trimethylenediamine

Three steps

• (2E)-dodecenoyl-CoAReach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. Acetylation of Lysine
  3. (2E)-dodecenoyl-CoA formation

  Catalysed by DHPScytosol, mitochondrial matrixOne of 3 routes

• 4,8,12-trimethyltridecanoyl-CoAReach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. Acetylation of Lysine
  3. propanoyl-CoA C-acyltransferase (3-ketopristanoyl-CoA)

  Catalysed by DHPS, ACAA1, MYO5Bcytosol, mitochondrial matrix, peroxisomeOne of 2 routes

• (6Z,9Z,12Z)-octadecatrienoyl-CoAReach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. Acetylation of Lysine
  3. long-chain-fatty-acid-CoA ligase (gamma-linolenate)

  Catalysed by DHPS, SLC27A2, ACSL4, ACSL3 and 5 morecytosol, mitochondrial matrixOne of 7 routes

• butanoyl-CoAReach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. Acetylation of Lysine
  3. Butanoate:CoA ligase (AMP-forming)

  Catalysed by DHPS, ACSM4, ACSM1, ACSM2A and 3 morecytosol, mitochondrial matrixOne of 9 routes

• dodecanoyl-CoAReach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. Acetylation of Lysine
  3. long-chain-fatty-acid-CoA ligase (lauric acid)

  Catalysed by DHPS, SLC27A2, ACSL4, ACSL3 and 5 morecytosol, mitochondrial matrixOne of 9 routes

• glutaryl-CoAReach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. Acetylation of Lysine
  3. Production of Glutaryl Carnitine

  Catalysed by DHPS, CPT1A, CPT1C, CPT1Bcytosol, mitochondrial matrixOne of 2 routes

• eicosanoyl-CoAReach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. Acetylation of Lysine
  3. long-chain-fatty-acid-CoA ligase (eicosanoate)

  Catalysed by DHPS, SLC27A2, ACSL4, ACSL3 and 5 morecytosol, mitochondrial matrixOne of 12 routes

• itaconyl-CoAReach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. Acetylation of Lysine
  3. Itaconate:CoA ligase (GDP-forming)

  Catalysed by DHPS, SUCLG1, SUCLG2, SUCLA2cytosol, mitochondrial matrixOne of 2 routes

• (9Z,12Z)-octadecadienoyl-CoAReach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. Acetylation of Lysine
  3. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)

  Catalysed by DHPS, SLC27A2, ACSL4, ACSL3 and 5 morecytosol, mitochondrial matrixOne of 13 routes

• tetradecanoyl-CoAReach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. Acetylation of Lysine
  3. long-chain-fatty-acid-CoA ligase (myristic acid)

  Catalysed by DHPS, SLC27A2, ACSL4, ACSL3 and 5 morecytosol, mitochondrial matrixOne of 11 routes

• octanoyl-CoAReach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. Acetylation of Lysine
  3. Octanoyl-CoA:L-carnitine O-octanoyltransferase

  Catalysed by DHPS, CROTcytosol, mitochondrial matrixOne of 20 routes

• phytanoyl-CoAReach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. Acetylation of Lysine
  3. phytanate-CoA ligase

  Catalysed by DHPScytosol, mitochondrial matrixOne of 5 routes

• octadecanoyl-CoAReach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. Acetylation of Lysine
  3. long-chain-fatty-acid-CoA ligase (stearate)

  Catalysed by DHPS, SLC27A2, ACSL4, ACSL3 and 4 morecytosol, mitochondrial matrixOne of 15 routes

• D-alanineReach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. transport of alanine and lysine (cytosol to extracellular)
  3. D-alanine(out) + L-alanine(in) = D-alanine(in) + L-alanine(out)

  Catalysed by DHPS, SLC7A6, SLC7A10cytosol, extracellular space, inner side of the membrane, outer side of the membraneOne of 2 routes

• sarcosineReach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. transport of glycine and lysine (cytosol to extracellular)
  3. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2

  Catalysed by DHPS, SLC7A6, PIPOXcytosol, extracellular spaceOne of 2 routes

• (6S)-5,6,7,8-tetrahydrofolateReach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. transport of glycine and lysine (cytosol to extracellular)
  3. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine

  Catalysed by DHPS, SLC7A6, SHMT1, SHMT2cytosol, extracellular space

• 2-(N(omega)-L-arginino)succinateReach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. transport of arginine and lysine (cytosol to extracellular)
  3. 2-(Nomega-L-arginino)succinate arginine-lyase (fumarate-forming)

  Catalysed by DHPS, SLC3A2, SLC7A5, SLC7A6 and 1 morecytosol, extracellular spaceOne of 4 routes

• carnosineReach from here →
  1. primary-amine oxidase (1,3-diaminopropane)
  2. Beta-Aminopropion Aldehyde:NAD+ Oxidoreductase, Mitochondrial
  3. beta-alanine + L-histidine + ATP = carnosine + ADP + phosphate + H(+)

