Proteins/UNIPROT:Q9UK08

GNG8

ProteinUNIPROT:Q9UK08

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

Function from UniProtKB (Q9UK08), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

122 statements

122 statements · 3 reference databases · Subject: GNG8 · Sources: Hetionet, Reactome, WikiPathways

Order

GNG8 covaries with DLL3ProteinHetionet hetionet:covaries:10683-94235Inferred only
GNG8 covaries with LRRC10BProteinHetionet hetionet:covaries:390205-94235Inferred only
GNG8 covaries with PFKFB4ProteinHetionet hetionet:covaries:5210-94235Inferred only
GNG8 covaries with TMEM160ProteinHetionet hetionet:covaries:54958-94235Inferred only
GNG8 covaries with VPS37DProteinHetionet hetionet:covaries:155382-94235Inferred only
GNG8 covaries with ZDHHC16ProteinHetionet hetionet:covaries:84287-94235Inferred only
GNG8 participates in Activation of G protein gated Potassium channelsPathwayReactome R-HSA-1296041Inferred only
GNG8 participates in Activation of GABAB receptorsPathwayReactome R-HSA-991365Inferred only
GNG8 participates in Activation of kainate receptors upon glutamate bindingPathwayReactome R-HSA-451326Inferred only
GNG8 participates in ADORA2B mediated anti-inflammatory cytokines productionPathwayReactome R-HSA-9660821Inferred only
GNG8 participates in ADP signalling through P2Y purinoceptor 1PathwayReactome R-HSA-418592Inferred only
GNG8 participates in ADP signalling through P2Y purinoceptor 12PathwayReactome R-HSA-392170Inferred only

