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Proteins/UNIPROT:Q86TX2

ACOT1

Protein·UNIPROT:Q86TX2Acyl-coenzyme A thioesterase 1

Open in the graph

Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. More active towards saturated and unsaturated long chain fatty acyl-CoAs (C12-C20)..

Function from UniProtKB (Q86TX2), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

73 statements

73 statements · 5 reference databases · Subject: ACOT1 · Sources: Hetionet, Human-GEM, Reactome, Rhea, WikiPathways

Search this listOrder

UBC interacts with ACOT1ProteinHetionet hetionet:interacts:641371-7316Inferred only
ACOT1 participates in 7 oxo C and 7 beta HC pathwaysPathwayWikiPathways WP5064Inferred only
ACOT1 participates in Cholesterol biosynthesis pathway in hepatocytesPathwayWikiPathways WP5329Inferred only
ACOT1 participates in Fatty acid metabolismPathwayReactome R-HSA-8978868Inferred only
ACOT1 participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
ACOT1 participates in Metabolism of lipidsPathwayReactome R-HSA-556833Inferred only
ACOT1 participates in Mitochondrial Fatty Acid Beta-OxidationPathwayReactome R-HSA-77289Inferred only
ACOT1 participates in Omega 3 omega 6 fatty acid synthesisPathwayWikiPathways WP4723Inferred only
ACOT1 participates in Oxysterols derived from cholesterolPathwayWikiPathways WP4545Inferred only
(11Z,14Z,17Z)-eicosatrienoyl-CoA is a substrate of ACOT1CompoundHuman-GEM MAR00382Inferred only
(11Z,14Z)-eicosadienoyl-CoA is a substrate of ACOT1CompoundHuman-GEM MAR00430Inferred only
(11Z)-eicosenoyl-CoA is a substrate of ACOT1CompoundHuman-GEM MAR00294Inferred only

