prostaglandin J2

Three steps

• N-(acetyl)-sphing-4-enineReach from here →
  1. Transport of Prostaglandin J2, Lactate Antiport
  2. transport of acetate and L-lactate (cytosol to extracellular)
  3. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate

  Catalysed by SLC16A4, SLC16A5, SLC16A3, SLC16A7 and 3 moreextracellular space, cytosol

• gamma-Glu-AlaReach from here →
  1. prostaglandin J2 hydrolysis
  2. transport of GSH and prostaglandin D2 (cytosol to extracellular)
  3. gamma-glutamyltransferase (alanine)

  Catalysed by SLCO2A1, GGT1, GGT5, GGTLC2 and 3 morecytosol, extracellular space

• 3,3',5-triiodo-L-thyronineReach from here →
  1. prostaglandin J2 hydrolysis
  2. transport of prostaglandin D2 (cytosol to extracellular)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 4 routes

• malonaldehydeReach from here →
  1. prostaglandin J2 hydrolysis
  2. prostaglandin-D synthase (prostaglandin D2)
  3. thromboxane A synthase (12(S)-HHT)

  Catalysed by HPGDS, PTGDS, TBXAS1cytosol, endoplasmic reticulumOne of 2 routes

• a 3-acylpyruvateReach from here →
  1. Transport of Prostaglandin J2, Lactate Antiport
  2. (S)-Lactate:NAD+ oxidoreductase
  3. a 3-acylpyruvate + H2O = a carboxylate + pyruvate + H(+)

  Catalysed by LDHB, LDHAL6B, FAHD1extracellular space, cytosol, mitochondrial matrix

• acetoacetyl-CoAReach from here →
  1. Transport of Prostaglandin J2, Lactate Antiport
  2. transport of acetoacetate and L-lactate (cytosol to extracellular)
  3. acetoacetate + ATP + CoA = acetoacetyl-CoA + AMP + diphosphate

  Catalysed by SLC16A4, SLC16A5, SLC16A7, SLC16A8 and 2 moreextracellular space, cytosolOne of 2 routes

• butanoyl-CoAReach from here →
  1. Transport of Prostaglandin J2, Lactate Antiport
  2. transport of butyrate and L-lactate (cytosol to extracellular)
  3. Butanoate:CoA ligase (AMP-forming)

  Catalysed by SLC16A4, SLC16A5, SLC16A3, SLC16A7 and 8 moreextracellular space, cytosolOne of 2 routes

• prostaglandin E1Reach from here →
  1. prostaglandin J2 hydrolysis
  2. transport of prostaglandin D2 (cytosol to extracellular)
  3. transport of prostaglandin E1 (cytosol to extracellular)

  Catalysed by SLCO1B1cytosol, extracellular spaceOne of 6 routes

• prostaglandin I2Reach from here →
  1. prostaglandin J2 hydrolysis
  2. transport of prostaglandin D2 (cytosol to extracellular)
  3. transport of prostaglandin I2 (cytosol to extracellular)

  Catalysed by SLCO1B1cytosol, extracellular spaceOne of 7 routes

• (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. prostaglandin J2 hydrolysis
  2. transport of GSH and prostaglandin D2 (cytosol to extracellular)
  3. Glutathione: 15-HPETE oxidoreductase

  Catalysed by SLCO2A1, GPX5, GPX1, GPX2 and 6 morecytosol, extracellular space

• thromboxane A2Reach from here →
  1. prostaglandin J2 hydrolysis
  2. prostaglandin-D synthase (prostaglandin D2)
  3. thromboxane A synthase (prostaglandin H2)

  Catalysed by HPGDS, PTGDS, TBXAS1cytosol, endoplasmic reticulumOne of 2 routes

• leukotriene A4Reach from here →
  1. prostaglandin J2 hydrolysis
  2. transport of prostaglandin D2 (cytosol to extracellular)
  3. transport of leukotriene A4 (cytosol to extracellular)

