CHEBI:18095

Three steps

• 3-oxopropanoateReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of beta-alanine and chloride (cytosol to extracellular)
  3. 3-oxopropanoate + L-alanine = beta-alanine + pyruvate

  Catalysed by CLTRN, SLC6A20, SLC6A6, SLC6A14 and 1 moreextracellular space, cytosolOne of 2 routes

• thiosulfateReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. thiosulfate(in) + sulfate(out) = thiosulfate(out) + sulfate(in)

  Catalysed by CLTRN, SLC6A20, SLC26A6, SLC25A14 and 3 moreextracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• 4-methylthio-2-oxobutanoic acidReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of chloride and methionine (cytosol to extracellular)
  3. L-Methionine:oxygen oxidoreductase (deaminating)

  Catalysed by CLTRN, SLC6A20, SLC6A14, IL4I1extracellular space, cytosol

• di-mu-sulfido-diiron(2+)Reach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of chloride and cysteine (cytosol to extracellular)
  3. De novo synthesis of 2Fe2S

  Catalysed by CLTRN, SLC6A20, SLC6A14, NDUFAB1 and 6 moreextracellular space, cytosol, mitochondrial matrix

• serotoninReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of chloride (cytosol to extracellular)
  3. transport of serotonin (cytosol to extracellular)

  Catalysed by CLTRN, SLC6A20, SLC12A2, SLC12A1 and 1 moreextracellular space, cytosol

• (S)-3-methyl-2-oxopentanoateReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of chloride and isoleucine (cytosol to extracellular)
  3. L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate

  Catalysed by CLTRN, SLC6A20, SLC6A14, BCAT2 and 1 moreextracellular space, cytosol

• an acylcholineReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of chloride and choline (cytosol to extracellular)
  3. an acylcholine + H2O = a carboxylate + choline + H(+)

  Catalysed by CLTRN, SLC6A20, SLC5A7, BCHEextracellular space, cytosol

• 5-aminolevulinateReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA

  Catalysed by CLTRN, SLC6A20, SLC6A9, SLC6A14 and 2 moreextracellular space, cytosol

• 3-methyl-2-oxovaleric acidReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of chloride and isoleucine (cytosol to extracellular)
  3. L-Leucine:2-oxoglutarate aminotransferase

  Catalysed by CLTRN, SLC6A20, SLC6A14, BCAT1extracellular space, cytosolOne of 2 routes

• 3-(4-hydroxyphenyl)pyruvateReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. Transport of L-Tyrosine by Atb0 Transporter
  3. L-tyrosine:2-oxoglutarate aminotransferase

  Catalysed by CLTRN, SLC6A20, SLC6A14, GOT2 and 2 moreextracellular space, cytosolOne of 3 routes

• glycochenodeoxycholateReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. chenodeoxycholoyl-CoA + glycine = glycochenodeoxycholate + CoA + H(+)

  Catalysed by CLTRN, SLC6A20, SLC6A9, SLC6A14 and 1 moreextracellular space, cytosol

• taurocholateReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  3. Choloyl-CoA:glycine N-choloyltransferase

  Catalysed by CLTRN, SLC6A20, SLC6A6, BAATextracellular space, cytosol, peroxisomeOne of 3 routes

• taurodeoxycholateReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  3. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)

  Catalysed by CLTRN, SLC6A20, SLC6A6, BAATextracellular space, cytosolOne of 2 routes

• glycochenodeoxycholic acidReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by CLTRN, SLC6A20, SLC6A9, SLC6A14 and 1 moreextracellular space, cytosol, peroxisomeOne of 3 routes

• 3-hydroxyanthranilateReach from here →
  1. Transport of Hydroxy-Proline
  2. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
  3. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)

  Catalysed by SLC1A4, KYNUextracellular space, cytosol

• glyoxylateReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. glycine + 2-oxoglutarate = glyoxylate + L-glutamate

  Catalysed by CLTRN, SLC6A20, SLC6A9, SLC6A14 and 1 moreextracellular space, cytosolOne of 11 routes

• glycolithocholic acidReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. bile acid-CoA:amino acid N-acyltransferase (glycine)

  Catalysed by CLTRN, SLC6A20, SLC6A9, SLC6A14 and 1 moreextracellular space, cytosolOne of 2 routes

• L-2-amino-3-oxobutanoic acidReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. Acetyl-CoA:glycine C-acetyltransferase

  Catalysed by CLTRN, SLC6A20, SLC6A9, SLC6A14 and 1 moreextracellular space, cytosol, mitochondrial matrix

