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Proteins/UNIPROT:Q9NTJ5
Phosphoinositide phosphatase which catalyzes the hydrolysis of phosphatidylinositol 4-phosphate (PtdIns(4)P). Can also catalyze the hydrolysis of phosphatidylinositol 3-phosphate (PtdIns(3)P) and has low activity towards phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P2) (By similarity). Shows a very robust PtdIns(4)P phosphatase activity when it binds PtdIns(4)P in a 'cis' configuration in the cellular environment, with much less activity seen when it binds PtdIns(4)P in 'trans' configuration. PtdIns(4)P phosphatase activity (when it binds PtdIns(4)P in 'trans' configuration) is enhanced in the presence of PLEKHA3..
Function from UniProtKB (Q9NTJ5), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
426 statements
426 statements · 6 reference databases · Subject: SACM1L · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways · Rows fetched: 300
6 reactions
MAM00555c+watera 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)+phosphate(3-)
Catalysed by MTMR7 or MTMR1 or MTMR2 or MTMR8 or TNS2 or NT5DC3 or FIG4 or SGPP1 or CTDSPL2 or PTPRQ or MTMR6 or DUSP11 and 8 more alternatives
Reaction pageLeft to right
4 names
Resolves to: SACM1L
Human-GEM MAR06545CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)+water1-phosphatidyl-1D-myo-inositol+phosphate(3-)
Catalysed by MTMR1 or MTMR2 or MTMR8 or TNS2 or NT5DC3 or FIG4 or CTDSPL2 or PTPRQ or MTMR6 or INPPL1 or PMPCA or INPP5F and 1 more alternative
Reaction pageLeft to rightBalance undeterminableEC 3.1.3.-cytosol
Human-GEM MAR06547CC BY 4.0Reference data
water+MAM02734cMAM00551c+phosphate(3-)
Catalysed by MTMR7 or MTMR2 or MTMR8 or TNS2 or NT5DC3 or FIG4 or CTDSPL2 or PTPRQ or MTMR6 or INPPL1 or INPP5F or ASB12 and 3 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 3.1.3.-cytosol
Human-GEM MAR06557CC BY 4.0Reference data
water+MAM02735ca 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate)+phosphate(3-)
Catalysed by MTMR7 or PHPT1 or MTMR1 or MTMR2 or MTMR8 or TNS2 or NT5DC3 or FIG4 or NT5C or CTDSPL2 or PTPRQ or MTMR6 and 8 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 3.1.3.-cytosol
Human-GEM MAR06591CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)+watera 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)+hydrogenphosphate
Catalysed by SYNJ2 or SYNJ1 or MTM1 or MTMR1 or MTMR2 or MTMR3 or MTMR14 or MTMR8 or SACM1L or MTMR4 or MTMR7 or MTMR6
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:12316CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)+watera 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)+hydrogenphosphate
Catalysed by SYNJ2 or SYNJ1 or SACM1L or INPP5F
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:55652CC BY 4.0Reference data