  Catalysed by SLCO1B1cytosol, extracellular spaceOne of 4 routes

• (13S)-hydroperoxy-(9Z,11E)-octadecadienoateReach from here →
  1. Transport of Prostaglandin J2, Lactate Antiport
  2. (S)-Lactate:ferricytochrome-c 2-oxidoreductase
  3. 13(S)-HPODE to 13-oxy-radical-octadecadienoate conversion

  Catalysed by CYB5D1extracellular space, cytosol, mitochondrial matrix

• (R)-S-lactoylglutathioneReach from here →
  1. prostaglandin J2 hydrolysis
  2. transport of GSH and prostaglandin D2 (cytosol to extracellular)
  3. (R)-S-Lactoylglutathione methylglyoxal-lyase (isomerizing)

  Catalysed by SLCO2A1, GLO1, GLOD4cytosol, extracellular spaceOne of 2 routes

• N-acetyl-D-glucosamine 6-phosphateReach from here →
  1. Transport of Prostaglandin J2, Lactate Antiport
  2. transport of acetate and L-lactate (cytosol to extracellular)
  3. N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate

  Catalysed by SLC16A4, SLC16A5, SLC16A3, SLC16A7 and 3 moreextracellular space, cytosol

• 2-oxo-3-sulfanylpropanoateReach from here →
  1. Transport of Prostaglandin J2, Lactate Antiport
  2. (S)-Lactate:NAD+ oxidoreductase
  3. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)

  Catalysed by LDHB, LDHAL6B, MPSTextracellular space, cytosol, mitochondrial matrix

• S-formylglutathioneReach from here →
  1. prostaglandin J2 hydrolysis
  2. transport of GSH and prostaglandin D2 (cytosol to extracellular)
  3. alcohol dehydrogenase (formaldehyde)

  Catalysed by SLCO2A1, ADH1C, ADH1A, ADH5 and 3 morecytosol, extracellular space

• 2-methyl-3-oxopropanoateReach from here →
  1. Transport of Prostaglandin J2, Lactate Antiport
  2. (S)-Lactate:NAD+ oxidoreductase
  3. (R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine

  Catalysed by LDHB, LDHAL6B, AGXT2extracellular space, cytosol, mitochondrial matrix

• L-methionineReach from here →
  1. Transport of Prostaglandin J2, Lactate Antiport
  2. (S)-Lactate:NAD+ oxidoreductase
  3. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O

  Catalysed by LDHB, LDHAL6B, TYW1B, TYW1extracellular space, cytosol, mitochondrial matrix

• dehydroepiandrosterone 3-sulfateReach from here →
  1. prostaglandin J2 hydrolysis
  2. transport of prostaglandin D2 (cytosol to extracellular)
  3. transport of dehydroepiandrosterone sulfate (cytosol to extracellular)

  Catalysed by SLCO1B1cytosol, extracellular spaceOne of 2 routes

• glutathioneReach from here →
  1. Transport of Prostaglandin J2, Lactate Antiport
  2. transport of L-lactate and urate (cytosol to extracellular)
  3. urate(out) + glutathione(in) = urate(in) + glutathione(out)

  Catalysed by SLC22A12, SLC22A13extracellular space, cytosol, inner side of the membrane, outer side of the membrane

• L-alanineReach from here →
  1. Transport of Prostaglandin J2, Lactate Antiport
  2. (S)-Lactate:NAD+ oxidoreductase
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by LDHB, LDHAL6B, AGXT2extracellular space, cytosol, mitochondrial matrixOne of 18 routes

• leukotriene C4Reach from here →
  1. prostaglandin J2 hydrolysis
  2. transport of prostaglandin D2 (cytosol to extracellular)
  3. transport of leukotriene C4 (cytosol to extracellular)

  Catalysed by SLCO1B1cytosol, extracellular spaceOne of 6 routes

• N-acetylputrescineReach from here →
  1. Transport of Prostaglandin J2, Lactate Antiport
  2. transport of acetate and L-lactate (cytosol to extracellular)
  3. N-acetylputrescine + H2O = putrescine + acetate

  Catalysed by SLC16A4, SLC16A5, SLC16A3, SLC16A7 and 3 moreextracellular space, cytosol

