decanoyl-CoA

Three steps

• (R)-3-aminoisobutyric acidReach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by AGXT2cytosol, mitochondrial matrix

• phosphatidic acidReach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. acyl-CoA:sphingosine N-acyltransferase
  3. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase

  Catalysed by ASAH1, ACER2, ACER1, ASAH2 and 9 morecytosol, Golgi apparatus, mitochondrial matrixOne of 7 routes

• (R)-carnitineReach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  3. dodecanoyl-CoA + (R)-carnitine = O-dodecanoyl-R-carnitine + CoA

  Catalysed by CPT1A, CPT1C, CPT1B, CPT2cytosolOne of 3 routes

• L-citrullineReach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of citrulline and glycine (cytosol to extracellular)

  Catalysed by GLYAT, GLYATL2, GLYATL1, SLC7A9 and 2 morecytosol, mitochondrial matrix, extracellular spaceOne of 8 routes

• L-valineReach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of glycine and valine (cytosol to extracellular)

  Catalysed by GLYAT, GLYATL2, GLYATL1, SLC7A5cytosol, mitochondrial matrix, extracellular spaceOne of 20 routes

• L-arginineReach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of arginine and glycine (cytosol to extracellular)

  Catalysed by GLYAT, GLYATL2, GLYATL1, SLC7A6cytosol, mitochondrial matrix, extracellular spaceOne of 18 routes

• CHEBI:16523Reach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of D-serine and glycine (cytosol to extracellular)

  Catalysed by GLYAT, GLYATL2, GLYATL1, SLC3A2 and 1 morecytosol, mitochondrial matrix, extracellular spaceOne of 2 routes

• protein polypeptide chainReach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. PROTEIN_BS

  Catalysed by GLYAT, GLYATL2, GLYATL1cytosol, mitochondrial matrixOne of 5 routes

• CHEBI:16633Reach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by SCLYcytosol, mitochondrial matrix

• Met-tRNA(Met)Reach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. L-Methionine:tRNAMet ligase (AMP-forming)

  Catalysed by NAGS, MARS1cytosol, mitochondrial matrix

• 4-methylsulfanyl-2-oxobutanoateReach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine

  Catalysed by NAGS, AADATcytosol, mitochondrial matrix

• 8-hydroxydodecanoateReach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. Lauroyl-CoA hydrolase
  3. dodecanoate + reduced [NADPH--hemoprotein reductase] + O2 = 8-hydroxydodecanoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by ACOT7, BAAT, ACOT1, ACOT13 and 1 morecytosol

• 10-hydroxydodecanoateReach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. Lauroyl-CoA hydrolase
  3. dodecanoate + reduced [NADPH--hemoprotein reductase] + O2 = 10-hydroxydodecanoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by ACOT7, BAAT, ACOT1, ACOT13 and 1 morecytosol

• 9-hydroxydodecanoateReach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. Lauroyl-CoA hydrolase
  3. dodecanoate + reduced [NADPH--hemoprotein reductase] + O2 = 9-hydroxydodecanoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by ACOT7, BAAT, ACOT1, ACOT13 and 1 morecytosol

• 2-oxobutanoateReach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. N-acetylglutamate synthase (N-acetyl-L-cystathionine)
  3. L-cystathionine cysteine-lyase (deaminating

  Catalysed by NAGS, CTHcytosol, mitochondrial matrixOne of 2 routes

• CHEBI:16856Reach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. transport of GSH and leukotriene E4 (cytosol to extracellular)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 29 morecytosol, extracellular spaceOne of 4 routes

• CHEBI:16857Reach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of glycine and threonine (cytosol to extracellular)

  Catalysed by GLYAT, GLYATL2, GLYATL1, SLC3A2 and 2 morecytosol, mitochondrial matrix, extracellular spaceOne of 19 routes

• pantetheine 4'-phosphateReach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. acid phosphatase 2, lysosomal (CoA)
  3. Dephospho-CoA nucleotidohydrolase

  Catalysed by ACP2, ENPP3, ENPP1cytosol, lysosomeOne of 2 routes

• psychosineReach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. acyl-CoA:sphingosine N-acyltransferase
  3. UDP-alpha-D-galactose:sphingosine 1-beta-galactosyltransferase

