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Proteins/UNIPROT:P00325
Catalyzes the NAD-dependent oxidation of all-trans-retinol and its derivatives such as all-trans-4-hydroxyretinol and may participate in retinoid metabolism. In vitro can also catalyze the NADH-dependent reduction of all-trans-retinal and its derivatives such as all-trans-4-oxoretinal. Catalyzes in the oxidative direction with higher efficiency. Has the same affinity for all-trans-4-hydroxyretinol and all-trans-4-oxoretinal..
Function from UniProtKB (P00325), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 2 · metabolized by
2 compounds
2 compounds.
0 reported routes2 assembled routes
103 statements
103 statements · 8 reference databases · Subject: ADH1B · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
12 reactions
4 names
Resolves to: ADH1B
Reaction pageReversibleBalancedEC 1.1.1.1cytosol
Human-GEM MAR01684CC BY 4.0Reference data
ethanol+NAD(+)acetaldehyde+proton+NADH(2-)
Catalysed by ADH6 or ADH1A or ADH7 or ADH1B or ADH5 or ADH4 or ADH1C
Reaction pageLeft to rightBalancedEC 1.1.1.1, 1.1.1.71cytosol
Human-GEM MAR03905CC BY 4.0Reference data
methanol+NAD(+)formaldehyde+proton+NADH(2-)
Catalysed by ADHFE1 or ADH6 or ADH1A or ADH7 or ADH1B or ADH5 or ADH4 or ADH1C
Reaction pageLeft to rightBalancedEC 1.1.1.244cytosol
Human-GEM MAR04202CC BY 4.0Reference data
(5-hydroxyindol-3-yl)acetaldehyde+proton+NADPH(4-)MAM01110c+NADP(3-)
Catalysed by ADHFE1 or ADH6 or ADH1A or ADH7 or ADH1B or ADH5 or ADH4 or ADH1C
Reaction pageReversibleBalancedEC 1.1.1.1cytosol
Human-GEM MAR04561CC BY 4.0Reference data
NAD(+)+all-trans-retinolproton+NADH(2-)+all-trans-retinal
Catalysed by HSD17B6 or RDH5 or SDR16C5 or ADH6 or ADH1A or ADH7 or ADH1B or ADH5 or ADH4 or ADH1C
Reaction pageLeft to rightBalancedEC 1.1.1.1, 1.1.1.105cytosol
Human-GEM MAR06631CC BY 4.0Reference data
NAD(+)+all-trans-retinolproton+NADH(2-)+all-trans-retinal
Catalysed by HSD17B6 or RDH5 or SDR16C5 or ADH6 or ADH1A or ADH7 or ADH1B or ADH5 or ADH4 or ADH1C
Reaction pageLeft to rightBalancedEC 1.1.1.1, 1.1.1.105endoplasmic reticulum
Human-GEM MAR06633CC BY 4.0Reference data
NAD(+)+all-trans-4-hydroxyretinolproton+NADH(2-)+all-trans-4-hydroxyretinal
Catalysed by ADH1B
Reaction pageLeft to rightBalancedEC 1.1.1.1cytosol
Human-GEM MAR20067CC BY 4.0Reference data
all-trans-4-oxoretinol+NAD(+)proton+NADH(2-)+MAM20060c
Catalysed by ADH1B
Reaction pageLeft to rightBalancedEC 1.1.1.-cytosol
Human-GEM MAR20068CC BY 4.0Reference data
all-trans-retinol+NAD(1-)all-trans-retinal+NADH(2-)+hydron
Catalysed by DHRS7C or HSD17B6 or RDH16 or ADH1B or ADH4 or ADH7 or HSD17B13 or DHRS9
Reaction pageLeft to rightBalanced
Rhea RHEA:21284CC BY 4.0Reference data
all-trans-4-hydroxyretinol+NAD(1-)all-trans-4-hydroxyretinal+NADH(2-)+hydron
Reaction pageLeft to rightBalanced
Rhea RHEA:55936CC BY 4.0Reference data
all-trans-4-oxoretinol+NAD(1-)CHEBI:139347+NADH(2-)+hydron
Reaction pageRight to leftBalanced
Rhea RHEA:60632CC BY 4.0Reference data