CHEBI:1146900

Two steps

• CHEBI:15467Reach from here →
  1. Acetoacetate:CoA ligase (AMP-forming)
  2. 3-hydroxy-3-methylglutaryl-CoA synthase (acetoacetyl-CoA)

  Catalysed by AACS, HMGCS1cytosolOne of 3 routes

• CHEBI:15570Reach from here →
  1. glycine N-acyltransferase (N-arachidonoylglycine)
  2. transport of D-alanine and glycine (cytosol to extracellular)

  Catalysed by GLYAT, GLYATL2, GLYATL1, SLC3A2 and 1 moremitochondrial matrix, extracellular space, cytosolOne of 3 routes

• (S)-malateReach from here →
  1. ATP citrate lyase (citrate)
  2. transport of malate and OAA (cytosol to mitochondria)

  Catalysed by ACLYcytosol, mitochondrial matrixOne of 5 routes

• L-leucineReach from here →
  1. glycine N-acyltransferase (N-arachidonoylglycine)
  2. transport of glycine and leucine (cytosol to extracellular)

  Catalysed by GLYAT, GLYATL2, GLYATL1, SLC7A5mitochondrial matrix, extracellular space, cytosolOne of 21 routes

• CHEBI:15611Reach from here →
  1. glycine N-acyltransferase (N-arachidonoylglycine)
  2. S-Adenosyl-L-methionine:glycine N-methyltransferase

  Catalysed by GLYAT, GLYATL2, GLYATL1, GNMTmitochondrial matrix, cytosol

• CHEBI:15699Reach from here →
  1. glycine N-acyltransferase (N-arachidonoylglycine)
  2. transport of glycine and homoserine (cytosol to extracellular)

  Catalysed by GLYAT, GLYATL2, GLYATL1, SLC7A5mitochondrial matrix, extracellular space, cytosolOne of 17 routes

• betaine aldehydeReach from here →
  1. Acetyl-CoA:choline O-acetyltransferase
  2. choline dehydrogenase (choline)

  Catalysed by CHAT, CHDHnucleus, cytosolOne of 3 routes

• trimethylenediamineReach from here →
  1. diamine N-acetyltransferase (N1-acetylspermidine)
  2. deoxyhypusine synthase (1,3-diaminopropane)

  Catalysed by SAT1, SAT2, DHPScytosolOne of 2 routes

• hexadecanoic acidReach from here →
  1. Carnitine O-Palmitoyltransferase
  2. Utilized Transport

  Catalysed by CPT1A, CPT1C, CPT1Bcytosol, endoplasmic reticulumOne of 4 routes

• 1-acylglycerone 3-phosphateReach from here →
  1. acyl-CoA:sphingosine N-acyltransferase
  2. Acyl-CoA:glycerone-phosphate O-acyltransferase

  Catalysed by ASAH1, ACER2, ACER1, ASAH2 and 1 moreGolgi apparatus, cytosol

• CHEBI:15971Reach from here →
  1. glycine N-acyltransferase (N-arachidonoylglycine)
  2. transport of glycine and histidine (cytosol to extracellular)

  Catalysed by GLYAT, GLYATL2, GLYATL1, SLC7A6mitochondrial matrix, extracellular space, cytosolOne of 11 routes

• phosphatidylethanolamineReach from here →
  1. acyl-CoA:sphingosine N-acyltransferase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphoethanolamine O-acyltransferase

  Catalysed by ASAH1, ACER2, ACER1, ASAH2 and 5 moreGolgi apparatus, cytosol

• 11-cis-retinalReach from here →
  1. Palmitoyl-CoA:retinol O-acyltransferase
  2. 11-cis-retinol:NAD+ oxidoreductase

  Catalysed by DGAT1, LRAT, AWAT1, AWAT2 and 8 morecytosolOne of 4 routes

• 1,2-diacyl-sn-glycero-3-phosphocholine(1+)Reach from here →
  1. acyl-CoA:sphingosine N-acyltransferase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase

  Catalysed by ASAH1, ACER2, ACER1, ASAH2 and 4 moreGolgi apparatus, cytosol

• hexadecan-1-olReach from here →
  1. Palmitate:CoA ligase (AMP-forming)
  2. formate dehydrogenase (palmitoyl-CoA)

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 6 morecytosol, peroxisome

• 11-cis-retinyl hexadecanoateReach from here →
  1. Palmitate:CoA ligase (AMP-forming)
  2. Palmitoyl-CoA:retinol O-acyltransferase

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 9 morecytosolOne of 3 routes

• L-cystineReach from here →
  1. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  2. Transport of L-Cystine (L-Alanine antiport) by B0, +At Transporter

