aldehydo-N-acetyl-D-mannosamine

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

105 compounds within 3 steps: 4 in 1, 6 in 2, 95 in 3

Three steps

D-serineReach from here →
1. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
2. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
3. D-serine = pyruvate + NH4(+)
Catalysed by NPL, SRRcytosol
N-acetylneuraminateReach from here →
1. ATP:N-acyl-D-mannosamine 6-phosphotransferase
2. N-acetylneuraminate synthase
3. N-acetylneuraminate 9-phosphate + H2O = N-acetylneuraminate + phosphate
Catalysed by GNE, NANS, NANPcytosol
(R)-lactic acidReach from here →
1. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
2. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
3. (R)-Lactate:NAD+ oxidoreductase
Catalysed by NPL, LDHDcytosol
(S)-lactic acidReach from here →
1. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
2. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
3. (S)-Lactate:NAD+ oxidoreductase
Catalysed by NPL, LDHB, LDHAL6Bcytosol, mitochondrial matrixOne of 5 routes
2-iminopropanoateReach from here →
1. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
2. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
3. 2-iminopropanoate + H2O = pyruvate + NH4(+)
Catalysed by NPL, RIDAcytosol
phosphoenolpyruvic acidReach from here →
1. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
2. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
3. pyruvate kinase (dTDP)
Catalysed by NPL, PKM, PKLRcytosol
a 3-acylpyruvateReach from here →
1. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
2. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
3. a 3-acylpyruvate + H2O = a carboxylate + pyruvate + H(+)
Catalysed by NPL, FAHD1cytosol
2-oxo-3-sulfanylpropanoateReach from here →
1. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
2. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
3. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)
Catalysed by NPL, MPSTcytosol
2-methyl-3-oxopropanoateReach from here →
1. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
2. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
3. (R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine
Catalysed by NPL, AGXT2cytosol
N-acetyl-alpha-D-glucosamine 1-phosphateReach from here →
1. N-acetyl-D-glucosamine 2-epimerase
2. ATP:N-acetyl-D-glucosamine 6-phosphotransferase
3. N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate
Catalysed by RENBP, NAGK, PGM3cytosol
L-methionineReach from here →
1. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
2. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
3. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O
Catalysed by NPL, TYW1B, TYW1cytosol
L-alanineReach from here →
1. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
2. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
Catalysed by NPL, AGXT2cytosol, mitochondrial matrixOne of 18 routes
a neolactoside IV(3)-alpha-NeuAc-nLc4Cer(d18:1(4E))Reach from here →
1. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
2. CTP:N-acetylneuraminate cytidylyltransferase
3. ST3 beta-galactoside alpha-2,3-sialyltransferase (CMP-N-acetylneuraminate)
Catalysed by NPL, CMAS, ST3GAL6cytosol, nucleusOne of 3 routes
(3S)-citramalyl-CoAReach from here →
1. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
2. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
3. (3S)-citramalyl-CoA = pyruvate + acetyl-CoA
Catalysed by NPL, CLYBLcytosol
D-glucosamine 6-phosphateReach from here →
1. N-acetyl-D-glucosamine 2-epimerase
2. ATP:N-acetyl-D-glucosamine 6-phosphotransferase
3. D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H(+)
Catalysed by RENBP, NAGK, GNPNAT1cytosolOne of 2 routes
5-amino-2-oxopentanoateReach from here →
1. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
2. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
3. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
Catalysed by NPL, AGXT2cytosol
a ganglioside GM3 (d18:1(4E))Reach from here →
1. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
2. CTP:N-acetylneuraminate cytidylyltransferase
3. ST3 beta-galactoside alpha-2,3-sialyltransferase (CMP-N-acetylneuraminate)
Catalysed by NPL, CMAS, ST3GAL5cytosol, nucleusOne of 3 routes
(4R)-4-hydroxy-2-oxoglutarateReach from here →
1. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
2. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
3. (4R)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate
Catalysed by NPL, HOGA1cytosol
2-acetamido-2-deoxy-D-glucopyranose 1-phosphateReach from here →
1. N-acetyl-D-glucosamine 2-epimerase
2. ATP:N-acetyl-D-glucosamine 6-phosphotransferase
3. phosphoglucomutase (N-acetylglucosamine-6-phosphate)
Catalysed by RENBP, NAGK, PGM3cytosol
a ganglioside GM2 (d18:1(4E))Reach from here →
1. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
2. CTP:N-acetylneuraminate cytidylyltransferase
3. lactosylceramide alpha-2,3-sialyltransferase (CMP-N-acetylneuraminate)
Catalysed by NPL, CMAS, ST6GALNAC2, ST3GAL5cytosol, nucleus
(4S)-4-hydroxy-2-oxoglutarateReach from here →
1. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
2. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
3. (4S)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate
Catalysed by NPL, HOGA1cytosol
ganglioside GM1 (d18:1(4E)/18:0)Reach from here →
1. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
2. CTP:N-acetylneuraminate cytidylyltransferase
3. ganglioside GA1 (d18:1(4E)/18:0) + CMP-N-acetyl-beta-neuraminate = ganglioside GM1 (d18:1(4E)/18:0) + CMP + H(+)
Catalysed by NPL, CMAS, ST3GAL5cytosol, nucleus
a ganglioside GM1 (d18:1(4E))Reach from here →
1. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
2. CTP:N-acetylneuraminate cytidylyltransferase
3. ST3 beta-galactoside alpha-2,3-sialyltransferase (CMP-N-acetylneuraminate)
Catalysed by NPL, CMAS, ST3GAL5cytosol, nucleus
a ganglioside GD3 (d18:1(4E))Reach from here →
1. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
2. CTP:N-acetylneuraminate cytidylyltransferase
3. ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase (CMP-N-acetylneuraminate)
Catalysed by NPL, CMAS, ST8SIA1cytosol, nucleusOne of 4 routes
a ganglioside GT3 (d18:1(4E))Reach from here →
1. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
2. CTP:N-acetylneuraminate cytidylyltransferase
3. alpha-N-acetylneuraminate alpha-2,8-sialyltransferase (CMP-N-acetylneuraminate)
Catalysed by NPL, CMAS, ST8SIA5, ST8SIA1cytosol, nucleusOne of 3 routes
a ganglioside GD1a (d18:1(4E))Reach from here →
1. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
2. CTP:N-acetylneuraminate cytidylyltransferase
3. ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase (CMP-N-acetylneuraminate)
Catalysed by NPL, CMAS, ST6GALNAC3, ST6GALNAC6 and 2 morecytosol, nucleusOne of 4 routes
a ganglioside GT1a (d18:1(4E))Reach from here →
1. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
2. CTP:N-acetylneuraminate cytidylyltransferase
3. ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase (CMP-N-acetylneuraminate)
Catalysed by NPL, CMAS, ST8SIA5cytosol, nucleusOne of 3 routes
a ganglioside GT1b (d18:1(4E))Reach from here →
1. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
2. CTP:N-acetylneuraminate cytidylyltransferase
3. beta-galactoside alpha-2,3-sialyltransferase (CMP-N-acetylneuraminate)
Catalysed by NPL, CMAS, ST3GAL1, ST3GAL4 and 1 morecytosol, nucleusOne of 4 routes
a ganglioside GQ1b (d18:1(4E))Reach from here →
1. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
2. CTP:N-acetylneuraminate cytidylyltransferase
3. ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase (CMP-N-acetylneuraminate)
Catalysed by NPL, CMAS, ST8SIA5cytosol, nucleusOne of 4 routes
a ganglioside GM4 (d18:1(4E))Reach from here →
1. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
2. CTP:N-acetylneuraminate cytidylyltransferase
3. a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + CMP-N-acetyl-beta-neuraminate = a ganglioside GM4 (d18:1(4E)) + CMP + H(+)
Catalysed by NPL, CMAS, ST3GAL5cytosol, nucleus
ganglioside GM2 (d18:1(4E)/18:0)Reach from here →
1. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
2. CTP:N-acetylneuraminate cytidylyltransferase
3. ganglioside GA2 (d18:1(4E)/18:0) + CMP-N-acetyl-beta-neuraminate = ganglioside GM2 (d18:1(4E)/18:0) + CMP + H(+)
Catalysed by NPL, CMAS, ST3GAL5cytosol, nucleus
a ganglioside GD2 (d18:1(4E))Reach from here →
1. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
2. CTP:N-acetylneuraminate cytidylyltransferase
3. ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase (CMP-N-acetylneuraminate)
Catalysed by NPL, CMAS, ST8SIA1cytosol, nucleus
a ganglioside GM1b (d18:1(4E))Reach from here →
1. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
2. CTP:N-acetylneuraminate cytidylyltransferase
3. a ganglioside GA1 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GM1b (d18:1(4E)) + CMP + H(+)
Catalysed by NPL, CMAS, ST3GAL1, ST3GAL4 and 1 morecytosol, nucleus
a ganglioside GD1alpha (d18:1(4E))Reach from here →
1. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
2. CTP:N-acetylneuraminate cytidylyltransferase
3. a ganglioside GM1b (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GD1alpha (d18:1(4E)) + CMP + H(+)
Catalysed by NPL, CMAS, ST6GALNAC3, ST6GALNAC6 and 2 morecytosol, nucleus
a ganglioside GT1aalpha (d18:1(4E))Reach from here →
1. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
2. CTP:N-acetylneuraminate cytidylyltransferase
3. a ganglioside GD1a (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GT1aalpha (d18:1(4E)) + CMP + H(+)
