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Proteins/UNIPROT:O75795

UGT2B17

Protein·UNIPROT:O75795UDP-glucuronosyltransferase 2B171 compound

Open in the graph

UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile. Catalyzes the glucuronidation of endogenous steroid hormones such as androgens (epitestosterone, androsterone) and estrogens (estradiol, epiestradiol)..

Function from UniProtKB (O75795), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 1 · metabolized by

Inferred

Assembled routes, not reported.

What routes through it

1 compound

1 compound.

0 reported routes1 assembled route

testosteroneCompoundCHEBI:17347Inferred only18 paths9 endpoints

What the reference databases state

Statements

35 statements

35 statements · 6 reference databases · Subject: UGT2B17 · Sources: Bgee, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways

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UGT2B17 is expressed in colonAnatomyHuman Protein Atlas ENSG00000197888Inferred only
UGT2B17 is expressed in duodenumAnatomyHuman Protein Atlas ENSG00000197888Inferred only
UGT2B17 is expressed in ileal mucosaAnatomyBgee ENSG00000197888Inferred only
UGT2B17 is expressed in mucosa of sigmoid colonAnatomyBgee ENSG00000197888Inferred only
UGT2B17 is expressed in mucosa of transverse colonAnatomyBgee ENSG00000197888Inferred only
UGT2B17 is expressed in rectumAnatomyHuman Protein Atlas ENSG00000197888Inferred only
UGT2B17 is expressed in Small intestineAnatomyHuman Protein Atlas ENSG00000197888Inferred only
UGT2B17 is expressed in vermiform appendixAnatomyHuman Protein Atlas ENSG00000197888Inferred only
17alpha-estradiol is metabolised by UGT2B17CompoundRhea RHEA:52872Inferred only
17alpha-estradiol is metabolised by UGT2B17CompoundRhea RHEA:52868Inferred only
17beta-estradiol is metabolised by UGT2B17CompoundHuman-GEM MAR07648Inferred only
17beta-estradiol is metabolised by UGT2B17CompoundRhea RHEA:52464Inferred only

Show the remaining 23

17beta-hydroxy-5alpha-androstan-3-one is metabolised by UGT2B17CompoundRhea RHEA:53000Inferred only
3,3'-diiodo-L-thyronine is metabolised by UGT2B17CompoundHuman-GEM MAR06828Inferred only
3,3'-diiodo-L-thyronine is metabolised by UGT2B17CompoundHuman-GEM MAR06830Inferred only
3,3',5-triiodo-L-thyronine is metabolised by UGT2B17CompoundHuman-GEM MAR06799Inferred only
3,3',5-triiodo-L-thyronine is metabolised by UGT2B17CompoundHuman-GEM MAR06798Inferred only
all-trans-4-hydroxyretinoate is metabolised by UGT2B17CompoundHuman-GEM MAR06704Inferred only
all-trans-4-hydroxyretinoate is metabolised by UGT2B17CompoundHuman-GEM MAR06705Inferred only
androsterone is metabolised by UGT2B17CompoundHuman-GEM MAR07965Inferred only
bilirubin IXalpha is metabolised by UGT2B17CompoundHuman-GEM MAR04766Inferred only
glucuronate acceptor is metabolised by UGT2B17CompoundRhea RHEA:21032Inferred only
L-thyroxine is metabolised by UGT2B17CompoundHuman-GEM MAR06801Inferred only
L-thyroxine is metabolised by UGT2B17CompoundHuman-GEM MAR06800Inferred only
testosterone is metabolised by UGT2B17CompoundHuman-GEM MAR07959Inferred only
testosterone is metabolised by UGT2B17CompoundRhea RHEA:52456Inferred only
UGT2B17 participates in Aspirin ADMEPathwayReactome R-HSA-9749641Inferred only
UGT2B17 participates in Biological oxidationsPathwayReactome R-HSA-211859Inferred only
UGT2B17 participates in Drug ADMEPathwayReactome R-HSA-9748784Inferred only
UGT2B17 participates in GlucuronidationPathwayReactome R-HSA-156588Inferred only
UGT2B17 participates in GlucuronidationPathwayWikiPathways WP698Inferred only
UGT2B17 participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
UGT2B17 participates in Metapathway biotransformation Phase I and IIPathwayWikiPathways WP702Inferred only
UGT2B17 participates in Phase II - Conjugation of compoundsPathwayReactome R-HSA-156580Inferred only
UGT2B17 participates in Prednisone ADMEPathwayReactome R-HSA-9757110Inferred only

Reactions

53 reactions

MAM01220c+UDP-alpha-D-glucuronateMAM01240c+proton+UDP
Catalysed by UGT2B10 or UGT2A3 or UGT2B28 or UGT3A1 or UGT2B4 or UGT1A6 or UGT3A2 or UGT2B7 or UGT2A1 or UGT2B15 or UGT2B17 or UGT2B11 and 8 more alternatives
Reaction page

Other names

3 names

Resolves to: UGT2B17

Also called: C19-steroid-specific UDP-glucuronosyltransferaseC19-steroid-specific UDPGTUDPGT 2B17

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Reversible

Balanced

EC 2.4.1.17

cytosol

Human-GEM MAR02461CC BY 4.0Reference data

MAM01220r+UDP-alpha-D-glucuronateMAM01240r+proton+UDP

Catalysed by UGT2B10 or UGT2A3 or UGT2B28 or UGT3A1 or UGT2B4 or UGT1A6 or UGT3A2 or UGT2B7 or UGT2A1 or UGT2B15 or UGT2B17 or UGT2B11 and 8 more alternatives