  Catalysed by SLC7A9, SLC3A1mitochondrial matrix, extracellular space, cytosolOne of 5 routes

• (R)-3-aminoisobutyric acidReach from here →
  1. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by AGXT2mitochondrial matrix

• phosphatidic acidReach from here →
  1. acyl-CoA:sphingosine N-acyltransferase
  2. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase

  Catalysed by ASAH1, ACER2, ACER1, ASAH2 and 9 moreGolgi apparatus, mitochondrial matrixOne of 7 routes

• L-citrullineReach from here →
  1. glycine N-acyltransferase (N-arachidonoylglycine)
  2. transport of citrulline and glycine (cytosol to extracellular)

  Catalysed by GLYAT, GLYATL2, GLYATL1, SLC7A9 and 2 moremitochondrial matrix, extracellular space, cytosolOne of 8 routes

• L-valineReach from here →
  1. glycine N-acyltransferase (N-arachidonoylglycine)
  2. transport of glycine and valine (cytosol to extracellular)

  Catalysed by GLYAT, GLYATL2, GLYATL1, SLC7A5mitochondrial matrix, extracellular space, cytosolOne of 20 routes

• L-arginineReach from here →
  1. glycine N-acyltransferase (N-arachidonoylglycine)
  2. transport of arginine and glycine (cytosol to extracellular)

  Catalysed by GLYAT, GLYATL2, GLYATL1, SLC7A6mitochondrial matrix, extracellular space, cytosolOne of 18 routes

• CHEBI:16523Reach from here →
  1. glycine N-acyltransferase (N-arachidonoylglycine)
  2. transport of D-serine and glycine (cytosol to extracellular)

  Catalysed by GLYAT, GLYATL2, GLYATL1, SLC3A2 and 1 moremitochondrial matrix, extracellular space, cytosolOne of 2 routes

• protein polypeptide chainReach from here →
  1. glycine N-acyltransferase (N-arachidonoylglycine)
  2. PROTEIN_BS

  Catalysed by GLYAT, GLYATL2, GLYATL1mitochondrial matrix, cytosolOne of 5 routes

• CHEBI:16633Reach from here →
  1. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  2. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by SCLYmitochondrial matrix, cytosol

• Met-tRNA(Met)Reach from here →
  1. N-acetylglutamate synthase (N-acetylmethionine)
  2. L-Methionine:tRNAMet ligase (AMP-forming)

  Catalysed by NAGS, MARS1mitochondrial matrix, cytosol

• 4-methylsulfanyl-2-oxobutanoateReach from here →
  1. N-acetylglutamate synthase (N-acetylmethionine)
  2. glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine

  Catalysed by NAGS, AADATmitochondrial matrix

• 2-oxobutanoateReach from here →
  1. N-acetylglutamate synthase (N-acetyl-L-cystathionine)
  2. L-cystathionine cysteine-lyase (deaminating

  Catalysed by NAGS, CTHmitochondrial matrix, cytosolOne of 2 routes

• CHEBI:16856Reach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. transport of GSH and leukotriene E4 (cytosol to extracellular)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 29 morecytosol, extracellular spaceOne of 4 routes

• CHEBI:16857Reach from here →
  1. glycine N-acyltransferase (N-arachidonoylglycine)
  2. transport of glycine and threonine (cytosol to extracellular)

  Catalysed by GLYAT, GLYATL2, GLYATL1, SLC3A2 and 2 moremitochondrial matrix, extracellular space, cytosolOne of 19 routes

• pantetheine 4'-phosphateReach from here →
  1. acid phosphatase 2, lysosomal (CoA)
  2. Dephospho-CoA nucleotidohydrolase

  Catalysed by ACP2, ENPP3, ENPP1lysosome, cytosolOne of 2 routes

• psychosineReach from here →
  1. acyl-CoA:sphingosine N-acyltransferase
  2. UDP-alpha-D-galactose:sphingosine 1-beta-galactosyltransferase

  Catalysed by ASAH1, ACER2, ACER1, ASAH2Golgi apparatus, cytosol

• glyoxylic acidReach from here →
  1. glycine N-acyltransferase (N-arachidonoylglycine)
  2. glycine:oxygen oxidoreductase (deaminating)

  Catalysed by GLYAT, GLYATL2, GLYATL1, DAOmitochondrial matrix, peroxisome

• 1-acyl-sn-glycerol 3-phosphateReach from here →
  1. acyl-CoA:sphingosine N-acyltransferase
  2. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase

  Catalysed by ASAH1, ACER2, ACER1, ASAH2 and 4 moreGolgi apparatus, mitochondrial matrix

