N-carbamoyl-beta-alanine

Three steps

• pregnenolone sulfateReach from here →
  1. Transport of 3-Ureidopropionate
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Steryl-Sulfatase

  Catalysed by SLC26A6, STSextracellular space, cytosol, Golgi apparatusOne of 2 routes

• androsterone 3alpha-sulfateReach from here →
  1. Transport of 3-Ureidopropionate
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. steroid sulfatase (androsterone sulfate)

  Catalysed by SLC26A6, STSextracellular space, cytosolOne of 3 routes

• N-(9Z-octadecenoyl)glycineReach from here →
  1. Transport of 3-Ureidopropionate
  2. transport of chloride and glycine (cytosol to extracellular)
  3. (9Z)-octadecenoyl-CoA + glycine = N-(9Z-octadecenoyl)glycine + CoA + H(+)

  Catalysed by SLC6A9, SLC6A14, GLYATL3, GLYATL2extracellular space, cytosol

• N-(9Z-octadecenoyl)-L-phenylalanineReach from here →
  1. Transport of 3-Ureidopropionate
  2. Transport of L-Phenylalanine by Atb0 Transporter
  3. L-phenylalanine + (9Z)-octadecenoate = N-(9Z-octadecenoyl)-L-phenylalanine + H2O

  Catalysed by SLC6A14, PM20D1extracellular space, cytosol

• N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanineReach from here →
  1. Transport of 3-Ureidopropionate
  2. Transport of L-Phenylalanine by Atb0 Transporter
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-phenylalanine = N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanine + H2O

  Catalysed by SLC6A14, PM20D1extracellular space, cytosol

• N-(9Z-octadecenoyl)-L-leucineReach from here →
  1. Transport of 3-Ureidopropionate
  2. transport of chloride and leucine (cytosol to extracellular)
  3. N-(9Z-octadecenoyl)-L-leucine + H2O = L-leucine + (9Z)-octadecenoate

  Catalysed by SLC6A14, PM20D1extracellular space, cytosol

• N-octadecanoylglycineReach from here →
  1. Transport of 3-Ureidopropionate
  2. transport of chloride and glycine (cytosol to extracellular)
  3. octadecanoyl-CoA + glycine = N-octadecanoylglycine + CoA + H(+)

  Catalysed by SLC6A9, SLC6A14, GLYATL2extracellular space, cytosol

• N-(9Z-hexadecenoyl)-glycineReach from here →
  1. Transport of 3-Ureidopropionate
  2. transport of chloride and glycine (cytosol to extracellular)
  3. (9Z)-hexadecenoyl-CoA + glycine = N-(9Z-hexadecenoyl)-glycine + CoA + H(+)

  Catalysed by SLC6A9, SLC6A14, GLYATL2extracellular space, cytosol

• cholesterol sulfateReach from here →
  1. Transport of 3-Ureidopropionate
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Steryl-Sulfatase

  Catalysed by SLC26A6, STSextracellular space, cytosol, Golgi apparatusOne of 2 routes

• 5alpha-dihydrotestosterone sulfateReach from here →
  1. Transport of 3-Ureidopropionate
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. steroid sulfatase (5-alpha-dihydrotestosterone)

  Catalysed by SLC26A6, STSextracellular space, cytosolOne of 3 routes

• acetoacetateReach from here →
  1. Transport of 3-Ureidopropionate
  2. transport of chloride and formate (cytosol to extracellular)
  3. transport of acetoacetate and formate (cytosol to extracellular)

  Catalysed by SLC26A4, SLC16A4, SLC16A5extracellular space, cytosolOne of 2 routes

• an aryl sulfateReach from here →
  1. Transport of 3-Ureidopropionate
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. an aryl sulfate + H2O = a phenol + sulfate + H(+)

  Catalysed by SLC26A6, ARSL, ARSF, ARSK and 3 moreextracellular space, cytosol

• N-hexadecanoylglycineReach from here →
  1. Transport of 3-Ureidopropionate
  2. transport of chloride and glycine (cytosol to extracellular)
  3. hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)

