propionyl-CoA

Three steps

• N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-serineReach from here →
  1. Active Transport
  2. Utilized Transport
  3. N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-serine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-serine

  Catalysed by FAAH, PM20D1mitochondrial matrix, cytosol, endoplasmic reticulum

• an N-(fatty acyl)-glycineReach from here →
  1. Propanoyl-CoA hydrolase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. a fatty acyl-CoA + glycine = an N-(fatty acyl)-glycine + CoA + H(+)

  Catalysed by ACOT7, GLYAT, GLYATL2, GLYATL1cytosol, mitochondrial matrix

• 1-(10Z-heptadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamineReach from here →
  1. Propanoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
  3. 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine + (9Z,12Z)-octadecadienoyl-CoA = 1-(10Z-heptadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + CoA

  Catalysed by ACOT7, SLC27A2, ACSL4, ACSL3 and 6 morecytosol

• N-(9Z,12Z-octadecadienoyl)-glycineReach from here →
  1. Propanoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
  3. (9Z,12Z)-octadecadienoyl-CoA + glycine = N-(9Z,12Z-octadecadienoyl)-glycine + CoA + H(+)

  Catalysed by ACOT7, SLC27A2, ACSL4, ACSL3 and 6 morecytosolOne of 2 routes

• cholesteryl (7Z)-octadecenoateReach from here →
  1. Propanoyl-CoA hydrolase
  2. carnitine O-palmitoyltransferase ((7Z)-octadecenoyl-CoA)
  3. (7Z)-octadecenoyl-CoA + cholesterol = cholesteryl (7Z)-octadecenoate + CoA

  Catalysed by ACOT7, CPT1A, CPT1C, CPT1B and 1 morecytosol

• acetoneReach from here →
  1. Propanoyl-CoA hydrolase
  2. transport of acetoacetate and propanoate (cytosol to extracellular)
  3. Acetoacetate carboxy-lyase (acetone-forming)

  Catalysed by ACOT7, SLC16A4, SLC16A5, SLC16A7 and 2 morecytosol, extracellular space, mitochondrial matrix

• acetylcholineReach from here →
  1. Propanoyl-CoA hydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. Acetyl-CoA:choline O-acetyltransferase

  Catalysed by ACOT7, CHATcytosol, nucleusOne of 3 routes

• acetylpyruvateReach from here →
  1. Propanoyl-CoA hydrolase
  2. transport of propanoate and pyruvate (cytosol to extracellular)
  3. acetylpyruvate + H2O = acetate + pyruvate + H(+)

  Catalysed by ACOT7, SLC16A4, SLC16A5, SLC16A3 and 4 morecytosol, extracellular spaceOne of 2 routes

• CHEBI:15467Reach from here →
  1. Propanoyl-CoA hydrolase
  2. Acetoacetate:CoA ligase (AMP-forming)
  3. 3-hydroxy-3-methylglutaryl-CoA synthase (acetoacetyl-CoA)

  Catalysed by ACOT7, AACS, HMGCS1cytosolOne of 3 routes

• CHEBI:15570Reach from here →
  1. Propanoyl-CoA hydrolase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of D-alanine and glycine (cytosol to extracellular)

  Catalysed by ACOT7, GLYAT, GLYATL2, GLYATL1 and 2 morecytosol, mitochondrial matrix, extracellular spaceOne of 3 routes

• (S)-malateReach from here →
  1. Propanoyl-CoA hydrolase
  2. ATP citrate lyase (citrate)
  3. transport of malate and OAA (cytosol to mitochondria)

  Catalysed by ACOT7, ACLYcytosol, mitochondrial matrixOne of 7 routes

• L-leucineReach from here →
  1. Propanoyl-CoA hydrolase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of glycine and leucine (cytosol to extracellular)

  Catalysed by ACOT7, GLYAT, GLYATL2, GLYATL1 and 1 morecytosol, mitochondrial matrix, extracellular spaceOne of 23 routes

• CHEBI:15611Reach from here →
  1. Propanoyl-CoA hydrolase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. S-Adenosyl-L-methionine:glycine N-methyltransferase

  Catalysed by ACOT7, GLYAT, GLYATL2, GLYATL1 and 1 morecytosol, mitochondrial matrix

• 12(S)-HPETEReach from here →
  1. Active Transport
  2. Utilized Transport
  3. arachidonate:oxygen 12-oxidoreductase

  Catalysed by ALOX12mitochondrial matrix, cytosol, endoplasmic reticulumOne of 4 routes

• 15(S)-HPETEReach from here →
  1. Active Transport
  2. Utilized Transport
  3. arachidonate:oxygen 15-oxidoreductase

  Catalysed by ALOX15B, ALOX15mitochondrial matrix, cytosol, endoplasmic reticulumOne of 4 routes

• 5(S)-HPETEReach from here →
  1. Active Transport
  2. Utilized Transport
  3. Arachidonate:oxygen 5-oxidoreductase

