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Proteins/UNIPROT:O75912
Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). Has probably no preference for any of the diacylglycerols in terms of the acyl chain composition, especially for the acyl chain at the sn-2 position. By controlling the diacylglycerol/DAG-mediated activation of RASGRP3, negatively regulates the Rap1 signaling pathway. May play a role in presynaptic diacylglycerol/DAG signaling and control neurotransmitter release during metabotropic glutamate receptor-dependent long-term depression (By similarity)..
Function from UniProtKB (O75912), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
16 statements
16 statements · 4 reference databases · Subject: DGKI · Sources: Hetionet, Human-GEM, Reactome, Rhea
6 reactions
a 1,2-diacyl-sn-glycerol+ATPADP+proton+phosphatidic acid
Reaction pageReversibleBalance undeterminableEC 2.7.1.107nucleus
Human-GEM MAR00141CC BY 4.0Reference data
a 1,2-diacyl-sn-glycerol+ATPADP+proton+phosphatidic acid
Catalysed by
2 names
Resolves to: DGKI
Reaction pageLeft to rightBalance undeterminableEC 2.7.1.107cytosol
Human-GEM MAR00604CC BY 4.0Reference data
a 1,2-diacyl-sn-glycerol+ATP(4-)a 1,2-diacyl-sn-glycero-3-phosphate+ADP(3-)+hydron
Catalysed by DGKI or DGKA or DGKG or DGKE or DGKQ or DGKZ or DGKD or AGK or DGKK or DGKH or DGKB
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:10272CC BY 4.0Reference data
1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol+ATP(4-)1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate+ADP(3-)+hydron
Catalysed by DGKI or DGKA or DGKG or DGKE or DGKQ or DGKZ or DGKD or DGKB
Reaction pageLeft to rightBalanced
Rhea RHEA:40323CC BY 4.0Reference data
1,2-di-(9Z-octadecenoyl)-sn-glycerol+ATP(4-)1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate+ADP(3-)+hydron
Catalysed by DGKI or DGKA or DGKG or DGKE or DGKQ or DGKZ or DGKD or AGK or DGKK or DGKH or DGKB
Reaction pageLeft to rightBalanced
Rhea RHEA:40327CC BY 4.0Reference data
1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol+ATP(4-)1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate+ADP(3-)+hydron
Catalysed by DGKI or DGKG or DGKE or DGKB
Reaction pageLeft to rightBalanced
Rhea RHEA:40339CC BY 4.0Reference data