  Catalysed by SLC6A9, SLC6A14, GLYATL3extracellular space, cytosol

• N-dodecanoylglycineReach from here →
  1. Transport of 3-Ureidopropionate
  2. transport of chloride and glycine (cytosol to extracellular)
  3. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)

  Catalysed by SLC6A9, SLC6A14, GLYATL2extracellular space, cytosol

• N-decanoylglycineReach from here →
  1. Transport of 3-Ureidopropionate
  2. transport of chloride and glycine (cytosol to extracellular)
  3. decanoyl-CoA + glycine = N-decanoylglycine + CoA + H(+)

  Catalysed by SLC6A9, SLC6A14, GLYATL2extracellular space, cytosol

• N-octanoylglycineReach from here →
  1. Transport of 3-Ureidopropionate
  2. transport of chloride and glycine (cytosol to extracellular)
  3. octanoyl-CoA + glycine = N-octanoylglycine + CoA + H(+)

  Catalysed by SLC6A9, SLC6A14, GLYATL2extracellular space, cytosol

• D-histidineReach from here →
  1. 3-ureidopropanoate amidohydrolase
  2. beta-alanine + L-arginine = 3-guanidinopropanoate + L-ornithine
  3. D-histidine(in) + L-ornithine(out) + H(+)(in) = D-histidine(out) + L-ornithine(in) + H(+)(out)

  Catalysed by UPB1, GATM, SLC25A2cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-homoarginineReach from here →
  1. 3-ureidopropanoate amidohydrolase
  2. beta-alanine + L-arginine = 3-guanidinopropanoate + L-ornithine
  3. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)

  Catalysed by UPB1, GATM, SLC25A2cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• L-homocarnosineReach from here →
  1. Transport of 3-Ureidopropionate
  2. transport of chloride and histidine (cytosol to extracellular)
  3. Formation of homocarnosine

  Catalysed by SLC6A14, CARNS1extracellular space, cytosolOne of 3 routes

• N(1)-(5-phospho-beta-D-ribosyl)glycinamideReach from here →
  1. Transport of 3-Ureidopropionate
  2. transport of chloride and glycine (cytosol to extracellular)
  3. 5-phospho-beta-D-ribosylamine + glycine + ATP = N(1)-(5-phospho-beta-D-ribosyl)glycinamide + ADP + phosphate + H(+)

  Catalysed by SLC6A9, SLC6A14, GARTextracellular space, cytosol

• L-cystine-bis-glycineReach from here →
  1. Transport of 3-Ureidopropionate
  2. transport of chloride and glycine (cytosol to extracellular)
  3. L-cystine-bis-glycine + 2 H2O = L-cystine + 2 glycine

  Catalysed by SLC6A9, SLC6A14, DPEP1, DPEP2extracellular space, cytosol

• glycyldehydrophenylalanineReach from here →
  1. Transport of 3-Ureidopropionate
  2. transport of chloride and glycine (cytosol to extracellular)
  3. glycyldehydrophenylalanine + H2O = 2,3-didehydrophenylalanine + glycine

  Catalysed by SLC6A9, SLC6A14, DPEP1extracellular space, cytosol

• 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidineReach from here →
  1. Transport of 3-Ureidopropionate
  2. Transport of L-Glutamine by Atb0 Transporter
  3. N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + L-glutamine + ATP + H2O = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + L-glutamate + ADP + phosphate + H(+)

  Catalysed by SLC6A14, PFASextracellular space, cytosol

• kinetensinReach from here →
  1. Transport of 3-Ureidopropionate
  2. Transport of L-Phenylalanine by Atb0 Transporter
  3. Chymase

  Catalysed by SLC6A14, CMA1extracellular space, cytosolOne of 3 routes

• an N-(fatty acyl)-glycineReach from here →
  1. Transport of 3-Ureidopropionate
  2. transport of chloride and glycine (cytosol to extracellular)
  3. a fatty acyl-CoA + glycine = an N-(fatty acyl)-glycine + CoA + H(+)

