2,4-dinitrophenyl-S-glutathione

Three steps

• an acylcholineReach from here →
  1. transport of acetylcholine (cytosol to extracellular)
  2. Acetylcholine aectylhydrolase
  3. an acylcholine + H2O = a carboxylate + choline + H(+)

  Catalysed by SLCO1B3, BCHE, ACHEextracellular space, cytosol

• 5-aminolevulinateReach from here →
  1. transport of leukotriene C4 (cytosol to extracellular)
  2. leukotriene C4 hydrolysis
  3. succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA

  Catalysed by SLCO1B1, ALAS1, ALAS2extracellular space, cytosol

• glycochenodeoxycholateReach from here →
  1. solute carrier organic anion transporter (cholate)
  2. cholate(in) + glutathione(in) + ATP + H2O = cholate(out) + glutathione(out) + ADP + phosphate + H(+)
  3. glycochenodeoxycholate(in) + glutathione(in) + ATP + H2O = glycochenodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)

  Catalysed by SLCO1A2, SLCO1B3, ABCC4extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 3 routes

• glycochenodeoxycholic acidReach from here →
  1. solute carrier organic anion transporter (chenodiol)
  2. chenodeoxycholate:CoA ligase (AMP-forming)
  3. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by SLCO1A2, SLCO1B3, SLC27A5, BAATextracellular space, cytosol, peroxisomeOne of 5 routes

• glyoxylateReach from here →
  1. transport of leukotriene C4 (cytosol to extracellular)
  2. leukotriene C4 hydrolysis
  3. glycine + 2-oxoglutarate = glyoxylate + L-glutamate

  Catalysed by SLCO1B1, AADATextracellular space, cytosolOne of 11 routes

• L-2-amino-3-oxobutanoic acidReach from here →
  1. transport of leukotriene C4 (cytosol to extracellular)
  2. leukotriene C4 hydrolysis
  3. Acetyl-CoA:glycine C-acetyltransferase

  Catalysed by SLCO1B1, GCATextracellular space, cytosol, mitochondrial matrix

• D-glucoseReach from here →
  1. solute carrier organic anion transporter (chenodiol)
  2. a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate + chenodeoxycholate = beta-D-glucosyl-(1->3)-O-chenodeoxycholate + a di-trans,poly-cis-dolichyl phosphate + H(+)
  3. beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H2O = chenodeoxycholate + D-glucose

  Catalysed by SLCO1A2, SLCO1B3, GBA2extracellular space, cytosol

• L-erythro-7,8-dihydrobiopterinReach from here →
  1. transport of prostaglandin E2 (cytosol to extracellular)
  2. prostaglandin E2(out) + a dicarboxylate(in) = prostaglandin E2(in) + a dicarboxylate(out)
  3. L-erythro-7,8-dihydrobiopterin(out) + a dicarboxylate(in) = L-erythro-7,8-dihydrobiopterin(in) + a dicarboxylate(out)

  Catalysed by SLCO1A2, SLCO1B3, SLC22A6, SLC22A8extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• tert-butanolReach from here →
  1. solute carrier organic anion transporter (cholate)
  2. cholate(in) + glutathione(in) + ATP + H2O = cholate(out) + glutathione(out) + ADP + phosphate + H(+)
  3. tert-butyl hydroperoxide + 2 glutathione = tert-butanol + glutathione disulfide + H2O

  Catalysed by SLCO1A2, SLCO1B3, ABCC4, CLIC2 and 4 moreextracellular space, cytosol, inner side of the membrane, outer side of the membrane

• L-ornithineReach from here →
  1. transport of histamine (cytosol to extracellular)
  2. L-histidine + H(+) = histamine + CO2
  3. L-histidine(in) + L-ornithine(out) + H(+)(in) = L-histidine(out) + L-ornithine(in) + H(+)(out)

  Catalysed by SLCO1A2, SLCO1B3, HDC, SLC25A2extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 7 routes

• N-(acetyl)-sphing-4-enineReach from here →
  1. transport of acetylcholine (cytosol to extracellular)
  2. Acetylcholine aectylhydrolase
  3. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate

  Catalysed by SLCO1B3, BCHE, ACHE, ASAH1extracellular space, cytosol

• gamma-Glu-AlaReach from here →
  1. solute carrier organic anion transporter (cholate)
  2. solute carrier organic anion transporter (cholate)
  3. gamma-glutamyltransferase (alanine)

