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Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed

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Atlas Graph Access Compounds Outcomes Proteins Interactions Papers Articles Pathways Processes Anatomy Cell types Organisms Materials Assessments

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Catalyst

The evidence graph for human biochemistry. Every edge carries its source, its study design, and a grade computed from both.

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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Reaction

17beta-estradiol+proton+NADPH(4-)+dioxygen2-hydroxy-17beta-estradiol+water+NADP(3-)

Left to right · Balanced · EC 1.14.14.1

Compartment: GO:0005829

Inferred

Reference data, not a finding. Evidence key

Catalysts

CYP3A43
CYP2D6
CYP3A5
CYP2C18
CYP2E1
CYP2J2
CYP19A1
CYP1B1
CYP2C9
CYP2C8
CYP1A1
CYP1A2
CYP4B1
CYP3A4
CYP3A7
CYP2C19
CYP2S1
CYP4F11
CYP4Z1
CYP4F12
CYP2B6
CYP2F1
CYP2A13
CYP2A7
CYP2A6

Human-GEM MAR02042·2.0.1·CC BY 4.0Reference data