a 6-(N-acetyl-alpha-D-glucosaminyl)-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol

Three steps

• CHEBI:15519Reach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. phosphatidylinositol glycan anchor biosynthesis class W
  3. propanoyl-CoA C-acyltransferase

  Catalysed by PIGL, PIGW, ACAA1, SCP2 and 1 moreendoplasmic reticulum, peroxisomeOne of 2 routes

• palmitoyl-CoAReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. phosphatidylinositol glycan anchor biosynthesis class W
  3. Palmitate:CoA ligase (AMP-forming)

  Catalysed by PIGL, PIGW, SLC27A2, ACSL4 and 6 moreendoplasmic reticulum, cytosolOne of 11 routes

• oleoyl-CoAReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. phosphatidylinositol glycan anchor biosynthesis class W
  3. Transport of octadecenoyl-CoA into Mitochondrial Matrix

  Catalysed by PIGL, PIGW, CPT1A, CPT1C and 1 moreendoplasmic reticulum, cytosolOne of 11 routes

• phenylacetyl-CoAReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. phosphatidylinositol glycan anchor biosynthesis class W
  3. Phenylacetate:CoA ligase

  Catalysed by PIGL, PIGWendoplasmic reticulum, cytosolOne of 3 routes

• propionyl-CoAReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. phosphatidylinositol glycan anchor biosynthesis class W
  3. Propanoate:CoA ligase (AMP-forming)

  Catalysed by PIGL, PIGW, ACSS3, ACSS2 and 1 moreendoplasmic reticulum, cytosolOne of 46 routes

• (S)-malateReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. (S)-malate + NAD(+) = pyruvate + CO2 + NADH

  Catalysed by PIGL, SLC16A4, SLC16A5, SLC16A3 and 3 moreendoplasmic reticulum, extracellular space, cytosolOne of 2 routes

• 10-formyltetrahydrofolic acidReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. transport of acetate and formate (cytosol to extracellular)
  3. Formate:tetrahydrofolate ligase (ADP-forming)

  Catalysed by PIGL, SLC16A4, SLC16A5, SLC16A1 and 1 moreendoplasmic reticulum, extracellular space, cytosolOne of 2 routes

• CHEBI:15650Reach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. phosphatidylinositol glycan anchor biosynthesis class W
  3. N-acetyl-LTE4 to leukotriene E4 conversion

  Catalysed by PIGL, PIGW, ZDHHC11B, NAA10 and 30 moreendoplasmic reticulum, cytosolOne of 2 routes

• CHEBI:15727Reach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. phosphatidylinositol glycan anchor biosynthesis class W
  3. N-alpha-acetyltransferase 10, NatA catalytic subunit (acetylcarnosine)

  Catalysed by PIGL, PIGW, NAA10endoplasmic reticulum, cytosol

• CHEBI:15746Reach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. phosphatidylinositol glycan anchor biosynthesis class W
  3. diamine N-acetyltransferase (N1-acetylspermine)

  Catalysed by PIGL, PIGW, SAT1, SAT2endoplasmic reticulum, cytosolOne of 2 routes

• alpha-D-glucosamine 6-phosphateReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate
  3. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase

  Catalysed by PIGL, AMDHD2, CEMP1endoplasmic reticulum, cytosol

• 2-methyl-3-oxopropanoic acidReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by PIGL, SLC16A4, SLC16A5, SLC16A3 and 3 moreendoplasmic reticulum, extracellular space, cytosol, mitochondrial matrix

• 11-cis-retinolReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. phosphatidylinositol glycan anchor biosynthesis class W
  3. Palmitoyl-CoA:retinol O-acyltransferase

  Catalysed by PIGL, PIGW, DGAT1, LRAT and 3 moreendoplasmic reticulum, cytosol

• (17R,20S)-17,20-dihydroxypregn-4-en-3-oneReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. cytochrome P450 (17alpha-hydroxyprogesterone)
  3. (17R,20S)-17,20-dihydroxypregn-4-en-3-one + NAD(+) = 17alpha-hydroxyprogesterone + NADH + H(+)

  Catalysed by PIGL, CYP17A1, AKR1C1endoplasmic reticulumOne of 2 routes

• androst-4-ene-3,17-dioneReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. cytochrome P450 (17alpha-hydroxyprogesterone)
  3. cytochrome P450 (17alpha-hydroxyprogesterone)

  Catalysed by PIGL, CYP17A1endoplasmic reticulum, cytosolOne of 5 routes

• oxaloacetateReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. phosphatidylinositol glycan anchor biosynthesis class W
  3. ATP citrate lyase (citrate)

  Catalysed by PIGL, PIGW, ACLYendoplasmic reticulum, cytosolOne of 4 routes

• (S)-lactateReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)

