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Proteins/UNIPROT:P51668
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1. Ubiquitinates STUB1-associated HSP90AB1 in vitro. Lacks inherent specificity for any particular lysine residue of ubiquitin. Essential for viral activation of IRF3. Mediates polyubiquitination of CYP3A4..
Function from UniProtKB (P51668), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
476 statements
476 statements · 4 reference databases · Subject: UBE2D1 · Sources: gene ontology, Hetionet, Reactome, WikiPathways · Rows fetched: 300
1 reaction
12 names
Resolves to: UBE2D1
Reaction pageLeft to rightBalance undeterminableEC 2.3.2.23, 2.3.2.27, 6.2.1.45cytosol
Human-GEM MAR09491CC BY 4.0Reference data