taurocholate

Three steps

• CHEBI:15519Reach from here →
  1. solute carrier organic anion transporter (GSH)
  2. solute carrier organic anion transporter (cholate)
  3. Cholate:CoA ligase (AMP-forming)

  Catalysed by SLCO1A2, SLCO1B3, SLC27A2, SLC27A5extracellular space, cytosol, endoplasmic reticulum

• (S)-malateReach from here →
  1. taurocholate(in) + glutathione(in) + ATP + H2O = taurocholate(out) + glutathione(out) + ADP + phosphate + H(+)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. transport of malate and sulfite (cytosol to mitochondria)

  Catalysed by ABCC4, TSTD1, SLC25A10inner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 2 routes

• L-leucineReach from here →
  1. solute carrier organic anion transporter (GSH)
  2. cystine to cysteine conversion
  3. transport of cysteine and leucine (cytosol to extracellular)

  Catalysed by SLCO1A2, SLCO1B3, SLC7A9, SLC3A1extracellular space, cytosolOne of 3 routes

• 12(S)-HPETEReach from here →
  1. solute carrier organic anion transporter (GSH)
  2. transport of arachidonate and GSH (cytosol to extracellular)
  3. arachidonate:oxygen 12-oxidoreductase

  Catalysed by SLCO1A2, SLCO1B3, ALOX12extracellular space, cytosolOne of 4 routes

• 15(S)-HPETEReach from here →
  1. solute carrier organic anion transporter (GSH)
  2. Glutathione: 5-HPETE oxidoreductase
  3. Glutathione: 15-HPETE oxidoreductase

  Catalysed by SLCO1A2, SLCO1B3, GPX5, GPX1 and 7 moreextracellular space, cytosolOne of 7 routes

• 5(S)-HPETEReach from here →
  1. solute carrier organic anion transporter (GSH)
  2. transport of arachidonate and GSH (cytosol to extracellular)
  3. Arachidonate:oxygen 5-oxidoreductase

  Catalysed by SLCO1A2, SLCO1B3, ALOX5extracellular space, cytosol

• CHEBI:15699Reach from here →
  1. solute carrier organic anion transporter (GSH)
  2. cystine to cysteine conversion
  3. transport of cysteine and homoserine (cytosol to extracellular)

  Catalysed by SLCO1A2, SLCO1B3, SLC7A5extracellular space, cytosolOne of 3 routes

• formateReach from here →
  1. solute carrier organic anion transporter (GSH)
  2. alcohol dehydrogenase (formaldehyde)
  3. S-formylglutathione + H2O = formate + glutathione + H(+)

  Catalysed by SLCO1A2, SLCO1B3, ADH1C, ADH1A and 5 moreextracellular space, cytosol

• CHEBI:15971Reach from here →
  1. solute carrier organic anion transporter (GSH)
  2. cystine to cysteine conversion
  3. transport of cysteine and histidine (cytosol to extracellular)

  Catalysed by SLCO1A2, SLCO1B3, SLC7A6extracellular space, cytosolOne of 2 routes

• (R)-lactateReach from here →
  1. solute carrier organic anion transporter (GSH)
  2. (R)-S-Lactoylglutathione methylglyoxal-lyase (isomerizing)
  3. (R)-S-lactoylglutathione + H2O = (R)-lactate + glutathione + H(+)

  Catalysed by SLCO1A2, SLCO1B3, GLO1, GLOD4 and 1 moreextracellular space, cytosol

• methanethiolReach from here →
  1. taurocholate(in) + glutathione(in) + ATP + H2O = taurocholate(out) + glutathione(out) + ADP + phosphate + H(+)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. methanethiol + O2 + H2O = hydrogen sulfide + formaldehyde + H2O2 + H(+)

  Catalysed by ABCC4, TSTD1, SELENBP1inner side of the membrane, outer side of the membrane

• octan-1-olReach from here →
  1. solute carrier organic anion transporter (S-glutathionyl-2-4-dinitrobenzene)
  2. solute carrier organic anion transporter (chenodiol)
  3. octyl beta-D-glucose + chenodeoxycholate = beta-D-glucosyl-(1->3)-O-chenodeoxycholate + octan-1-ol

  Catalysed by SLCO1A2, SLCO1B3, GBA2extracellular space, cytosol

• sulfateReach from here →
  1. solute carrier organic anion transporter (GSH)
  2. transport of GSH and sulfoglycolithocholate (cytosol to extracellular)
  3. steroid sulfatase (sulfoglycolithocholate)