Show the remaining 110

GNG8 participates in Adrenaline,noradrenaline inhibits insulin secretionPathwayReactome R-HSA-400042Inferred only
GNG8 participates in Anti-inflammatory response favouring Leishmania parasite infectionPathwayReactome R-HSA-9662851Inferred only
GNG8 participates in Aquaporin-mediated transportPathwayReactome R-HSA-445717Inferred only
GNG8 participates in Beta-catenin independent WNT signalingPathwayReactome R-HSA-3858494Inferred only
GNG8 participates in Ca2+ pathwayPathwayReactome R-HSA-4086398Inferred only
GNG8 participates in Calcium regulation in cardiac cellsPathwayWikiPathways WP536Inferred only
GNG8 participates in Cancer pathwaysPathwayWikiPathways WP5434Inferred only
GNG8 participates in Cellular responses to mechanical stimuliPathwayReactome R-HSA-9855142Inferred only
GNG8 participates in Cellular responses to stimuliPathwayReactome R-HSA-8953897Inferred only
GNG8 participates in Chaperonin-mediated protein foldingPathwayReactome R-HSA-390466Inferred only
GNG8 participates in Chemokine signalingPathwayWikiPathways WP3929Inferred only
GNG8 participates in Class B/2 (Secretin family receptors)PathwayReactome R-HSA-373080Inferred only
GNG8 participates in Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta foldingPathwayReactome R-HSA-6814122Inferred only
GNG8 participates in DiseasePathwayReactome R-HSA-1643685Inferred only
GNG8 participates in ESR-mediated signalingPathwayReactome R-HSA-8939211Inferred only
GNG8 participates in Extra-nuclear estrogen signalingPathwayReactome R-HSA-9009391Inferred only
GNG8 participates in Focal adhesion PI3K Akt mTOR signalingPathwayWikiPathways WP3932Inferred only
GNG8 participates in G alpha (12/13) signalling eventsPathwayReactome R-HSA-416482Inferred only
GNG8 participates in G alpha (i) signalling eventsPathwayReactome R-HSA-418594Inferred only
GNG8 participates in G alpha (q) signalling eventsPathwayReactome R-HSA-416476Inferred only
GNG8 participates in G alpha (s) signalling eventsPathwayReactome R-HSA-418555Inferred only
GNG8 participates in G alpha (z) signalling eventsPathwayReactome R-HSA-418597Inferred only
GNG8 participates in G beta:gamma signalling through BTKPathwayReactome R-HSA-8964315Inferred only
GNG8 participates in G beta:gamma signalling through CDC42PathwayReactome R-HSA-8964616Inferred only
GNG8 participates in G beta:gamma signalling through PI3KgammaPathwayReactome R-HSA-392451Inferred only
GNG8 participates in G beta:gamma signalling through PLC betaPathwayReactome R-HSA-418217Inferred only
GNG8 participates in G protein gated Potassium channelsPathwayReactome R-HSA-1296059Inferred only
GNG8 participates in G protein signalingPathwayWikiPathways WP35Inferred only
GNG8 participates in G-protein activationPathwayReactome R-HSA-202040Inferred only
GNG8 participates in G-protein beta:gamma signallingPathwayReactome R-HSA-397795Inferred only
GNG8 participates in GABA B receptor activationPathwayReactome R-HSA-977444Inferred only
GNG8 participates in GABA receptor activationPathwayReactome R-HSA-977443Inferred only
GNG8 participates in Glucagon signaling in metabolic regulationPathwayReactome R-HSA-163359Inferred only
GNG8 participates in Glucagon-like Peptide-1 (GLP1) regulates insulin secretionPathwayReactome R-HSA-381676Inferred only
GNG8 participates in Glucagon-type ligand receptorsPathwayReactome R-HSA-420092Inferred only
GNG8 participates in GPCR downstream signallingPathwayReactome R-HSA-388396Inferred only
GNG8 participates in GPCR ligand bindingPathwayReactome R-HSA-500792Inferred only
GNG8 participates in GPER1 signalingPathwayReactome R-HSA-9634597Inferred only
GNG8 participates in HemostasisPathwayReactome R-HSA-109582Inferred only
GNG8 participates in High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cellsPathwayReactome R-HSA-9856530Inferred only
GNG8 participates in Infectious diseasePathwayReactome R-HSA-5663205Inferred only
GNG8 participates in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunitsPathwayReactome R-HSA-997272Inferred only
GNG8 participates in Integration of energy metabolismPathwayReactome R-HSA-163685Inferred only
GNG8 participates in Inwardly rectifying K+ channelsPathwayReactome R-HSA-1296065Inferred only
GNG8 participates in Leishmania infectionPathwayReactome R-HSA-9658195Inferred only
GNG8 participates in Leishmania parasite growth and survivalPathwayReactome R-HSA-9664433Inferred only
GNG8 participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
GNG8 participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
GNG8 participates in Myometrial relaxation and contraction pathwaysPathwayWikiPathways WP289Inferred only
GNG8 participates in Neuronal SystemPathwayReactome R-HSA-112316Inferred only
GNG8 participates in Neurotransmitter receptors and postsynaptic signal transmissionPathwayReactome R-HSA-112314Inferred only
GNG8 participates in Opioid SignallingPathwayReactome R-HSA-111885Inferred only
GNG8 participates in Parasitic Infection PathwaysPathwayReactome R-HSA-9824443Inferred only
GNG8 participates in PI3K Akt signalingPathwayWikiPathways WP4172Inferred only
GNG8 participates in Platelet activation, signaling and aggregationPathwayReactome R-HSA-76002Inferred only
GNG8 participates in Platelet homeostasisPathwayReactome R-HSA-418346Inferred only
