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Proteins/UNIPROT:O94925
Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate, the main excitatory neurotransmitter in the brain..
[Isoform 2]: Lacks catalytic activity..
Function from UniProtKB (O94925), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · substrate of
1 compound
1 compound.
0 reported routes1 assembled route
4 rows
172 statements
172 statements · 8 reference databases · Subject: GLS · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
2 reactions
L-glutamine+waterL-glutamate(1-)+proton+ammonium
Catalysed by GLS
Reaction pageLeft to rightBalancedEC 3.5.1.2, 3.5.1.38mitochondrial matrix
Human-GEM MAR03892CC BY 4.0Reference data
4 names
Resolves to: GLS
Reaction pageDirection not assertedBalanced
Rhea RHEA:15889CC BY 4.0Reference data