  Catalysed by SLCO1A2, SLCO1B3, STSextracellular space, cytosolOne of 13 routes

• ureaReach from here →
  1. taurocholate(in) + glutathione(in) + ATP + H2O = taurocholate(out) + glutathione(out) + ADP + phosphate + H(+)
  2. urate(out) + glutathione(in) = urate(in) + glutathione(out)
  3. Peroxidase

  Catalysed by ABCC4, SLC22A13, MPOinner side of the membrane, outer side of the membrane, nucleusOne of 3 routes

• dimethylarsinateReach from here →
  1. taurocholate(in) + glutathione(in) + ATP + H2O = taurocholate(out) + glutathione(out) + ADP + phosphate + H(+)
  2. methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O
  3. methylarsonous acid + S-adenosyl-L-methionine = dimethylarsinate + S-adenosyl-L-homocysteine + 2 H(+)

  Catalysed by ABCC4, GSTO1, GSTO2, HEMK2inner side of the membrane, outer side of the membrane

• L-cystineReach from here →
  1. solute carrier organic anion transporter (GSH)
  2. Glutathione: 5-HPETE oxidoreductase
  3. cystine to cysteine conversion

  Catalysed by SLCO1A2, SLCO1B3, GPX5, GPX1 and 7 moreextracellular space, cytosolOne of 5 routes

• L-citrullineReach from here →
  1. solute carrier organic anion transporter (GSH)
  2. cystine to cysteine conversion
  3. transport of citrulline and cysteine (cytosol to extracellular)

  Catalysed by SLCO1A2, SLCO1B3, SLC7A6extracellular space, cytosolOne of 2 routes

• iodideReach from here →
  1. solute carrier organic anion transporter (GSH)
  2. transport of GSH and thyroxine (cytosol to extracellular)
  3. 3,3',5-triiodo-L-thyronine,iodide:acceptor oxidoreductase (iodinating)

  Catalysed by SLCO1A2, SLCO1B3, DIO1, DIO2extracellular space, cytosolOne of 9 routes

• L-valineReach from here →
  1. solute carrier organic anion transporter (GSH)
  2. cystine to cysteine conversion
  3. transport of cysteine and valine (cytosol to extracellular)

  Catalysed by SLCO1A2, SLCO1B3, SLC7A5extracellular space, cytosolOne of 3 routes

• L-arginineReach from here →
  1. solute carrier organic anion transporter (GSH)
  2. cystine to cysteine conversion
  3. transport of arginine and cysteine (cytosol to extracellular)

  Catalysed by SLCO1A2, SLCO1B3, SLC7A6extracellular space, cytosolOne of 5 routes

• protein polypeptide chainReach from here →
  1. solute carrier organic anion transporter (GSH)
  2. cystine to cysteine conversion
  3. PROTEIN_BS

  Catalysed by SLCO1A2, SLCO1B3extracellular space, cytosol

• (S)-lactateReach from here →
  1. solute carrier organic anion transporter (GSH)
  2. transport of GSH and prostaglandin E2 (cytosol to extracellular)
  3. prostaglandin E2(out) + 2 (S)-lactate(in) = prostaglandin E2(in) + 2 (S)-lactate(out)

  Catalysed by SLCO1A2, SLCO1B3, SLCO2A1extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 15 routes

• taurochenodeoxycholate 3-sulfateReach from here →
  1. solute carrier organic anion transporter (GSH)
  2. solute carrier organic anion transporter (GSH)
  3. taurochenodeoxycholate + 3'-phosphoadenylyl sulfate = taurochenodeoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by SLCO1A2, SLCO1B3, SLC7A9, SULT2A1extracellular space, cytosol

• dopamine quinoneReach from here →
  1. solute carrier organic anion transporter (GSH)
  2. transport of dopamine and GSH (cytosol to extracellular)
  3. Peroxidase

  Catalysed by SLCO1A2, SLCO1B3, MPOextracellular space, cytosol, lysosomeOne of 4 routes

• formaldehydeReach from here →
  1. solute carrier organic anion transporter (GSH)
  2. alcohol dehydrogenase (formaldehyde)
  3. alcohol dehydrogenase (formaldehyde)

  Catalysed by SLCO1A2, SLCO1B3, ADH1C, ADH1A and 4 moreextracellular space, cytosol

• CHEBI:16857Reach from here →
  1. solute carrier organic anion transporter (GSH)
  2. cystine to cysteine conversion
  3. transport of cysteine and threonine (cytosol to extracellular)

