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Proteins/UNIPROT:Q13574
Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes. Also plays an important role in the biosynthesis of complex lipids (Probable). Does not exhibit an acyl chain-dependent substrate specificity among diacylglycerol species. Can also phosphorylate 1-alkyl-2-acylglycerol in vitro but less efficiently and with a preference for alkylacylglycerols containing an arachidonoyl group. The biological processes it is involved in include T cell activation since it negatively regulates T-cell receptor signaling which is in part mediated by diacylglycerol (By similarity). By generating phosphatidic acid, stimulates PIP5KIA activity which regulates actin polymerization. Through the same mechanism could also positively regulate insulin-induced translocation of SLC2A4 to the cell membrane (By similarity)..
[Isoform 1]: Regulates RASGRP1 activity..
[Isoform 2]: Does not regulate RASGRP1 activity..
Function from UniProtKB (Q13574), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
132 statements
132 statements · 8 reference databases · Subject: DGKZ · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
20 reactions
a 1,2-diacyl-sn-glycerol+ATPADP+proton+phosphatidic acid
Reaction pageReversibleBalance undeterminableEC 2.7.1.107nucleus
Human-GEM MAR00141CC BY 4.0Reference data
a 1,2-diacyl-sn-glycerol+ATPADP+proton+phosphatidic acid
Catalysed by
4 names
Resolves to: DGKZ
Reaction pageLeft to rightBalance undeterminableEC 2.7.1.107cytosol
Human-GEM MAR00604CC BY 4.0Reference data
a 1,2-diacyl-sn-glycerol+ATP(4-)a 1,2-diacyl-sn-glycero-3-phosphate+ADP(3-)+hydron
Catalysed by DGKI or DGKA or DGKG or DGKE or DGKQ or DGKZ or DGKD or AGK or DGKK or DGKH or DGKB
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:10272CC BY 4.0Reference data
a 1-O-alkyl-sn-glycerol+ATP(4-)a 1-O-alkyl-sn-glycero-3-phosphate+ADP(3-)+hydron
Catalysed by DGKA or DGKQ or DGKZ
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:16937CC BY 4.0Reference data
1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol+ATP(4-)1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate+ADP(3-)+hydron
Catalysed by DGKI or DGKA or DGKG or DGKE or DGKQ or DGKZ or DGKD or DGKB
Reaction pageLeft to rightBalanced
Rhea RHEA:40323CC BY 4.0Reference data
1,2-di-(9Z-octadecenoyl)-sn-glycerol+ATP(4-)1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate+ADP(3-)+hydron
Catalysed by DGKI or DGKA or DGKG or DGKE or DGKQ or DGKZ or DGKD or AGK or DGKK or DGKH or DGKB
Reaction pageLeft to rightBalanced
Rhea RHEA:40327CC BY 4.0Reference data
CHEBI:87223+ATP(4-)CHEBI:77094+ADP(3-)+hydron
Reaction pageLeft to rightBalanced
Rhea RHEA:40331CC BY 4.0Reference data
CHEBI:77096+ATP(4-)1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate+ADP(3-)+hydron
Reaction pageLeft to rightBalanced
Rhea RHEA:40335CC BY 4.0Reference data
CHEBI:77125+ATP(4-)1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate+ADP(3-)+hydron
Reaction pageLeft to rightBalanced
Rhea RHEA:40351CC BY 4.0Reference data
1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol+ATP(4-)1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate+ADP(3-)+hydron
Catalysed by DGKZ
Reaction pageLeft to rightBalanced
Rhea RHEA:40359CC BY 4.0Reference data
1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol+ATP(4-)CHEBI:77186+ADP(3-)+hydron
Reaction pageLeft to rightBalanced
Rhea RHEA:40403CC BY 4.0Reference data
CHEBI:77185+ATP(4-)CHEBI:77187+ADP(3-)+hydron
Reaction pageLeft to rightBalanced
Rhea RHEA:40407CC BY 4.0Reference data