• a cholesterol esterReach from here →
  1. acyl-CoA:sphingosine N-acyltransferase
  2. an acyl-CoA + cholesterol = a cholesterol ester + CoA

  Catalysed by ASAH1, ACER2, ACER1, ASAH2 and 2 moreGolgi apparatus

• taurolithocholateReach from here →
  1. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  2. bile acid-CoA:amino acid N-acyltransferase (lithocholate)

  Catalysed by BAATcytosolOne of 2 routes

• L-isoleucineReach from here →
  1. glycine N-acyltransferase (N-arachidonoylglycine)
  2. transport of glycine and isoleucine (cytosol to extracellular)

  Catalysed by GLYAT, GLYATL2, GLYATL1, SLC7A5mitochondrial matrix, extracellular space, cytosolOne of 18 routes

• CHEBI:17203Reach from here →
  1. glycine N-acyltransferase (N-arachidonoylglycine)
  2. transport of glycine and proline (cytosol to extracellular)

  Catalysed by GLYAT, GLYATL2, GLYATL1, SLC7A5 and 1 moremitochondrial matrix, extracellular space, cytosolOne of 15 routes

• S-(4,8-dimethylnonanoyl)-4'-phosphopantetheineReach from here →
  1. Carnitine Dimethyl Nonanoyl Transferase, Revsible, Peroxisomal
  2. 4,8-dimethylnonanoyl-CoA + H2O = S-(4,8-dimethylnonanoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

  Catalysed by CRAT, CROT, NUDT19peroxisome

• S-(9Z,12Z,15Z-octadecatrienoyl)-4'-phosphopantetheineReach from here →
  1. long-chain-fatty-acid-CoA ligase (linolenate)
  2. (9Z,12Z,15Z)-octadecatrienoyl-CoA + H2O = S-(9Z,12Z,15Z-octadecatrienoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 5 morecytosol

• S-(9Z,12Z-octadecadienoyl)-4'-phosphopantetheineReach from here →
  1. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
  2. (9Z,12Z)-octadecadienoyl-CoA + H2O = S-(9Z,12Z-octadecadienoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 5 morecytosol

• S-(9Z-hexadecenoyl)-4'-phosphopantetheineReach from here →
  1. long-chain-fatty-acid-CoA ligase (palmitolate)
  2. (9Z)-hexadecenoyl-CoA + H2O = S-(9Z-hexadecenoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 5 morecytosol

• itaconateReach from here →
  1. Itaconate:CoA ligase (GDP-forming)
  2. Itaconate:CoA ligase (GDP-forming)

  Catalysed by SUCLG1, SUCLG2, SUCLA2mitochondrial matrixOne of 4 routes

• N-octadecanoyl-heptadecasphing-4-enineReach from here →
  1. long-chain-fatty-acid-CoA ligase (stearate)
  2. heptadecasphing-4-enine + octadecanoyl-CoA = N-octadecanoyl-heptadecasphing-4-enine + CoA + H(+)

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosol

• all-trans-retinolReach from here →
  1. Palmitoyl-CoA:retinol O-acyltransferase
  2. all-trans-Retinol 11-cis-trans-isomerase

  Catalysed by DGAT1, LRAT, AWAT1, AWAT2 and 1 morecytosolOne of 2 routes

• linoleic acidReach from here →
  1. Carnitine O-Palmitoyltransferase
  2. Utilized Transport

  Catalysed by CPT1A, CPT1C, CPT1Bcytosol, endoplasmic reticulumOne of 3 routes

• 1-(alk-1-enyl)-2-acyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. acyl-CoA:sphingosine N-acyltransferase
  2. Acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase

  Catalysed by ASAH1, ACER2, ACER1, ASAH2 and 4 moreGolgi apparatus, cytosol

• O-hexadecanoyl-(R)-carnitineReach from here →
  1. Carnitine O-Palmitoyltransferase
  2. palmitoyl-CoA:L-carnitine O-palmitoyltransferase

  Catalysed by CPT1A, CPT1C, CPT1B, CPT2cytosol, peroxisomeOne of 14 routes

• AH2Reach from here →
  1. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  2. uridine(34) in tRNA + 5,10-methylenetetrahydrofolate + taurine + GTP + A + H2O = 5-taurinomethyluridine(34) in tRNA + 7,8-dihydrofolate + GDP + AH2 + phosphate + H(+)

  Catalysed by BAAT, MTO1cytosolOne of 6 routes

• 1-O-acyl-sn-glycero-3-phosphocholine(1+)Reach from here →
  1. Palmitoyl-CoA:retinol O-acyltransferase
  2. Lecithin Retinol Acyltransferase (11-Cis)

  Catalysed by DGAT1, LRAT, AWAT1, AWAT2 and 1 morecytosol