D-aspartate

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

303 compounds within 3 steps: 3 in 1, 39 in 2, 261 in 3

Three steps

glyoxylic acidReach from here →
1. D-aspartate + O2 + H2O = oxaloacetate + H2O2 + NH4(+)
2. D-aspartate:2-oxoglutarate aminotransferase
3. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
Catalysed by DDO, GOT2, HOGA1mitochondrial matrix
ferrocytochrome cReach from here →
1. D-aspartate(in) + sulfate(out) = D-aspartate(out) + sulfate(in)
2. sulfite(in) + sulfate(out) = sulfite(out) + sulfate(in)
3. sulfite:ferricytochrome-c oxidoreductase
Catalysed by SLC25A14, SLC25A30, SUOXinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosol
N-acetyl-L-aspartateReach from here →
1. D-aspartate + O2 + H2O = oxaloacetate + H2O2 + NH4(+)
2. L-Aspartate:2-oxoglutarate aminotransferase
3. acetyl-CoA:L-aspartate N-acetyltransferase
Catalysed by DDO, GOT2, NAT8Lmitochondrial matrixOne of 2 routes
(R)-3-hydroxybutyric acidReach from here →
1. D-aspartate + O2 + H2O = oxaloacetate + H2O2 + NH4(+)
2. Oxaloacetate Decarboxylase
3. transport of (R)-3-hydroxybutanoate and pyruvate (cytosol to extracellular)
Catalysed by DDO, FAHD1, SLC16A4, SLC16A5 and 4 morecytosol, extracellular spaceOne of 2 routes
3-hydroxypyruvateReach from here →
1. D-aspartate + O2 + H2O = oxaloacetate + H2O2 + NH4(+)
2. Oxaloacetate Decarboxylase
3. L-serine + pyruvate = 3-hydroxypyruvate + L-alanine
Catalysed by DDO, FAHD1, AGXTcytosol
L-isoleucineReach from here →
1. D-aspartate(out) + K(+)(in) + 3 Na(+)(out) + H(+)(out) = D-aspartate(in) + K(+)(out) + 3 Na(+)(in) + H(+)(in)
2. K(+)(in) + L-cysteine(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-cysteine(in) + 3 Na(+)(in) + H(+)(in)
3. transport of cysteine and isoleucine (cytosol to extracellular)
Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 2 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 6 routes
CHEBI:17203Reach from here →
1. D-aspartate + O2 + H2O = oxaloacetate + H2O2 + NH4(+)
2. L-Aspartate:2-oxoglutarate aminotransferase
3. Aspartate Intake by System Asct-1 Transporter
Catalysed by DDO, GOT2mitochondrial matrix, extracellular space, cytosolOne of 6 routes
estroneReach from here →
1. D-aspartate(in) + sulfate(out) = D-aspartate(out) + sulfate(in)
2. estrone 3-sulfate + H2O = estrone + sulfate + H(+)
3. Estrone 3-sulfate sulfohydrolase
Catalysed by SLC25A14, SLC25A30, STSinner side of the membrane, outer side of the membrane, cytosolOne of 3 routes
propanoateReach from here →
1. D-aspartate(in) + sulfate(out) = D-aspartate(out) + sulfate(in)
2. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)
3. propanoate(out) + dehydroepiandrosterone 3-sulfate(in) = propanoate(in) + dehydroepiandrosterone 3-sulfate(out)
Catalysed by SLC25A14, SLC25A30, STS, SLC22A9inner side of the membrane, outer side of the membraneOne of 4 routes
anilineReach from here →
1. D-aspartate + O2 + H2O = oxaloacetate + H2O2 + NH4(+)
2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
3. Acetyl-CoA:arylamine N-acetyltransferase
Catalysed by DDO, CS, NAT2, NAT1mitochondrial matrix, cytosol
aceneuramateReach from here →
1. D-aspartate + O2 + H2O = oxaloacetate + H2O2 + NH4(+)
2. Oxaloacetate Decarboxylase
3. aceneuramate = aldehydo-N-acetyl-D-mannosamine + pyruvate
Catalysed by DDO, FAHD1, NPLcytosol
CHEBI:17312Reach from here →
1. D-aspartate + O2 + H2O = oxaloacetate + H2O2 + NH4(+)
2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
3. N1,N12-diacetylspermine to N1-acetylspermine conversion
Catalysed by DDO, CSmitochondrial matrix, cytosolOne of 2 routes
5'-deoxyadenosineReach from here →
1. D-aspartate + O2 + H2O = oxaloacetate + H2O2 + NH4(+)
2. Oxaloacetate Decarboxylase
3. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O
Catalysed by DDO, FAHD1, TYW1B, TYW1cytosol
enol-oxaloacetateReach from here →
1. D-aspartate + O2 + H2O = oxaloacetate + H2O2 + NH4(+)
2. transport of malate and OAA (cytosol to mitochondria)
