Proteins/UNIPROT:Q01860

POU5F1

ProteinUNIPROT:Q01860

Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 or SOX15 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency..

Function from UniProtKB (Q01860), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

163 statements

163 statements · 4 reference databases · Subject: POU5F1 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

PROB1 covaries with POU5F1ProteinHetionet hetionet:covaries:389333-5460Inferred only
POU5F1 interacts with CTCFProteinHetionet hetionet:interacts:10664-5460Inferred only
POU5F1 interacts with FOXD3ProteinHetionet hetionet:interacts:27022-5460Inferred only
POU5F1 participates in Cardiac progenitor differentiationPathwayWikiPathways WP2406Inferred only
POU5F1 participates in Cell lineage map for neuronal differentiationPathwayWikiPathways WP5417Inferred only
POU5F1 participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
POU5F1 participates in Endoderm differentiationPathwayWikiPathways WP2853Inferred only
POU5F1 participates in Formation of the anterior neural platePathwayReactome R-HSA-9823739Inferred only
POU5F1 participates in GastrulationPathwayReactome R-HSA-9758941Inferred only
POU5F1 participates in Germ layer formation at gastrulationPathwayReactome R-HSA-9754189Inferred only
POU5F1 participates in Glucocorticoid receptor pathwayPathwayWikiPathways WP2880Inferred only
POU5F1 participates in HDAC6 interactions in the central nervous systemPathwayWikiPathways WP5426Inferred only

