Met-tRNA(Met)

Three steps

• malonic acidReach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. sulfotransferase (thioredoxin)
  3. transport of malonate and sulfite (cytosol to mitochondria)

  Catalysed by SULT1A3, SLC25A10cytosol, mitochondrial matrixOne of 2 routes

• L-lysineReach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. thioredoxin phosphorylation
  3. L-lysine(in) + L-leucine(out) + Na(+)(out) = L-lysine(out) + L-leucine(in) + Na(+)(in)

  Catalysed by SLC7A7cytosol, inner side of the membrane, outer side of the membraneOne of 3 routes

• putrescineReach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. mitothioredoxin phosphorylation
  3. Putrescine Export via Putrescine/Arginine Antiporter

  Catalysed by SLC3A2, SLC7A7cytosol, extracellular space

• N-carbamoyl-L-aspartateReach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. thioredoxin phosphorylation
  3. carbamoyl phosphate + L-aspartate = N-carbamoyl-L-aspartate + phosphate + H(+)

  Catalysed by CADcytosol

• thiosulfateReach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. sulfotransferase (thioredoxin)
  3. 3-mercaptopyruvate:sulfide sulfurtransferase

  Catalysed by SULT1A3, MPST, TSTcytosolOne of 7 routes

• 4-methylthio-2-oxobutanoic acidReach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. thioredoxin phosphorylation
  3. L-Methionine:oxygen oxidoreductase (deaminating)

  Catalysed by IL4I1cytosol

• di-mu-sulfido-diiron(2+)Reach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. thioredoxin phosphorylation
  3. De novo synthesis of 2Fe2S

  Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 3 morecytosol, mitochondrial matrix

• (S)-3-methyl-2-oxopentanoateReach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. thioredoxin phosphorylation
  3. L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate

  Catalysed by BCAT2, BCAT1cytosol

• D-cysteineReach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. thioredoxin phosphorylation
  3. D-cysteine(out) + L-alanine(in) = D-cysteine(in) + L-alanine(out)

  Catalysed by SLC7A10cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• D-serineReach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. thioredoxin phosphorylation
  3. D-serine(out) + L-alanine(in) = D-serine(in) + L-alanine(out)

  Catalysed by SLC7A10cytosol, inner side of the membrane, outer side of the membraneOne of 10 routes

• 5-aminolevulinateReach from here →
  1. 10-Formyltetrahydrofolate:L-methionyl-tRNA N-formyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA

  Catalysed by MTFMT, SHMT1, ALAS1, ALAS2cytosol

• 3-methyl-2-oxovaleric acidReach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. thioredoxin phosphorylation
  3. L-Leucine:2-oxoglutarate aminotransferase

  Catalysed by BCAT1cytosolOne of 2 routes

• 3-(4-hydroxyphenyl)pyruvateReach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. thioredoxin phosphorylation
  3. L-tyrosine:2-oxoglutarate aminotransferase

  Catalysed by GOT2, GOT1, TATcytosolOne of 3 routes

• glycochenodeoxycholateReach from here →
  1. 10-Formyltetrahydrofolate:L-methionyl-tRNA N-formyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. chenodeoxycholoyl-CoA + glycine = glycochenodeoxycholate + CoA + H(+)

  Catalysed by MTFMT, SHMT1, BAATcytosol

• glycochenodeoxycholic acidReach from here →
  1. 10-Formyltetrahydrofolate:L-methionyl-tRNA N-formyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by MTFMT, SHMT1, BAATcytosol, peroxisomeOne of 3 routes

• glyoxylateReach from here →
  1. 10-Formyltetrahydrofolate:L-methionyl-tRNA N-formyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. glycine + 2-oxoglutarate = glyoxylate + L-glutamate

  Catalysed by MTFMT, SHMT1, AADATcytosolOne of 11 routes

• glycolithocholic acidReach from here →
  1. 10-Formyltetrahydrofolate:L-methionyl-tRNA N-formyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. bile acid-CoA:amino acid N-acyltransferase (glycine)