  Catalysed by SLCO1A2, SLCO1B3, SLC7A5extracellular space, cytosolOne of 4 routes

• ferrocytochrome cReach from here →
  1. taurocholate(in) + glutathione(in) + ATP + H2O = taurocholate(out) + glutathione(out) + ADP + phosphate + H(+)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. sulfite:ferricytochrome-c oxidoreductase

  Catalysed by ABCC4, TSTD1, SUOXinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosol

• (R)-lactaldehydeReach from here →
  1. solute carrier organic anion transporter (GSH)
  2. (R)-S-Lactoylglutathione methylglyoxal-lyase (isomerizing)
  3. (R)-Lactaldehyde:NAD+ oxidoreductase (glutathione-formylating)

  Catalysed by SLCO1A2, SLCO1B3, GLO1, GLOD4 and 7 moreextracellular space, cytosol

• L-isoleucineReach from here →
  1. solute carrier organic anion transporter (GSH)
  2. cystine to cysteine conversion
  3. transport of cysteine and isoleucine (cytosol to extracellular)

  Catalysed by SLCO1A2, SLCO1B3, SLC7A5extracellular space, cytosolOne of 4 routes

• CHEBI:17203Reach from here →
  1. solute carrier organic anion transporter (GSH)
  2. cystine to cysteine conversion
  3. transport of cysteine and proline (cytosol to extracellular)

  Catalysed by SLCO1A2, SLCO1B3, SLC7A5extracellular space, cytosolOne of 3 routes

• dehydroascorbic acidReach from here →
  1. solute carrier organic anion transporter (GSH)
  2. transport of dopamine and GSH (cytosol to extracellular)
  3. dopamine,ascorbate:oxygen oxidoreductase (beta-hydroxylating)

  Catalysed by SLCO1A2, SLCO1B3, DBHextracellular space, cytosolOne of 19 routes

• estroneReach from here →
  1. solute carrier organic anion transporter (S-glutathionyl-2-4-dinitrobenzene)
  2. transport of estrone 3-sulfate (cytosol to extracellular)
  3. Estrone 3-sulfate sulfohydrolase

  Catalysed by SLCO1A2, SLCO1B3, SLCO1B1, STSextracellular space, cytosolOne of 3 routes

• propanoateReach from here →
  1. solute carrier organic anion transporter (S-glutathionyl-2-4-dinitrobenzene)
  2. transport of estrone 3-sulfate (cytosol to extracellular)
  3. propanoate(in) + estrone 3-sulfate(out) = propanoate(out) + estrone 3-sulfate(in)

  Catalysed by SLCO1A2, SLCO1B3, SLCO1B1, SLC22A9extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• O-hexadecanoyl-(R)-carnitineReach from here →
  1. taurocholate(out) + glutarate(in) = taurocholate(in) + glutarate(out)
  2. glutarate(in) + (R)-carnitine(out) = glutarate(out) + (R)-carnitine(in)
  3. (R)-carnitine + hexadecanoyl-CoA = O-hexadecanoyl-(R)-carnitine + CoA

  Catalysed by SLC22A24, SLC22A8, CPT2, CPT1A and 1 moreinner side of the membrane, outer side of the membraneOne of 3 routes

• 3,3',5-triiodo-L-thyronine sulfateReach from here →
  1. solute carrier organic anion transporter (GSH)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. aryl sulfotransferase (PAPS)

  Catalysed by SLCO1A2, SLCO1B3, SULT1A3, SULT1A4 and 2 moreextracellular space, cytosolOne of 2 routes

• L-thyroxine sulfateReach from here →
  1. solute carrier organic anion transporter (GSH)
  2. transport of GSH and thyroxine (cytosol to extracellular)
  3. L-thyroxine + 3'-phosphoadenylyl sulfate = L-thyroxine sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by SLCO1A2, SLCO1B3, SULT1A3, SULT1A4 and 1 moreextracellular space, cytosol

• 3,3'-diiodo-L-thyronineReach from here →
  1. solute carrier organic anion transporter (GSH)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)

  Catalysed by SLCO1A2, SLCO1B3, DIO1, DIO3 and 1 moreextracellular space, cytosolOne of 3 routes

• N-acetylserotoninReach from here →
  1. solute carrier organic anion transporter (GSH)
  2. transport of GSH and serotonin (cytosol to extracellular)
  3. acetyl-CoA:aralkylamine N-acetyltransferase

  Catalysed by SLCO1A2, SLCO1B3, AANATextracellular space, cytosol

• xanthineReach from here →
  1. taurocholate(in) + glutathione(in) + ATP + H2O = taurocholate(out) + glutathione(out) + ADP + phosphate + H(+)
  2. urate(out) + glutathione(in) = urate(in) + glutathione(out)
  3. xanthine + NAD(+) + H2O = urate + NADH + H(+)

