10-formyltetrahydrofolic acid

Three steps

• CHEBI:17895Reach from here →
  1. 10-formyltetrahydrofolate:NADP+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. transport of glycine and tyrosine (cytosol to extracellular)

  Catalysed by ALDH1L1, ALDH1L2, SHMT1, SLC7A5cytosol, extracellular spaceOne of 4 routes

• CHEBI:18019Reach from here →
  1. 10-formyltetrahydrofolate:NADP+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. transport of glycine and lysine (cytosol to extracellular)

  Catalysed by ALDH1L1, ALDH1L2, SHMT1, SLC7A6cytosol, extracellular spaceOne of 2 routes

• L-glutamineReach from here →
  1. 10-formyltetrahydrofolate:NADP+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. transport of glutamine and glycine (cytosol to extracellular)

  Catalysed by ALDH1L1, ALDH1L2, SHMT1, SLC7A5cytosol, extracellular spaceOne of 4 routes

• N(1)-(5-phospho-D-ribosyl)glycinamideReach from here →
  1. 10-formyltetrahydrofolate:NADP+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. 5-Phospho-D-ribosylamine:glycine ligase (ADP-forming)

  Catalysed by ALDH1L1, ALDH1L2, SHMT1, GARTcytosol

• (6S)-5-methyl-5,6,7,8-tetrahydrofolateReach from here →
  1. 10-formyltetrahydrofolate:NADP+ oxidoreductase
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase (10-formyl-THF)
  3. 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) + (6S)-5-methyl-5,6,7,8-tetrahydrofolate(out) = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out) + (6S)-5-methyl-5,6,7,8-tetrahydrofolate(in)

  Catalysed by ALDH1L1, ALDH1L2, ATIC, SLC19A1cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• ophthalmateReach from here →
  1. 10-formyltetrahydrofolate:NADP+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. gamma-L-glutamyl-(2S)-2-aminobutanoate + glycine + ATP = ophthalmate + ADP + phosphate + H(+)

  Catalysed by ALDH1L1, ALDH1L2, SHMT1, GSScytosol

• N(omega),N('omega)-dimethyl-L-arginineReach from here →
  1. 10-formyltetrahydrofolate:NADP+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine

  Catalysed by ALDH1L1, ALDH1L2, SHMT1, AGXT2cytosol

• CHEBI:240943Reach from here →
  1. 10-formyltetrahydrofolate:NADP+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. glycine N-acyltransferase (2-methylbutyryl-CoA)

  Catalysed by ALDH1L1, ALDH1L2, SHMT1, GLYAT and 2 morecytosol, mitochondrial matrix

• folic acidReach from here →
  1. 10-formyltetrahydrofolate:NADP+ oxidoreductase
  2. 5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
  3. dihydrofolate:NAD+ oxidoreductase

  Catalysed by ALDH1L1, ALDH1L2, DHFR, DHFR2cytosolOne of 2 routes

• phenylacetylglycineReach from here →
  1. 10-formyltetrahydrofolate:NADP+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. phenylacetyl-CoA:glycine N-phenylacetyltransferase

  Catalysed by ALDH1L1, ALDH1L2, SHMT1, GLYATcytosolOne of 3 routes

• selenomethionineReach from here →
  1. 10-formyltetrahydrofolate:NADP+ oxidoreductase
  2. histamine N-methyltransferase (SAM)
  3. Methionine Synthase

  Catalysed by ALDH1L1, ALDH1L2, HNMTcytosol, nucleusOne of 2 routes

• CHEBI:28666Reach from here →
  1. 10-formyltetrahydrofolate:NADP+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. LTD4 hydrolysis

  Catalysed by ALDH1L1, ALDH1L2, SHMT1cytosol

• Gly-tRNA(Gly)Reach from here →
  1. 10-formyltetrahydrofolate:NADP+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. glycine:tRNA(Gly) ligase (AMP-forming)

  Catalysed by ALDH1L1, ALDH1L2, SHMT1, GARS1cytosol

• chlorine(.)Reach from here →
  1. 10-formyltetrahydrofolate:NADP+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. transport of chloride and glycine (cytosol to extracellular)

  Catalysed by ALDH1L1, ALDH1L2, SHMT1, SLC6A9 and 1 morecytosol, extracellular spaceOne of 3 routes

• glycocholateReach from here →
  1. 10-formyltetrahydrofolate:NADP+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by ALDH1L1, ALDH1L2, SHMT1, BAATcytosol, peroxisomeOne of 3 routes

• 5-aminolevulinateReach from here →
  1. 10-formyltetrahydrofolate:NADP+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA

