L-glutamate 5-semialdehyde

Three steps

• N(1)-(5-phospho-D-ribosyl)glycinamideReach from here →
  1. L-ornithine + 2-oxoglutarate = L-glutamate 5-semialdehyde + L-glutamate
  2. L-Arginine:glycine amidinotransferase
  3. 5-Phospho-D-ribosylamine:glycine ligase (ADP-forming)

  Catalysed by OAT, GATM, GARTcytosol

• 2-phenylethylamineReach from here →
  1. L-ornithine + 2-oxoglutarate = L-glutamate 5-semialdehyde + L-glutamate
  2. transport of ornithine and phenylalanine (cytosol to extracellular)
  3. L-phenylalanine carboxy-lyase (phenylethylamine-forming)

  Catalysed by OAT, SLC7A6, DDCextracellular space, cytosol

• 2-formamido-N(1)-(5-phospho-D-ribosyl)acetamidineReach from here →
  1. L-ornithine + 2-oxoglutarate = L-glutamate 5-semialdehyde + L-glutamate
  2. transport of glutamine and ornithine (cytosol to extracellular)
  3. 5'-Phosphoribosylformylglycinamide:L-glutamine amido-ligase (ADP-forming)

  Catalysed by OAT, SLC7A6, PFASextracellular space, cytosol

• ophthalmateReach from here →
  1. L-ornithine + 2-oxoglutarate = L-glutamate 5-semialdehyde + L-glutamate
  2. L-Arginine:glycine amidinotransferase
  3. gamma-L-glutamyl-(2S)-2-aminobutanoate + glycine + ATP = ophthalmate + ADP + phosphate + H(+)

  Catalysed by OAT, GATM, GSScytosol

• S-methylmercury-L-cysteineReach from here →
  1. L-ornithine + 2-oxoglutarate = L-glutamate 5-semialdehyde + L-glutamate
  2. transport of methionine and ornithine (cytosol to extracellular)
  3. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)

  Catalysed by OAT, SLC7A6, SLC7A8extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 6 routes

• 2-aminoisobutanoateReach from here →
  1. L-ornithine + 2-oxoglutarate = L-glutamate 5-semialdehyde + L-glutamate
  2. transport of alanine and ornithine (cytosol to extracellular)
  3. 2-aminoisobutanoate(out) + L-alanine(in) = 2-aminoisobutanoate(in) + L-alanine(out)

  Catalysed by OAT, SLC7A6, SLC7A10extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• biocytinReach from here →
  1. L-ornithine + 2-oxoglutarate = L-glutamate 5-semialdehyde + L-glutamate
  2. L-ornithine(out) + L-lysine(in) = L-ornithine(in) + L-lysine(out)
  3. biocytin + H2O = biotin + L-lysine

  Catalysed by OAT, SLC25A2, SLC25A15, BTDinner side of the membrane, outer side of the membrane

• 5-(3,3-dimethylguanidino)-2-oxopentanoateReach from here →
  1. L-ornithine + 2-oxoglutarate = L-glutamate 5-semialdehyde + L-glutamate
  2. N(omega),N(omega)-dimethyl-L-arginine(in) + L-ornithine(out) = N(omega),N(omega)-dimethyl-L-arginine(out) + L-ornithine(in)
  3. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by OAT, SLC25A2, AGXT2inner side of the membrane, outer side of the membraneOne of 6 routes

• N(omega),N('omega)-dimethyl-L-arginineReach from here →
  1. L-ornithine + 2-oxoglutarate = L-glutamate 5-semialdehyde + L-glutamate
  2. L-Arginine:glycine amidinotransferase
  3. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine

  Catalysed by OAT, GATM, AGXT2cytosolOne of 2 routes

• 5,6,7,8-tetrahydrofolic acidReach from here →
  1. L-ornithine + 2-oxoglutarate = L-glutamate 5-semialdehyde + L-glutamate
  2. L-Arginine:glycine amidinotransferase
  3. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase

  Catalysed by OAT, GATM, SHMT1cytosolOne of 2 routes

• S-disulfanyl-L-cysteineReach from here →
  1. L-ornithine + 2-oxoglutarate = L-glutamate 5-semialdehyde + L-glutamate
  2. transport of cysteine and ornithine (cytosol to extracellular)
  3. S-sulfanyl-L-cysteine + L-cysteine = S-disulfanyl-L-cysteine + L-alanine

  Catalysed by OAT, SLC7A6, CARS2extracellular space, cytosol

• CHEBI:240943Reach from here →
  1. L-ornithine + 2-oxoglutarate = L-glutamate 5-semialdehyde + L-glutamate
  2. L-Arginine:glycine amidinotransferase
  3. glycine N-acyltransferase (2-methylbutyryl-CoA)

