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Proteins/UNIPROT:Q06830
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (By similarity)..
Function from UniProtKB (Q06830), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
376 statements
376 statements · 6 reference databases · Subject: PRDX1 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways · Rows fetched: 300
4 reactions
2CHEBI:16856+hydrogen peroxideglutathione disulfide+2water
Catalysed by GPX7 or PRDX1 or PRDX6 or PRDX5 or GPX8 or PRDX3 or GPX4 or PRDX2 or GPX2 or GPX6 or GPX3 or GPX5 and 1 more alternative
10 names
Resolves to: PRDX1
Human-GEM MAR04116CC BY 4.0Reference data
2CHEBI:16856+hydrogen peroxideglutathione disulfide+2water
Catalysed by GPX7 or PRDX1 or PRDX6 or PRDX5 or GPX8 or GPX4 or PRDX2 or GPX2 or GPX6 or GPX3 or GPX5 or GPX1
Reaction pageLeft to rightBalancedEC 1.11.1.9, 1.11.1.24, 1.11.1.25, 1.11.1.26, 1.11.1.27, 1.11.1.28, 1.11.1.29extracellular space
Human-GEM MAR04120CC BY 4.0Reference data
2CHEBI:16856+hydrogen peroxideglutathione disulfide+2water
Catalysed by GPX7 or PRDX1 or PRDX6 or PRDX5 or GPX8 or PRDX3 or GPX4 or PRDX2 or GPX2 or GPX6 or GPX3 or GPX5 and 1 more alternative
Reaction pageLeft to rightBalancedEC 1.11.1.9, 1.11.1.24, 1.11.1.25, 1.11.1.26, 1.11.1.27, 1.11.1.28, 1.11.1.29mitochondrial matrix
Human-GEM MAR04121CC BY 4.0Reference data
a hydroperoxide+[thioredoxin]-dithiolan alcohol+[thioredoxin]-disulfide+water
Catalysed by PRDX5 or PRDX3 or PRDX2 or PRDX1 or PRDX4
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:62620CC BY 4.0Reference data