• (R)-lactic acidReach from here →
  1. Transport of Hydroxy-Proline
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. (R)-Lactate:NAD+ oxidoreductase

  Catalysed by SLC1A4, AGXT2, LDHDextracellular space, cytosol, mitochondrial matrix

• (S)-lactic acidReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of chloride and formate (cytosol to extracellular)
  3. transport of formate and L-lactate (cytosol to extracellular)

  Catalysed by CLTRN, SLC6A20, SLC26A4, SLC16A4 and 5 moreextracellular space, cytosolOne of 7 routes

• 25-hydroxycholesterolReach from here →
  1. Transport of Hydroxy-Proline
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. cholesterol + AH2 + O2 = 25-hydroxycholesterol + A + H2O

  Catalysed by SLC1A4, MOCOS, CH25Hextracellular space, cytosol

• 2-iminopropanoateReach from here →
  1. Transport of Hydroxy-Proline
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. 2-iminopropanoate + H2O = pyruvate + NH4(+)

  Catalysed by SLC1A4, AGXT2, RIDAextracellular space, cytosol, mitochondrial matrix

• phosphoenolpyruvic acidReach from here →
  1. Transport of Hydroxy-Proline
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. pyruvate kinase (dTDP)

  Catalysed by SLC1A4, AGXT2, PKM, PKLRextracellular space, cytosol, mitochondrial matrix

• N-acetyl-beta-neuraminic acidReach from here →
  1. Transport of Hydroxy-Proline
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)

  Catalysed by SLC1A4, AGXT2, NPLextracellular space, cytosol, mitochondrial matrix

• S(8)-aminomethyldihydrolipoamideReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. dihydrolipoyl dehydrogenase ([protein]-N6-(lipoyl)lysine)

  Catalysed by CLTRN, SLC6A20, SLC6A9, SLC6A14 and 2 moreextracellular space, cytosol, mitochondrial matrix

• all-trans-13,14-dihydroretinolReach from here →
  1. Transport of Hydroxy-Proline
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2

  Catalysed by SLC1A4, MOCOS, RETSATextracellular space, cytosol

• 3,3',5-triiodo-L-thyronineReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of chloride and iodide (cytosol to extracellular)
  3. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)

  Catalysed by CLTRN, SLC6A20, SLC26A4, DIO1 and 2 moreextracellular space, cytosolOne of 5 routes

• 3,3',5'-triiodo-L-thyronineReach from here →
  1. Transport of Hydroxy-Proline
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. 3,3',5'-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH2

  Catalysed by SLC1A4, MOCOS, DIO1, DIO3extracellular space, cytosol

• a 3-acylpyruvateReach from here →
  1. Transport of Hydroxy-Proline
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. a 3-acylpyruvate + H2O = a carboxylate + pyruvate + H(+)

  Catalysed by SLC1A4, AGXT2, FAHD1extracellular space, cytosol, mitochondrial matrix

• (R)-methylmalonyl-CoAReach from here →
  1. Transport of Hydroxy-Proline
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. aldehyde dehydrogenase (2-methyl-3-oxopropanoate)

  Catalysed by SLC1A4, ALDH6A1extracellular space, cytosol, mitochondrial matrixOne of 2 routes

• (S)-methylmalonyl-CoAReach from here →
  1. Transport of Hydroxy-Proline
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. (S)-methylmalonyl-CoA hydrolase

  Catalysed by SLC1A4extracellular space, cytosol, mitochondrial matrix

• 3'-dephospho-CoAReach from here →
  1. Transport of Hydroxy-Proline
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. acid phosphatase 2, lysosomal (CoA)

  Catalysed by SLC1A4, ACP2extracellular space, cytosol, mitochondrial matrix, lysosomeOne of 2 routes

• (2E)-dodecenoyl-CoAReach from here →
  1. Transport of Hydroxy-Proline
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. (2E)-dodecenoyl-CoA formation

  Catalysed by SLC1A4extracellular space, cytosol, mitochondrial matrixOne of 3 routes

• 4,8,12-trimethyltridecanoyl-CoAReach from here →
  1. Transport of Hydroxy-Proline
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. propanoyl-CoA C-acyltransferase (3-ketopristanoyl-CoA)

  Catalysed by SLC1A4, ACAA1, MYO5Bextracellular space, cytosol, mitochondrial matrix, peroxisomeOne of 2 routes

• (6Z,9Z,12Z)-octadecatrienoyl-CoAReach from here →
  1. Transport of Hydroxy-Proline
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. long-chain-fatty-acid-CoA ligase (gamma-linolenate)

