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Proteins/UNIPROT:O75897
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of phenolic compounds. Can also sulfonate estrogenic compounds, however, the dietary flavonoids (phytoestrogen) and environmental estrogens, like bisphenol A are better substrates than 17beta-estradiol (E2). Mediates the sulfation of doxorubicin and its analog epirubicin, two antitumor anthracyclines..
Function from UniProtKB (O75897), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · metabolized by
1 compound
1 compound.
0 reported routes1 assembled route
12 statements
12 statements · 4 reference databases · Subject: SULT1C4 · Sources: Human-GEM, Reactome, Rhea, WikiPathways
4 reactions
3,3'-diiodo-L-thyronine+3'-phospho-5'-adenylyl sulfate3,3'-diiodo-L-thyronine sulfate+proton+adenosine 3',5'-bismonophosphate
Catalysed by NDST1 or UST or CHST10 or SULT4A1 or CHST7 or HS2ST1 or CHST9 or GAL3ST2 or NDST3 or SULT1B1 or HS6ST3 or GAL3ST4
4 names
Resolves to: SULT1C4
Reaction pageLeft to rightBalancedEC 2.8.2.-cytosol
Human-GEM MAR06829CC BY 4.0Reference data
a phenol+3'-phosphoadenylyl sulfatean aryl sulfate+adenosine 3',5'-bisphosphate+hydron
Catalysed by SULT1C2 or SULT1B1 or SULT1C4 or SULT1A3 or SULT1A4 or SULT1A1 or SULT1A2 or SULT1C3
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:12164CC BY 4.0Reference data
17beta-estradiol+3'-phosphoadenylyl sulfate17beta-estradiol 3-sulfate+adenosine 3',5'-bisphosphate+hydron
Catalysed by SULT1C4 or SULT1E1 or SULT1A1
Reaction pageLeft to rightBalanced
Rhea RHEA:52372CC BY 4.0Reference data
bisphenol A+3'-phosphoadenylyl sulfatebisphenyl A sulfate+adenosine 3',5'-bisphosphate+hydron
Catalysed by SULT1C4
Reaction pageLeft to rightBalanced
Rhea RHEA:66580CC BY 4.0Reference data