  Catalysed by SLC6A9, SLC6A14, GLYATL2extracellular space, cytosol

• N-(9Z,12Z-octadecadienoyl)-glycineReach from here →
  1. Transport of 3-Ureidopropionate
  2. transport of chloride and glycine (cytosol to extracellular)
  3. (9Z,12Z)-octadecadienoyl-CoA + glycine = N-(9Z,12Z-octadecadienoyl)-glycine + CoA + H(+)

  Catalysed by SLC6A9, SLC6A14, GLYATL2extracellular space, cytosol

• acetaldehydeReach from here →
  1. Transport of 3-Ureidopropionate
  2. Transport of L-Threonine by Atb0 Transporter
  3. L-threonine acetaldehyde-lyase (glycine-forming)

  Catalysed by SLC6A14extracellular space, cytosol

• acetylcholineReach from here →
  1. Transport of 3-Ureidopropionate
  2. transport of chloride and choline (cytosol to extracellular)
  3. Acetyl-CoA:choline O-acetyltransferase

  Catalysed by SLC5A7, CHATextracellular space, cytosolOne of 3 routes

• pyruvateReach from here →
  1. 3-ureidopropanoate amidohydrolase
  2. 3-oxopropanoate + L-alanine = beta-alanine + pyruvate
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by UPB1, AGXT2cytosol, mitochondrial matrixOne of 18 routes

• all-trans-retinoic acidReach from here →
  1. Transport of 3-Ureidopropionate
  2. transport of chloride and formate (cytosol to extracellular)
  3. transport of formate and retinoate (cytosol to extracellular)

  Catalysed by SLC26A4, SLC16A4, SLC16A5extracellular space, cytosolOne of 2 routes

• 4a-hydroxytetrahydrobiopterinReach from here →
  1. Transport of 3-Ureidopropionate
  2. Transport of L-Phenylalanine by Atb0 Transporter
  3. L-phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase(4-hydroxylating)

  Catalysed by SLC6A14, PAHextracellular space, cytosolOne of 3 routes

• CHEBI:15477Reach from here →
  1. Transport of 3-Ureidopropionate
  2. 2-Methylbutyrylglycine Transport, Extracellular
  3. glycine N-acyltransferase (2-methylbutyryl-CoA)

  Catalysed by SLC6A5, GLYAT, GLYATL2, GLYATL1extracellular space, cytosol, mitochondrial matrix

• propionyl-CoAReach from here →
  1. Transport of 3-Ureidopropionate
  2. Carnitine Transport by Atb0
  3. Active Transport

  Catalysed by SLC6A14extracellular space, cytosol, mitochondrial matrixOne of 2 routes

• CHEBI:15570Reach from here →
  1. 3-ureidopropanoate amidohydrolase
  2. 3-oxopropanoate + L-alanine = beta-alanine + pyruvate
  3. alanine racemase

  Catalysed by UPB1, AGXT2cytosolOne of 5 routes

• (S)-malateReach from here →
  1. Transport of 3-Ureidopropionate
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of malate and sulfate (cytosol to mitochondria)

  Catalysed by SLC26A6, SLC25A10extracellular space, cytosol, mitochondrial matrixOne of 4 routes

• CHEBI:15611Reach from here →
  1. Transport of 3-Ureidopropionate
  2. transport of chloride and glycine (cytosol to extracellular)
  3. S-Adenosyl-L-methionine:glycine N-methyltransferase

  Catalysed by SLC6A9, SLC6A14, GNMTextracellular space, cytosol

• 10-formyltetrahydrofolic acidReach from here →
  1. Transport of 3-Ureidopropionate
  2. transport of chloride and formate (cytosol to extracellular)
  3. Formate:tetrahydrofolate ligase (ADP-forming)