  Catalysed by OAT, GATM, GLYAT, GLYATL2 and 1 morecytosol, mitochondrial matrix

• phenylacetylglycineReach from here →
  1. L-ornithine + 2-oxoglutarate = L-glutamate 5-semialdehyde + L-glutamate
  2. L-Arginine:glycine amidinotransferase
  3. phenylacetyl-CoA:glycine N-phenylacetyltransferase

  Catalysed by OAT, GATM, GLYATcytosolOne of 3 routes

• 5-hydroxytryptophanReach from here →
  1. L-ornithine + 2-oxoglutarate = L-glutamate 5-semialdehyde + L-glutamate
  2. transport of ornithine and tryptophan (cytosol to extracellular)
  3. L-Tryptophan, Tetrahydrobiopterin:Oxygen Oxidoreductase (5-Hydroxylating)

  Catalysed by OAT, SLC7A6, TPH1, TPH2extracellular space, cytosolOne of 2 routes

• CHEBI:28666Reach from here →
  1. L-ornithine + 2-oxoglutarate = L-glutamate 5-semialdehyde + L-glutamate
  2. L-Arginine:glycine amidinotransferase
  3. LTD4 hydrolysis

  Catalysed by OAT, GATMcytosol

• pyridoxine 5'-phosphateReach from here →
  1. L-ornithine + 2-oxoglutarate = L-glutamate 5-semialdehyde + L-glutamate
  2. transport of alanine and ornithine (cytosol to extracellular)
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by OAT, SLC7A6, SCLYextracellular space, cytosol

• N-acetyl-L-cysteineReach from here →
  1. L-ornithine + 2-oxoglutarate = L-glutamate 5-semialdehyde + L-glutamate
  2. transport of cysteine and ornithine (cytosol to extracellular)
  3. N-acetylglutamate synthase (N-acetyl-L-cysteine)

  Catalysed by OAT, SLC7A6, NAGSextracellular space, cytosol, mitochondrial matrix

• K(+)Reach from here →
  1. L-ornithine + 2-oxoglutarate = L-glutamate 5-semialdehyde + L-glutamate
  2. transport of cysteine and ornithine (cytosol to extracellular)
  3. K(+)(in) + L-cysteine(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-cysteine(in) + 3 Na(+)(in) + H(+)(in)

  Catalysed by OAT, SLC7A6, SLC1A1extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• Cys-tRNA(Cys)Reach from here →
  1. L-ornithine + 2-oxoglutarate = L-glutamate 5-semialdehyde + L-glutamate
  2. transport of cysteine and ornithine (cytosol to extracellular)
  3. L-Cysteine:tRNA(Cys) ligase (AMP-forming)

  Catalysed by OAT, SLC7A6, CARS1extracellular space, cytosol

• Phe-tRNA(Phe)Reach from here →
  1. L-ornithine + 2-oxoglutarate = L-glutamate 5-semialdehyde + L-glutamate
  2. transport of ornithine and phenylalanine (cytosol to extracellular)
  3. L-Phenylalanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by OAT, SLC7A6, FARSB, FARSAextracellular space, cytosol

• Gly-tRNA(Gly)Reach from here →
  1. L-ornithine + 2-oxoglutarate = L-glutamate 5-semialdehyde + L-glutamate
  2. L-Arginine:glycine amidinotransferase
  3. glycine:tRNA(Gly) ligase (AMP-forming)

  Catalysed by OAT, GATM, GARS1cytosol

• Trp-tRNA(Trp)Reach from here →
  1. L-ornithine + 2-oxoglutarate = L-glutamate 5-semialdehyde + L-glutamate
  2. transport of ornithine and tryptophan (cytosol to extracellular)
  3. L-Tryptophan -tRNA(Trp) ligase (AMP-forming)

  Catalysed by OAT, SLC7A6, WARS1extracellular space, cytosol

• Ile-tRNA(Ile)Reach from here →
  1. L-ornithine + 2-oxoglutarate = L-glutamate 5-semialdehyde + L-glutamate
  2. transport of isoleucine and ornithine (cytosol to extracellular)
  3. L-Isoleucine:tRNA(Ile) ligase (AMP-forming)

  Catalysed by OAT, SLC7A6, IARS1extracellular space, cytosol

• Gln-tRNA(Gln)Reach from here →
  1. L-ornithine + 2-oxoglutarate = L-glutamate 5-semialdehyde + L-glutamate
  2. transport of glutamine and ornithine (cytosol to extracellular)
  3. L-Glutamine:tRNA(Gln) ligase (AMP-forming)

