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Proteins/UNIPROT:O15047
Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery, forms H3K4me1, H3K4me2 and H3K4me3 methylation marks at active chromatin sites where transcription and DNA repair take place. Responsible for H3K4me3 enriched promoters and transcriptional programming of inner mass stem cells and neuron progenitors during embryogenesis (By similarity). Required for H3K4me1 mark at stalled replication forks. Mediates FANCD2-dependent nucleosome remodeling and RAD51 nucleofilaments stabilization at reversed forks, protecting them from nucleolytic degradation. Does not methylate 'Lys-4' of histone H3 if the neighboring 'Lys-9' residue is already methylated. Binds RNAs involved in RNA processing and the DNA damage response..
Function from UniProtKB (O15047), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
77 statements
77 statements · 5 reference databases · Subject: SETD1A · Sources: gene ontology, Hetionet, Human Protein Atlas, Reactome, WikiPathways
10 reactions
8 names
Resolves to: SETD1A
Reaction pageReversibleBalance undeterminableEC 2.1.1.354nucleus
Human-GEM MAR04241CC BY 4.0Reference data
MAM00204c+S-adenosyl-L-methionineMAM00213c+proton+CHEBI:16680
Catalysed by KMT2C & KMT2B or KMT2D & KMT2C or SETD1A or SUV39H1 or DOT1L or NSD2 or KMT5B or ASH1L or KMT2A or KMT5C or SETDB2 or SETD1B and 11 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 2.1.1.354cytosol
Human-GEM MAR06975CC BY 4.0Reference data
MAM00213c+S-adenosyl-L-methionineMAM00212c+proton+CHEBI:16680
Catalysed by KMT2C & KMT2B or KMT2D & KMT2C or SETD1A or SUV39H1 or DOT1L or NSD2 or KMT5B or ASH1L or KMT2A or KMT5C or SETDB2 or SETD1B and 11 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 2.1.1.354cytosol
Human-GEM MAR06976CC BY 4.0Reference data
MAM00212c+S-adenosyl-L-methionineMAM00211c+proton+CHEBI:16680
Catalysed by KMT2C & KMT2B or KMT2D & KMT2C or SETD1A or SUV39H1 or DOT1L or NSD2 or KMT5B or ASH1L or KMT2A or KMT5C or SETDB2 or SETD1B and 11 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 2.1.1.354cytosol
Human-GEM MAR06977CC BY 4.0Reference data
MAM00204n+S-adenosyl-L-methionineproton+MAM02129n+CHEBI:16680
Catalysed by KMT2C & KMT2B or KMT2D & KMT2C or SETD1A or SUV39H1 or DOT1L or EZH2 or EZH1 or NSD2 or KMT5B or ASH1L or KMT2A or KMT5C and 12 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 2.1.1.354nucleus
Human-GEM MAR08025CC BY 4.0Reference data
MAM02129n+S-adenosyl-L-methionineMAM00212n+proton+CHEBI:16680
Catalysed by KMT2C & KMT2B or KMT2D & KMT2C or SETD1A or SUV39H1 or DOT1L or EZH2 or EZH1 or NSD2 or KMT5B or ASH1L or KMT2A or KMT5C and 12 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 2.1.1.354nucleus
Human-GEM MAR08026CC BY 4.0Reference data
MAM00212n+S-adenosyl-L-methionineMAM00211n+proton+CHEBI:16680
Catalysed by KMT2C & KMT2B or KMT2D & KMT2C or SETD1A or SUV39H1 or DOT1L or EZH2 or EZH1 or NSD2 or KMT5B or ASH1L or KMT2A or KMT5C and 12 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 2.1.1.354nucleus
Human-GEM MAR08027CC BY 4.0Reference data
L-lysyl(4)-[histone H3]+S-adenosyl-L-methionineN(6)-methyl-L-lysyl(4)-[histone H3]+S-adenosyl-L-homocysteine+hydron
Catalysed by KMT2D or SETD1A or KMT2A or KMT2C or SETD7 or SETD4 or KMT2B or SETD1B
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:60264CC BY 4.0Reference data
N(6)-methyl-L-lysyl(4)-[histone H3]+S-adenosyl-L-methionineN(6),N(6)-dimethyl-L-lysyl(4)-[histone H3]+S-adenosyl-L-homocysteine+hydron
Catalysed by SETD1A or KMT2A or SETD4 or KMT2B or SETD1B
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:60268CC BY 4.0Reference data
N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3]+S-adenosyl-L-methionineN(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3]+S-adenosyl-L-homocysteine+hydron
Catalysed by SETD1A or PRDM7 or SETD1B
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:60272CC BY 4.0Reference data