  Catalysed by SLC26A4, MTHFD1extracellular space, cytosolOne of 2 routes

• (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterinReach from here →
  1. Transport of 3-Ureidopropionate
  2. Transport of L-Phenylalanine by Atb0 Transporter
  3. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine

  Catalysed by SLC6A14, PAHextracellular space, cytosolOne of 2 routes

• CHEBI:15699Reach from here →
  1. 3-ureidopropanoate amidohydrolase
  2. 3-oxopropanoate + L-alanine = beta-alanine + pyruvate
  3. transport of alanine and homoserine (cytosol to extracellular)

  Catalysed by UPB1, AGXT2, SLC7A5cytosol, extracellular spaceOne of 54 routes

• betaine aldehydeReach from here →
  1. Transport of 3-Ureidopropionate
  2. transport of chloride and choline (cytosol to extracellular)
  3. choline dehydrogenase (choline)

  Catalysed by SLC5A7, CHDHextracellular space, cytosolOne of 3 routes

• trimethylenediamineReach from here →
  1. Transport of 3-Ureidopropionate
  2. transport of chloride and lysine (cytosol to extracellular)
  3. deoxyhypusine synthase (1,3-diaminopropane)

  Catalysed by SLC6A14, DHPSextracellular space, cytosol

• hexadecanoic acidReach from here →
  1. Transport of 3-Ureidopropionate
  2. Carnitine Transport by Atb0
  3. Utilized Transport

  Catalysed by SLC6A14extracellular space, cytosol, endoplasmic reticulumOne of 2 routes

• CHEBI:15765Reach from here →
  1. Transport of 3-Ureidopropionate
  2. Transport of L-Tyrosine by Atb0 Transporter
  3. L-Tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)

  Catalysed by SLC6A14, THextracellular space, cytosolOne of 5 routes

• malonateReach from here →
  1. Transport of 3-Ureidopropionate
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. malonate(in) + sulfate(out) = malonate(out) + sulfate(in)

  Catalysed by SLC26A6, SLC25A14, SLC25A30, SLC25A10extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• N-carbamoyl-L-aspartic acidReach from here →
  1. 3-ureidopropanoate amidohydrolase
  2. L-aspartate + H(+) = beta-alanine + CO2
  3. carbamoyl-phosphate:L-aspartate carbamoyltransferase

  Catalysed by UPB1, GADL1, CSAD, CADcytosol

• alpha-D-glucosamine 6-phosphateReach from here →
  1. Transport of 3-Ureidopropionate
  2. Transport of L-Glutamine by Atb0 Transporter
  3. L-glutamine:D-fructose-6-phosphate isomerase (deaminating)

  Catalysed by SLC6A14, GFPT2, GFPT1extracellular space, cytosol

• ureaReach from here →
  1. 3-ureidopropanoate amidohydrolase
  2. beta-alanine + L-arginine = 3-guanidinopropanoate + L-ornithine
  3. 3-guanidinopropanoate + H2O = urea + beta-alanine

  Catalysed by UPB1, GATM, AGMATcytosolOne of 4 routes

• succinic semialdehydeReach from here →
  1. Transport of 3-Ureidopropionate
  2. transport of 4-aminobutyrate and chloride (cytosol to extracellular)
  3. 4-aminobutanoate:2-oxoglutarate aminotransferase

  Catalysed by SLC6A12, ABATextracellular space, cytosol, mitochondrial matrix

• L-cystineReach from here →
  1. 3-ureidopropanoate amidohydrolase
  2. 3-oxopropanoate + L-alanine = beta-alanine + pyruvate
  3. Transport of L-Cystine (L-Alanine antiport) by B0, +At Transporter

  Catalysed by UPB1, AGXT2, SLC7A9, SLC3A1cytosol, extracellular spaceOne of 9 routes

• (R)-3-aminoisobutyric acidReach from here →
  1. 3-ureidopropanoate amidohydrolase
  2. 3-oxopropanoate + L-alanine = beta-alanine + pyruvate
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by UPB1, AGXT2cytosol, mitochondrial matrix