  Catalysed by OAT, SLC7A6, QARS1extracellular space, cytosol

• isocyanateReach from here →
  1. L-ornithine + 2-oxoglutarate = L-glutamate 5-semialdehyde + L-glutamate
  2. Amino Acid-Polyamine-Organocation (Apc) Tcdb:2.A.3.8.15
  3. L-citrulline + H(+) = isocyanate + L-ornithine

  Catalysed by OAT, SLC7A9, LACC1extracellular space, cytosol

• Asn-tRNA(Asn)Reach from here →
  1. L-ornithine + 2-oxoglutarate = L-glutamate 5-semialdehyde + L-glutamate
  2. transport of asparagine and ornithine (cytosol to extracellular)
  3. L-Asparagine:tRNA(Asn) ligase (AMP-forming)

  Catalysed by OAT, SLC7A6, NARS1extracellular space, cytosol

• chlorine(.)Reach from here →
  1. L-ornithine + 2-oxoglutarate = L-glutamate 5-semialdehyde + L-glutamate
  2. L-Arginine:glycine amidinotransferase
  3. transport of arginine and chloride (cytosol to extracellular)

  Catalysed by OAT, GATM, SLC6A14cytosol, extracellular spaceOne of 31 routes

• glycocholateReach from here →
  1. L-ornithine + 2-oxoglutarate = L-glutamate 5-semialdehyde + L-glutamate
  2. L-Arginine:glycine amidinotransferase
  3. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by OAT, GATM, BAATcytosol, peroxisomeOne of 3 routes

• hydrogen sulfideReach from here →
  1. L-ornithine + 2-oxoglutarate = L-glutamate 5-semialdehyde + L-glutamate
  2. transport of cysteine and ornithine (cytosol to extracellular)
  3. L-cysteine hydrogen-sulfide-lyase (deaminating

  Catalysed by OAT, SLC7A6, CTHextracellular space, cytosolOne of 2 routes

• L-aspartateReach from here →
  1. L-ornithine + 2-oxoglutarate = L-glutamate 5-semialdehyde + L-glutamate
  2. transport of alanine and ornithine (cytosol to extracellular)
  3. oxaloacetate + L-alanine = L-aspartate + pyruvate

  Catalysed by OAT, SLC7A6, AGXT2extracellular space, cytosolOne of 19 routes

• acetateReach from here →
  1. L-ornithine + 2-oxoglutarate = L-glutamate 5-semialdehyde + L-glutamate
  2. N2-Acetyl-L-ornithine amidohydrolase
  3. N2-Acetyl-L-ornithine amidohydrolase

  Catalysed by OAT, ACY1cytosol

• CHEBI:30249Reach from here →
  1. L-ornithine + 2-oxoglutarate = L-glutamate 5-semialdehyde + L-glutamate
  2. transport of ornithine and tryptophan (cytosol to extracellular)
  3. L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)

  Catalysed by OAT, SLC7A6, IDO1, TDO2 and 1 moreextracellular space, cytosol

• 4-methylthio-2-oxobutanoic acidReach from here →
  1. L-ornithine + 2-oxoglutarate = L-glutamate 5-semialdehyde + L-glutamate
  2. transport of methionine and ornithine (cytosol to extracellular)
  3. L-Methionine:oxygen oxidoreductase (deaminating)

  Catalysed by OAT, SLC7A6, IL4I1extracellular space, cytosol

• di-mu-sulfido-diiron(2+)Reach from here →
  1. L-ornithine + 2-oxoglutarate = L-glutamate 5-semialdehyde + L-glutamate
  2. transport of cysteine and ornithine (cytosol to extracellular)
  3. De novo synthesis of 2Fe2S

  Catalysed by OAT, SLC7A6, NDUFAB1, FDXR and 5 moreextracellular space, cytosol, mitochondrial matrix

• (S)-3-methyl-2-oxopentanoateReach from here →
  1. L-ornithine + 2-oxoglutarate = L-glutamate 5-semialdehyde + L-glutamate
  2. transport of isoleucine and ornithine (cytosol to extracellular)
  3. L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate

  Catalysed by OAT, SLC7A6, BCAT2, BCAT1extracellular space, cytosol

• D-cysteineReach from here →
  1. L-ornithine + 2-oxoglutarate = L-glutamate 5-semialdehyde + L-glutamate
  2. transport of alanine and ornithine (cytosol to extracellular)
  3. D-cysteine(out) + L-alanine(in) = D-cysteine(in) + L-alanine(out)

  Catalysed by OAT, SLC7A6, SLC7A10extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• D-serineReach from here →
  1. L-ornithine + 2-oxoglutarate = L-glutamate 5-semialdehyde + L-glutamate
  2. transport of alanine and ornithine (cytosol to extracellular)
  3. D-serine(out) + L-alanine(in) = D-serine(in) + L-alanine(out)

  Catalysed by OAT, SLC7A6, SLC7A10extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 10 routes