  Catalysed by AOC2, AOC1, AOC3, ALDH2 and 2 morecytosol, mitochondrial matrix

• 4-guanidinobutanoateReach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. transport of arginine and lysine (cytosol to extracellular)
  3. 4-aminobutanoate + L-arginine = 4-guanidinobutanoate + L-ornithine

  Catalysed by DHPS, SLC3A2, SLC7A5, SLC7A6 and 1 morecytosol, extracellular space

• L-dopaReach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. transport of lysine and phenylalanine (cytosol to extracellular)
  3. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)

  Catalysed by DHPS, SLC7A6, SLC7A8cytosol, extracellular space, inner side of the membrane, outer side of the membraneOne of 2 routes

• 3-guanidinopropanoateReach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. transport of arginine and lysine (cytosol to extracellular)
  3. beta-alanine + L-arginine = 3-guanidinopropanoate + L-ornithine

  Catalysed by DHPS, SLC3A2, SLC7A5, SLC7A6 and 1 morecytosol, extracellular spaceOne of 2 routes

• L-histidineReach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. transport of arginine and lysine (cytosol to extracellular)
  3. L-histidine(out) + L-arginine(in) + Na(+)(out) = L-histidine(in) + L-arginine(out) + Na(+)(in)

  Catalysed by DHPS, SLC3A2, SLC7A5, SLC7A6cytosol, extracellular space, inner side of the membrane, outer side of the membraneOne of 7 routes

• D-ornithineReach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. transport of lysine and ornithine (cytosol to extracellular)
  3. D-ornithine(in) + L-ornithine(out) = D-ornithine(out) + L-ornithine(in)

  Catalysed by DHPS, SLC7A5, SLC7A6, SLC25A2cytosol, extracellular space, inner side of the membrane, outer side of the membraneOne of 2 routes

• an N-acylglycineReach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. transport of glycine and lysine (cytosol to extracellular)
  3. an acyl-CoA + glycine = an N-acylglycine + CoA + H(+)

  Catalysed by DHPS, SLC7A6, GLYATL3, GLYAT and 1 morecytosol, extracellular space

• 2-oxo-3-sulfanylpropanoateReach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. transport of cysteine and lysine (cytosol to extracellular)
  3. L-Cysteine:2-oxoglutarate aminotransferase

  Catalysed by DHPS, SLC7A6, GOT2, GOT1cytosol, extracellular spaceOne of 3 routes

• guanidinoacetateReach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. transport of arginine and lysine (cytosol to extracellular)
  3. L-Arginine:glycine amidinotransferase

  Catalysed by DHPS, SLC3A2, SLC7A5, SLC7A6 and 1 morecytosol, extracellular spaceOne of 5 routes

• sphing-4-enineReach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. Acetylation of Lysine
  3. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by DHPS, ASAH1, ACER2, ACER1 and 1 morecytosol, mitochondrial matrix, Golgi apparatusOne of 2 routes

• D-threonineReach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. transport of alanine and lysine (cytosol to extracellular)
  3. D-threonine(out) + L-alanine(in) = D-threonine(in) + L-alanine(out)

  Catalysed by DHPS, SLC7A6, SLC7A10cytosol, extracellular space, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-dopaquinoneReach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. transport of lysine and tyrosine (cytosol to extracellular)
  3. L-Tyrosine,L-dopa:oxygen oxidoreductase

  Catalysed by DHPS, SLC7A6, TYRcytosol, extracellular space

• glutathioneReach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. transport of glycine and lysine (cytosol to extracellular)
  3. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)

  Catalysed by DHPS, SLC7A6, GSScytosol, extracellular space

• L-threonineReach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. transport of alanine and lysine (cytosol to extracellular)
  3. L-threonine(out) + L-alanine(in) = L-threonine(in) + L-alanine(out)

  Catalysed by DHPS, SLC7A6, SLC7A10cytosol, extracellular space, inner side of the membrane, outer side of the membraneOne of 8 routes

• L-kynurenineReach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. transport of alanine and lysine (cytosol to extracellular)
  3. L-kynurenine + H2O = anthranilate + L-alanine + H(+)

  Catalysed by DHPS, SLC7A6, KYNUcytosol, extracellular spaceOne of 5 routes

• leukotriene C4Reach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. transport of glycine and lysine (cytosol to extracellular)
  3. leukotriene C4 hydrolysis

  Catalysed by DHPS, SLC7A6cytosol, extracellular space

• taurocyamineReach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. transport of arginine and lysine (cytosol to extracellular)
  3. taurine + L-arginine = taurocyamine + L-ornithine

  Catalysed by DHPS, SLC3A2, SLC7A5, SLC7A6 and 1 morecytosol, extracellular space

• L-glutamate 5-semialdehydeReach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. transport of lysine and ornithine (cytosol to extracellular)
  3. L-ornithine + 2-oxoglutarate = L-glutamate 5-semialdehyde + L-glutamate