Show the remaining 61

(13Z)-eicosenoyl-CoA is a substrate of ACOT1CompoundHuman-GEM MAR00290Inferred only
(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA is a substrate of ACOT1CompoundHuman-GEM MAR00362Inferred only
(5Z)-tetradecenoyl-CoA is a substrate of ACOT1CompoundHuman-GEM MAR00210Inferred only
(6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA is a substrate of ACOT1CompoundHuman-GEM MAR00354Inferred only
(6Z,9Z,12Z)-octadecatrienoyl-CoA is a substrate of ACOT1CompoundHuman-GEM MAR00402Inferred only
(7Z)-hexadecenoyl-CoA is a substrate of ACOT1CompoundHuman-GEM MAR00234Inferred only
(7Z)-octadecenoyl-CoA is a substrate of ACOT1CompoundHuman-GEM MAR00272Inferred only
(7Z)-tetradecenoyl-CoA is a substrate of ACOT1CompoundHuman-GEM MAR00206Inferred only
(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA is a substrate of ACOT1CompoundHuman-GEM MAR00358Inferred only
(8Z,11Z,14Z)-eicosatrienoyl-CoA is a substrate of ACOT1CompoundHuman-GEM MAR00406Inferred only
(9Z,12Z,15Z)-octadecatrienoyl-CoA is a substrate of ACOT1CompoundHuman-GEM MAR00350Inferred only
(9Z,12Z)-octadecadienoyl-CoA is a substrate of ACOT1CompoundHuman-GEM MAR00276Inferred only
(9Z,12Z)-octadecadienoyl-CoA is a substrate of ACOT1CompoundHuman-GEM MAR00398Inferred only
(9Z)-heptadecenoyl-CoA is a substrate of ACOT1CompoundHuman-GEM MAR00246Inferred only
(9Z)-hexadecenoyl-CoA is a substrate of ACOT1CompoundRhea RHEA:40131Inferred only
(9Z)-hexadecenoyl-CoA is a substrate of ACOT1CompoundHuman-GEM MAR00230Inferred only
(9Z)-octadecenoyl-CoA is a substrate of ACOT1CompoundRhea RHEA:40139Inferred only
14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate is a substrate of ACOT1CompoundHuman-GEM MAR01068Inferred only
arachidonoyl-CoA is a substrate of ACOT1CompoundHuman-GEM MAR00410Inferred only
arachidonoyl-CoA is a substrate of ACOT1CompoundHuman-GEM MAR03015Inferred only
CHEBI:1146900 is a substrate of ACOT1CompoundHuman-GEM MAR03814Inferred only
CHEBI:1146900 is a substrate of ACOT1CompoundHuman-GEM MAR01068Inferred only
CHEBI:1146900 is a substrate of ACOT1CompoundHuman-GEM MAR06486Inferred only
CHEBI:1146900 is a substrate of ACOT1CompoundHuman-GEM MAR06484Inferred only
CHEBI:1146900 is a substrate of ACOT1CompoundHuman-GEM MAR06473Inferred only
CHEBI:1146900 is a substrate of ACOT1CompoundHuman-GEM MAR06472Inferred only
CHEBI:1146900 is a substrate of ACOT1CompoundHuman-GEM MAR06471Inferred only
CHEBI:1146900 is a substrate of ACOT1CompoundHuman-GEM MAR06453Inferred only
CHEBI:1146900 is a substrate of ACOT1CompoundHuman-GEM MAR06451Inferred only
CHEBI:1146900 is a substrate of ACOT1CompoundHuman-GEM MAR06450Inferred only
CHEBI:1146900 is a substrate of ACOT1CompoundHuman-GEM MAR06448Inferred only
CHEBI:1146900 is a substrate of ACOT1CompoundHuman-GEM MAR06436Inferred only
CHEBI:1146900 is a substrate of ACOT1CompoundHuman-GEM MAR06435Inferred only
CHEBI:1146900 is a substrate of ACOT1CompoundHuman-GEM MAR06433Inferred only
CHEBI:1146900 is a substrate of ACOT1CompoundHuman-GEM MAR06432Inferred only
CHEBI:1146900 is a substrate of ACOT1CompoundHuman-GEM MAR03981Inferred only
CHEBI:1146900 is a substrate of ACOT1CompoundHuman-GEM MAR03844Inferred only
CHEBI:1146900 is a substrate of ACOT1CompoundHuman-GEM MAR01065Inferred only
CHEBI:1146900 is a substrate of ACOT1CompoundHuman-GEM MAR01066Inferred only
CHEBI:1146900 is a substrate of ACOT1CompoundHuman-GEM MAR01067Inferred only
CHEBI:1146900 is a substrate of ACOT1CompoundHuman-GEM MAR03810Inferred only
CHEBI:1146900 is a substrate of ACOT1CompoundHuman-GEM MAR01069Inferred only
CHEBI:1146900 is a substrate of ACOT1CompoundHuman-GEM MAR01070Inferred only
CHEBI:1146900 is a substrate of ACOT1CompoundHuman-GEM MAR01295Inferred only
CHEBI:28701 is a substrate of ACOT1CompoundHuman-GEM MAR01716Inferred only
decanoyl-CoA is a substrate of ACOT1CompoundRhea RHEA:40059Inferred only
dodecanoyl-CoA is a substrate of ACOT1CompoundRhea RHEA:30135Inferred only
dodecanoyl-CoA is a substrate of ACOT1CompoundHuman-GEM MAR00189Inferred only
eicosanoyl-CoA is a substrate of ACOT1CompoundRhea RHEA:40147Inferred only
eicosanoyl-CoA is a substrate of ACOT1CompoundHuman-GEM MAR00284Inferred only
heptadecanoyl-CoA is a substrate of ACOT1CompoundHuman-GEM MAR00238Inferred only
hexadecanoyl-CoA is a substrate of ACOT1CompoundRhea RHEA:16645Inferred only
nonadecanoyl-CoA is a substrate of ACOT1CompoundHuman-GEM MAR00280Inferred only
octadecanoyl-CoA is a substrate of ACOT1CompoundHuman-GEM MAR00250Inferred only
octadecanoyl-CoA is a substrate of ACOT1CompoundRhea RHEA:30139Inferred only
oleoyl-CoA is a substrate of ACOT1CompoundHuman-GEM MAR00264Inferred only
palmitoyl-CoA is a substrate of ACOT1CompoundHuman-GEM MAR00223Inferred only
palmitoyl-CoA is a substrate of ACOT1CompoundHuman-GEM MAR00709Inferred only
propionyl-CoA is a substrate of ACOT1CompoundHuman-GEM MAR03799Inferred only
tetradecanoyl-CoA is a substrate of ACOT1CompoundRhea RHEA:40119Inferred only
tetradecanoyl-CoA is a substrate of ACOT1CompoundHuman-GEM MAR00197Inferred only

