ferricytochrome c

Three steps

• L-glutamineReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of alanine and glutamine (cytosol to extracellular)

  Catalysed by LDHD, AGXT2, SLC3A2, SLC7A5 and 1 moremitochondrial matrix, cytosol, extracellular spaceOne of 20 routes

• dTTPReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. pyruvate kinase (dTDP)
  3. DTTP Nucleotidohydrolase

  Catalysed by LDHD, PKM, PKLR, ENTPD3 and 2 moremitochondrial matrix, cytosol, extracellular spaceOne of 11 routes

• CHEBI:18095Reach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. Transport of Hydroxy-Proline

  Catalysed by LDHD, AGXT2, SLC1A4mitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• N-carbamoyl-beta-alanineReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Transport of 3-Ureidopropionate

  Catalysed by SUOX, SLC26A6mitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• hydrogen cyanideReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. sulfite(in) + sulfate(out) = sulfite(out) + sulfate(in)
  3. thiosulfate:cyanide sulfurtranserase

  Catalysed by SUOX, SLC25A14, SLC25A30, MPST and 1 moremitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• S-methylmercury-L-cysteineReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O
  3. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)

  Catalysed by LDHD, TYW1B, TYW1, SLC7A8mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• 2-(alpha-Hydroxypropyl)thiamine diphosphateReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
  3. branched chain keto acid dehydrogenase E1 (2-oxobutyrate)

  Catalysed by LDHD, AGXT2, BCKDHA, BCKDHBmitochondrial matrix, cytosol

• 2-aminoisobutanoateReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. 2-aminoisobutanoate(out) + L-alanine(in) = 2-aminoisobutanoate(in) + L-alanine(out)

  Catalysed by LDHD, AGXT2, SLC7A10mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• D-isoleucineReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. D-serine = pyruvate + NH4(+)
  3. D-isoleucine(out) + D-serine(in) = D-isoleucine(in) + D-serine(out)

  Catalysed by LDHD, SRR, SLC7A10mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membrane

• 3-carboxy-4-methyl-5-propyl-2-furanpropanoateReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. 3-carboxy-4-methyl-5-propyl-2-furanpropanoate(out) + a dicarboxylate(in) = 3-carboxy-4-methyl-5-propyl-2-furanpropanoate(in) + a dicarboxylate(out)

  Catalysed by SUOX, SLC25A35, SLC25A34, SLC22A6 and 1 moremitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-sepiapterinReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. L-sepiapterin(out) + a dicarboxylate(in) = L-sepiapterin(in) + a dicarboxylate(out)

  Catalysed by SUOX, SLC25A35, SLC25A34, SLC22A6 and 1 moremitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• N(omega),N('omega)-dimethyl-L-arginineReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by LDHD, AGXT2mitochondrial matrix, cytosolOne of 3 routes

• (S)-lactoyl-AMPReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
  3. (S)-lactate + ATP + H(+) = (S)-lactoyl-AMP + diphosphate

  Catalysed by LDHD, LDHA, LDHB, LDHC and 4 moremitochondrial matrix, cytosol

• (S)-lactoyl-CoAReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
  3. (S)-lactate + ATP + CoA = (S)-lactoyl-CoA + AMP + diphosphate

  Catalysed by LDHD, LDHA, LDHB, LDHC and 3 moremitochondrial matrix, cytosol

• N-acetylneuraminate 9-phosphateReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. pyruvate kinase (dTDP)
  3. N-acetylneuraminate synthase

  Catalysed by LDHD, PKM, PKLR, NANSmitochondrial matrix, cytosol

• CHEBI:240943Reach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. 2-Methylbutyrylglycine Transport, Extracellular

  Catalysed by SUOX, SLC26A6, SLC6A5mitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• a quinolReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. (S)-malate + NAD(+) = pyruvate + CO2 + NADH
  3. (S)-malate + a quinone = enol-oxaloacetate + a quinol

  Catalysed by LDHD, ME2, SDHB, SDHAmitochondrial matrix, cytosol

• hypochlorous acidReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Peroxidase