  Catalysed by ASAH1, ACER2, ACER1, ASAH2cytosol, Golgi apparatus

• glyoxylic acidReach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. glycine:oxygen oxidoreductase (deaminating)

  Catalysed by GLYAT, GLYATL2, GLYATL1, DAOcytosol, mitochondrial matrix, peroxisome

• 1-acyl-sn-glycerol 3-phosphateReach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. acyl-CoA:sphingosine N-acyltransferase
  3. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase

  Catalysed by ASAH1, ACER2, ACER1, ASAH2 and 4 morecytosol, Golgi apparatus, mitochondrial matrixOne of 9 routes

• a cholesterol esterReach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. acyl-CoA:sphingosine N-acyltransferase
  3. an acyl-CoA + cholesterol = a cholesterol ester + CoA

  Catalysed by ASAH1, ACER2, ACER1, ASAH2 and 2 morecytosol, Golgi apparatus

• taurolithocholateReach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. bile acid-CoA:amino acid N-acyltransferase (lithocholate)

  Catalysed by BAATcytosolOne of 2 routes

• L-isoleucineReach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of glycine and isoleucine (cytosol to extracellular)

  Catalysed by GLYAT, GLYATL2, GLYATL1, SLC7A5cytosol, mitochondrial matrix, extracellular spaceOne of 18 routes

• CHEBI:17203Reach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of glycine and proline (cytosol to extracellular)

  Catalysed by GLYAT, GLYATL2, GLYATL1, SLC7A5 and 1 morecytosol, mitochondrial matrix, extracellular spaceOne of 15 routes

• CHEBI:17208Reach from here →
  1. decanoyl-CoA + glycine = N-decanoylglycine + CoA + H(+)
  2. N-decanoylglycine + 2 L-ascorbate + O2 = N-decanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
  3. 12,13-epoxy-9-hydroperoxy... to 12,13-epoxylinoleic acid-radical conversion

  Catalysed by GLYATL2, PAMcytosolOne of 3 routes

• S-(4,8-dimethylnonanoyl)-4'-phosphopantetheineReach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. Carnitine Dimethyl Nonanoyl Transferase, Revsible, Peroxisomal
  3. 4,8-dimethylnonanoyl-CoA + H2O = S-(4,8-dimethylnonanoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

  Catalysed by CRAT, CROT, NUDT19cytosol, peroxisome

• S-(9Z,12Z,15Z-octadecatrienoyl)-4'-phosphopantetheineReach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. long-chain-fatty-acid-CoA ligase (linolenate)
  3. (9Z,12Z,15Z)-octadecatrienoyl-CoA + H2O = S-(9Z,12Z,15Z-octadecatrienoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 5 morecytosol

• S-(9Z,12Z-octadecadienoyl)-4'-phosphopantetheineReach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
  3. (9Z,12Z)-octadecadienoyl-CoA + H2O = S-(9Z,12Z-octadecadienoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 5 morecytosol

• S-(9Z-hexadecenoyl)-4'-phosphopantetheineReach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. long-chain-fatty-acid-CoA ligase (palmitolate)
  3. (9Z)-hexadecenoyl-CoA + H2O = S-(9Z-hexadecenoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 5 morecytosol

• itaconateReach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. Itaconate:CoA ligase (GDP-forming)
  3. Itaconate:CoA ligase (GDP-forming)

  Catalysed by SUCLG1, SUCLG2, SUCLA2cytosol, mitochondrial matrixOne of 4 routes

• N-octadecanoyl-heptadecasphing-4-enineReach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. heptadecasphing-4-enine + octadecanoyl-CoA = N-octadecanoyl-heptadecasphing-4-enine + CoA + H(+)

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosol

• dehydroascorbic acidReach from here →
  1. decanoyl-CoA + glycine = N-decanoylglycine + CoA + H(+)
  2. N-decanoylglycine + 2 L-ascorbate + O2 = N-decanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
  3. prostaglandin-F synthase (monodehydroascorbate)

  Catalysed by GLYATL2, PAMcytosolOne of 2 routes

• all-trans-retinolReach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. Palmitoyl-CoA:retinol O-acyltransferase
  3. all-trans-Retinol 11-cis-trans-isomerase