  Catalysed by DHPS, SLC7A5, SLC7A6, OATcytosol, extracellular space

• 3-hydroxy-L-kynurenineReach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. transport of alanine and lysine (cytosol to extracellular)
  3. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)

  Catalysed by DHPS, SLC7A6, KYNUcytosol, extracellular space

• L,L-cystathionineReach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. Acetylation of Lysine
  3. N-acetylglutamate synthase (N-acetyl-L-cystathionine)

  Catalysed by DHPS, NAGScytosol, mitochondrial matrix

• gamma-L-glutamyl-L-cysteineReach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. transport of cysteine and lysine (cytosol to extracellular)
  3. L-glutamate:L-cysteine gamma-ligase (ADP-forming)

  Catalysed by DHPS, SLC7A6, GCLC, GCLMcytosol, extracellular spaceOne of 2 routes

• L-homocysteineReach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. transport of lysine and methionine (cytosol to extracellular)
  3. S-methyl-L-methionine + L-homocysteine = 2 L-methionine + H(+)

  Catalysed by DHPS, SLC7A6, BHMT2cytosol, extracellular space

• carbamoyl phosphateReach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. transport of citrulline and lysine (cytosol to extracellular)
  3. Carbamoyl-phosphate:L-ornithine carbamoyltransferase

  Catalysed by DHPS, SLC7A5, SLC7A6, OTCcytosol, extracellular space, mitochondrial matrixOne of 4 routes

• S-methyl-L-methionineReach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. transport of lysine and methionine (cytosol to extracellular)
  3. S-methyl-L-methionine + L-homocysteine = 2 L-methionine + H(+)

  Catalysed by DHPS, SLC7A6, BHMT2cytosol, extracellular space

• N-acetylputrescineReach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. S-adenosyl 3-(methylsulfanyl)propylamine + putrescine = S-methyl-5'-thioadenosine + spermidine + H(+)
  3. acetyl-CoA:putrescine N-acetyltransferase

  Catalysed by DHPS, SRM, SAT1, SAT2cytosolOne of 2 routes

• 4-aminobutanalReach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. S-adenosyl 3-(methylsulfanyl)propylamine + putrescine = S-methyl-5'-thioadenosine + spermidine + H(+)
  3. putrescine + O2 + H2O = 4-aminobutanal + H2O2 + NH4(+)

  Catalysed by DHPS, SRM, AOC1cytosol

• L-tyrosineReach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. transport of glycine and lysine (cytosol to extracellular)
  3. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine

  Catalysed by DHPS, SLC7A6, AADATcytosol, extracellular spaceOne of 2 routes

• (S)-2-amino-6-oxohexanoateReach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. N6-(L-1,3-Dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming)
  3. L-saccharopine + NAD(+) + H2O = (S)-2-amino-6-oxohexanoate + L-glutamate + NADH + H(+)

  Catalysed by DHPS, AASScytosol, mitochondrial matrix

• N(omega),N(omega)-dimethyl-L-arginineReach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. transport of arginine and lysine (cytosol to extracellular)
  3. N(omega),N(omega)-dimethyl-L-arginine(in) + L-arginine(out) = N(omega),N(omega)-dimethyl-L-arginine(out) + L-arginine(in)

  Catalysed by DHPS, SLC3A2, SLC7A5, SLC7A6 and 1 morecytosol, extracellular space, inner side of the membrane, outer side of the membraneOne of 6 routes

• an acyl-CoAReach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. Acetylation of Lysine
  3. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by DHPS, ASAH1, ACER2, ACER1 and 1 morecytosol, mitochondrial matrix, Golgi apparatusOne of 2 routes

• trans-4-hydroxy-L-prolineReach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. transport of alanine and lysine (cytosol to extracellular)
  3. trans-4-hydroxy-L-proline(out) + L-alanine(in) + Na(+)(out) = trans-4-hydroxy-L-proline(in) + L-alanine(out) + Na(+)(in)

  Catalysed by DHPS, SLC7A6, SLC1A4cytosol, extracellular space, inner side of the membrane, outer side of the membraneOne of 2 routes

• histamineReach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. transport of histidine and lysine (cytosol to extracellular)
  3. L-histidine carboxy-lyase (histamine-forming)

  Catalysed by DHPS, SLC7A5, SLC7A6, HDCcytosol, extracellular space

• 5-guanidino-2-oxopentanoateReach from here →
  1. deoxyhypusine synthase (1,3-diaminopropane)
  2. transport of arginine and lysine (cytosol to extracellular)
  3. L-arginine + O2 + H2O = 5-guanidino-2-oxopentanoate + H2O2 + NH4(+)

  Catalysed by DHPS, SLC3A2, SLC7A5, SLC7A6 and 1 morecytosol, extracellular space