  Catalysed by SUOX, SLC26A6, LPOmitochondrial matrix, cytosol, extracellular spaceOne of 4 routes

• potassium atomReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of chloride (cytosol to extracellular)

  Catalysed by SUOX, SLC26A6, SLC12A2, SLC12A1mitochondrial matrix, cytosol, extracellular spaceOne of 3 routes

• selenomethionineReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
  3. Selenomethionine methanethiol-lyase (deaminating)

  Catalysed by LDHD, AGXT2, CTHmitochondrial matrix, cytosol

• CHEBI:27760Reach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
  3. Selenocystathionine Lysteine-lyase (deaminating)

  Catalysed by LDHD, AGXT2, CTHmitochondrial matrix, cytosol

• 3-mercaptolactic acidReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)
  3. 3-Mercaptolactate:NAD+ oxidoreductase

  Catalysed by LDHD, MPST, LDHB, LDHC and 2 moremitochondrial matrix, cytosol

• 2-oxopentanoateReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine
  3. 2-oxopentanoate + N(omega),N(omega)-dimethyl-L-arginine = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-2-aminopentanoate

  Catalysed by LDHD, AGXT2mitochondrial matrix, cytosol

• 3beta-hydroxyandrost-5-en-17-oneReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)
  3. 3beta-Hydroxyandrost-5-en-17-one 3-sulfate sulfohydrolase

  Catalysed by SUOX, STSmitochondrial matrix, cytosolOne of 3 routes

• 17alpha-hydroxypregnenoloneReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. cytochrome P450 (17alpha-hydroxypregnenolone)

  Catalysed by LDHD, SLC16A4, SLC16A5, SLC16A3 and 3 moremitochondrial matrix, cytosol, extracellular space, endoplasmic reticulum

• pyridoxine 5'-phosphateReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by LDHD, AGXT2, SCLYmitochondrial matrix, cytosol

• N-glycoloylneuraminateReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
  3. CMP-N-acetylneuraminate monooxygenase (N-acetylneuraminate)

  Catalysed by LDHD, NPLmitochondrial matrix, cytosol

• a carboxylateReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. a 3-acylpyruvate + H2O = a carboxylate + pyruvate + H(+)
  3. a 3-acylpyruvate + H2O = a carboxylate + pyruvate + H(+)

  Catalysed by LDHD, FAHD1mitochondrial matrix, cytosol

• K(+)Reach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. K(+)(in) + L-aspartate(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-aspartate(in) + 3 Na(+)(in) + H(+)(in)

  Catalysed by SUOX, SLC25A14, SLC25A30, SLC1A7 and 4 moremitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• Asp-tRNA(Asp)Reach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. L-Aspartate:tRNA(Asp) ligase (AMP-forming)

  Catalysed by SUOX, SLC25A14, SLC25A30, DARS1mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membrane

• hydrogen sulfideReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)
  3. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)

  Catalysed by LDHD, MPSTmitochondrial matrix, cytosolOne of 3 routes

• citric acidReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. Pyruvate:carbon-dioxide ligase (ADP-forming)
  3. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)

  Catalysed by LDHD, PC, CSmitochondrial matrix, cytosolOne of 14 routes

• (indol-3-yl)acetateReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. (indol-3-yl)acetate(out) + a dicarboxylate(in) = (indol-3-yl)acetate(in) + a dicarboxylate(out)

  Catalysed by SUOX, SLC25A35, SLC25A34, SLC22A6 and 1 moremitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• isocitric acidReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. pyruvate kinase (dTDP)
  3. transport of isocitrate and PEP (cytosol to mitochondria)

  Catalysed by LDHD, PKM, PKLR, SLC25A1mitochondrial matrix, cytosolOne of 8 routes

• glutarateReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)
  3. dehydroepiandrosterone 3-sulfate(out) + glutarate(in) = dehydroepiandrosterone 3-sulfate(in) + glutarate(out)

