hydrolase
  2. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  3. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)

  Catalysed by HAGH, HAGHL, LDHD, LDHA and 4 morecytosol, mitochondrial matrixOne of 16 routes

• taurochenodeoxycholate 3-sulfateReach from here →
  1. (R)-S-Lactoylglutathione hydrolase
  2. solute carrier organic anion transporter (GSH)
  3. taurochenodeoxycholate + 3'-phosphoadenylyl sulfate = taurochenodeoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by HAGH, HAGHL, SLCO1A2, SLC7A9 and 2 morecytosol, extracellular space

• dopamine quinoneReach from here →
  1. (R)-S-Lactoylglutathione hydrolase
  2. transport of dopamine and GSH (cytosol to extracellular)
  3. Peroxidase

  Catalysed by HAGH, HAGHL, SLCO1A2, SLCO1B3 and 1 morecytosol, extracellular space, lysosomeOne of 4 routes

• 2-oxobutanoateReach from here →
  1. (R)-S-Lactoylglutathione hydrolase
  2. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  3. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate

  Catalysed by HAGH, HAGHL, LDHD, AGXT2cytosol, mitochondrial matrix

• 2-oxoglutaramateReach from here →
  1. (R)-S-Lactoylglutathione hydrolase
  2. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  3. L-Glutamine:pyruvate aminotransferase

  Catalysed by HAGH, HAGHL, LDHD, KYAT1cytosol, mitochondrial matrixOne of 2 routes

• formaldehydeReach from here →
  1. (R)-S-Lactoylglutathione hydrolase
  2. alcohol dehydrogenase (formaldehyde)
  3. alcohol dehydrogenase (formaldehyde)

  Catalysed by HAGH, HAGHL, ADH1C, ADH1A and 4 morecytosol

• 3-fumarylpyruvateReach from here →
  1. (R)-S-Lactoylglutathione hydrolase
  2. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  3. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)

  Catalysed by HAGH, HAGHL, LDHD, FAHD1cytosol, mitochondrial matrix

• CHEBI:16857Reach from here →
  1. (R)-S-Lactoylglutathione hydrolase
  2. cystine to cysteine conversion
  3. transport of cysteine and threonine (cytosol to extracellular)

  Catalysed by HAGH, HAGHL, SLC7A5cytosol, extracellular spaceOne of 4 routes

• (R)-3-hydroxybutyric acidReach from here →
  1. (R)-S-Lactoylglutathione hydrolase
  2. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  3. transport of (R)-3-hydroxybutanoate and pyruvate (cytosol to extracellular)

  Catalysed by HAGH, HAGHL, LDHD, SLC16A4 and 5 morecytosol, mitochondrial matrix, extracellular spaceOne of 2 routes

• 3-hydroxypyruvateReach from here →
  1. (R)-S-Lactoylglutathione hydrolase
  2. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  3. L-serine + pyruvate = 3-hydroxypyruvate + L-alanine

  Catalysed by HAGH, HAGHL, LDHD, AGXTcytosol, mitochondrial matrix

• L-isoleucineReach from here →
  1. (R)-S-Lactoylglutathione hydrolase
  2. cystine to cysteine conversion
  3. transport of cysteine and isoleucine (cytosol to extracellular)

  Catalysed by HAGH, HAGHL, SLC7A5cytosol, extracellular spaceOne of 4 routes

• CHEBI:17203Reach from here →
  1. (R)-S-Lactoylglutathione hydrolase
  2. cystine to cysteine conversion
  3. transport of cysteine and proline (cytosol to extracellular)

  Catalysed by HAGH, HAGHL, SLC7A5cytosol, extracellular spaceOne of 3 routes

• dehydroascorbic acidReach from here →
  1. (R)-S-Lactoylglutathione hydrolase
  2. transport of dopamine and GSH (cytosol to extracellular)
  3. dopamine,ascorbate:oxygen oxidoreductase (beta-hydroxylating)

  Catalysed by HAGH, HAGHL, SLCO1A2, SLCO1B3 and 1 morecytosol, extracellular spaceOne of 19 routes

• aceneuramateReach from here →
  1. (R)-S-Lactoylglutathione hydrolase
  2. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  3. aceneuramate = aldehydo-N-acetyl-D-mannosamine + pyruvate

  Catalysed by HAGH, HAGHL, LDHD, NPLcytosol, mitochondrial matrix

• 5'-deoxyadenosineReach from here →
  1. (R)-S-Lactoylglutathione hydrolase
  2. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  3. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O

  Catalysed by HAGH, HAGHL, LDHD, TYW1B and 1 morecytosol, mitochondrial matrix

• 3,3',5-triiodo-L-thyronine sulfateReach from here →
  1. (R)-S-Lactoylglutathione hydrolase
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. aryl sulfotransferase (PAPS)

  Catalysed by HAGH, HAGHL, SLCO1A2, SLCO1B3 and 4 morecytosol, extracellular spaceOne of 2 routes

• L-thyroxine sulfateReach from here →
  1. (R)-S-Lactoylglutathione hydrolase
  2. transport of GSH and thyroxine (cytosol to extracellular)
  3. L-thyroxine + 3'-phosphoadenylyl sulfate = L-thyroxine sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by HAGH, HAGHL, SLCO1A2, SLCO1B3 and 3 morecytosol, extracellular space

• 3,3'-diiodo-L-thyronineReach from here →
  1. (R)-S-Lactoylglutathione hydrolase
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)

  Catalysed by HAGH, HAGHL, SLCO1A2, SLCO1B3 and 3 morecytosol, extracellular spaceOne of 3 routes