  Catalysed by ABCC4, SLC22A13, XDHinner side of the membrane, outer side of the membraneOne of 2 routes

• CHEBI:17724Reach from here →
  1. solute carrier organic anion transporter (GSH)
  2. Formation of Homocystine
  3. Trimethylaminoacetate:L-homosysteine S-methyltransferase

  Catalysed by SLCO1A2, SLCO1B3, BHMT, BHMT2extracellular space, cytosol

• glycine betaineReach from here →
  1. taurocholate(out) + glutarate(in) = taurocholate(in) + glutarate(out)
  2. glutarate(in) + (R)-carnitine(out) = glutarate(out) + (R)-carnitine(in)
  3. glycine betaine(out) + (R)-carnitine(in) = glycine betaine(in) + (R)-carnitine(out)

  Catalysed by SLC22A24, SLC22A8, SLC22A5inner side of the membrane, outer side of the membraneOne of 2 routes

• 5-hydroxy-L-tryptophanReach from here →
  1. solute carrier organic anion transporter (GSH)
  2. transport of GSH and serotonin (cytosol to extracellular)
  3. 5-hydroxy-L-tryptophan + H(+) = serotonin + CO2

  Catalysed by SLCO1A2, SLCO1B3, DDCextracellular space, cytosol

• prostaglandin F1Reach from here →
  1. solute carrier organic anion transporter (GSH)
  2. transport of GSH and prostaglandin E1 (cytosol to extracellular)
  3. prostaglandin E1 + NADPH + H(+) = prostaglandin F1 + NADP(+)

  Catalysed by SLCO1A2, SLCO1B3, SLCO2A1, DHRS1extracellular space, cytosol

• 17beta-estradiol 17-O-(3-sulfo-beta-D-glucuronate)Reach from here →
  1. taurocholate(out) + glutarate(in) = taurocholate(in) + glutarate(out)
  2. 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + glutarate(in) = 17beta-estradiol 17-O-(beta-D-glucuronate)(in) + glutarate(out)
  3. 17beta-estradiol 17-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate = 17beta-estradiol 17-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by SLC22A24, SLC22A8, CHST10inner side of the membrane, outer side of the membrane

• CHEBI:17895Reach from here →
  1. solute carrier organic anion transporter (GSH)
  2. cystine to cysteine conversion
  3. transport of cysteine and tyrosine (cytosol to extracellular)

  Catalysed by SLCO1A2, SLCO1B3, SLC7A5extracellular space, cytosolOne of 4 routes

• butanoateReach from here →
  1. solute carrier organic anion transporter (S-glutathionyl-2-4-dinitrobenzene)
  2. transport of estrone 3-sulfate (cytosol to extracellular)
  3. butanoate(out) + estrone 3-sulfate(in) = butanoate(in) + estrone 3-sulfate(out)

  Catalysed by SLCO1A2, SLCO1B3, SLCO1B1, SLC22A9extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• fumaric acidReach from here →
  1. taurocholate(in) + glutathione(in) + ATP + H2O = taurocholate(out) + glutathione(out) + ADP + phosphate + H(+)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. transport of fumarate and sulfite (cytosol to mitochondria)

  Catalysed by ABCC4, TSTD1, SLC25A10inner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 2 routes

• CHEBI:18019Reach from here →
  1. solute carrier organic anion transporter (GSH)
  2. cystine to cysteine conversion
  3. transport of cysteine and lysine (cytosol to extracellular)

  Catalysed by SLCO1A2, SLCO1B3, SLC7A6extracellular space, cytosolOne of 2 routes

• L-glutamineReach from here →
  1. solute carrier organic anion transporter (GSH)
  2. cystine to cysteine conversion
  3. transport of cysteine and glutamine (cytosol to extracellular)

  Catalysed by SLCO1A2, SLCO1B3, SLC3A2, SLC7A5 and 1 moreextracellular space, cytosolOne of 4 routes

• 5-hydroxyisourateReach from here →
  1. taurocholate(in) + glutathione(in) + ATP + H2O = taurocholate(out) + glutathione(out) + ADP + phosphate + H(+)
  2. urate(out) + glutathione(in) = urate(in) + glutathione(out)
  3. urate:oxygen oxidoreductase

  Catalysed by ABCC4, SLC22A13inner side of the membrane, outer side of the membrane, cytosol