Show the remaining 151

POU5F1 participates in let 7 inhibition of ES cell reprogrammingPathwayWikiPathways WP3299Inferred only
POU5F1 participates in Mesodermal commitment pathwayPathwayWikiPathways WP2857Inferred only
POU5F1 participates in Nuclear receptors meta pathwayPathwayWikiPathways WP2882Inferred only
POU5F1 participates in POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferationPathwayReactome R-HSA-2892247Inferred only
POU5F1 participates in POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiationPathwayReactome R-HSA-2892245Inferred only
POU5F1 participates in Pre implantation embryoPathwayWikiPathways WP3527Inferred only
POU5F1 participates in ReproductionPathwayReactome R-HSA-1474165Inferred only
POU5F1 participates in Specification of primordial germ cellsPathwayReactome R-HSA-9827857Inferred only
POU5F1 participates in Specification of the neural plate borderPathwayReactome R-HSA-9834899Inferred only
POU5F1 participates in Sudden infant death syndrome SIDS susceptibility pathwaysPathwayWikiPathways WP706Inferred only
POU5F1 participates in Transcriptional regulation of pluripotent stem cellsPathwayReactome R-HSA-452723Inferred only
POU5F1 participates in Wnt signaling and pluripotencyPathwayWikiPathways WP399Inferred only
POU5F1 regulates negative regulation of miRNA transcriptionBiological processgene ontology Q01860|GO:1902894Inferred only
POU5F1 regulates negative regulation of transcription by RNA polymerase IIBiological processgene ontology Q01860|GO:0000122Inferred only
POU5F1 regulates positive regulation of canonical Wnt signaling pathwayBiological processgene ontology Q01860|GO:0090263Inferred only
POU5F1 regulates positive regulation of transcription by RNA polymerase IIBiological processgene ontology Q01860|GO:0045944Inferred only
POU5F1 regulates regulation of asymmetric cell divisionBiological processgene ontology Q01860|GO:0009786Inferred only
POU5F1 regulates regulation of DNA-templated transcriptionBiological processgene ontology Q01860|GO:0006355Inferred only
POU5F1 regulates regulation of gene expressionBiological processgene ontology Q01860|GO:0010468Inferred only
POU5F1 regulates regulation of transcription by RNA polymerase IIBiological processgene ontology Q01860|GO:0006357Inferred only
POU5F1 increases the expression of AATKProteinHetionet hetionet:regulates:5460-9625Inferred only
POU5F1 decreases the expression of ADGRG1ProteinHetionet hetionet:regulates:5460-9289Inferred only
POU5F1 decreases the expression of ADH5ProteinHetionet hetionet:regulates:5460-128Inferred only
POU5F1 decreases the expression of ADRB2ProteinHetionet hetionet:regulates:5460-154Inferred only
POU5F1 increases the expression of ALDOCProteinHetionet hetionet:regulates:5460-230Inferred only
POU5F1 increases the expression of AMDHD2ProteinHetionet hetionet:regulates:5460-51005Inferred only
POU5F1 increases the expression of ARID5BProteinHetionet hetionet:regulates:5460-84159Inferred only
POU5F1 decreases the expression of AURKBProteinHetionet hetionet:regulates:5460-9212Inferred only
POU5F1 increases the expression of BHLHE40ProteinHetionet hetionet:regulates:5460-8553Inferred only
POU5F1 decreases the expression of BRCA1ProteinHetionet hetionet:regulates:5460-672Inferred only
POU5F1 decreases the expression of BRIX1ProteinHetionet hetionet:regulates:5460-55299Inferred only
POU5F1 increases the expression of C2CD2LProteinHetionet hetionet:regulates:5460-9854Inferred only
POU5F1 increases the expression of CASP3ProteinHetionet hetionet:regulates:5460-836Inferred only
POU5F1 increases the expression of CASP7ProteinHetionet hetionet:regulates:5460-840Inferred only
POU5F1 decreases the expression of CBLBProteinHetionet hetionet:regulates:5460-868Inferred only
POU5F1 increases the expression of CCDC92ProteinHetionet hetionet:regulates:5460-80212Inferred only
POU5F1 decreases the expression of CCNA2ProteinHetionet hetionet:regulates:5460-890Inferred only
POU5F1 decreases the expression of CCNB2ProteinHetionet hetionet:regulates:5460-9133Inferred only
POU5F1 decreases the expression of CCND1ProteinHetionet hetionet:regulates:5460-595Inferred only
POU5F1 decreases the expression of CDC45ProteinHetionet hetionet:regulates:5460-8318Inferred only
POU5F1 decreases the expression of CDK1ProteinHetionet hetionet:regulates:5460-983Inferred only
POU5F1 decreases the expression of CDK4ProteinHetionet hetionet:regulates:5460-1019Inferred only
POU5F1 increases the expression of CDK7ProteinHetionet hetionet:regulates:5460-1022Inferred only
POU5F1 decreases the expression of CEBPBProteinHetionet hetionet:regulates:5460-1051Inferred only
POU5F1 increases the expression of CES1ProteinHetionet hetionet:regulates:5460-1066Inferred only
POU5F1 increases the expression of CHMP6ProteinHetionet hetionet:regulates:5460-79643Inferred only
POU5F1 decreases the expression of CNDP2ProteinHetionet hetionet:regulates:5460-55748Inferred only
POU5F1 increases the expression of CNOT4ProteinHetionet hetionet:regulates:5460-4850Inferred only
POU5F1 increases the expression of CPVLProteinHetionet hetionet:regulates:5460-54504Inferred only