  Catalysed by SLCO1A2, SLCO1B3, GGT1, GGT5 and 4 moreextracellular space, cytosol

• S(8)-aminomethyldihydrolipoamideReach from here →
  1. transport of leukotriene C4 (cytosol to extracellular)
  2. leukotriene C4 hydrolysis
  3. dihydrolipoyl dehydrogenase ([protein]-N6-(lipoyl)lysine)

  Catalysed by SLCO1B1, GLDC, GCSHextracellular space, cytosol, mitochondrial matrix

• taurineReach from here →
  1. transport of serotonin (cytosol to extracellular)
  2. acetyl-CoA:aralkylamine N-acetyltransferase
  3. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)

  Catalysed by SLCO1A2, SLCO1B3, AANAT, BAATextracellular space, cytosolOne of 2 routes

• 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholineReach from here →
  1. transport of arachidonate (cytosol to extracellular)
  2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate
  3. 1-O-hexadecyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by SLCO1B1, SLC27A2, ACSL4, ACSL3 and 9 moreextracellular space, cytosol

• (R)-methylmalonyl-CoAReach from here →
  1. transport of serotonin (cytosol to extracellular)
  2. acetyl-CoA:aralkylamine N-acetyltransferase
  3. aldehyde dehydrogenase (2-methyl-3-oxopropanoate)

  Catalysed by SLCO1A2, SLCO1B3, AANAT, ALDH6A1extracellular space, cytosol, mitochondrial matrixOne of 2 routes

• (S)-methylmalonyl-CoAReach from here →
  1. transport of serotonin (cytosol to extracellular)
  2. acetyl-CoA:aralkylamine N-acetyltransferase
  3. (S)-methylmalonyl-CoA hydrolase

  Catalysed by SLCO1A2, SLCO1B3, AANATextracellular space, cytosol, mitochondrial matrix

• 3'-dephospho-CoAReach from here →
  1. transport of serotonin (cytosol to extracellular)
  2. acetyl-CoA:aralkylamine N-acetyltransferase
  3. acid phosphatase 2, lysosomal (CoA)

  Catalysed by SLCO1A2, SLCO1B3, AANAT, ACP2extracellular space, cytosol, lysosomeOne of 2 routes

• (2E)-dodecenoyl-CoAReach from here →
  1. transport of serotonin (cytosol to extracellular)
  2. acetyl-CoA:aralkylamine N-acetyltransferase
  3. (2E)-dodecenoyl-CoA formation

  Catalysed by SLCO1A2, SLCO1B3, AANATextracellular space, cytosol, mitochondrial matrixOne of 3 routes

• 4,8,12-trimethyltridecanoyl-CoAReach from here →
  1. transport of serotonin (cytosol to extracellular)
  2. acetyl-CoA:aralkylamine N-acetyltransferase
  3. propanoyl-CoA C-acyltransferase (3-ketopristanoyl-CoA)

  Catalysed by SLCO1A2, SLCO1B3, AANAT, ACAA1 and 1 moreextracellular space, cytosol, peroxisomeOne of 2 routes

• (6Z,9Z,12Z)-octadecatrienoyl-CoAReach from here →
  1. transport of serotonin (cytosol to extracellular)
  2. acetyl-CoA:aralkylamine N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (gamma-linolenate)

  Catalysed by SLCO1A2, SLCO1B3, AANAT, SLC27A2 and 7 moreextracellular space, cytosolOne of 7 routes

• butanoyl-CoAReach from here →
  1. transport of serotonin (cytosol to extracellular)
  2. acetyl-CoA:aralkylamine N-acetyltransferase
  3. Butanoate:CoA ligase (AMP-forming)

  Catalysed by SLCO1A2, SLCO1B3, AANAT, ACSM4 and 5 moreextracellular space, cytosolOne of 12 routes

• dodecanoyl-CoAReach from here →
  1. transport of serotonin (cytosol to extracellular)
  2. acetyl-CoA:aralkylamine N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (lauric acid)

  Catalysed by SLCO1A2, SLCO1B3, AANAT, SLC27A2 and 7 moreextracellular space, cytosolOne of 9 routes

• glutaryl-CoAReach from here →
  1. solute carrier organic anion transporter (glycocholate)
  2. glycocholate(out) + glutarate(in) = glycocholate(in) + glutarate(out)
  3. glutarate + succinyl-CoA = glutaryl-CoA + succinate

  Catalysed by SLCO1A2, SLCO1B3, SLC22A24, SUGCTextracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 6 routes

• eicosanoyl-CoAReach from here →
  1. transport of serotonin (cytosol to extracellular)
  2. acetyl-CoA:aralkylamine N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (eicosanoate)