  Catalysed by ALDH1L1, ALDH1L2, SHMT1, ALAS1 and 1 morecytosol

• glycochenodeoxycholateReach from here →
  1. 10-formyltetrahydrofolate:NADP+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. chenodeoxycholoyl-CoA + glycine = glycochenodeoxycholate + CoA + H(+)

  Catalysed by ALDH1L1, ALDH1L2, SHMT1, BAATcytosol

• glycochenodeoxycholic acidReach from here →
  1. 10-formyltetrahydrofolate:NADP+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by ALDH1L1, ALDH1L2, SHMT1, BAATcytosol, peroxisomeOne of 3 routes

• glyoxylateReach from here →
  1. 10-formyltetrahydrofolate:NADP+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. glycine + 2-oxoglutarate = glyoxylate + L-glutamate

  Catalysed by ALDH1L1, ALDH1L2, SHMT1, AADATcytosolOne of 11 routes

• glycolithocholic acidReach from here →
  1. 10-formyltetrahydrofolate:NADP+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. bile acid-CoA:amino acid N-acyltransferase (glycine)

  Catalysed by ALDH1L1, ALDH1L2, SHMT1, BAATcytosolOne of 2 routes

• L-2-amino-3-oxobutanoic acidReach from here →
  1. 10-formyltetrahydrofolate:NADP+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. Acetyl-CoA:glycine C-acetyltransferase

  Catalysed by ALDH1L1, ALDH1L2, SHMT1, GCATcytosol, mitochondrial matrix

• L-ornithineReach from here →
  1. 10-formyltetrahydrofolate:NADP+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. L-Arginine:glycine amidinotransferase

  Catalysed by ALDH1L1, ALDH1L2, SHMT1, GATMcytosolOne of 5 routes

• S(8)-aminomethyldihydrolipoamideReach from here →
  1. 10-formyltetrahydrofolate:NADP+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. dihydrolipoyl dehydrogenase ([protein]-N6-(lipoyl)lysine)

  Catalysed by ALDH1L1, ALDH1L2, SHMT1, GLDC and 1 morecytosol, mitochondrial matrix

• sarcosineReach from here →
  1. 10-formyltetrahydrofolate:NADP+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2

  Catalysed by ALDH1L1, ALDH1L2, SHMT1, PIPOXcytosolOne of 2 routes

• (6S)-5,6,7,8-tetrahydrofolateReach from here →
  1. 10-formyltetrahydrofolate:NADP+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine

  Catalysed by ALDH1L1, ALDH1L2, SHMT1, SHMT2cytosolOne of 9 routes

• XMPReach from here →
  1. phosphoribosylaminoimidazolecarboxamide formyltransferase (10-formyl-THF)
  2. IMP 1,2-hydrolase (decyclizing)
  3. IMP:NAD+ oxidoreductase

  Catalysed by ATIC, IMPDH2, IMPDH1cytosol

• N(6)-(1,2-dicarboxyethyl)-AMPReach from here →
  1. phosphoribosylaminoimidazolecarboxamide formyltransferase (10-formyl-THF)
  2. IMP 1,2-hydrolase (decyclizing)
  3. IMP:L-aspartate ligase (GDP-forming)

  Catalysed by ATIC, ADSS2, ADSS1cytosol

• an N-acylglycineReach from here →
  1. 10-formyltetrahydrofolate:NADP+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. an acyl-CoA + glycine = an N-acylglycine + CoA + H(+)

  Catalysed by ALDH1L1, ALDH1L2, SHMT1, GLYATL3 and 2 morecytosol

• guanidinoacetateReach from here →
  1. 10-formyltetrahydrofolate:NADP+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. L-Arginine:glycine amidinotransferase

  Catalysed by ALDH1L1, ALDH1L2, SHMT1, GATMcytosolOne of 2 routes

• L-methionineReach from here →
  1. 10-formyltetrahydrofolate:NADP+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. transport of glycine and methionine (cytosol to extracellular)

  Catalysed by ALDH1L1, ALDH1L2, SHMT1, SLC7A5cytosol, extracellular spaceOne of 6 routes

• L-tryptophanReach from here →
  1. 10-formyltetrahydrofolate:NADP+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. transport of glycine and tryptophan (cytosol to extracellular)

  Catalysed by ALDH1L1, ALDH1L2, SHMT1, SLC7A5cytosol, extracellular spaceOne of 5 routes

• glutathioneReach from here →
  1. 10-formyltetrahydrofolate:NADP+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)

  Catalysed by ALDH1L1, ALDH1L2, SHMT1, GSScytosol

• L-alanineReach from here →
  1. 10-formyltetrahydrofolate:NADP+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. transport of alanine and glycine (cytosol to extracellular)

  Catalysed by ALDH1L1, ALDH1L2, SHMT1, SLC3A2 and 2 morecytosol, extracellular spaceOne of 6 routes

