Loading the page.
Proteins/UNIPROT:P80108
Hydrolyzes the inositol phosphate linkage of glycosylphosphatidylinositol (GPI)-anchored membrane proteins, thereby releasing them from the cell surface. Cleaves on the inositol side of the anchor, leaving the phosphate group attached to the membrane. This release of GPI-anchored proteins can modulate diverse biological processes, including the activation of signaling pathways..
Function from UniProtKB (P80108), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
17 statements
17 statements · 4 reference databases · Subject: GPLD1 · Sources: gene ontology, Hetionet, Human-GEM, Reactome
2 reactions
a 6-(alpha-D-glucosaminyl)-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol+waterMAM01142r+2proton+phosphatidic acid
Catalysed by GPLD1
Reaction pageLeft to rightBalance undeterminableEC 3.1.4.50endoplasmic reticulum
Human-GEM MAR07188CC BY 4.0Reference data
[protein]-C-terminal carboxyl phosphoethanolamide-(1-radyl-2-octadecanoyl)-GPI(deacylinositol-H7)+water[protein]-C-terminal carboxyl phosphoethanolamide-glycosylinositol (deacylinositol-H7)+CHEBI:235465+
6 names
Resolves to: GPLD1
Catalysed by GPLD1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:86263CC BY 4.0Reference data