  Catalysed by ALOX5mitochondrial matrix, cytosol, endoplasmic reticulum

• 10-formyltetrahydrofolic acidReach from here →
  1. Propanoyl-CoA hydrolase
  2. transport of formate and propanoate (cytosol to extracellular)
  3. Formate:tetrahydrofolate ligase (ADP-forming)

  Catalysed by ACOT7, SLC16A4, SLC16A5, SLC16A1 and 1 morecytosol, extracellular spaceOne of 2 routes

• CHEBI:15699Reach from here →
  1. Propanoyl-CoA hydrolase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of glycine and homoserine (cytosol to extracellular)

  Catalysed by ACOT7, GLYAT, GLYATL2, GLYATL1 and 1 morecytosol, mitochondrial matrix, extracellular spaceOne of 17 routes

• betaine aldehydeReach from here →
  1. Propanoyl-CoA hydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. choline dehydrogenase (choline)

  Catalysed by ACOT7, CHAT, CHDHcytosol, nucleusOne of 3 routes

• trimethylenediamineReach from here →
  1. Propanoyl-CoA hydrolase
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. deoxyhypusine synthase (1,3-diaminopropane)

  Catalysed by ACOT7, SAT1, SAT2, DHPScytosolOne of 2 routes

• 1-acylglycerone 3-phosphateReach from here →
  1. Propanoyl-CoA hydrolase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. Acyl-CoA:glycerone-phosphate O-acyltransferase

  Catalysed by ACOT7, ASAH1, ACER2, ACER1 and 2 morecytosol, Golgi apparatus

• CHEBI:15971Reach from here →
  1. Propanoyl-CoA hydrolase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of glycine and histidine (cytosol to extracellular)

  Catalysed by ACOT7, GLYAT, GLYATL2, GLYATL1 and 1 morecytosol, mitochondrial matrix, extracellular spaceOne of 12 routes

• phosphatidylethanolamineReach from here →
  1. Propanoyl-CoA hydrolase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. Acyl-CoA:1-acyl-sn-glycero-3-phosphoethanolamine O-acyltransferase

  Catalysed by ACOT7, ASAH1, ACER2, ACER1 and 6 morecytosol, Golgi apparatus

• 11-cis-retinalReach from here →
  1. Propanoyl-CoA hydrolase
  2. Palmitoyl-CoA:retinol O-acyltransferase
  3. 11-cis-retinol:NAD+ oxidoreductase

  Catalysed by ACOT7, DGAT1, LRAT, AWAT1 and 9 morecytosolOne of 4 routes

• 1,2-diacyl-sn-glycero-3-phosphocholine(1+)Reach from here →
  1. Propanoyl-CoA hydrolase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase

  Catalysed by ACOT7, ASAH1, ACER2, ACER1 and 5 morecytosol, Golgi apparatus

• hexadecan-1-olReach from here →
  1. Propanoyl-CoA hydrolase
  2. Palmitate:CoA ligase (AMP-forming)
  3. formate dehydrogenase (palmitoyl-CoA)

  Catalysed by ACOT7, SLC27A2, ACSL4, ACSL3 and 7 morecytosol, peroxisome

• sulfateReach from here →
  1. Active Transport
  2. Carnitine Transport by Atb0
  3. transport of chloride and sulfate (cytosol to extracellular)

  Catalysed by SLC6A14, SLC26A6mitochondrial matrix, cytosol, extracellular space

• 11-cis-retinyl hexadecanoateReach from here →
  1. Propanoyl-CoA hydrolase
  2. Palmitate:CoA ligase (AMP-forming)
  3. Palmitoyl-CoA:retinol O-acyltransferase

  Catalysed by ACOT7, SLC27A2, ACSL4, ACSL3 and 10 morecytosolOne of 3 routes

• 2-methyl-3-oxopropanoic acidReach from here →
  1. Propanoyl-CoA hydrolase
  2. transport of propanoate and pyruvate (cytosol to extracellular)
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by ACOT7, SLC16A4, SLC16A5, SLC16A3 and 4 morecytosol, extracellular space, mitochondrial matrix

• L-cystineReach from here →
  1. Propanoyl-CoA hydrolase
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. Transport of L-Cystine (L-Alanine antiport) by B0, +At Transporter

  Catalysed by ACOT7, SLC7A9, SLC3A1cytosol, mitochondrial matrix, extracellular spaceOne of 5 routes

• (R)-3-aminoisobutyric acidReach from here →
  1. Propanoyl-CoA hydrolase
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by ACOT7, AGXT2cytosol, mitochondrial matrix

• phosphatidic acidReach from here →
  1. Propanoyl-CoA hydrolase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase

  Catalysed by ACOT7, ASAH1, ACER2, ACER1 and 10 morecytosol, Golgi apparatus, mitochondrial matrixOne of 7 routes

• (R)-carnitineReach from here →
  1. Active Transport
  2. solute carrier (L-carnitine)
  3. O-octanoyl-(R)-carnitine(in) + (R)-carnitine(out) = O-octanoyl-(R)-carnitine(out) + (R)-carnitine(in)