3. (S)-malate + a quinone = enol-oxaloacetate + a quinol
Catalysed by DDO, SDHB, SDHAmitochondrial matrix, cytosol
3,3'-diiodo-L-thyronineReach from here →
1. D-aspartate(in) + sulfate(out) = D-aspartate(out) + sulfate(in)
2. Steryl-Sulfatase
3. Steryl-Sulfatase
Catalysed by SLC25A14, SLC25A30, STSinner side of the membrane, outer side of the membrane, Golgi apparatusOne of 3 routes
N-acetylserotoninReach from here →
1. D-aspartate(out) + K(+)(in) + 3 Na(+)(out) + H(+)(out) = D-aspartate(in) + K(+)(out) + 3 Na(+)(in) + H(+)(in)
2. serotonin(out) + K(+)(in) + Na(+)(out) + H(+)(in) = serotonin(in) + K(+)(out) + Na(+)(in) + H(+)(out)
3. acetyl-CoA:aralkylamine N-acetyltransferase
Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 3 moreinner side of the membrane, outer side of the membrane, cytosol
(7Z,10Z,13Z)-hexadecatrienoyl-CoAReach from here →
1. D-aspartate + O2 + H2O = oxaloacetate + H2O2 + NH4(+)
2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
3. Fatty Acid Beta Oxidation (C18:3->C16:3), Mitochondrial
Catalysed by DDO, CS, HADHA, ACADVL and 1 moremitochondrial matrix
glycine betaineReach from here →
1. D-aspartate(in) + sulfate(out) = D-aspartate(out) + sulfate(in)
2. transport of chloride and sulfate (cytosol to extracellular)
3. transport of betaine and chloride (cytosol to extracellular)
Catalysed by SLC25A14, SLC25A30, SLC26A6, SLC6A12inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 3 routes
urateReach from here →
1. D-aspartate(in) + sulfate(out) = D-aspartate(out) + sulfate(in)
2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
3. urate(out) + a dicarboxylate(in) = urate(in) + a dicarboxylate(out)
Catalysed by SLC25A14, SLC25A30, SLC25A35, SLC25A34 and 1 moreinner side of the membrane, outer side of the membraneOne of 2 routes
5-hydroxy-L-tryptophanReach from here →
1. D-aspartate(out) + K(+)(in) + 3 Na(+)(out) + H(+)(out) = D-aspartate(in) + K(+)(out) + 3 Na(+)(in) + H(+)(in)
2. serotonin(out) + K(+)(in) + Na(+)(out) + H(+)(in) = serotonin(in) + K(+)(out) + Na(+)(in) + H(+)(out)
3. 5-hydroxy-L-tryptophan + H(+) = serotonin + CO2
Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 3 moreinner side of the membrane, outer side of the membrane
CHEBI:17895Reach from here →
1. D-aspartate(out) + K(+)(in) + 3 Na(+)(out) + H(+)(out) = D-aspartate(in) + K(+)(out) + 3 Na(+)(in) + H(+)(in)
2. K(+)(in) + L-cysteine(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-cysteine(in) + 3 Na(+)(in) + H(+)(in)
3. transport of cysteine and tyrosine (cytosol to extracellular)
Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 2 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 6 routes
CHEBI:17927Reach from here →
1. D-aspartate + O2 + H2O = oxaloacetate + H2O2 + NH4(+)
2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
3. N1,N8-diacetylspermidine to N1-acetylspermidine conversion
Catalysed by DDO, CSmitochondrial matrix, cytosol
butanoateReach from here →
1. D-aspartate(in) + sulfate(out) = D-aspartate(out) + sulfate(in)
2. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)
3. dehydroepiandrosterone 3-sulfate(in) + butanoate(out) = dehydroepiandrosterone 3-sulfate(out) + butanoate(in)
Catalysed by SLC25A14, SLC25A30, STS, SLC22A9inner side of the membrane, outer side of the membraneOne of 4 routes
CHEBI:18019Reach from here →
1. D-aspartate(out) + K(+)(in) + 3 Na(+)(out) + H(+)(out) = D-aspartate(in) + K(+)(out) + 3 Na(+)(in) + H(+)(in)
2. K(+)(in) + L-cysteine(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-cysteine(in) + 3 Na(+)(in) + H(+)(in)
3. transport of cysteine and lysine (cytosol to extracellular)
Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 2 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 3 routes
thiocyanateReach from here →
1. D-aspartate(in) + sulfate(out) = D-aspartate(out) + sulfate(in)
2. thiosulfate(in) + sulfate(out) = thiosulfate(out) + sulfate(in)
3. thiosulfate:cyanide sulfurtranserase
