Loading the page.
Proteins/UNIPROT:Q9BVH7
Predominantly catalyzes the biosynthesis of ganglioside GD1alpha from GM1b in the brain, by transferring the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc to the GalNAc residue on the NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc sequence of GM1b. GD1alpha is a critical molecule in the communication and interaction between neuronal cells and their supportive cells, particularly in brain tissues, and functions as an adhesion molecule in the process of metastasis (By similarity). Also shows activity towards sialyl Lc4Cer (N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine) generating disialyl Lc4Cer, which can lead to the synthesis of disialyl Lewis a (Le(a)), suggested to be a cancer-associated antigen..
Function from UniProtKB (Q9BVH7), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
18 statements
18 statements · 4 reference databases · Subject: ST6GALNAC5 · Sources: Hetionet, Human-GEM, Reactome, Rhea
4 reactions
CMP-N-acetyl-beta-neuraminate+MAM02010ccytidine 5'-monophosphate+a ganglioside GD1a (d18:1(4E))+proton
Catalysed by ST6GALNAC5 or ST6GALNAC4 or ST6GALNAC6 or ST6GALNAC3
Reaction pageLeft to rightBalance undeterminableEC 2.4.99.-, 2.4.3.7cytosol
Human-GEM MAR00823CC BY 4.0Reference data
CMP-N-acetyl-beta-neuraminate+MAM02010gcytidine 5'-monophosphate
7 names
Resolves to: ST6GALNAC5
Catalysed by ST6GALNAC5 or ST6GALNAC4 or ST6GALNAC6 or ST6GALNAC3
Reaction pageLeft to rightBalance undeterminableEC 2.4.99.-, 2.4.3.7Golgi apparatus
Human-GEM MAR08168CC BY 4.0Reference data
a ganglioside GM1b (d18:1(4E))+CMP-N-acetyl-beta-neuraminatea ganglioside GD1alpha (d18:1(4E))+CMP+hydron
Catalysed by ST6GALNAC3 or ST6GALNAC6 or ST6GALNAC5 or ST6GALNAC4
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:41968CC BY 4.0Reference data
N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine+CMP-N-acetyl-beta-neuraminateN-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine+CMP+hydron
Catalysed by ST6GALNAC6 or ST6GALNAC5
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:47884CC BY 4.0Reference data