GNG8 participates in Potassium ChannelsPathwayReactome R-HSA-1296071Inferred only
GNG8 participates in Presynaptic function of Kainate receptorsPathwayReactome R-HSA-500657Inferred only
GNG8 participates in Prostacyclin signalling through prostacyclin receptorPathwayReactome R-HSA-392851Inferred only
GNG8 participates in Protein foldingPathwayReactome R-HSA-391251Inferred only
GNG8 participates in Ras signalingPathwayWikiPathways WP4223Inferred only
GNG8 participates in Regulation of insulin secretionPathwayReactome R-HSA-422356Inferred only
GNG8 participates in Response of endothelial cells to shear stressPathwayReactome R-HSA-9860931Inferred only
GNG8 participates in Signal amplificationPathwayReactome R-HSA-392518Inferred only
GNG8 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
GNG8 participates in Signaling by GPCRPathwayReactome R-HSA-372790Inferred only
GNG8 participates in Signaling by Nuclear ReceptorsPathwayReactome R-HSA-9006931Inferred only
GNG8 participates in Signaling by WNTPathwayReactome R-HSA-195721Inferred only
GNG8 participates in Thrombin signalling through proteinase activated receptors (PARs)PathwayReactome R-HSA-456926Inferred only
GNG8 participates in Thromboxane signalling through TP receptorPathwayReactome R-HSA-428930Inferred only
GNG8 participates in Transmission across Chemical SynapsesPathwayReactome R-HSA-112315Inferred only
GNG8 participates in Transport of small moleculesPathwayReactome R-HSA-382551Inferred only
GNG8 participates in Vasopressin regulates renal water homeostasis via AquaporinsPathwayReactome R-HSA-432040Inferred only
GNG8 increases the expression of ABCB6ProteinHetionet hetionet:regulates:94235-10058Inferred only
GNG8 decreases the expression of ADH5ProteinHetionet hetionet:regulates:94235-128Inferred only
GNG8 increases the expression of ALDOCProteinHetionet hetionet:regulates:94235-230Inferred only
GNG8 increases the expression of AMDHD2ProteinHetionet hetionet:regulates:94235-51005Inferred only
GNG8 increases the expression of ANKHD1ProteinHetionet hetionet:regulates:94235-54882Inferred only
GNG8 decreases the expression of CANT1ProteinHetionet hetionet:regulates:94235-124583Inferred only
GNG8 increases the expression of CCR7ProteinHetionet hetionet:regulates:94235-1236Inferred only
GNG8 decreases the expression of COPS7BProteinHetionet hetionet:regulates:94235-64708Inferred only
GNG8 decreases the expression of DDAH1ProteinHetionet hetionet:regulates:94235-23576Inferred only
GNG8 decreases the expression of DPYSL2ProteinHetionet hetionet:regulates:94235-1808Inferred only
GNG8 decreases the expression of FAT1ProteinHetionet hetionet:regulates:94235-2195Inferred only
GNG8 decreases the expression of GNASProteinHetionet hetionet:regulates:94235-2778Inferred only
GNG8 increases the expression of HERPUD1ProteinHetionet hetionet:regulates:94235-9709Inferred only
GNG8 decreases the expression of ICMTProteinHetionet hetionet:regulates:94235-23463Inferred only
GNG8 increases the expression of IKBKEProteinHetionet hetionet:regulates:94235-9641Inferred only
GNG8 decreases the expression of KAT6AProteinHetionet hetionet:regulates:94235-7994Inferred only
GNG8 decreases the expression of MFFProteinHetionet hetionet:regulates:94235-56947Inferred only
GNG8 decreases the expression of MIFProteinHetionet hetionet:regulates:94235-4282Inferred only
GNG8 increases the expression of MRPL35ProteinHetionet hetionet:regulates:94235-51318Inferred only
GNG8 decreases the expression of NME1ProteinHetionet hetionet:regulates:94235-4830Inferred only
GNG8 decreases the expression of NRIP1ProteinHetionet hetionet:regulates:94235-8204Inferred only
GNG8 increases the expression of PCK2ProteinHetionet hetionet:regulates:94235-5106Inferred only
GNG8 decreases the expression of PSMD10ProteinHetionet hetionet:regulates:94235-5716Inferred only
GNG8 decreases the expression of RPIAProteinHetionet hetionet:regulates:94235-22934Inferred only
GNG8 decreases the expression of RRP1BProteinHetionet hetionet:regulates:94235-23076Inferred only
GNG8 decreases the expression of RUVBL1ProteinHetionet hetionet:regulates:94235-8607Inferred only
GNG8 decreases the expression of SLC35B1ProteinHetionet hetionet:regulates:94235-10237Inferred only
GNG8 decreases the expression of SPOCK1ProteinHetionet hetionet:regulates:94235-6695Inferred only
GNG8 increases the expression of SPP1ProteinHetionet hetionet:regulates:94235-6696Inferred only
GNG8 increases the expression of SSBP2ProteinHetionet hetionet:regulates:94235-23635Inferred only
GNG8 decreases the expression of STK25ProteinHetionet hetionet:regulates:94235-10494Inferred only
GNG8 decreases the expression of TATDN2ProteinHetionet hetionet:regulates:94235-9797Inferred only
GNG8 decreases the expression of TCERG1ProteinHetionet hetionet:regulates:94235-10915Inferred only
GNG8 decreases the expression of TGFBRAP1ProteinHetionet hetionet:regulates:94235-9392Inferred only
GNG8 decreases the expression of TMEM50AProteinHetionet hetionet:regulates:94235-23585Inferred only
GNG8 decreases the expression of TXNDC9ProteinHetionet hetionet:regulates:94235-10190Inferred only
GNG8 decreases the expression of ZFP64ProteinHetionet hetionet:regulates:94235-55734Inferred only

Other names

7 names

Resolves to: GNG8

Also called: Gamma-9GNG9GNGT9IOSsubunit gamma-8

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