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Proteins/UNIPROT:O15440
ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Mediates ATP-dependent transport of endogenous metabolites such as cAMP and cGMP, folic acid and N-lactoyl-amino acids (in vitro). Also acts as a general glutamate conjugate and analog transporter that can limit the brain levels of endogenous metabolites, drugs, and toxins. Confers resistance to the antiviral agent PMEA. Able to transport several anticancer drugs including methotrexate, and nucleotide analogs in vitro, however it does with low affinity, thus the exact role of ABCC5 in mediating resistance still needs to be elucidated. Acts as a heme transporter required for the translocation of cytosolic heme to the secretory pathway. May play a role in energy metabolism by regulating the glucagon-like peptide 1 (GLP-1) secretion from enteroendocrine cells (By similarity)..
Function from UniProtKB (O15440), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · transported by
1 compound
1 compound.
0 reported routes1 assembled route
678 statements
678 statements · 6 reference databases · Subject: ABCC5 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways · Rows fetched: 300
20 reactions
ATP+CHEBI:16856+waterADP+CHEBI:16856+proton+phosphate(3-)
Transported by ABCC5
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR05442CC BY 4.0Reference data
6 names
Resolves to: ABCC5
Transported by ABCC5
Reaction pageLeft to rightBalance undeterminablecytosol, extracellular space
Human-GEM MAR05443CC BY 4.0Reference data
ATP+water+2,4-dinitrophenyl-S-glutathioneADP+proton+phosphate(3-)+2,4-dinitrophenyl-S-glutathione
Transported by ABCC5
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR05444CC BY 4.0Reference data
ATP+water+MAM02901cADP+proton+phosphate(3-)+MAM02901e
Transported by ABCC5
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR05445CC BY 4.0Reference data
ATP+3',5'-cyclic AMP+waterADP+3',5'-cyclic AMP+proton+phosphate(3-)
Transported by ABCC5 or ABCC11 or ABCC4
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR07691CC BY 4.0Reference data
ATP+3',5'-cyclic GMP+waterADP+3',5'-cyclic GMP+proton+phosphate(3-)
Transported by ABCC5 or ABCC11 or ABCC4
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR07692CC BY 4.0Reference data
ATP+folic acid+waterADP+folic acid+proton+phosphate(3-)
Transported by ABCC2 or ABCC1 or ABCC5 or ABCG2 or ABCC4
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR09882CC BY 4.0Reference data
(6R)-5,10-methylenetetrahydrofolic acid+ATP+water(6R)-5,10-methylenetetrahydrofolic acid+ADP+proton+phosphate(3-)
Transported by ABCB4 or ABCC2 or ABCC1 or ABCC5 or ABCG2 or ABCC11 or ABCC4
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR11809CC BY 4.0Reference data
3',5'-cyclic AMP+ATP(4-)+water3',5'-cyclic AMP+ADP(3-)+hydrogenphosphate+hydron
Transported by ABCC4 or ABCC5 or ABCC11
Reaction pageLeft to rightBalanced
Rhea RHEA:66184CC BY 4.0Reference data
3',5'-cyclic GMP+ATP(4-)+water3',5'-cyclic GMP+ADP(3-)+hydrogenphosphate+hydron
Transported by ABCC4 or ABCC5 or ABCC11
Reaction pageLeft to rightBalanced
Rhea RHEA:66188CC BY 4.0Reference data
N-[(S)-lactoyl]-L-phenylalanine+ATP(4-)+waterN-[(S)-lactoyl]-L-phenylalanine+ADP(3-)+hydrogenphosphate+hydron
Transported by ABCC5
Reaction pageLeft to rightBalanced
Rhea RHEA:66720CC BY 4.0Reference data
N-acetyl-L-aspartyl-L-glutamate+ATP(4-)+waterN-acetyl-L-aspartyl-L-glutamate+ADP(3-)+hydrogenphosphate+hydron
Transported by ABCC5
Reaction pageLeft to rightBalanced
Rhea RHEA:66728CC BY 4.0Reference data