  Catalysed by SLC1A4, SLC27A2, ACSL4, ACSL3 and 5 moreextracellular space, cytosol, mitochondrial matrixOne of 7 routes

• butanoyl-CoAReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. Carnitine Transport by Atb0
  3. transport of butyryl-CoA and L-carnitine (cytosol to mitochondria)

  Catalysed by CLTRN, SLC6A20, SLC6A14, SLC33A1 and 2 moreextracellular space, cytosol, mitochondrial matrixOne of 11 routes

• dodecanoyl-CoAReach from here →
  1. Transport of Hydroxy-Proline
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. long-chain-fatty-acid-CoA ligase (lauric acid)

  Catalysed by SLC1A4, SLC27A2, ACSL4, ACSL3 and 5 moreextracellular space, cytosol, mitochondrial matrixOne of 9 routes

• glutaryl-CoAReach from here →
  1. Transport of Hydroxy-Proline
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. Production of Glutaryl Carnitine

  Catalysed by SLC1A4, CPT1A, CPT1C, CPT1Bextracellular space, cytosol, mitochondrial matrixOne of 2 routes

• eicosanoyl-CoAReach from here →
  1. Transport of Hydroxy-Proline
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. long-chain-fatty-acid-CoA ligase (eicosanoate)

  Catalysed by SLC1A4, SLC27A2, ACSL4, ACSL3 and 5 moreextracellular space, cytosol, mitochondrial matrixOne of 12 routes

• itaconyl-CoAReach from here →
  1. Transport of Hydroxy-Proline
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. Itaconate:CoA ligase (GDP-forming)

  Catalysed by SLC1A4, SUCLG1, SUCLG2, SUCLA2extracellular space, cytosol, mitochondrial matrixOne of 2 routes

• (9Z,12Z)-octadecadienoyl-CoAReach from here →
  1. Transport of Hydroxy-Proline
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)

  Catalysed by SLC1A4, SLC27A2, ACSL4, ACSL3 and 5 moreextracellular space, cytosol, mitochondrial matrixOne of 13 routes

• tetradecanoyl-CoAReach from here →
  1. Transport of Hydroxy-Proline
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. long-chain-fatty-acid-CoA ligase (myristic acid)

  Catalysed by SLC1A4, SLC27A2, ACSL4, ACSL3 and 5 moreextracellular space, cytosol, mitochondrial matrixOne of 11 routes

• octanoyl-CoAReach from here →
  1. Transport of Hydroxy-Proline
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. Octanoyl-CoA:L-carnitine O-octanoyltransferase

  Catalysed by SLC1A4, CROTextracellular space, cytosol, mitochondrial matrixOne of 20 routes

• phytanoyl-CoAReach from here →
  1. Transport of Hydroxy-Proline
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. phytanate-CoA ligase

  Catalysed by SLC1A4extracellular space, cytosol, mitochondrial matrixOne of 5 routes

• octadecanoyl-CoAReach from here →
  1. Transport of Hydroxy-Proline
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. long-chain-fatty-acid-CoA ligase (stearate)

  Catalysed by SLC1A4, SLC27A2, ACSL4, ACSL3 and 4 moreextracellular space, cytosol, mitochondrial matrixOne of 15 routes

• prostaglandin H2Reach from here →
  1. Transport of Hydroxy-Proline
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + 2 O2 = prostaglandin H2 + A + H2O

  Catalysed by SLC1A4, MOCOS, PTGS1, PTGS2extracellular space, cytosolOne of 2 routes

• (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. Transport of Hydroxy-Proline
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O

  Catalysed by SLC1A4, MOCOS, TBXAS1, PTGS2 and 1 moreextracellular space, cytosol

• sarcosineReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2

  Catalysed by CLTRN, SLC6A20, SLC6A9, SLC6A14 and 1 moreextracellular space, cytosolOne of 2 routes

• 7,8-dihydrofolateReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  3. uridine(34) in tRNA + 5,10-methylenetetrahydrofolate + taurine + GTP + A + H2O = 5-taurinomethyluridine(34) in tRNA + 7,8-dihydrofolate + GDP + AH2 + phosphate + H(+)

  Catalysed by CLTRN, SLC6A20, SLC6A6, MTO1extracellular space, cytosol

• (6S)-5,6,7,8-tetrahydrofolateReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine

  Catalysed by CLTRN, SLC6A20, SLC6A9, SLC6A14 and 2 moreextracellular space, cytosol