Reaction pageLeft to rightBalancedEC 2.4.1.17endoplasmic reticulum

Human-GEM MAR02462CC BY 4.0Reference data

MAM00274c+proton+UDPMAM01220c+UDP-alpha-D-glucuronate

Catalysed by UGT2B10 or UGT2A3 or UGT2B28 or UGT3A1 or UGT2B4 or UGT1A6 or UGT3A2 or UGT2B7 or UGT2A1 or UGT2B15 or UGT2B17 or UGT2B11 and 8 more alternatives

Reaction pageReversibleBalancedEC 2.4.1.17cytosol

Human-GEM MAR02463CC BY 4.0Reference data

MAM01220r+UDP-alpha-D-glucuronateMAM00274r+proton+UDP

Catalysed by UGT2B10 or UGT2A3 or UGT2B28 or UGT3A1 or UGT2B4 or UGT1A6 or UGT3A2 or UGT2B7 or UGT2A1 or UGT2B15 or UGT2B17 or UGT2B11 and 8 more alternatives

Reaction pageLeft to rightBalancedEC 2.4.1.17endoplasmic reticulum

Human-GEM MAR02464CC BY 4.0Reference data

MAM00314c+UDP-alpha-D-glucuronateMAM00323c+proton+UDP

Catalysed by UGT2B10 or UGT2A3 or UGT2B28 or UGT3A1 or UGT2B4 or UGT1A6 or UGT3A2 or UGT2B7 or UGT2A1 or UGT2B15 or UGT2B17 or UGT2B11 and 8 more alternatives

Reaction pageReversibleBalancedEC 2.4.1.17cytosol

Human-GEM MAR02467CC BY 4.0Reference data

MAM00314r+UDP-alpha-D-glucuronateMAM00323r+proton+UDP

Catalysed by UGT2B10 or UGT2A3 or UGT2B28 or UGT3A1 or UGT2B4 or UGT1A6 or UGT3A2 or UGT2B7 or UGT2A1 or UGT2B15 or UGT2B17 or UGT2B11 and 8 more alternatives

Reaction pageLeft to rightBalancedEC 2.4.1.17endoplasmic reticulum

Human-GEM MAR02468CC BY 4.0Reference data

MAM00314c+UDP-alpha-D-glucuronateMAM00327c+proton+UDP

Catalysed by UGT2B10 or UGT2A3 or UGT2B28 or UGT3A1 or UGT2B4 or UGT1A6 or UGT3A2 or UGT2B7 or UGT2A1 or UGT2B15 or UGT2B17 or UGT2B11 and 8 more alternatives

Reaction pageReversibleBalancedEC 2.4.1.17cytosol

Human-GEM MAR02469CC BY 4.0Reference data

MAM00314r+UDP-alpha-D-glucuronateMAM00327r+proton+UDP

Catalysed by UGT2B10 or UGT2A3 or UGT2B28 or UGT3A1 or UGT2B4 or UGT1A6 or UGT3A2 or UGT2B7 or UGT2A1 or UGT2B15 or UGT2B17 or UGT2B11 and 8 more alternatives

Reaction pageLeft to rightBalancedEC 2.4.1.17endoplasmic reticulum

Human-GEM MAR02470CC BY 4.0Reference data

UDP-alpha-D-glucuronate+MAM03337rproton+UDP+MAM03341r

Catalysed by UGT2B10 or UGT2B28 or UGT2B4 or UGT1A6 or UGT2B7 or UGT2B15 or UGT2B17 or UGT2B11 or UGT1A5 or UGT1A9 or UGT1A1 or UGT1A10 and 3 more alternatives

Reaction pageLeft to rightBalancedEC 2.4.1.17endoplasmic reticulum

Human-GEM MAR02617CC BY 4.0Reference data

UDP-alpha-D-glucuronate+MAM03338rproton+UDP+MAM03342r

Catalysed by UGT2B10 or UGT2B28 or UGT2B4 or UGT1A6 or UGT2B7 or UGT2B15 or UGT2B17 or UGT2B11 or UGT1A5 or UGT1A9 or UGT1A1 or UGT1A10 and 3 more alternatives

Reaction pageLeft to rightBalancedEC 2.4.1.17endoplasmic reticulum

Human-GEM MAR02627CC BY 4.0Reference data

UDP-alpha-D-glucuronate+MAM03339rproton+UDP+MAM03343r

Catalysed by UGT2B10 or UGT2B28 or UGT2B4 or UGT1A6 or UGT2B7 or UGT2B15 or UGT2B17 or UGT2B11 or UGT1A5 or UGT1A9 or UGT1A1 or UGT1A10 and 3 more alternatives

Reaction pageLeft to rightBalancedEC 2.4.1.17endoplasmic reticulum

Human-GEM MAR02631CC BY 4.0Reference data

UDP-alpha-D-glucuronate+MAM03340rproton+UDP+MAM03344r

Catalysed by UGT2B10 or UGT2B28 or UGT2B4 or UGT1A6 or UGT2B7 or UGT2B15 or UGT2B17 or UGT2B11 or UGT1A5 or UGT1A9 or UGT1A1 or UGT1A10 and 3 more alternatives

Reaction pageLeft to rightBalancedEC 2.4.1.17endoplasmic reticulum

Human-GEM MAR02637CC BY 4.0Reference data

Show the remaining 41