  Catalysed by MTFMT, SHMT1, BAATcytosolOne of 2 routes

• L-2-amino-3-oxobutanoic acidReach from here →
  1. 10-Formyltetrahydrofolate:L-methionyl-tRNA N-formyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. Acetyl-CoA:glycine C-acetyltransferase

  Catalysed by MTFMT, SHMT1, GCATcytosol, mitochondrial matrix

• D-glucopyranose 6-phosphateReach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. 2'-deoxyadenosine 5'-triphosphate:oxydized-thioredoxin 2'-oxidoreductase
  3. dATP:D-glucose 6-phosphotransferase

  Catalysed by TXN, RRM1, RRM2, RRM2B and 5 morecytosol

• L-ornithineReach from here →
  1. 10-Formyltetrahydrofolate:L-methionyl-tRNA N-formyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. L-Arginine:glycine amidinotransferase

  Catalysed by MTFMT, SHMT1, GATMcytosolOne of 56 routes

• gamma-Glu-AlaReach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. thioredoxin phosphorylation
  3. gamma-glutamyltransferase (alanine)

  Catalysed by GGT1, GGT5, GGTLC2, GGT6 and 2 morecytosol, extracellular space

• S(8)-aminomethyldihydrolipoamideReach from here →
  1. 10-Formyltetrahydrofolate:L-methionyl-tRNA N-formyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. dihydrolipoyl dehydrogenase ([protein]-N6-(lipoyl)lysine)

  Catalysed by MTFMT, SHMT1, GLDC, GCSHcytosol, mitochondrial matrix

• D-alanineReach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. thioredoxin phosphorylation
  3. D-alanine(out) + L-alanine(in) = D-alanine(in) + L-alanine(out)

  Catalysed by SLC7A10cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• sarcosineReach from here →
  1. 10-Formyltetrahydrofolate:L-methionyl-tRNA N-formyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2

  Catalysed by MTFMT, SHMT1, PIPOXcytosolOne of 2 routes

• (6S)-5,6,7,8-tetrahydrofolateReach from here →
  1. 10-Formyltetrahydrofolate:L-methionyl-tRNA N-formyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine

  Catalysed by MTFMT, SHMT1, SHMT2cytosolOne of 3 routes

• (6R)-5,10-methenyltetrahydrofolateReach from here →
  1. 10-Formyltetrahydrofolate:L-methionyl-tRNA N-formyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. 5,10-methylenetetrahydrofolate:NAD+ oxidoreductase

  Catalysed by MTFMT, SHMT1, MTHFD2, MTHFD2Lcytosol, mitochondrial matrixOne of 8 routes

• 2-(N(omega)-L-arginino)succinateReach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. thioredoxin phosphorylation
  3. L-Citrulline:L-aspartate ligase (AMP-forming)

  Catalysed by ASS1cytosolOne of 4 routes

• 4-guanidinobutanoateReach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. mitothioredoxin phosphorylation
  3. 4-aminobutanoate + L-arginine = 4-guanidinobutanoate + L-ornithine

  Catalysed by GATMcytosol

• L-dopaReach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. thioredoxin phosphorylation
  3. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)

  Catalysed by SLC7A8cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• dCMPReach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. 2'-deoxyadenosine 5'-diphosphate:oxidized-thioredoxin 2'-oxidoreductase
  3. cytidine/uridine monophosphate kinase (dADP)

  Catalysed by TXN, RRM1, RRM2, RRM2B and 2 morecytosolOne of 21 routes

• N(6)-(1,2-dicarboxyethyl)-AMPReach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. thioredoxin phosphorylation
  3. IMP:L-aspartate ligase (GDP-forming)

  Catalysed by ADSS2, ADSS1cytosolOne of 2 routes

• 3-guanidinopropanoateReach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. mitothioredoxin phosphorylation
  3. beta-alanine + L-arginine = 3-guanidinopropanoate + L-ornithine

  Catalysed by GATMcytosol

• L-histidineReach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. thioredoxin phosphorylation
  3. L-histidine(in) + L-phenylalanine(out) = L-histidine(out) + L-phenylalanine(in)