POU5F1 increases the expression of CSRP1ProteinHetionet hetionet:regulates:5460-1465Inferred only
POU5F1 increases the expression of DCTDProteinHetionet hetionet:regulates:5460-1635Inferred only
POU5F1 decreases the expression of DDIT4ProteinHetionet hetionet:regulates:5460-54541Inferred only
POU5F1 decreases the expression of DERAProteinHetionet hetionet:regulates:5460-51071Inferred only
POU5F1 decreases the expression of DRAP1ProteinHetionet hetionet:regulates:5460-10589Inferred only
POU5F1 decreases the expression of DSCC1ProteinHetionet hetionet:regulates:5460-79075Inferred only
POU5F1 decreases the expression of DUSP4ProteinHetionet hetionet:regulates:5460-1846Inferred only
POU5F1 increases the expression of ECH1ProteinHetionet hetionet:regulates:5460-1891Inferred only
POU5F1 increases the expression of ELOVL6ProteinHetionet hetionet:regulates:5460-79071Inferred only
POU5F1 decreases the expression of ENOPH1ProteinHetionet hetionet:regulates:5460-58478Inferred only
POU5F1 increases the expression of ERAP2ProteinHetionet hetionet:regulates:5460-64167Inferred only
POU5F1 increases the expression of ERBB3ProteinHetionet hetionet:regulates:5460-2065Inferred only
POU5F1 decreases the expression of EXT1ProteinHetionet hetionet:regulates:5460-2131Inferred only
POU5F1 decreases the expression of EZH2ProteinHetionet hetionet:regulates:5460-2146Inferred only
POU5F1 decreases the expression of FANCLProteinHetionet hetionet:regulates:5460-55120Inferred only
POU5F1 decreases the expression of FOSL1ProteinHetionet hetionet:regulates:5460-8061Inferred only
POU5F1 increases the expression of GDPD5ProteinHetionet hetionet:regulates:5460-81544Inferred only
POU5F1 decreases the expression of HADHProteinHetionet hetionet:regulates:5460-3033Inferred only
POU5F1 decreases the expression of HAT1ProteinHetionet hetionet:regulates:5460-8520Inferred only
POU5F1 decreases the expression of HDAC2ProteinHetionet hetionet:regulates:5460-3066Inferred only
POU5F1 increases the expression of HERC6ProteinHetionet hetionet:regulates:5460-55008Inferred only
POU5F1 decreases the expression of HIF1AProteinHetionet hetionet:regulates:5460-3091Inferred only
POU5F1 decreases the expression of HMGA2ProteinHetionet hetionet:regulates:5460-8091Inferred only
POU5F1 increases the expression of HSPA1AProteinHetionet hetionet:regulates:5460-3303Inferred only
POU5F1 increases the expression of HSPB1ProteinHetionet hetionet:regulates:5460-3315Inferred only
POU5F1 increases the expression of IGFBP3ProteinHetionet hetionet:regulates:5460-3486Inferred only
POU5F1 increases the expression of IL1BProteinHetionet hetionet:regulates:5460-3553Inferred only
POU5F1 increases the expression of IL4RProteinHetionet hetionet:regulates:5460-3566Inferred only
POU5F1 decreases the expression of INPP4BProteinHetionet hetionet:regulates:5460-8821Inferred only
POU5F1 decreases the expression of ITGAEProteinHetionet hetionet:regulates:5460-3682Inferred only
POU5F1 increases the expression of ITGB1BP1ProteinHetionet hetionet:regulates:5460-9270Inferred only
POU5F1 decreases the expression of KIF11ProteinHetionet hetionet:regulates:5460-3832Inferred only
POU5F1 decreases the expression of KIF15ProteinHetionet hetionet:regulates:5460-56992Inferred only
POU5F1 decreases the expression of KIF20AProteinHetionet hetionet:regulates:5460-10112Inferred only
POU5F1 decreases the expression of KIF4AProteinHetionet hetionet:regulates:5460-24137Inferred only
POU5F1 decreases the expression of LOXL1ProteinHetionet hetionet:regulates:5460-4016Inferred only
POU5F1 increases the expression of LRP10ProteinHetionet hetionet:regulates:5460-26020Inferred only
POU5F1 increases the expression of LRPAP1ProteinHetionet hetionet:regulates:5460-4043Inferred only
POU5F1 decreases the expression of LSM5ProteinHetionet hetionet:regulates:5460-23658Inferred only
POU5F1 increases the expression of MALProteinHetionet hetionet:regulates:5460-4118Inferred only
POU5F1 increases the expression of MAN2B1ProteinHetionet hetionet:regulates:5460-4125Inferred only
POU5F1 decreases the expression of MCM10ProteinHetionet hetionet:regulates:5460-55388Inferred only
POU5F1 increases the expression of MMP1ProteinHetionet hetionet:regulates:5460-4312Inferred only
POU5F1 decreases the expression of MPC2ProteinHetionet hetionet:regulates:5460-25874Inferred only
POU5F1 decreases the expression of MTERF3ProteinHetionet hetionet:regulates:5460-51001Inferred only
POU5F1 decreases the expression of MVPProteinHetionet hetionet:regulates:5460-9961Inferred only
POU5F1 decreases the expression of MYCProteinHetionet hetionet:regulates:5460-4609Inferred only
POU5F1 increases the expression of MYL9ProteinHetionet hetionet:regulates:5460-10398Inferred only
POU5F1 increases the expression of MYLKProteinHetionet hetionet:regulates:5460-4638Inferred only
POU5F1 increases the expression of NET1ProteinHetionet hetionet:regulates:5460-10276Inferred only
POU5F1 increases the expression of NPC1ProteinHetionet hetionet:regulates:5460-4864Inferred only
POU5F1 decreases the expression of NUSAP1ProteinHetionet hetionet:regulates:5460-51203Inferred only
