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4-hydroxy-17beta-estradiol

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

4 compounds within 3 steps: 3 in 1, 1 in 2, 0 in 3

Does it reach a compound?

One step

4-hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate)Reach from here →
1. 4-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate = 4-hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate) + UDP + H(+)
Catalysed by UGT1A8
17beta-estradiol 4-O-(beta-D-glucuronate)Reach from here →
1. 4-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 4-O-(beta-D-glucuronate) + UDP + H(+)
Catalysed by UGT1A9, UGT2B7, UGT1A8
4-methoxy-17beta-estradiolReach from here →
1. 4-hydroxy-17beta-estradiol + S-adenosyl-L-methionine = 4-methoxy-17beta-estradiol + S-adenosyl-L-homocysteine + H(+)
Catalysed by COMT

Two steps

4-methoxy-17beta-estradiol 3-O-(beta-D-glucuronate)Reach from here →
1. 4-hydroxy-17beta-estradiol + S-adenosyl-L-methionine = 4-methoxy-17beta-estradiol + S-adenosyl-L-homocysteine + H(+)
2. 4-methoxy-17beta-estradiol + UDP-alpha-D-glucuronate = 4-methoxy-17beta-estradiol 3-O-(beta-D-glucuronate) + UDP + H(+)
Catalysed by COMT, UGT1A8