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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Proteins/UNIPROT:O75310

UGT2B11

Protein·UNIPROT:O75310UDP-glucuronosyltransferase 2B11

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UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile. Exhibits narrow substrate specificity and very low catalytic activity compared to other UGT2B subfamily members. Preferentially glucuronidates catechol estrogens. Also conjugates estriol and 3alpha-hydroxysteroids with activities 30-90 fold lower than UGT2B7. Shows no activity toward testosterone, hyodeoxycholic acid or most drugs. Physiological role remains unclear due to limited substrate range and low catalytic efficiency..

Function from UniProtKB (O75310), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

21 statements

21 statements · 4 reference databases · Subject: UGT2B11 · Sources: Human-GEM, Reactome, Rhea, WikiPathways

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17beta-estradiol is metabolised by UGT2B11CompoundHuman-GEM MAR07648Inferred only
3,3'-diiodo-L-thyronine is metabolised by UGT2B11CompoundHuman-GEM MAR06828Inferred only
3,3'-diiodo-L-thyronine is metabolised by UGT2B11CompoundHuman-GEM MAR06830Inferred only
3,3',5-triiodo-L-thyronine is metabolised by UGT2B11CompoundHuman-GEM MAR06799Inferred only
3,3',5-triiodo-L-thyronine is metabolised by UGT2B11CompoundHuman-GEM MAR06798Inferred only
a beta-D-glucuronoside is metabolised by UGT2B11CompoundRhea RHEA:63692Inferred only
alcohol glucuronate acceptor is metabolised by UGT2B11CompoundRhea RHEA:63692Inferred only
all-trans-4-hydroxyretinoate is metabolised by UGT2B11CompoundHuman-GEM MAR06705Inferred only
all-trans-4-hydroxyretinoate is metabolised by UGT2B11CompoundHuman-GEM MAR06704Inferred only
bilirubin IXalpha is metabolised by UGT2B11CompoundHuman-GEM MAR04766Inferred only
glucuronate acceptor is metabolised by UGT2B11CompoundRhea RHEA:21032Inferred only
L-thyroxine is metabolised by UGT2B11CompoundHuman-GEM MAR06800Inferred only

Show the remaining 9

L-thyroxine is metabolised by UGT2B11CompoundHuman-GEM MAR06801Inferred only
UGT2B11 participates in Aspirin ADMEPathwayReactome R-HSA-9749641Inferred only
UGT2B11 participates in Biological oxidationsPathwayReactome R-HSA-211859Inferred only
UGT2B11 participates in Drug ADMEPathwayReactome R-HSA-9748784Inferred only
UGT2B11 participates in GlucuronidationPathwayWikiPathways WP698Inferred only
UGT2B11 participates in GlucuronidationPathwayReactome R-HSA-156588Inferred only
UGT2B11 participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
UGT2B11 participates in Metapathway biotransformation Phase I and IIPathwayWikiPathways WP702Inferred only
UGT2B11 participates in Phase II - Conjugation of compoundsPathwayReactome R-HSA-156580Inferred only

Reactions

46 reactions

MAM01220c+UDP-alpha-D-glucuronateMAM01240c+proton+UDP
Catalysed by UGT2B10 or UGT2A3 or UGT2B28 or UGT3A1 or UGT2B4 or UGT1A6 or UGT3A2 or UGT2B7 or UGT2A1 or UGT2B15 or UGT2B17 or UGT2B11 and 8 more alternatives
Reaction page

Other names

1 name

Resolves to: UGT2B11

Also called: UDPGT 2B11

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Reversible

Balanced

EC 2.4.1.17

cytosol

Human-GEM MAR02461CC BY 4.0Reference data

MAM01220r+UDP-alpha-D-glucuronateMAM01240r+proton+UDP

Catalysed by UGT2B10 or UGT2A3 or UGT2B28 or UGT3A1 or UGT2B4 or UGT1A6 or UGT3A2 or UGT2B7 or UGT2A1 or UGT2B15 or UGT2B17 or UGT2B11 and 8 more alternatives

Reaction pageLeft to rightBalancedEC 2.4.1.17endoplasmic reticulum

Human-GEM MAR02462CC BY 4.0Reference data

MAM00274c+proton+UDPMAM01220c+UDP-alpha-D-glucuronate

Catalysed by UGT2B10 or UGT2A3 or UGT2B28 or UGT3A1 or UGT2B4 or UGT1A6 or UGT3A2 or UGT2B7 or UGT2A1 or UGT2B15 or UGT2B17 or UGT2B11 and 8 more alternatives