POU5F1 decreases the expression of OIP5ProteinHetionet hetionet:regulates:5460-11339Inferred only
POU5F1 decreases the expression of PARP2ProteinHetionet hetionet:regulates:5460-10038Inferred only
POU5F1 decreases the expression of PCNAProteinHetionet hetionet:regulates:5460-5111Inferred only
POU5F1 decreases the expression of PEG10ProteinHetionet hetionet:regulates:5460-23089Inferred only
POU5F1 increases the expression of PFKLProteinHetionet hetionet:regulates:5460-5211Inferred only
POU5F1 decreases the expression of PGAM1ProteinHetionet hetionet:regulates:5460-5223Inferred only
POU5F1 increases the expression of PLAC8ProteinHetionet hetionet:regulates:5460-51316Inferred only
POU5F1 increases the expression of PLCB3ProteinHetionet hetionet:regulates:5460-5331Inferred only
POU5F1 decreases the expression of PMS1ProteinHetionet hetionet:regulates:5460-5378Inferred only
POU5F1 increases the expression of POLD4ProteinHetionet hetionet:regulates:5460-57804Inferred only
POU5F1 increases the expression of POLE2ProteinHetionet hetionet:regulates:5460-5427Inferred only
POU5F1 increases the expression of PPP2R5BProteinHetionet hetionet:regulates:5460-5526Inferred only
POU5F1 decreases the expression of PPP2R5EProteinHetionet hetionet:regulates:5460-5529Inferred only
POU5F1 decreases the expression of PRIM1ProteinHetionet hetionet:regulates:5460-5557Inferred only
POU5F1 increases the expression of PSMD9ProteinHetionet hetionet:regulates:5460-5715Inferred only
POU5F1 increases the expression of PSME2ProteinHetionet hetionet:regulates:5460-5721Inferred only
POU5F1 decreases the expression of PXNProteinHetionet hetionet:regulates:5460-5829Inferred only
POU5F1 decreases the expression of RAD51ProteinHetionet hetionet:regulates:5460-5888Inferred only
POU5F1 increases the expression of RELBProteinHetionet hetionet:regulates:5460-5971Inferred only
POU5F1 decreases the expression of RFC4ProteinHetionet hetionet:regulates:5460-5984Inferred only
POU5F1 decreases the expression of RFC5ProteinHetionet hetionet:regulates:5460-5985Inferred only
POU5F1 decreases the expression of RND3ProteinHetionet hetionet:regulates:5460-390Inferred only
POU5F1 decreases the expression of RNH1ProteinHetionet hetionet:regulates:5460-6050Inferred only
POU5F1 decreases the expression of RPIAProteinHetionet hetionet:regulates:5460-22934Inferred only
POU5F1 increases the expression of RRAGAProteinHetionet hetionet:regulates:5460-10670Inferred only
POU5F1 decreases the expression of RRP1BProteinHetionet hetionet:regulates:5460-23076Inferred only
POU5F1 increases the expression of RRP8ProteinHetionet hetionet:regulates:5460-23378Inferred only
POU5F1 decreases the expression of S100A4ProteinHetionet hetionet:regulates:5460-6275Inferred only
POU5F1 increases the expression of SERPINA3ProteinHetionet hetionet:regulates:5460-12Inferred only
POU5F1 increases the expression of SH3BP5ProteinHetionet hetionet:regulates:5460-9467Inferred only
POU5F1 decreases the expression of SLC15A2ProteinHetionet hetionet:regulates:5460-6565Inferred only
POU5F1 increases the expression of SLC25A4ProteinHetionet hetionet:regulates:5460-291Inferred only
POU5F1 decreases the expression of SLC35F2ProteinHetionet hetionet:regulates:5460-54733Inferred only
POU5F1 decreases the expression of SPDEFProteinHetionet hetionet:regulates:5460-25803Inferred only
POU5F1 increases the expression of SPP1ProteinHetionet hetionet:regulates:5460-6696Inferred only
POU5F1 increases the expression of SPTLC2ProteinHetionet hetionet:regulates:5460-9517Inferred only
POU5F1 increases the expression of STIMATEProteinHetionet hetionet:regulates:5460-375346Inferred only
POU5F1 decreases the expression of SUV39H1ProteinHetionet hetionet:regulates:5460-6839Inferred only
POU5F1 increases the expression of SYNGR3ProteinHetionet hetionet:regulates:5460-9143Inferred only
POU5F1 increases the expression of TCTAProteinHetionet hetionet:regulates:5460-6988Inferred only
POU5F1 decreases the expression of THAP11ProteinHetionet hetionet:regulates:5460-57215Inferred only
POU5F1 increases the expression of TIAM1ProteinHetionet hetionet:regulates:5460-7074Inferred only
POU5F1 decreases the expression of TIMELESSProteinHetionet hetionet:regulates:5460-8914Inferred only
POU5F1 decreases the expression of TIMM9ProteinHetionet hetionet:regulates:5460-26520Inferred only
POU5F1 decreases the expression of TIPARPProteinHetionet hetionet:regulates:5460-25976Inferred only
POU5F1 decreases the expression of TSEN2ProteinHetionet hetionet:regulates:5460-80746Inferred only
POU5F1 decreases the expression of TTI1ProteinHetionet hetionet:regulates:5460-9675Inferred only
POU5F1 decreases the expression of TUBA1AProteinHetionet hetionet:regulates:5460-7846Inferred only
POU5F1 decreases the expression of ZW10ProteinHetionet hetionet:regulates:5460-9183Inferred only
POU5F1 decreases the expression of ZWINTProteinHetionet hetionet:regulates:5460-11130Inferred only

Other names

9 names

Resolves to: POU5F1

Also called: Oct-3Oct-4OCT3OCT4Octamer-binding protein 3Octamer-binding protein 4Octamer-binding transcription factor 3OTF-3OTF3

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