  Catalysed by DGAT1, LRAT, AWAT1, AWAT2 and 1 morecytosolOne of 2 routes

• linoleic acidReach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. Carnitine O-Palmitoyltransferase
  3. Utilized Transport

  Catalysed by CPT1A, CPT1C, CPT1Bcytosol, endoplasmic reticulumOne of 3 routes

• 1-(alk-1-enyl)-2-acyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. acyl-CoA:sphingosine N-acyltransferase
  3. Acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase

  Catalysed by ASAH1, ACER2, ACER1, ASAH2 and 4 morecytosol, Golgi apparatus

• O-hexadecanoyl-(R)-carnitineReach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. Carnitine O-Palmitoyltransferase
  3. palmitoyl-CoA:L-carnitine O-palmitoyltransferase

  Catalysed by CPT1A, CPT1C, CPT1B, CPT2cytosol, peroxisomeOne of 14 routes

• AH2Reach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. uridine(34) in tRNA + 5,10-methylenetetrahydrofolate + taurine + GTP + A + H2O = 5-taurinomethyluridine(34) in tRNA + 7,8-dihydrofolate + GDP + AH2 + phosphate + H(+)

  Catalysed by BAAT, MTO1cytosolOne of 6 routes

• 1-O-acyl-sn-glycero-3-phosphocholine(1+)Reach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. Palmitoyl-CoA:retinol O-acyltransferase
  3. Lecithin Retinol Acyltransferase (11-Cis)

  Catalysed by DGAT1, LRAT, AWAT1, AWAT2 and 1 morecytosol

• S-methyl-5'-thioadenosineReach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. S-adenosylmethioninamine:spermidine 3-aminopropyltransferase

  Catalysed by SAT1, SAT2, SRM, SMScytosolOne of 2 routes

• 5-aminolevulinic acidReach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. succinyl-CoA:glycine C-succinyltransferase (decarboxylating)

  Catalysed by GLYAT, GLYATL2, GLYATL1, ALAS1 and 2 morecytosol, mitochondrial matrixOne of 2 routes

• all-trans-retinyl hexadecanoateReach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. Palmitoyl-CoA:retinol O-acyltransferase
  3. all-trans-retinyl hexadecanoate + H2O = 11-cis-retinol + hexadecanoate + H(+)

  Catalysed by DGAT1, LRAT, AWAT1, AWAT2 and 2 morecytosol

• Ala-tRNA(Ala)Reach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. L-Alanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by AARS1cytosol, mitochondrial matrix

• CHEBI:17769Reach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. spermidine:(acceptor) oxidoreductase

  Catalysed by SAT1, SAT2cytosol

• a 1,2-diacyl-sn-glycerolReach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. acyl-CoA:sphingosine N-acyltransferase
  3. a 2-acylglycerol + an acyl-CoA = a 1,2-diacyl-sn-glycerol + CoA

  Catalysed by ASAH1, ACER2, ACER1, ASAH2 and 3 morecytosol, Golgi apparatus

• a triacylglycerolReach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. acyl-CoA:sphingosine N-acyltransferase
  3. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase

  Catalysed by ASAH1, ACER2, ACER1, ASAH2 and 5 morecytosol, Golgi apparatus

• CHEBI:17895Reach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of glycine and tyrosine (cytosol to extracellular)

  Catalysed by GLYAT, GLYATL2, GLYATL1, SLC7A5cytosol, mitochondrial matrix, extracellular spaceOne of 19 routes

• butanoateReach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. Butanoate:CoA ligase (AMP-forming)
  3. butanoyl-CoA + H2O = butanoate + CoA + H(+)

  Catalysed by ACSM4, ACSM1, ACSM2A, ACSM3 and 8 morecytosol

• CHEBI:18019Reach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of glycine and lysine (cytosol to extracellular)

  Catalysed by GLYAT, GLYATL2, GLYATL1, SLC7A6cytosol, mitochondrial matrix, extracellular spaceOne of 10 routes

• L-glutamineReach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of glutamine and glycine (cytosol to extracellular)

  Catalysed by GLYAT, GLYATL2, GLYATL1, SLC7A5cytosol, mitochondrial matrix, extracellular spaceOne of 29 routes