  Catalysed by PIGL, SLC16A4, SLC16A5, SLC16A3 and 7 moreendoplasmic reticulum, extracellular space, cytosol

• 2-oxobutanoateReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. transport of 2-hydroxybutyrate and acetate (cytosol to extracellular)
  3. 2-hydroxybutyrate:NAD+ oxidoreductase

  Catalysed by PIGL, SLC16A4, SLC16A5, SLC16A7 and 5 moreendoplasmic reticulum, extracellular space, cytosolOne of 2 routes

• 2-oxoglutaramateReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. L-Glutamine:pyruvate aminotransferase

  Catalysed by PIGL, SLC16A4, SLC16A5, SLC16A3 and 3 moreendoplasmic reticulum, extracellular space, cytosolOne of 2 routes

• 3-fumarylpyruvateReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)

  Catalysed by PIGL, SLC16A4, SLC16A5, SLC16A3 and 3 moreendoplasmic reticulum, extracellular space, cytosol

• ferrocytochrome cReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. transport of acetate and L-lactate (cytosol to extracellular)
  3. (S)-Lactate:ferricytochrome-c 2-oxidoreductase

  Catalysed by PIGL, SLC16A4, SLC16A5, SLC16A3 and 4 moreendoplasmic reticulum, extracellular space, cytosol, mitochondrial matrix

• 3-hydroxypyruvateReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. L-serine + pyruvate = 3-hydroxypyruvate + L-alanine

  Catalysed by PIGL, SLC16A4, SLC16A5, SLC16A3 and 3 moreendoplasmic reticulum, extracellular space, cytosol

• 4-methylumbelliferoneReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. 4-methylumbelliferyl acetate + H2O = 4-methylumbelliferone + acetate + H(+)
  3. 4-methylumbelliferyl acetate + H2O = 4-methylumbelliferone + acetate + H(+)

  Catalysed by PIGL, CES2, ESD, CES1endoplasmic reticulum

• anilineReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. phosphatidylinositol glycan anchor biosynthesis class W
  3. Acetyl-CoA:arylamine N-acetyltransferase

  Catalysed by PIGL, PIGW, NAT2, NAT1endoplasmic reticulum, cytosol

• aceneuramateReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. aceneuramate = aldehydo-N-acetyl-D-mannosamine + pyruvate

  Catalysed by PIGL, SLC16A4, SLC16A5, SLC16A3 and 3 moreendoplasmic reticulum, extracellular space, cytosol

• CHEBI:17312Reach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. phosphatidylinositol glycan anchor biosynthesis class W
  3. N1,N12-diacetylspermine to N1-acetylspermine conversion

  Catalysed by PIGL, PIGWendoplasmic reticulum, cytosolOne of 2 routes

• 5'-deoxyadenosineReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O

  Catalysed by PIGL, SLC16A4, SLC16A5, SLC16A3 and 4 moreendoplasmic reticulum, extracellular space, cytosol

• L-cysteineReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. phosphatidylinositol glycan anchor biosynthesis class W
  3. N-acetylglutamate synthase (N-acetyl-L-cysteine)

  Catalysed by PIGL, PIGW, NAGSendoplasmic reticulum, mitochondrial matrix

• (7Z,10Z,13Z)-hexadecatrienoyl-CoAReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. phosphatidylinositol glycan anchor biosynthesis class W
  3. Fatty Acid Beta Oxidation (C18:3->C16:3), Mitochondrial

  Catalysed by PIGL, PIGW, HADHA, ACADVL and 1 moreendoplasmic reticulum, mitochondrial matrix

• urateReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. transport of acetate and L-lactate (cytosol to extracellular)
  3. transport of L-lactate and urate (cytosol to extracellular)

  Catalysed by PIGL, SLC16A4, SLC16A5, SLC16A3 and 4 moreendoplasmic reticulum, extracellular space, cytosol

• a 1,2-diacyl-sn-glycerolReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. glycoprotein-phosphatidylinositol phosphatidohydrolase
  3. Diacylglycerol Phosphate Kinase (Homo Sapiens)

  Catalysed by PIGL, GPLD1, DGKI, DGKZendoplasmic reticulum, nucleusOne of 8 routes

• all-trans-retinalReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. transport of acetate and retinoate (cytosol to extracellular)
  3. retinoate reduction

  Catalysed by PIGL, SLC16A4, SLC16A5, SLC16A7endoplasmic reticulum, extracellular space, cytosol

• CHEBI:17927Reach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. phosphatidylinositol glycan anchor biosynthesis class W
  3. N1,N8-diacetylspermidine to N1-acetylspermidine conversion

  Catalysed by PIGL, PIGWendoplasmic reticulum, cytosol

• 4-fumarylacetoacetateReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. transport of acetate and acetoacetate (cytosol to extracellular)
  3. 4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)