  Catalysed by SLC25A20mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 8 routes

• L-citrullineReach from here →
  1. Propanoyl-CoA hydrolase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of citrulline and glycine (cytosol to extracellular)

  Catalysed by ACOT7, GLYAT, GLYATL2, GLYATL1 and 3 morecytosol, mitochondrial matrix, extracellular spaceOne of 8 routes

• iodideReach from here →
  1. Active Transport
  2. Carnitine Transport by Atb0
  3. transport of chloride and iodide (cytosol to extracellular)

  Catalysed by SLC6A14, SLC26A4mitochondrial matrix, cytosol, extracellular space

• L-valineReach from here →
  1. Propanoyl-CoA hydrolase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of glycine and valine (cytosol to extracellular)

  Catalysed by ACOT7, GLYAT, GLYATL2, GLYATL1 and 1 morecytosol, mitochondrial matrix, extracellular spaceOne of 22 routes

• L-arginineReach from here →
  1. Propanoyl-CoA hydrolase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of arginine and glycine (cytosol to extracellular)

  Catalysed by ACOT7, GLYAT, GLYATL2, GLYATL1 and 1 morecytosol, mitochondrial matrix, extracellular spaceOne of 20 routes

• CHEBI:16523Reach from here →
  1. Propanoyl-CoA hydrolase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of D-serine and glycine (cytosol to extracellular)

  Catalysed by ACOT7, GLYAT, GLYATL2, GLYATL1 and 2 morecytosol, mitochondrial matrix, extracellular spaceOne of 2 routes

• protein polypeptide chainReach from here →
  1. Propanoyl-CoA hydrolase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. PROTEIN_BS

  Catalysed by ACOT7, GLYAT, GLYATL2, GLYATL1cytosol, mitochondrial matrixOne of 5 routes

• N(2)-acetyl-L-ornithineReach from here →
  1. Propanoyl-CoA hydrolase
  2. transport of acetate and propanoate (cytosol to extracellular)
  3. N2-Acetyl-L-ornithine amidohydrolase

  Catalysed by ACOT7, SLC16A4, SLC16A5, SLC16A7 and 2 morecytosol, extracellular space

• CHEBI:16633Reach from here →
  1. Propanoyl-CoA hydrolase
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by ACOT7, SCLYcytosol, mitochondrial matrix

• Met-tRNA(Met)Reach from here →
  1. Propanoyl-CoA hydrolase
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. L-Methionine:tRNAMet ligase (AMP-forming)

  Catalysed by ACOT7, NAGS, MARS1cytosol, mitochondrial matrix

• (S)-lactateReach from here →
  1. Propanoyl-CoA hydrolase
  2. transport of propanoate and pyruvate (cytosol to extracellular)
  3. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)

  Catalysed by ACOT7, SLC16A4, SLC16A5, SLC16A3 and 8 morecytosol, extracellular space

• 4-methylsulfanyl-2-oxobutanoateReach from here →
  1. Propanoyl-CoA hydrolase
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine

  Catalysed by ACOT7, NAGS, AADATcytosol, mitochondrial matrix

• 2-oxobutanoateReach from here →
  1. Propanoyl-CoA hydrolase
  2. N-acetylglutamate synthase (N-acetyl-L-cystathionine)
  3. L-cystathionine cysteine-lyase (deaminating

  Catalysed by ACOT7, NAGS, CTHcytosol, mitochondrial matrixOne of 4 routes

• 2-oxoglutaramateReach from here →
  1. Propanoyl-CoA hydrolase
  2. transport of propanoate and pyruvate (cytosol to extracellular)
  3. L-Glutamine:pyruvate aminotransferase

  Catalysed by ACOT7, SLC16A4, SLC16A5, SLC16A3 and 4 morecytosol, extracellular spaceOne of 2 routes

• 3-fumarylpyruvateReach from here →
  1. Propanoyl-CoA hydrolase
  2. transport of propanoate and pyruvate (cytosol to extracellular)
  3. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)

  Catalysed by ACOT7, SLC16A4, SLC16A5, SLC16A3 and 4 morecytosol, extracellular space

• CHEBI:16856Reach from here →
  1. Propanoyl-CoA hydrolase
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. transport of GSH and leukotriene E4 (cytosol to extracellular)

  Catalysed by ACOT7, ZDHHC11B, NAA10, ESCO2 and 30 morecytosol, extracellular spaceOne of 6 routes

• CHEBI:16857Reach from here →
  1. Propanoyl-CoA hydrolase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of glycine and threonine (cytosol to extracellular)

  Catalysed by ACOT7, GLYAT, GLYATL2, GLYATL1 and 3 morecytosol, mitochondrial matrix, extracellular spaceOne of 20 routes

• pantetheine 4'-phosphateReach from here →
  1. Propanoyl-CoA hydrolase
  2. acid phosphatase 2, lysosomal (CoA)
  3. Dephospho-CoA nucleotidohydrolase

  Catalysed by ACOT7, ACP2, ENPP3, ENPP1cytosol, lysosomeOne of 2 routes