  Catalysed by SLCO1A2, SLCO1B3, AANAT, SLC27A2 and 7 moreextracellular space, cytosolOne of 12 routes

• itaconyl-CoAReach from here →
  1. transport of serotonin (cytosol to extracellular)
  2. acetyl-CoA:aralkylamine N-acetyltransferase
  3. Itaconate:CoA ligase (GDP-forming)

  Catalysed by SLCO1A2, SLCO1B3, AANAT, SUCLG1 and 2 moreextracellular space, cytosol, mitochondrial matrixOne of 2 routes

• (9Z,12Z)-octadecadienoyl-CoAReach from here →
  1. transport of serotonin (cytosol to extracellular)
  2. acetyl-CoA:aralkylamine N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)

  Catalysed by SLCO1A2, SLCO1B3, AANAT, SLC27A2 and 7 moreextracellular space, cytosolOne of 13 routes

• tetradecanoyl-CoAReach from here →
  1. transport of serotonin (cytosol to extracellular)
  2. acetyl-CoA:aralkylamine N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (myristic acid)

  Catalysed by SLCO1A2, SLCO1B3, AANAT, SLC27A2 and 7 moreextracellular space, cytosolOne of 11 routes

• octanoyl-CoAReach from here →
  1. transport of serotonin (cytosol to extracellular)
  2. acetyl-CoA:aralkylamine N-acetyltransferase
  3. Octanoyl-CoA:L-carnitine O-octanoyltransferase

  Catalysed by SLCO1A2, SLCO1B3, AANAT, CROTextracellular space, cytosol, mitochondrial matrixOne of 20 routes

• phytanoyl-CoAReach from here →
  1. transport of serotonin (cytosol to extracellular)
  2. acetyl-CoA:aralkylamine N-acetyltransferase
  3. phytanate-CoA ligase

  Catalysed by SLCO1A2, SLCO1B3, AANATextracellular space, cytosolOne of 5 routes

• propanoyl-CoAReach from here →
  1. transport of estrone 3-sulfate (cytosol to extracellular)
  2. propanoate(in) + estrone 3-sulfate(out) = propanoate(out) + estrone 3-sulfate(in)
  3. propanoate + ATP + CoA = propanoyl-CoA + AMP + diphosphate

  Catalysed by SLCO1B1, SLC22A9, ACSM3, ACSS3 and 2 moreextracellular space, cytosol, inner side of the membrane, outer side of the membrane

• octadecanoyl-CoAReach from here →
  1. transport of serotonin (cytosol to extracellular)
  2. acetyl-CoA:aralkylamine N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (stearate)

  Catalysed by SLCO1A2, SLCO1B3, AANAT, SLC27A2 and 6 moreextracellular space, cytosolOne of 15 routes

• 13,14-dihydro-15-oxo-prostaglandin E2Reach from here →
  1. transport of prostaglandin E2 (cytosol to extracellular)
  2. prostaglandin E2 + NAD(+) = 15-oxoprostaglandin E2 + NADH + H(+)
  3. 13,14-dihydro-15-oxo-prostaglandin E2 + NADP(+) = 15-oxoprostaglandin E2 + NADPH + H(+)

  Catalysed by SLCO1A2, SLCO1B3, HPGD, PTGR1 and 2 moreextracellular space, cytosolOne of 2 routes

• (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. solute carrier organic anion transporter (cholate)
  2. solute carrier organic anion transporter (cholate)
  3. Glutathione: 15-HPETE oxidoreductase

  Catalysed by SLCO1A2, SLCO1B3, GPX5, GPX1 and 7 moreextracellular space, cytosolOne of 5 routes

• 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. transport of arachidonate (cytosol to extracellular)
  2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate
  3. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H2O

  Catalysed by SLCO1B1, ALOX15B, ALOX15, ALOX12 and 7 moreextracellular space, cytosolOne of 2 routes

• sarcosineReach from here →
  1. transport of leukotriene C4 (cytosol to extracellular)
  2. leukotriene C4 hydrolysis
  3. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2

  Catalysed by SLCO1B1, PIPOXextracellular space, cytosolOne of 2 routes

• 7,8-dihydrofolateReach from here →
  1. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)
  2. 3,3',5'-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH2
  3. uridine(34) in tRNA + 5,10-methylenetetrahydrofolate + taurine + GTP + A + H2O = 5-taurinomethyluridine(34) in tRNA + 7,8-dihydrofolate + GDP + AH2 + phosphate + H(+)