• glutathione disulfideReach from here →
  1. prostaglandin J2 hydrolysis
  2. transport of GSH and prostaglandin D2 (cytosol to extracellular)
  3. Glutathione: 5-HPETE oxidoreductase

  Catalysed by SLCO2A1, GPX5, GPX1, GPX2 and 6 morecytosol, extracellular spaceOne of 13 routes

• taurolithocholate 3-sulfateReach from here →
  1. prostaglandin J2 hydrolysis
  2. transport of prostaglandin D2 (cytosol to extracellular)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 4 routes

• histamineReach from here →
  1. prostaglandin J2 hydrolysis
  2. transport of prostaglandin D2 (cytosol to extracellular)
  3. transport of histamine (cytosol to extracellular)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 4 routes

• L-thyroxineReach from here →
  1. prostaglandin J2 hydrolysis
  2. transport of prostaglandin D2 (cytosol to extracellular)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 4 routes

• N(8)-acetylspermidineReach from here →
  1. Transport of Prostaglandin J2, Lactate Antiport
  2. transport of acetate and L-lactate (cytosol to extracellular)
  3. N(8)-acetylspermidine + H2O = spermidine + acetate

  Catalysed by SLC16A4, SLC16A5, SLC16A3, SLC16A7 and 3 moreextracellular space, cytosol

• (3S)-citramalyl-CoAReach from here →
  1. Transport of Prostaglandin J2, Lactate Antiport
  2. (S)-Lactate:NAD+ oxidoreductase
  3. (3S)-citramalyl-CoA = pyruvate + acetyl-CoA

  Catalysed by LDHB, LDHAL6B, CLYBLextracellular space, cytosol, mitochondrial matrix

• an N-acetyl-L-cysteine-S-conjugateReach from here →
  1. Transport of Prostaglandin J2, Lactate Antiport
  2. transport of acetate and L-lactate (cytosol to extracellular)
  3. an N-acetyl-L-cysteine-S-conjugate + H2O = an S-substituted L-cysteine + acetate

  Catalysed by SLC16A4, SLC16A5, SLC16A3, SLC16A7 and 3 moreextracellular space, cytosol

• 5-amino-2-oxopentanoateReach from here →
  1. Transport of Prostaglandin J2, Lactate Antiport
  2. (S)-Lactate:NAD+ oxidoreductase
  3. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine

  Catalysed by LDHB, LDHAL6B, AGXT2extracellular space, cytosol, mitochondrial matrix

• S-sulfanylglutathioneReach from here →
  1. prostaglandin J2 hydrolysis
  2. transport of GSH and prostaglandin D2 (cytosol to extracellular)
  3. Sulfide:glutathione,quinone oxidoreductase

  Catalysed by SLCO2A1, SQORcytosol, extracellular space, mitochondrial matrix

• dopamineReach from here →
  1. prostaglandin J2 hydrolysis
  2. transport of prostaglandin D2 (cytosol to extracellular)
  3. transport of dopamine (cytosol to extracellular)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 4 routes

• (2S)-2-phospholactateReach from here →
  1. prostaglandin J2 hydrolysis
  2. prostaglandin D2(out) + 2 (S)-lactate(in) = prostaglandin D2(in) + 2 (S)-lactate(out)
  3. (2S)-2-phospholactate + H2O = (S)-lactate + phosphate

  Catalysed by SLCO2A1, PGPcytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• glycolithocholate 3-sulfateReach from here →
  1. prostaglandin J2 hydrolysis
  2. transport of prostaglandin D2 (cytosol to extracellular)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 4 routes

• estrone 3-sulfateReach from here →
  1. prostaglandin J2 hydrolysis
  2. transport of prostaglandin D2 (cytosol to extracellular)
  3. transport of estrone 3-sulfate (cytosol to extracellular)

  Catalysed by SLCO1B1cytosol, extracellular spaceOne of 2 routes

• prostaglandin E2Reach from here →
  1. prostaglandin J2 hydrolysis
  2. aldo-keto reductase (prostaglandin D2)
  3. carbonyl reductase (NADPH) (prostaglandin F2alpha)

