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Proteins/UNIPROT:P06858
Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Although it has both phospholipase and triglyceride lipase activities it is primarily a triglyceride lipase with low but detectable phospholipase activity. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans..
Function from UniProtKB (P06858), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
565 statements
565 statements · 7 reference databases · Subject: LPL · Sources: Bgee, gene ontology, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways · Rows fetched: 300
13 reactions
MAM01570eMAM01569e+77243a triacylglycerol
Catalysed by MGLL or ABHD12 or SDC1 or ABHD6 or LPL or GPIHBP1
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.34, 3.1.1.23extracellular space
Human-GEM MAR00001CC BY 4.0Reference data
water+a triacylglycerola 1,2-diacyl-sn-glycerol+MAM01807e
Catalysed by
2 names
Resolves to: LPL
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.34extracellular space
Human-GEM MAR00002CC BY 4.0Reference data
MAM03147e10385a triacylglycerol+MAM03146e
Catalysed by MGLL or ABHD12 or SDC1 or ABHD6 or LPL or GPIHBP1
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.34, 3.1.1.23extracellular space
Human-GEM MAR00006CC BY 4.0Reference data
water+a triacylglycerola 1,2-diacyl-sn-glycerol+fatty acid
Catalysed by LPL
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.34extracellular space
Human-GEM MAR00007CC BY 4.0Reference data
a 1,2-diacyl-sn-glycerol+watera monoacylglycerol+fatty acid
Catalysed by LPL
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.34extracellular space
Human-GEM MAR00008CC BY 4.0Reference data
MAM02048e20CHEBI:1307929+160a cholesterol ester+MAM02047e
Catalysed by LPL
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.34extracellular space
Human-GEM MAR00013CC BY 4.0Reference data
MAM02353e680CHEBI:1307929+1515a cholesterol ester+MAM02352e
Catalysed by LPL
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.34extracellular space
Human-GEM MAR00014CC BY 4.0Reference data
a triacylglycerol+watera diacylglycerol+a fatty acid+hydron
Catalysed by DDHD2 or LPL or LIPF or ABHD2 or LIPC or PNLIP or CEL or AADAC or PNPLA4 or PNLIPRP2 or LIPE or PNLIPRP3 and 7 more alternatives
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:12044CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phosphocholine+watera 2-acyl-sn-glycero-3-phosphocholine+a fatty acid+hydron
Catalysed by LPL or LIPC or PLAAT3 or PLA2G15 or DDHD1 or ABHD3 or PLAAT5 or PLAAT1 or PNPLA8 or PLAAT2 or PLAAT4 or LIPG
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:18689CC BY 4.0Reference data
1,2,3-tri-(9Z-octadecenoyl)-glycerol+waterdi-(9Z)-octadecenoylglycerol+(9Z)-octadecenoate+hydron
Catalysed by DDHD2 or LPL or LIPC or PNLIP or CEL or PNLIPRP2 or LIPE or PLB1 or LIPG
Reaction pageLeft to rightBalanced
Rhea RHEA:38575CC BY 4.0Reference data
1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine+water(9Z-octadecenoyl)-sn-glycero-3-phosphocholine+(9Z)-octadecenoate+hydron
Catalysed by DDHD2 or LPL or LIPC or DDHD1
Reaction pageLeft to rightBalanced
Rhea RHEA:38699CC BY 4.0Reference data
1,2,3-tributanoylglycerol+waterdibutanoylglycerol+butanoate+hydron
Catalysed by LPL or LIPC or PNLIP or PNLIPRP2 or LIPG
Reaction pageLeft to rightBalanced
Rhea RHEA:40475CC BY 4.0Reference data