Proteins/UNIPROT:O94822

LTN1

ProteinUNIPROT:O94822

E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Within the RQC complex, LTN1 is recruited to stalled 60S ribosomal subunits by NEMF and mediates ubiquitination of stalled nascent chains. Ubiquitination leads to VCP/p97 recruitment for extraction and degradation of the incomplete translation product (By similarity)..

Function from UniProtKB (O94822), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

25 statements

25 statements · 3 reference databases · Subject: LTN1 · Sources: Hetionet, Reactome, WikiPathways

Order

LTN1 covaries with NDNProteinHetionet hetionet:covaries:26046-4692Inferred only
LTN1 covaries with NUDT16L1ProteinHetionet hetionet:covaries:26046-84309Inferred only
PPP1R18 covaries with LTN1ProteinHetionet hetionet:covaries:170954-26046Inferred only
IQCB1 interacts with LTN1ProteinHetionet hetionet:interacts:26046-9657Inferred only
LTN1 interacts with MMS19ProteinHetionet hetionet:interacts:26046-64210Inferred only
LTN1 interacts with STING1ProteinHetionet hetionet:interacts:26046-340061Inferred only
LTN1 interacts with TIRAPProteinHetionet hetionet:interacts:114609-26046Inferred only
UBC interacts with LTN1ProteinHetionet hetionet:interacts:26046-7316Inferred only
UBE2D2 interacts with LTN1ProteinHetionet hetionet:interacts:26046-7322Inferred only
LTN1 participates in Adaptive Immune SystemPathwayReactome R-HSA-1280218Inferred only
LTN1 participates in Antigen processing: Ubiquitination & Proteasome degradationPathwayReactome R-HSA-983168Inferred only
LTN1 participates in Class I MHC mediated antigen processing & presentationPathwayReactome R-HSA-983169Inferred only

Show the remaining 13

LTN1 participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
LTN1 participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
LTN1 participates in miR targeted genes in lymphocytesPathwayWikiPathways WP2004Inferred only
LTN1 participates in miR targeted genes in muscle cellPathwayWikiPathways WP2005Inferred only
LTN1 participates in Ribosome Quality Control (RQC) complex extracts and degrades nascent peptidePathwayReactome R-HSA-9954709Inferred only
LTN1 participates in Ribosome-associated quality controlPathwayReactome R-HSA-9948299Inferred only
LTN1 participates in TranslationPathwayReactome R-HSA-72766Inferred only
ADH5 decreases the expression of LTN1ProteinHetionet hetionet:regulates:128-26046Inferred only
CD320 decreases the expression of LTN1ProteinHetionet hetionet:regulates:51293-26046Inferred only
KEAP1 increases the expression of LTN1ProteinHetionet hetionet:regulates:9817-26046Inferred only
PABPC1 increases the expression of LTN1ProteinHetionet hetionet:regulates:26986-26046Inferred only
SUZ12 decreases the expression of LTN1ProteinHetionet hetionet:regulates:23512-26046Inferred only
UQCRC1 increases the expression of LTN1ProteinHetionet hetionet:regulates:7384-26046Inferred only

Other names

8 names

Resolves to: LTN1

Also called: C21orf10C21orf98KIAA0714RING finger protein 160RING-type E3 ubiquitin transferase listerinRNF160Zinc finger protein 294ZNF294

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