• 5-aminolevulinateReach from here →
  1. L-ornithine + 2-oxoglutarate = L-glutamate 5-semialdehyde + L-glutamate
  2. L-Arginine:glycine amidinotransferase
  3. succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA

  Catalysed by OAT, GATM, ALAS1, ALAS2cytosol

• 3-methyl-2-oxovaleric acidReach from here →
  1. L-ornithine + 2-oxoglutarate = L-glutamate 5-semialdehyde + L-glutamate
  2. transport of isoleucine and ornithine (cytosol to extracellular)
  3. L-Leucine:2-oxoglutarate aminotransferase

  Catalysed by OAT, SLC7A6, BCAT1extracellular space, cytosolOne of 2 routes

• 3-(4-hydroxyphenyl)pyruvateReach from here →
  1. L-ornithine + 2-oxoglutarate = L-glutamate 5-semialdehyde + L-glutamate
  2. transport of ornithine and tyrosine (cytosol to extracellular)
  3. L-tyrosine:2-oxoglutarate aminotransferase

  Catalysed by OAT, SLC7A6, GOT2, GOT1 and 1 moreextracellular space, cytosolOne of 3 routes

• glycochenodeoxycholateReach from here →
  1. L-ornithine + 2-oxoglutarate = L-glutamate 5-semialdehyde + L-glutamate
  2. L-Arginine:glycine amidinotransferase
  3. chenodeoxycholoyl-CoA + glycine = glycochenodeoxycholate + CoA + H(+)

  Catalysed by OAT, GATM, BAATcytosol

• glycochenodeoxycholic acidReach from here →
  1. L-ornithine + 2-oxoglutarate = L-glutamate 5-semialdehyde + L-glutamate
  2. L-Arginine:glycine amidinotransferase
  3. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by OAT, GATM, BAATcytosol, peroxisomeOne of 3 routes

• glyoxylateReach from here →
  1. L-ornithine + 2-oxoglutarate = L-glutamate 5-semialdehyde + L-glutamate
  2. L-Arginine:glycine amidinotransferase
  3. glycine + 2-oxoglutarate = glyoxylate + L-glutamate

  Catalysed by OAT, GATM, AADATcytosolOne of 12 routes

• glycolithocholic acidReach from here →
  1. L-ornithine + 2-oxoglutarate = L-glutamate 5-semialdehyde + L-glutamate
  2. L-Arginine:glycine amidinotransferase
  3. bile acid-CoA:amino acid N-acyltransferase (glycine)

  Catalysed by OAT, GATM, BAATcytosolOne of 2 routes

• L-2-amino-3-oxobutanoic acidReach from here →
  1. L-ornithine + 2-oxoglutarate = L-glutamate 5-semialdehyde + L-glutamate
  2. L-Arginine:glycine amidinotransferase
  3. Acetyl-CoA:glycine C-acetyltransferase

  Catalysed by OAT, GATM, GCATcytosol, mitochondrial matrix

• gamma-Glu-AlaReach from here →
  1. L-ornithine + 2-oxoglutarate = L-glutamate 5-semialdehyde + L-glutamate
  2. transport of alanine and ornithine (cytosol to extracellular)
  3. gamma-glutamyltransferase (alanine)

  Catalysed by OAT, SLC7A6, GGT1, GGT5 and 4 moreextracellular space, cytosol

• S(8)-aminomethyldihydrolipoamideReach from here →
  1. L-ornithine + 2-oxoglutarate = L-glutamate 5-semialdehyde + L-glutamate
  2. L-Arginine:glycine amidinotransferase
  3. dihydrolipoyl dehydrogenase ([protein]-N6-(lipoyl)lysine)

  Catalysed by OAT, GATM, GLDC, GCSHcytosol, mitochondrial matrix

• D-alanineReach from here →
  1. L-ornithine + 2-oxoglutarate = L-glutamate 5-semialdehyde + L-glutamate
  2. transport of alanine and ornithine (cytosol to extracellular)
  3. D-alanine(out) + L-alanine(in) = D-alanine(in) + L-alanine(out)

  Catalysed by OAT, SLC7A6, SLC7A10extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• sarcosineReach from here →
  1. L-ornithine + 2-oxoglutarate = L-glutamate 5-semialdehyde + L-glutamate
  2. L-Arginine:glycine amidinotransferase
  3. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2

  Catalysed by OAT, GATM, PIPOXcytosolOne of 2 routes

• (6S)-5,6,7,8-tetrahydrofolateReach from here →
  1. L-ornithine + 2-oxoglutarate = L-glutamate 5-semialdehyde + L-glutamate
  2. L-Arginine:glycine amidinotransferase
  3. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine

  Catalysed by OAT, GATM, SHMT1, SHMT2cytosol