  Catalysed by AKR1C3, CBR3, CBR1, DHRS4cytosolOne of 12 routes

• L-cysteinylglycineReach from here →
  1. prostaglandin J2 hydrolysis
  2. transport of GSH and prostaglandin D2 (cytosol to extracellular)
  3. glutathione gamma-glutamylaminopeptidase

  Catalysed by SLCO2A1, GGTLC3, GGT1, GGT5 and 3 morecytosol, extracellular spaceOne of 4 routes

• (4R)-4-hydroxy-2-oxoglutarateReach from here →
  1. Transport of Prostaglandin J2, Lactate Antiport
  2. (S)-Lactate:NAD+ oxidoreductase
  3. (4R)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate

  Catalysed by LDHB, LDHAL6B, HOGA1extracellular space, cytosol, mitochondrial matrix

• (4S)-4-hydroxy-2-oxoglutarateReach from here →
  1. Transport of Prostaglandin J2, Lactate Antiport
  2. (S)-Lactate:NAD+ oxidoreductase
  3. (4S)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate

  Catalysed by LDHB, LDHAL6B, HOGA1extracellular space, cytosol, mitochondrial matrix

• (R)-noradrenalineReach from here →
  1. prostaglandin J2 hydrolysis
  2. transport of prostaglandin D2 (cytosol to extracellular)
  3. transport of noradrenaline (cytosol to extracellular)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 4 routes

• CHEBI:730073Reach from here →
  1. Transport of Prostaglandin J2, Lactate Antiport
  2. transport of L-lactate and urate (cytosol to extracellular)
  3. Peroxidase

  Catalysed by SLC22A12, MPOextracellular space, cytosol, nucleusOne of 3 routes

• 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. prostaglandin J2 hydrolysis
  2. transport of prostaglandin D2 (cytosol to extracellular)
  3. Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.5

  Catalysed by SLCO1B1cytosol, extracellular spaceOne of 4 routes

• ursodeoxycholateReach from here →
  1. prostaglandin J2 hydrolysis
  2. transport of prostaglandin D2 (cytosol to extracellular)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 4 routes

• prostaglandin G2Reach from here →
  1. prostaglandin J2 hydrolysis
  2. transport of prostaglandin D2 (cytosol to extracellular)
  3. transport of prostaglandin G2 (cytosol to extracellular)

  Catalysed by SLCO1B1cytosol, extracellular spaceOne of 4 routes

• (12S)-hydroxy-(5Z,8E,10E)-heptadecatrienoateReach from here →
  1. prostaglandin J2 hydrolysis
  2. prostaglandin-D synthase (prostaglandin D2)
  3. prostaglandin H2 = (12S)-hydroxy-(5Z,8E,10E)-heptadecatrienoate + malonaldehyde

  Catalysed by HPGDS, PTGDS, TBXAS1, CYP2S1 and 1 morecytosol, endoplasmic reticulum

• thromboxane B2Reach from here →
  1. prostaglandin J2 hydrolysis
  2. transport of prostaglandin D2 (cytosol to extracellular)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by SLCO1B1cytosol, extracellular spaceOne of 6 routes

• 19-hydroxyprostaglandin H2Reach from here →
  1. prostaglandin J2 hydrolysis
  2. prostaglandin-D synthase (prostaglandin D2)
  3. prostaglandin H2 + reduced [NADPH--hemoprotein reductase] + O2 = 19-hydroxyprostaglandin H2 + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by HPGDS, PTGDS, CYP4F8cytosol, endoplasmic reticulum

• taurochenodeoxycholateReach from here →
  1. prostaglandin J2 hydrolysis
  2. transport of prostaglandin D2 (cytosol to extracellular)
  3. solute carrier organic anion transporter (S-glutathionyl-2-4-dinitrobenzene)

  Catalysed by SLCO1B1, SLCO1A2, SLC7A9, SLCO1B3cytosol, extracellular spaceOne of 4 routes