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Proteins/UNIPROT:Q13829
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(TNFAIP1) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA-dependent DNA polymerase delta activity..
Function from UniProtKB (Q13829), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
97 statements
97 statements · 3 reference databases · Subject: TNFAIP1 · Sources: gene ontology, Hetionet, Reactome
7 names
Resolves to: TNFAIP1