Catalysed by SLC25A14, SLC25A30, SLC26A1, SLC25A10 and 2 moreinner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 2 routes
4-fumarylacetoacetateReach from here →
1. D-aspartate(in) + sulfate(out) = D-aspartate(out) + sulfate(in)
2. transport of fumarate and sulfate (cytosol to mitochondria)
3. 4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)
Catalysed by SLC25A14, SLC25A30, SLC25A10, FAHinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosol
L-glutamineReach from here →
1. D-aspartate + O2 + H2O = oxaloacetate + H2O2 + NH4(+)
2. L-Aspartate:2-oxoglutarate aminotransferase
3. L-aspartate(in) + L-glutamine(out) = L-aspartate(out) + L-glutamine(in)
Catalysed by DDO, GOT2, SLC7A13mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 7 routes
dTDPReach from here →
1. D-aspartate + O2 + H2O = oxaloacetate + H2O2 + NH4(+)
2. Oxaloacetate Decarboxylase
3. pyruvate kinase (dTDP)
Catalysed by DDO, FAHD1, PKM, PKLRcytosol
dTTPReach from here →
1. D-aspartate + O2 + H2O = oxaloacetate + H2O2 + NH4(+)
2. GTP:oxaloacetate carboxy-lyase (adding GTP
3. pyruvate kinase (dTDP)
Catalysed by DDO, PCK1, PKM, PKLRcytosol
CHEBI:18095Reach from here →
1. D-aspartate(in) + sulfate(out) = D-aspartate(out) + sulfate(in)
2. transport of chloride and sulfate (cytosol to extracellular)
3. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
Catalysed by SLC25A14, SLC25A30, SLC26A6, CLTRN and 1 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosol
N-carbamoyl-beta-alanineReach from here →
1. D-aspartate(in) + sulfate(out) = D-aspartate(out) + sulfate(in)
2. transport of chloride and sulfate (cytosol to extracellular)
3. Transport of 3-Ureidopropionate
Catalysed by SLC25A14, SLC25A30, SLC26A6inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes
hydrogen cyanideReach from here →
1. D-aspartate(in) + sulfate(out) = D-aspartate(out) + sulfate(in)
2. sulfite(in) + sulfate(out) = sulfite(out) + sulfate(in)
3. thiosulfate:cyanide sulfurtranserase
Catalysed by SLC25A14, SLC25A30, MPST, TSTinner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 2 routes
3-carboxy-4-methyl-5-propyl-2-furanpropanoateReach from here →
1. D-aspartate(in) + sulfate(out) = D-aspartate(out) + sulfate(in)
2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
3. 3-carboxy-4-methyl-5-propyl-2-furanpropanoate(out) + a dicarboxylate(in) = 3-carboxy-4-methyl-5-propyl-2-furanpropanoate(in) + a dicarboxylate(out)
Catalysed by SLC25A14, SLC25A30, SLC25A35, SLC25A34 and 2 moreinner side of the membrane, outer side of the membraneOne of 2 routes
L-sepiapterinReach from here →
1. D-aspartate(in) + sulfate(out) = D-aspartate(out) + sulfate(in)
2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
3. L-sepiapterin(out) + a dicarboxylate(in) = L-sepiapterin(in) + a dicarboxylate(out)
Catalysed by SLC25A14, SLC25A30, SLC25A35, SLC25A34 and 2 moreinner side of the membrane, outer side of the membraneOne of 2 routes
5-(3,3'-dimethylguanidino)-2-oxopentanoateReach from here →
1. D-aspartate + O2 + H2O = oxaloacetate + H2O2 + NH4(+)
2. Oxaloacetate Decarboxylase
3. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
Catalysed by DDO, FAHD1, AGXT2cytosol
5-(3-methylguanidino)-2-oxopentanoateReach from here →
1. D-aspartate + O2 + H2O = oxaloacetate + H2O2 + NH4(+)
2. Oxaloacetate Decarboxylase
3. N(omega)-methyl-L-arginine + pyruvate = 5-(3-methylguanidino)-2-oxopentanoate + L-alanine
Catalysed by DDO, FAHD1, AGXT2cytosol
S-disulfanyl-L-cysteineReach from here →
1. D-aspartate(out) + K(+)(in) + 3 Na(+)(out) + H(+)(out) = D-aspartate(in) + K(+)(out) + 3 Na(+)(in) + H(+)(in)
2. K(+)(in) + L-cysteine(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-cysteine(in) + 3 Na(+)(in) + H(+)(in)
3. S-sulfanyl-L-cysteine + L-cysteine = S-disulfanyl-L-cysteine + L-alanine
Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 2 moreinner side of the membrane, outer side of the membrane
