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Proteins/UNIPROT:Q9H2H9
Symporter that cotransports short-chain neutral amino acids and sodium ions from the extracellular to the intracellular side of the cell membrane. The transport is elctrogenic, pH dependent and driven by the Na(+) electrochemical gradient. Participates in the astroglia-derived glutamine transport into GABAergic interneurons for neurotransmitter GABA de novo synthesis (By similarity). May also contributes to amino acid transport in placental trophoblasts. Also regulates synaptic plasticity..
Function from UniProtKB (Q9H2H9), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 5 · transported by
5 compounds
5 compounds.
0 reported routes5 assembled routes
464 statements
464 statements · 7 reference databases · Subject: SLC38A1 · Sources: Bgee, gene ontology, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways · Rows fetched: 300
22 reactions
L-alanine+sodium(1+)L-alanine+sodium(1+)
Transported by SLC6A15 or SLC1A5 or SLC38A1 or SLC1A4 or SLC38A2 or SLC38A4 or SLC6A19
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05305CC BY 4.0Reference data
9 names
Resolves to: SLC38A1
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05308CC BY 4.0Reference data
L-asparagine+sodium(1+)L-asparagine+sodium(1+)
Transported by SLC6A15 or SLC38A1 or SLC38A2 or SLC38A4
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05311CC BY 4.0Reference data
L-leucine+sodium(1+)L-leucine+sodium(1+)
Transported by SLC6A15 or SLC38A1 or SLC38A2 or SLC38A4 or SLC3A2 or SLC6A19
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05315CC BY 4.0Reference data
glycine+sodium(1+)glycine+sodium(1+)
Transported by SLC38A1 or SLC38A2 or SLC38A4 or SLC6A19
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05320CC BY 4.0Reference data
sodium(1+)+CHEBI:17203sodium(1+)+CHEBI:17203
Transported by SLC6A7 or SLC6A15 or SLC38A1 or SLC38A2 or SLC38A4 or SLC6A20
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05322CC BY 4.0Reference data
L-methionine+sodium(1+)L-methionine+sodium(1+)
Transported by SLC6A15 or SLC38A1 or SLC38A2 or SLC38A4 or SLC6A19 or SLC22A5
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05324CC BY 4.0Reference data
sodium(1+)+CHEBI:16857sodium(1+)+CHEBI:16857
Transported by SLC6A15 or SLC38A1 or SLC38A2 or SLC38A4
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05326CC BY 4.0Reference data
sodium(1+)+L-seryl residuesodium(1+)+L-seryl residue
Transported by SLC6A15 or SLC38A1 or SLC38A2 or SLC38A4 or SLC6A19
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR06375CC BY 4.0Reference data
proton+sodium(1+)+L-seryl residueproton+sodium(1+)+L-seryl residue
Transported by SLC38A5 or SLC38A1 or SLC38A2 or SLC38A4
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR06381CC BY 4.0Reference data
L-asparagine+proton+sodium(1+)L-asparagine+proton+sodium(1+)
Transported by SLC38A5 or SLC38A1 or SLC38A2 or SLC38A4
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR06382CC BY 4.0Reference data
sodium(1+)+selenomethioninesodium(1+)+selenomethionine
Transported by SLC6A19 & CLTRN or SLC6A19 & ACE2 or SLC38A1 or SLC38A2 or SLC22A5
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR11791CC BY 4.0Reference data