Reaction pageReversibleBalancedEC 2.4.1.17cytosol

Human-GEM MAR02463CC BY 4.0Reference data

MAM01220r+UDP-alpha-D-glucuronateMAM00274r+proton+UDP

Catalysed by UGT2B10 or UGT2A3 or UGT2B28 or UGT3A1 or UGT2B4 or UGT1A6 or UGT3A2 or UGT2B7 or UGT2A1 or UGT2B15 or UGT2B17 or UGT2B11 and 8 more alternatives

Reaction pageLeft to rightBalancedEC 2.4.1.17endoplasmic reticulum

Human-GEM MAR02464CC BY 4.0Reference data

MAM00314c+UDP-alpha-D-glucuronateMAM00323c+proton+UDP

Catalysed by UGT2B10 or UGT2A3 or UGT2B28 or UGT3A1 or UGT2B4 or UGT1A6 or UGT3A2 or UGT2B7 or UGT2A1 or UGT2B15 or UGT2B17 or UGT2B11 and 8 more alternatives

Reaction pageReversibleBalancedEC 2.4.1.17cytosol

Human-GEM MAR02467CC BY 4.0Reference data

MAM00314r+UDP-alpha-D-glucuronateMAM00323r+proton+UDP

Catalysed by UGT2B10 or UGT2A3 or UGT2B28 or UGT3A1 or UGT2B4 or UGT1A6 or UGT3A2 or UGT2B7 or UGT2A1 or UGT2B15 or UGT2B17 or UGT2B11 and 8 more alternatives

Reaction pageLeft to rightBalancedEC 2.4.1.17endoplasmic reticulum

Human-GEM MAR02468CC BY 4.0Reference data

MAM00314c+UDP-alpha-D-glucuronateMAM00327c+proton+UDP

Catalysed by UGT2B10 or UGT2A3 or UGT2B28 or UGT3A1 or UGT2B4 or UGT1A6 or UGT3A2 or UGT2B7 or UGT2A1 or UGT2B15 or UGT2B17 or UGT2B11 and 8 more alternatives

Reaction pageReversibleBalancedEC 2.4.1.17cytosol

Human-GEM MAR02469CC BY 4.0Reference data

MAM00314r+UDP-alpha-D-glucuronateMAM00327r+proton+UDP

Catalysed by UGT2B10 or UGT2A3 or UGT2B28 or UGT3A1 or UGT2B4 or UGT1A6 or UGT3A2 or UGT2B7 or UGT2A1 or UGT2B15 or UGT2B17 or UGT2B11 and 8 more alternatives

Reaction pageLeft to rightBalancedEC 2.4.1.17endoplasmic reticulum

Human-GEM MAR02470CC BY 4.0Reference data

UDP-alpha-D-glucuronate+MAM03337rproton+UDP+MAM03341r

Catalysed by UGT2B10 or UGT2B28 or UGT2B4 or UGT1A6 or UGT2B7 or UGT2B15 or UGT2B17 or UGT2B11 or UGT1A5 or UGT1A9 or UGT1A1 or UGT1A10 and 3 more alternatives

Reaction pageLeft to rightBalancedEC 2.4.1.17endoplasmic reticulum

Human-GEM MAR02617CC BY 4.0Reference data

UDP-alpha-D-glucuronate+MAM03338rproton+UDP+MAM03342r

Catalysed by UGT2B10 or UGT2B28 or UGT2B4 or UGT1A6 or UGT2B7 or UGT2B15 or UGT2B17 or UGT2B11 or UGT1A5 or UGT1A9 or UGT1A1 or UGT1A10 and 3 more alternatives

Reaction pageLeft to rightBalancedEC 2.4.1.17endoplasmic reticulum

Human-GEM MAR02627CC BY 4.0Reference data

UDP-alpha-D-glucuronate+MAM03339rproton+UDP+MAM03343r

Catalysed by UGT2B10 or UGT2B28 or UGT2B4 or UGT1A6 or UGT2B7 or UGT2B15 or UGT2B17 or UGT2B11 or UGT1A5 or UGT1A9 or UGT1A1 or UGT1A10 and 3 more alternatives

Reaction pageLeft to rightBalancedEC 2.4.1.17endoplasmic reticulum

Human-GEM MAR02631CC BY 4.0Reference data

UDP-alpha-D-glucuronate+MAM03340rproton+UDP+MAM03344r

Catalysed by UGT2B10 or UGT2B28 or UGT2B4 or UGT1A6 or UGT2B7 or UGT2B15 or UGT2B17 or UGT2B11 or UGT1A5 or UGT1A9 or UGT1A1 or UGT1A10 and 3 more alternatives

Reaction pageLeft to rightBalancedEC 2.4.1.17endoplasmic reticulum

Human-GEM MAR02637CC BY 4.0Reference data

Show the remaining 34