Reactions

85 reactions

water+dodecanoyl-CoACHEBI:1146900+proton+dodecanoate
Catalysed by ACOT1 or ACOT7 or BAAT or ACOT13
Reaction pageLeft to rightBalancedEC 3.1.2.2cytosol
Human-GEM MAR00189CC BY 4.0Reference data
water+MAM03050cCHEBI:1146900+proton+

Other names

8 names

Resolves to: ACOT1

Also called: Acyl-CoA thioesterase 1CTE-ICTE-IbCTE1Inducible cytosolic acyl-coenzyme A thioester hydrolaseLong chain acyl-CoA hydrolaseLong chain acyl-CoA thioester hydrolasePalmitoyl-coenzyme A thioesterase

← Every protein Find it in the graph →

MAM03051c

Catalysed by ACOT1 or ACOT7 or BAAT or ACOT13

Reaction pageLeft to rightBalancedEC 3.1.2.2cytosol

Human-GEM MAR00193CC BY 4.0Reference data

water+tetradecanoyl-CoACHEBI:1146900+proton+tetradecanoate

Catalysed by ACOT1 or ACOT7 or BAAT or ACOT13 or THEM4

Reaction pageLeft to rightBalancedEC 3.1.2.2cytosol

Human-GEM MAR00197CC BY 4.0Reference data

MAM00129c+waterMAM00128c+CHEBI:1146900+proton

Catalysed by ACOT1 or ACOT7 or BAAT or ACOT13 or THEM4

Reaction pageLeft to rightBalancedEC 3.1.2.2cytosol

Human-GEM MAR00201CC BY 4.0Reference data

(7Z)-tetradecenoyl-CoA+waterMAM00117c+CHEBI:1146900+proton

Catalysed by ACOT1 or ACOT7 or BAAT or ACOT13 or THEM4

Reaction pageLeft to rightBalancedEC 3.1.2.2cytosol

Human-GEM MAR00206CC BY 4.0Reference data

(5Z)-tetradecenoyl-CoA+waterCHEBI:1146900+proton+MAM02745c

Catalysed by ACOT1 or ACOT7 or BAAT or THEM4

Reaction pageLeft to rightBalancedEC 3.1.2.2cytosol

Human-GEM MAR00210CC BY 4.0Reference data

water+MAM02689cCHEBI:1146900+proton+MAM02690c

Catalysed by ACOT1 or ACOT7 or BAAT or ACOT13 or THEM4

Reaction pageLeft to rightBalancedEC 3.1.2.2cytosol

Human-GEM MAR00214CC BY 4.0Reference data

water+palmitoyl-CoACHEBI:1146900+proton+hexadecanoic acid

Catalysed by ACOT1 or ACOT7 or BAAT or ACOT13 or THEM4

Reaction pageLeft to rightBalancedEC 3.1.2.2cytosol

Human-GEM MAR00223CC BY 4.0Reference data

water+(9Z)-hexadecenoyl-CoACHEBI:1146900+proton+(9Z)-hexadecenoate

Catalysed by ACOT1 or ACOT7 or BAAT or ACOT13 or THEM4

Reaction pageLeft to rightBalancedEC 3.1.2.2cytosol

Human-GEM MAR00230CC BY 4.0Reference data

(7Z)-hexadecenoyl-CoA+waterMAM01197c+CHEBI:1146900+proton

Catalysed by ACOT1 or ACOT7 or BAAT or ACOT13 or THEM4

Reaction pageLeft to rightBalancedEC 3.1.2.2cytosol

Human-GEM MAR00234CC BY 4.0Reference data

water+heptadecanoyl-CoACHEBI:1146900+proton+MAM02456c

Catalysed by ACOT1 or ACOT7 or BAAT or ACOT13 or THEM4

Reaction pageLeft to rightBalancedEC 3.1.2.2cytosol

Human-GEM MAR00238CC BY 4.0Reference data

MAM00004c+waterMAM00003c+CHEBI:1146900+proton

Catalysed by ACOT1 or ACOT7 or BAAT or THEM4

Reaction pageLeft to rightBalancedEC 3.1.2.2cytosol

Human-GEM MAR00242CC BY 4.0Reference data

Show the remaining 73