(5Z)-dodecenoyl-CoAReach from here →
1. D-aspartate + O2 + H2O = oxaloacetate + H2O2 + NH4(+)
2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
3. acetyl-CoA C-acyltransferase (3-oxomyrist-7-enoyl-CoA)
Catalysed by DDO, CS, HADHA, ACAA2 and 1 moremitochondrial matrixOne of 2 routes
N-acetylneuraminate 9-phosphateReach from here →
1. D-aspartate + O2 + H2O = oxaloacetate + H2O2 + NH4(+)
2. GTP:oxaloacetate carboxy-lyase (adding GTP
3. N-acetylneuraminate synthase
Catalysed by DDO, PCK1, NANScytosolOne of 2 routes
(11Z)-docosenoyl-CoA(4-)Reach from here →
1. D-aspartate + O2 + H2O = oxaloacetate + H2O2 + NH4(+)
2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
3. long-chain-fatty-acid-CoA ligase (cis-cetoleic acid)
Catalysed by DDO, CS, SLC27A2, ACSL4 and 6 moremitochondrial matrix, cytosolOne of 5 routes
(7Z)-tetradecenoyl-CoAReach from here →
1. D-aspartate + O2 + H2O = oxaloacetate + H2O2 + NH4(+)
2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
3. long-chain-fatty-acid-CoA ligase ((7Z)-tetradecenoic acid)
Catalysed by DDO, CS, SLC27A2, ACSL4 and 6 moremitochondrial matrix, cytosolOne of 8 routes
serotonin O-sulfateReach from here →
1. D-aspartate(out) + K(+)(in) + 3 Na(+)(out) + H(+)(out) = D-aspartate(in) + K(+)(out) + 3 Na(+)(in) + H(+)(in)
2. serotonin(out) + K(+)(in) + Na(+)(out) + H(+)(in) = serotonin(in) + K(+)(out) + Na(+)(in) + H(+)(out)
3. serotonin + 3'-phosphoadenylyl sulfate = serotonin O-sulfate + adenosine 3',5'-bisphosphate + H(+)
Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 4 moreinner side of the membrane, outer side of the membrane
(4Z,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →
1. D-aspartate + O2 + H2O = oxaloacetate + H2O2 + NH4(+)
2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
3. Fatty Acid Beta Oxidation (C18:4->C16:4), Mitochondrial
Catalysed by DDO, CS, HADHA, ACADVL and 1 moremitochondrial matrixOne of 3 routes
(7Z,10Z)-hexadecadienoyl-CoAReach from here →
1. D-aspartate + O2 + H2O = oxaloacetate + H2O2 + NH4(+)
2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
3. Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial
Catalysed by DDO, CS, HADHA, ACADVL and 1 moremitochondrial matrix
(4Z,7Z)-decadienoyl-CoAReach from here →
1. D-aspartate + O2 + H2O = oxaloacetate + H2O2 + NH4(+)
2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
3. Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial
Catalysed by DDO, CS, ECHS1, ACAA2 and 1 moremitochondrial matrixOne of 2 routes
(5Z)-octenoyl-CoAReach from here →
1. D-aspartate + O2 + H2O = oxaloacetate + H2O2 + NH4(+)
2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
3. Fatty Acid Beta Oxidation (C10:2->C8:1), Mitochondrial
Catalysed by DDO, CS, ECHS1, ACAA2 and 1 moremitochondrial matrixOne of 2 routes
CHEBI:240943Reach from here →
1. D-aspartate(in) + sulfate(out) = D-aspartate(out) + sulfate(in)
2. transport of chloride and sulfate (cytosol to extracellular)
3. 2-Methylbutyrylglycine Transport, Extracellular
Catalysed by SLC25A14, SLC25A30, SLC26A6, SLC6A5inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes
a quinolReach from here →
1. D-aspartate + O2 + H2O = oxaloacetate + H2O2 + NH4(+)
2. transport of malate and OAA (cytosol to mitochondria)
3. (S)-malate + a quinone = enol-oxaloacetate + a quinol
Catalysed by DDO, SDHB, SDHAmitochondrial matrix, cytosol
hypochlorous acidReach from here →
1. D-aspartate(in) + sulfate(out) = D-aspartate(out) + sulfate(in)
2. transport of chloride and sulfate (cytosol to extracellular)
3. Peroxidase
Catalysed by SLC25A14, SLC25A30, SLC26A6, LPOinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 4 routes
potassium atomReach from here →
1. D-aspartate + O2 + H2O = oxaloacetate + H2O2 + NH4(+)
2. L-Aspartate:2-oxoglutarate aminotransferase
3. transport of aspartate (cytosol to extracellular)
Catalysed by DDO, GOT2, SLC1A7, SLC1A3 and 3 moremitochondrial matrix, extracellular space, cytosolOne of 5 routes