Catalysed by NPL, CMAS, ST6GALNAC6cytosol, nucleus
a ganglioside GQ1balpha (d18:1(4E))Reach from here →
1. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
2. CTP:N-acetylneuraminate cytidylyltransferase
3. a ganglioside GT1b (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GQ1balpha (d18:1(4E)) + CMP + H(+)
Catalysed by NPL, CMAS, ST6GALNAC6cytosol, nucleus
a ganglioside GD3Reach from here →
1. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
2. CTP:N-acetylneuraminate cytidylyltransferase
3. a ganglioside GM3 + CMP-N-acetyl-beta-neuraminate = a ganglioside GD3 + CMP + H(+)
Catalysed by NPL, CMAS, ST8SIA3, ST8SIA6cytosol, nucleus
a ganglioside GT3Reach from here →
1. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
2. CTP:N-acetylneuraminate cytidylyltransferase
3. a ganglioside GD3 + CMP-N-acetyl-beta-neuraminate = a ganglioside GT3 + CMP + H(+)
Catalysed by NPL, CMAS, ST8SIA1cytosol, nucleus
a ganglioside GD1aReach from here →
1. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
2. CTP:N-acetylneuraminate cytidylyltransferase
3. a ganglioside GM1 + CMP-N-acetyl-beta-neuraminate = a ganglioside GD1a + CMP + H(+)
Catalysed by NPL, CMAS, ST3GAL1, ST3GAL2cytosol, nucleus
N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramideReach from here →
1. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
2. CTP:N-acetylneuraminate cytidylyltransferase
3. a beta-D-Gal-(1<->1')-ceramide + CMP-N-acetyl-beta-neuraminate = N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramide + CMP + H(+)
Catalysed by NPL, CMAS, ST3GAL5cytosol, nucleus
a ganglioside GT1bReach from here →
1. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
2. CTP:N-acetylneuraminate cytidylyltransferase
3. a ganglioside GD1b + CMP-N-acetyl-beta-neuraminate = a ganglioside GT1b + CMP + H(+)
Catalysed by NPL, CMAS, ST3GAL1, ST3GAL2cytosol, nucleus
a ganglioside GD1b (d18:1(4E))Reach from here →
1. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
2. CTP:N-acetylneuraminate cytidylyltransferase
3. ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase (CMP-N-acetylneuraminate)
Catalysed by NPL, CMAS, ST8SIA1cytosol, nucleus
a ganglioside GD1c (d18:1(4E))Reach from here →
1. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
2. CTP:N-acetylneuraminate cytidylyltransferase
3. a ganglioside GM1b (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GD1c (d18:1(4E)) + CMP + H(+)
Catalysed by NPL, CMAS, ST8SIA5, ST8SIA6 and 1 morecytosol, nucleus
a ganglioside GQ1c (d18:1(4E))Reach from here →
1. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
2. CTP:N-acetylneuraminate cytidylyltransferase
3. a ganglioside GT1c (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GQ1c (d18:1(4E)) + CMP + H(+)
Catalysed by NPL, CMAS, ST3GAL4cytosol, nucleus
a ganglioside GP1c (d18:1(4E))Reach from here →
1. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
2. CTP:N-acetylneuraminate cytidylyltransferase
3. a ganglioside GQ1c (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GP1c (d18:1(4E)) + CMP + H(+)
Catalysed by NPL, CMAS, ST8SIA5cytosol, nucleus
N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enineReach from here →
1. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
2. CTP:N-acetylneuraminate cytidylyltransferase
3. N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine + CMP-N-acetyl-beta-neuraminate = N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine + CMP + H(+)
Catalysed by NPL, CMAS, ST6GALNAC6, ST6GALNAC5cytosol, nucleus
a ganglioside GM1bReach from here →
1. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
2. CTP:N-acetylneuraminate cytidylyltransferase
3. a ganglioside GA1 + CMP-N-acetyl-beta-neuraminate = a ganglioside GM1b + CMP + H(+)
Catalysed by NPL, CMAS, ST3GAL1, ST3GAL2cytosol, nucleus
ganglioside GD1a (18:1(4E)/18:0)Reach from here →
1. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
2. CTP:N-acetylneuraminate cytidylyltransferase
3. ganglioside GM1 (d18:1(4E)/18:0) + CMP-N-acetyl-beta-neuraminate = ganglioside GD1a (18:1(4E)/18:0) + CMP + H(+)
Catalysed by NPL, CMAS, ST3GAL1, ST3GAL2cytosol, nucleus
a neolactoside IV(3)-alpha-NeuAc-nLc4CerReach from here →
1. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
2. CTP:N-acetylneuraminate cytidylyltransferase
3. a neolactoside nLc4Cer + CMP-N-acetyl-beta-neuraminate = a neolactoside IV(3)-alpha-NeuAc-nLc4Cer + CMP + H(+)
Catalysed by NPL, CMAS, ST3GAL4cytosol, nucleus
a ganglioside GT1aReach from here →
1. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
2. CTP:N-acetylneuraminate cytidylyltransferase
3. a ganglioside GD1a + CMP-N-acetyl-beta-neuraminate = a ganglioside GT1a + CMP + H(+)
Catalysed by NPL, CMAS, ST8SIA6cytosol, nucleus