  Catalysed by SLCO1A2, SLCO1B3, DIO1, DIO3 and 1 moreextracellular space, cytosol

• (6S)-5,6,7,8-tetrahydrofolateReach from here →
  1. transport of leukotriene C4 (cytosol to extracellular)
  2. leukotriene C4 hydrolysis
  3. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine

  Catalysed by SLCO1B1, SHMT1, SHMT2extracellular space, cytosol

• leukotriene E4Reach from here →
  1. transport of leukotriene C4 (cytosol to extracellular)
  2. leukotriene C4 + H2O = leukotriene D4 + L-glutamate
  3. leukotriene D4 + H2O = leukotriene E4 + glycine

  Catalysed by SLCO1B1, GGT1, GGT5, DPEP1 and 1 moreextracellular space, cytosol

• (R)-S-lactoylglutathioneReach from here →
  1. solute carrier organic anion transporter (cholate)
  2. solute carrier organic anion transporter (cholate)
  3. (R)-S-Lactoylglutathione methylglyoxal-lyase (isomerizing)

  Catalysed by SLCO1A2, SLCO1B3, GLO1, GLOD4extracellular space, cytosolOne of 3 routes

• carnosineReach from here →
  1. transport of histamine (cytosol to extracellular)
  2. L-histidine + H(+) = histamine + CO2
  3. beta-alanine + L-histidine + ATP = carnosine + ADP + phosphate + H(+)

  Catalysed by SLCO1A2, SLCO1B3, HDC, CARNS1extracellular space, cytosol

• N-acetyl-D-glucosamine 6-phosphateReach from here →
  1. transport of acetylcholine (cytosol to extracellular)
  2. Acetylcholine aectylhydrolase
  3. N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate

  Catalysed by SLCO1B3, BCHE, ACHE, AMDHD2extracellular space, cytosol

• O-acetyl-(R)-carnitineReach from here →
  1. transport of arachidonate (cytosol to extracellular)
  2. Utilized Transport
  3. Acetyl-CoA:carnitine O-acetyltransferase

  Catalysed by SLCO1B1, CPT1A, CPT1C, CPT1Bextracellular space, cytosol, endoplasmic reticulumOne of 9 routes

• ethanolamineReach from here →
  1. transport of arachidonate (cytosol to extracellular)
  2. fatty acylamide amidohydrolase
  3. N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + H2O = ethanolamine + (5Z,8Z,11Z,14Z)-eicosatetraenoate

  Catalysed by SLCO1B1, FAAH, FAAH2extracellular space, cytosol

• an N-acylglycineReach from here →
  1. transport of leukotriene C4 (cytosol to extracellular)
  2. leukotriene C4 hydrolysis
  3. an acyl-CoA + glycine = an N-acylglycine + CoA + H(+)

  Catalysed by SLCO1B1, GLYATL3, GLYAT, GLYATL2extracellular space, cytosol

• S-formylglutathioneReach from here →
  1. solute carrier organic anion transporter (cholate)
  2. solute carrier organic anion transporter (cholate)
  3. alcohol dehydrogenase (formaldehyde)

  Catalysed by SLCO1A2, SLCO1B3, ADH1C, ADH1A and 4 moreextracellular space, cytosolOne of 2 routes

• guanidinoacetateReach from here →
  1. transport of leukotriene C4 (cytosol to extracellular)
  2. leukotriene C4 hydrolysis
  3. L-Arginine:glycine amidinotransferase

  Catalysed by SLCO1B1, GATMextracellular space, cytosolOne of 2 routes

• 3',5'-cyclic GMPReach from here →
  1. transport of prostaglandin E2 (cytosol to extracellular)
  2. prostaglandin E2(out) + a dicarboxylate(in) = prostaglandin E2(in) + a dicarboxylate(out)
  3. 3',5'-cyclic GMP(out) + a dicarboxylate(in) = 3',5'-cyclic GMP(in) + a dicarboxylate(out)

  Catalysed by SLCO1A2, SLCO1B3, SLC22A6extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• sphing-4-enineReach from here →
  1. transport of serotonin (cytosol to extracellular)
  2. acetyl-CoA:aralkylamine N-acetyltransferase
  3. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by SLCO1A2, SLCO1B3, AANAT, ASAH1 and 3 moreextracellular space, cytosol, Golgi apparatusOne of 2 routes

• spermidineReach from here →
  1. transport of serotonin (cytosol to extracellular)
  2. acetyl-CoA:aralkylamine N-acetyltransferase
  3. diamine N-acetyltransferase (N1-acetylspermidine)

  Catalysed by SLCO1A2, SLCO1B3, AANAT, SAT1 and 1 moreextracellular space, cytosolOne of 3 routes