  Catalysed by PIGL, SLC16A4, SLC16A5, SLC16A6 and 3 moreendoplasmic reticulum, extracellular space, cytosol

• dTDPReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. pyruvate kinase (dTDP)

  Catalysed by PIGL, SLC16A4, SLC16A5, SLC16A3 and 4 moreendoplasmic reticulum, extracellular space, cytosol

• 5-(3,3-dimethylguanidino)-2-oxopentanoateReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by PIGL, SLC16A4, SLC16A5, SLC16A3 and 3 moreendoplasmic reticulum, extracellular space, cytosol

• 5-(3,3'-dimethylguanidino)-2-oxopentanoateReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by PIGL, SLC16A4, SLC16A5, SLC16A3 and 3 moreendoplasmic reticulum, extracellular space, cytosol

• 5-(3-methylguanidino)-2-oxopentanoateReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. N(omega)-methyl-L-arginine + pyruvate = 5-(3-methylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by PIGL, SLC16A4, SLC16A5, SLC16A3 and 3 moreendoplasmic reticulum, extracellular space, cytosol

• (5Z)-dodecenoyl-CoAReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. phosphatidylinositol glycan anchor biosynthesis class W
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-7-enoyl-CoA)

  Catalysed by PIGL, PIGW, HADHA, ACAA2 and 1 moreendoplasmic reticulum, mitochondrial matrixOne of 2 routes

• (11Z)-docosenoyl-CoA(4-)Reach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. phosphatidylinositol glycan anchor biosynthesis class W
  3. long-chain-fatty-acid-CoA ligase (cis-cetoleic acid)

  Catalysed by PIGL, PIGW, SLC27A2, ACSL4 and 6 moreendoplasmic reticulum, cytosolOne of 5 routes

• (7Z)-tetradecenoyl-CoAReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. phosphatidylinositol glycan anchor biosynthesis class W
  3. long-chain-fatty-acid-CoA ligase ((7Z)-tetradecenoic acid)

  Catalysed by PIGL, PIGW, SLC27A2, ACSL4 and 6 moreendoplasmic reticulum, cytosolOne of 8 routes

• (4Z,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. phosphatidylinositol glycan anchor biosynthesis class W
  3. Fatty Acid Beta Oxidation (C18:4->C16:4), Mitochondrial

  Catalysed by PIGL, PIGW, HADHA, ACADVL and 1 moreendoplasmic reticulum, mitochondrial matrixOne of 3 routes

• (7Z,10Z)-hexadecadienoyl-CoAReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. phosphatidylinositol glycan anchor biosynthesis class W
  3. Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial

  Catalysed by PIGL, PIGW, HADHA, ACADVL and 1 moreendoplasmic reticulum, mitochondrial matrix

• (4Z,7Z)-decadienoyl-CoAReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. phosphatidylinositol glycan anchor biosynthesis class W
  3. Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial

  Catalysed by PIGL, PIGW, ECHS1, ACAA2 and 1 moreendoplasmic reticulum, mitochondrial matrixOne of 2 routes

• (5Z)-octenoyl-CoAReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. phosphatidylinositol glycan anchor biosynthesis class W
  3. Fatty Acid Beta Oxidation (C10:2->C8:1), Mitochondrial

  Catalysed by PIGL, PIGW, ECHS1, ACAA2 and 1 moreendoplasmic reticulum, mitochondrial matrixOne of 2 routes

• CHEBI:27540Reach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. phosphatidylinositol glycan anchor biosynthesis class W
  3. medium-chain acyl-CoA ligase (hexanoic acid)

  Catalysed by PIGL, PIGW, ACSM4, ACSM1 and 4 moreendoplasmic reticulum, cytosolOne of 6 routes

• 17alpha,21-dihydroxypregnenoloneReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. cytochrome P450 (17alpha-hydroxypregnenolone)
  3. cytochrome P450

  Catalysed by PIGL, CYP17A1, CYP21A2endoplasmic reticulum, cytosol

• elaidic acidReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. phosphatidylinositol glycan anchor biosynthesis class W
  3. long-chain-fatty-acid-CoA ligase (elaidate)

  Catalysed by PIGL, PIGW, SLC27A2, ACSL4 and 6 moreendoplasmic reticulum, cytosolOne of 5 routes

• 11-deoxycortisolReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. cytochrome P450 (17alpha-hydroxyprogesterone)
  3. cytochrome P450 (17alpha-hydroxyprogesterone)

  Catalysed by PIGL, CYP17A1, CYP21A2endoplasmic reticulum, cytosolOne of 3 routes

• 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholineReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
  3. 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine

  Catalysed by PIGL, ASAH1, PLA2G15endoplasmic reticulumOne of 3 routes