  Catalysed by SLC7A8cytosol, inner side of the membrane, outer side of the membraneOne of 5 routes

• an N-acylglycineReach from here →
  1. 10-Formyltetrahydrofolate:L-methionyl-tRNA N-formyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. an acyl-CoA + glycine = an N-acylglycine + CoA + H(+)

  Catalysed by MTFMT, SHMT1, GLYATL3, GLYAT and 1 morecytosol

• dGMPReach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. 2'-deoxyadenosine 5'-diphosphate:oxidized-thioredoxin 2'-oxidoreductase
  3. dADP to dATP conversion

  Catalysed by TXN, RRM1, RRM2, RRM2B and 1 morecytosol, mitochondrial matrixOne of 4 routes

• 2-oxo-3-sulfanylpropanoateReach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. thioredoxin phosphorylation
  3. L-Cysteine:2-oxoglutarate aminotransferase

  Catalysed by GOT2, GOT1cytosolOne of 3 routes

• guanidinoacetateReach from here →
  1. 10-Formyltetrahydrofolate:L-methionyl-tRNA N-formyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. L-Arginine:glycine amidinotransferase

  Catalysed by MTFMT, SHMT1, GATMcytosolOne of 4 routes

• D-threonineReach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. thioredoxin phosphorylation
  3. D-threonine(out) + L-alanine(in) = D-threonine(in) + L-alanine(out)

  Catalysed by SLC7A10cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-dopaquinoneReach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. thioredoxin phosphorylation
  3. L-Tyrosine,L-dopa:oxygen oxidoreductase

  Catalysed by TYRcytosol

• glutathioneReach from here →
  1. 10-Formyltetrahydrofolate:L-methionyl-tRNA N-formyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)

  Catalysed by MTFMT, SHMT1, GSScytosolOne of 3 routes

• L-threonineReach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. thioredoxin phosphorylation
  3. L-threonine(out) + L-alanine(in) = L-threonine(in) + L-alanine(out)

  Catalysed by SLC7A10cytosol, inner side of the membrane, outer side of the membraneOne of 8 routes

• L-saccharopineReach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. thioredoxin phosphorylation
  3. N6-(L-1,3-Dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming)

  Catalysed by AASScytosol, mitochondrial matrix

• L-kynurenineReach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. thioredoxin phosphorylation
  3. L-kynurenine + H2O = anthranilate + L-alanine + H(+)

  Catalysed by KYNUcytosolOne of 5 routes

• beta-alanineReach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. thioredoxin phosphorylation
  3. beta-alanine(out) + L-alanine(in) = beta-alanine(in) + L-alanine(out)

  Catalysed by SLC7A10cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• leukotriene C4Reach from here →
  1. 10-Formyltetrahydrofolate:L-methionyl-tRNA N-formyltransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. leukotriene C4 hydrolysis

  Catalysed by MTFMT, SHMT1cytosol

• taurocyamineReach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. mitothioredoxin phosphorylation
  3. taurine + L-arginine = taurocyamine + L-ornithine

  Catalysed by GATMcytosol

• N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagineReach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. thioredoxin phosphorylation
  3. N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O = N-acetyl-beta-D-glucosaminylamine + L-aspartate + H(+)

  Catalysed by AGAcytosol

• 3-hydroxy-L-kynurenineReach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. thioredoxin phosphorylation
  3. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)

  Catalysed by KYNUcytosol

• gamma-L-glutamyl-L-cysteineReach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. thioredoxin phosphorylation
  3. L-glutamate:L-cysteine gamma-ligase (ADP-forming)

  Catalysed by GCLC, GCLMcytosolOne of 2 routes

• 6-amino-2-oxohexanoateReach from here →
  1. glycyl-tRNA(gly) phosphorylation
  2. thioredoxin phosphorylation
  3. L-lysine:oxygen 2-oxidoreductase (deaminating)

  No catalyst recordedcytosol, peroxisome