• N-acetylserotoninReach from here →
  1. (R)-S-Lactoylglutathione hydrolase
  2. transport of GSH and serotonin (cytosol to extracellular)
  3. acetyl-CoA:aralkylamine N-acetyltransferase

  Catalysed by HAGH, HAGHL, SLCO1A2, SLCO1B3 and 1 morecytosol, extracellular space

• xanthineReach from here →
  1. (R)-S-lactoylglutathione + H2O = (R)-lactate + glutathione + H(+)
  2. urate(out) + glutathione(in) = urate(in) + glutathione(out)
  3. xanthine + NAD(+) + H2O = urate + NADH + H(+)

  Catalysed by HAGH, SLC22A13, XDHinner side of the membrane, outer side of the membraneOne of 2 routes

• CHEBI:17724Reach from here →
  1. (R)-S-Lactoylglutathione hydrolase
  2. Formation of Homocystine
  3. Trimethylaminoacetate:L-homosysteine S-methyltransferase

  Catalysed by HAGH, HAGHL, BHMT, BHMT2cytosol

• 5-hydroxy-L-tryptophanReach from here →
  1. (R)-S-Lactoylglutathione hydrolase
  2. transport of GSH and serotonin (cytosol to extracellular)
  3. 5-hydroxy-L-tryptophan + H(+) = serotonin + CO2

  Catalysed by HAGH, HAGHL, SLCO1A2, SLCO1B3 and 1 morecytosol, extracellular space

• prostaglandin F1Reach from here →
  1. (R)-S-Lactoylglutathione hydrolase
  2. transport of GSH and prostaglandin E1 (cytosol to extracellular)
  3. prostaglandin E1 + NADPH + H(+) = prostaglandin F1 + NADP(+)

  Catalysed by HAGH, HAGHL, SLCO2A1, DHRS1cytosol, extracellular space

• CHEBI:17895Reach from here →
  1. (R)-S-Lactoylglutathione hydrolase
  2. cystine to cysteine conversion
  3. transport of cysteine and tyrosine (cytosol to extracellular)

  Catalysed by HAGH, HAGHL, SLC7A5cytosol, extracellular spaceOne of 4 routes

• fumaric acidReach from here →
  1. (R)-S-lactoylglutathione + H2O = (R)-lactate + glutathione + H(+)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. transport of fumarate and sulfite (cytosol to mitochondria)

  Catalysed by HAGH, TSTD1, SLC25A10mitochondrial matrix, cytosolOne of 2 routes

• CHEBI:18019Reach from here →
  1. (R)-S-Lactoylglutathione hydrolase
  2. cystine to cysteine conversion
  3. transport of cysteine and lysine (cytosol to extracellular)

  Catalysed by HAGH, HAGHL, SLC7A6cytosol, extracellular spaceOne of 2 routes

• L-glutamineReach from here →
  1. (R)-S-Lactoylglutathione hydrolase
  2. cystine to cysteine conversion
  3. transport of cysteine and glutamine (cytosol to extracellular)

  Catalysed by HAGH, HAGHL, SLC3A2, SLC7A5 and 1 morecytosol, extracellular spaceOne of 4 routes

• 5-hydroxyisourateReach from here →
  1. (R)-S-lactoylglutathione + H2O = (R)-lactate + glutathione + H(+)
  2. urate(out) + glutathione(in) = urate(in) + glutathione(out)
  3. urate:oxygen oxidoreductase

  Catalysed by HAGH, SLC22A13inner side of the membrane, outer side of the membrane, cytosol

• dTDPReach from here →
  1. (R)-S-Lactoylglutathione hydrolase
  2. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  3. pyruvate kinase (dTDP)

  Catalysed by HAGH, HAGHL, LDHD, PKM and 1 morecytosol, mitochondrial matrix

• (R)-3,4-dihydroxymandelaldehydeReach from here →
  1. (R)-S-Lactoylglutathione hydrolase
  2. transport of GSH and noradrenaline (cytosol to extracellular)
  3. (R)-noradrenaline + O2 + H2O = (R)-3,4-dihydroxymandelaldehyde + H2O2 + NH4(+)

  Catalysed by HAGH, HAGHL, SLCO1A2, SLCO1B3 and 2 morecytosol, extracellular space

• CHEBI:18183Reach from here →
  1. (R)-S-Lactoylglutathione hydrolase
  2. gamma-glutamyltransferase (alanine)
  3. gamma-glutamylcyclotransferase ((5-L-glutamyl)-L-amino acid)

  Catalysed by HAGH, HAGHL, GGT1, GGT5 and 6 morecytosol, extracellular space

• hydrogen cyanideReach from here →
  1. (R)-S-lactoylglutathione + H2O = (R)-lactate + glutathione + H(+)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. thiosulfate:cyanide sulfurtranserase

  Catalysed by HAGH, TSTD1, MPST, TSTmitochondrial matrixOne of 2 routes

• (R)-normetanephrineReach from here →
  1. (R)-S-Lactoylglutathione hydrolase
  2. transport of GSH and noradrenaline (cytosol to extracellular)
  3. S-Adenosyl-L-methionine:catechol O-methyltransferase

  Catalysed by HAGH, HAGHL, SLCO1A2, SLCO1B3 and 2 morecytosol, extracellular space

• glycodeoxycholate 3-sulfateReach from here →
  1. (R)-S-lactoylglutathione + H2O = (R)-lactate + glutathione + H(+)
  2. glycodeoxycholate(in) + glutathione(in) + ATP + H2O = glycodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
  3. glycodeoxycholate + 3'-phosphoadenylyl sulfate = glycodeoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by HAGH, ABCC4, SULT2A1inner side of the membrane, outer side of the membrane