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Proteins/UNIPROT:O60266
Catalyzes the formation of the signaling molecule cAMP in response to G protein signaling. Participates in signaling cascades triggered by odorant receptors via its function in cAMP biosynthesis: specifically activated by G alpha protein GNAL/G(olf) in olfactory epithelium (By similarity). Mediates signaling cascades in primary cilia: specifically activated by G alpha protein GNAS/G(s) in primary cilia. Plays a role in regulating food intake and body fat accumulation in the paraventricular nucleus of the hypothalamus (PVH) by acting downstream of MC4R activation. Required for normal sperm motility and normal male fertility (By similarity)..
Function from UniProtKB (O60266), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
188 statements
188 statements · 6 reference databases · Subject: ADCY3 · Sources: gene ontology, Hetionet, Reactome, Rhea, UniProt, WikiPathways
3 reactions
7 names
Resolves to: ADCY3
GTP3',5'-cyclic GMP+diphosphate(3-)
Catalysed by GUCY1A1 & GUCY1B1 or GUCY2C or ADCY2 or GUCY2F or ADCY7 or GUCY2D or ADCY3 or ADCY10 or GUCY1A2 or ADCY8 or NPR2 or NPR1
Reaction pageLeft to rightBalancedEC 4.6.1.1, 4.6.1.2cytosol
Human-GEM MAR04022CC BY 4.0Reference data
ATP(4-)3',5'-cyclic AMP+diphosphate(3-)
Catalysed by ADCY6 or ADCY3 or ADCY9 or ADCY5 or ADCY8 or ADCY7 or ADCY2 or ADCY1 or ADCY4 or ADCY10
Reaction pageDirection not assertedBalanced
Rhea RHEA:15389CC BY 4.0Reference data