• leukotriene C4Reach from here →
  1. 10-formyltetrahydrofolate:NADP+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. leukotriene C4 hydrolysis

  Catalysed by ALDH1L1, ALDH1L2, SHMT1cytosol

• L-asparagineReach from here →
  1. 10-formyltetrahydrofolate:NADP+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. transport of asparagine and glycine (cytosol to extracellular)

  Catalysed by ALDH1L1, ALDH1L2, SHMT1cytosol, extracellular spaceOne of 4 routes

• L-phenylalanineReach from here →
  1. 10-formyltetrahydrofolate:NADP+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. transport of glycine and phenylalanine (cytosol to extracellular)

  Catalysed by ALDH1L1, ALDH1L2, SHMT1, SLC7A5cytosol, extracellular spaceOne of 7 routes

• L-tyrosineReach from here →
  1. 10-formyltetrahydrofolate:NADP+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine

  Catalysed by ALDH1L1, ALDH1L2, SHMT1, AADATcytosol

• N(omega),N(omega)-dimethyl-L-arginineReach from here →
  1. 10-formyltetrahydrofolate:NADP+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. N(omega),N(omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + glycine

  Catalysed by ALDH1L1, ALDH1L2, SHMT1, AGXT2cytosol

• (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinateReach from here →
  1. 10-formyltetrahydrofolate:NADP+ oxidoreductase
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase (10-formyl-THF)
  3. 1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole AMP-lyase

  Catalysed by ALDH1L1, ALDH1L2, ATIC, ADSLcytosolOne of 2 routes

• 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamideReach from here →
  1. 10-formyltetrahydrofolate:NADP+ oxidoreductase
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase (10-formyl-THF)
  3. (6R)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + (6S)-5,6,7,8-tetrahydrofolate

  Catalysed by ALDH1L1, ALDH1L2, ATICcytosolOne of 3 routes

• N-formimidoyl-L-glutamateReach from here →
  1. 10-formyltetrahydrofolate:NADP+ oxidoreductase
  2. 5-Formiminotetrahydrofolate:L-glutamate N-formiminotransferase
  3. 5-Formiminotetrahydrofolate:L-glutamate N-formiminotransferase

  Catalysed by ALDH1L1, ALDH1L2, FTCDcytosol

• N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycineReach from here →
  1. 10-formyltetrahydrofolate:NADP+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + CoA + H(+)

  Catalysed by ALDH1L1, ALDH1L2, SHMT1, GLYATL2cytosolOne of 2 routes

• N-benzoylglycineReach from here →
  1. 10-formyltetrahydrofolate:NADP+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. Hippurate (Benzoylglycinate) Formation

  Catalysed by ALDH1L1, ALDH1L2, SHMT1cytosol, mitochondrial matrixOne of 2 routes

• dTMPReach from here →
  1. 10-formyltetrahydrofolate:NADP+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. 5,10-Methylenetetrahydrofolate:dUMP C-methyltransferase

  Catalysed by ALDH1L1, ALDH1L2, SHMT1, TYMScytosolOne of 2 routes

• 3',3'-cGAMPReach from here →
  1. 10-formyltetrahydrofolate:NADP+ oxidoreductase
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase (10-formyl-THF)
  3. 3',3'-cGAMP(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) = 3',3'-cGAMP(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)

  Catalysed by ALDH1L1, ALDH1L2, ATIC, SLC19A1cytosol, inner side of the membrane, outer side of the membrane

• (2S)-2-aminobutanoateReach from here →
  1. 10-formyltetrahydrofolate:NADP+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine

  Catalysed by ALDH1L1, ALDH1L2, SHMT1, AGXT2cytosol

• glycodeoxycholateReach from here →
  1. 10-formyltetrahydrofolate:NADP+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. Glycodeoxycholate amidohydrolase

  Catalysed by ALDH1L1, ALDH1L2, SHMT1cytosolOne of 2 routes

• N-tetradecanoylglycineReach from here →
  1. 10-formyltetrahydrofolate:NADP+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)

  Catalysed by ALDH1L1, ALDH1L2, SHMT1, GLYATL2cytosol

• N-eicosanoylglycinateReach from here →
  1. 10-formyltetrahydrofolate:NADP+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. eicosanoyl-CoA + glycine = N-eicosanoylglycinate + CoA + H(+)

  Catalysed by ALDH1L1, ALDH1L2, SHMT1, BAATcytosol

• N-docosanoylglycineReach from here →
  1. 10-formyltetrahydrofolate:NADP+ oxidoreductase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. docosanoyl-CoA + glycine = N-docosanoylglycine + CoA + H(+)

  Catalysed by ALDH1L1, ALDH1L2, SHMT1, BAATcytosol