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Proteins/UNIPROT:Q9Y6Q9
Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit.
Function from UniProtKB (Q9Y6Q9), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
411 statements
411 statements · 7 reference databases · Subject: NCOA3 · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, WikiPathways · Rows fetched: 300
2 reactions
17 names
Resolves to: NCOA3
Human-GEM MAR09495CC BY 4.0Reference data
L-lysyl-[protein]+acetyl-CoAN(6)-acetyl-L-lysyl-[protein]+coenzyme A(4-)+hydron
Catalysed by HAT1 or CLOCK or TAF1 or BLOC1S1 or GTF2B or EP300 or NCOA1 or ESCO2 or ESCO1 or KAT6B or CREBBP or KAT6A and 12 more alternatives
Reaction pageReversibleBalance undeterminable
Rhea RHEA:45948CC BY 4.0Reference data