  Catalysed by SUOX, STS, SLC22A24, SLC22A8mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• 4-hydroxy-2-oxoglutaric acidReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. Pyruvate:carbon-dioxide ligase (ADP-forming)
  3. D-aspartate:2-oxoglutarate aminotransferase

  Catalysed by LDHD, PC, GOT2mitochondrial matrix, cytosol

• pentanoateReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)
  3. pentanoate(out) + dehydroepiandrosterone 3-sulfate(in) = pentanoate(in) + dehydroepiandrosterone 3-sulfate(out)

  Catalysed by SUOX, STS, SLC22A9mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• nonanoateReach from here →
  1. 13(S)-HPODE to 13-oxy-radical-octadecadienoate conversion
  2. 13(S)-HPODE to 13-oxy-radical-octadecadienoate conversion
  3. 13(S)-HPODE hydrolysis

  No catalyst recordedcytosol

• cis-aconitic acidReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. pyruvate kinase (dTDP)
  3. transport of cis-aconitate and PEP (cytosol to mitochondria)

  Catalysed by LDHD, PKM, PKLR, SLC25A1mitochondrial matrix, cytosolOne of 8 routes

• N-carbamoyl-L-aspartateReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. carbamoyl phosphate + L-aspartate = N-carbamoyl-L-aspartate + phosphate + H(+)

  Catalysed by SUOX, SLC25A14, SLC25A30, CADmitochondrial matrix, cytosol, inner side of the membrane, outer side of the membrane

• 4-methylthio-2-oxobutanoic acidReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O
  3. L-Methionine:oxygen oxidoreductase (deaminating)

  Catalysed by LDHD, TYW1B, TYW1, IL4I1mitochondrial matrix, cytosol

• a phenolReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. an aryl sulfate + H2O = a phenol + sulfate + H(+)
  3. an aryl sulfate + H2O = a phenol + sulfate + H(+)

  Catalysed by SUOX, ARSL, ARSF, ARSK and 3 moremitochondrial matrix, cytosol

• 2-oxohexanoateReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine
  3. 2-oxohexanoate + N(omega),N(omega)-dimethyl-L-arginine = L-2-aminohexanoate + 5-(3,3-dimethylguanidino)-2-oxopentanoate

  Catalysed by LDHD, AGXT2mitochondrial matrix, cytosol

• D-cysteineReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. D-cysteine(out) + L-alanine(in) = D-cysteine(in) + L-alanine(out)

  Catalysed by LDHD, AGXT2, SLC7A10mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-alpha-aminobutyric acidReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
  3. glutamic-pyruvic transaminase ((S)-2-aminobutanoate)

  Catalysed by LDHD, AGXT2, GPTmitochondrial matrix, cytosol

• glyoxylateReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. (S)-malate + NAD(+) = pyruvate + CO2 + NADH
  3. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)

  Catalysed by LDHD, ME2, CLYBLmitochondrial matrix, cytosolOne of 8 routes

• L-erythro-7,8-dihydrobiopterinReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. L-erythro-7,8-dihydrobiopterin(out) + a dicarboxylate(in) = L-erythro-7,8-dihydrobiopterin(in) + a dicarboxylate(out)

  Catalysed by SUOX, SLC25A35, SLC25A34, SLC22A6 and 1 moremitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (3S)-3-hydroxy-3-methylglutaryl-CoAReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. transport of acetoacetate and pyruvate (cytosol to mitochondria)
  3. (3S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA

  Catalysed by LDHD, HMGCL, HMGCLL1mitochondrial matrix, cytosol

• 13-cis-retinalReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. transport of pyruvate and retinoate (cytosol to extracellular)
  3. retinal dehydrogenase (13-cis-retinal)

  Catalysed by LDHD, SLC16A4, SLC16A5, SLC16A3 and 5 moremitochondrial matrix, cytosol, extracellular space, endoplasmic reticulum

• L-ornithineReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of alanine and ornithine (cytosol to extracellular)

  Catalysed by LDHD, AGXT2, SLC7A6mitochondrial matrix, cytosol, extracellular spaceOne of 7 routes