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Proteins/UNIPROT:P40394
Catalyzes the NAD-dependent oxidation of all-trans-retinol, alcohol, and omega-hydroxy fatty acids and their derivatives. Oxidizes preferentially all trans-retinol, all-trans-4-hydroxyretinol, 9-cis-retinol, 2-hexenol, and long chain omega-hydroxy fatty acids such as juniperic acid. In vitro can also catalyze the NADH-dependent reduction of all-trans-retinal and aldehydes and their derivatives. Reduces preferentially all trans-retinal, all-trans-4-oxoretinal and hexanal. Catalyzes in the oxidative direction with higher efficiency. Therefore may participate in retinoid metabolism, fatty acid omega-oxidation, and elimination of cytotoxic aldehydes produced by lipid peroxidation..
Function from UniProtKB (P40394), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 2 · metabolized by
2 compounds
2 compounds.
0 reported routes2 assembled routes
54 statements
54 statements · 8 reference databases · Subject: ADH7 · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
28 reactions
6 names
Resolves to: ADH7
Reaction pageReversibleBalancedEC 1.1.1.1mitochondrial matrix
Human-GEM MAR01130CC BY 4.0Reference data
MAM00599r+NAD(+)MAM00600r+proton+NADH(2-)
Catalysed by ADH6 or ADH1A or ADH7 or ADH5 or ADH4 or ADH1C
Reaction pageReversibleBalancedEC 1.1.1.1endoplasmic reticulum
Human-GEM MAR01131CC BY 4.0Reference data
MAM00596x+NAD(+)MAM00601x+proton+NADH(2-)
Catalysed by ADHFE1 or ADH6 or ADH1A or ADH7 or ADH5 or ADH4 or ADH1C
Reaction pageLeft to rightBalancedEC 1.1.1.1peroxisome
Human-GEM MAR01288CC BY 4.0Reference data
MAM00756c+proton+NADH(2-)MAM01093c+NAD(+)
Catalysed by ADHFE1 or ADH6 or ADH1A or ADH7 or ADH1B or ADH5 or ADH4 or ADH1C
Reaction pageReversibleBalancedEC 1.1.1.1cytosol
Human-GEM MAR01684CC BY 4.0Reference data
ethanol+NAD(+)acetaldehyde+proton+NADH(2-)
Catalysed by ADH6 or ADH1A or ADH7 or ADH1B or ADH5 or ADH4 or ADH1C
Reaction pageLeft to rightBalancedEC 1.1.1.1, 1.1.1.71cytosol
Human-GEM MAR03905CC BY 4.0Reference data
methanol+NAD(+)formaldehyde+proton+NADH(2-)
Catalysed by ADHFE1 or ADH6 or ADH1A or ADH7 or ADH1B or ADH5 or ADH4 or ADH1C
Reaction pageLeft to rightBalancedEC 1.1.1.244cytosol
Human-GEM MAR04202CC BY 4.0Reference data
(5-hydroxyindol-3-yl)acetaldehyde+proton+NADPH(4-)MAM01110c+NADP(3-)
Catalysed by ADHFE1 or ADH6 or ADH1A or ADH7 or ADH1B or ADH5 or ADH4 or ADH1C
Reaction pageReversibleBalancedEC 1.1.1.1cytosol
Human-GEM MAR04561CC BY 4.0Reference data
NAD(+)+all-trans-retinolproton+NADH(2-)+all-trans-retinal
Catalysed by HSD17B6 or RDH5 or SDR16C5 or ADH6 or ADH1A or ADH7 or ADH1B or ADH5 or ADH4 or ADH1C
Reaction pageLeft to rightBalancedEC 1.1.1.1, 1.1.1.105cytosol
Human-GEM MAR06631CC BY 4.0Reference data
NAD(+)+all-trans-retinolproton+NADH(2-)+all-trans-retinal
Catalysed by HSD17B6 or RDH5 or SDR16C5 or ADH6 or ADH1A or ADH7 or ADH1B or ADH5 or ADH4 or ADH1C
Reaction pageLeft to rightBalancedEC 1.1.1.1, 1.1.1.105endoplasmic reticulum
Human-GEM MAR06633CC BY 4.0Reference data
MAM00726c+proton+NADH(2-)MAM00730c+NAD(+)
Catalysed by ADHFE1 or ADH6 or ADH1A or ADH7 or ADH5 or ADH4 or ADH1C
Reaction pageReversibleBalancedEC 1.1.1.1cytosol
Human-GEM MAR06756CC BY 4.0Reference data