D-lysine

Three steps

• N(1)-(5-phospho-D-ribosyl)glycinamideReach from here →
  1. D-lysine(in) + L-ornithine(out) = D-lysine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. 5-Phospho-D-ribosylamine:glycine ligase (ADP-forming)

  Catalysed by SLC25A2, GATM, GARTinner side of the membrane, outer side of the membrane, cytosol

• 2-phenylethylamineReach from here →
  1. D-lysine(in) + L-ornithine(out) = D-lysine(out) + L-ornithine(in)
  2. transport of ornithine and phenylalanine (cytosol to extracellular)
  3. L-phenylalanine carboxy-lyase (phenylethylamine-forming)

  Catalysed by SLC25A2, SLC7A6, DDCinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• 2-formamido-N(1)-(5-phospho-D-ribosyl)acetamidineReach from here →
  1. D-lysine(in) + L-ornithine(out) = D-lysine(out) + L-ornithine(in)
  2. transport of glutamine and ornithine (cytosol to extracellular)
  3. 5'-Phosphoribosylformylglycinamide:L-glutamine amido-ligase (ADP-forming)

  Catalysed by SLC25A2, SLC7A6, PFASinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• ophthalmateReach from here →
  1. D-lysine(in) + L-ornithine(out) = D-lysine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. gamma-L-glutamyl-(2S)-2-aminobutanoate + glycine + ATP = ophthalmate + ADP + phosphate + H(+)

  Catalysed by SLC25A2, GATM, GSSinner side of the membrane, outer side of the membrane, cytosol

• S-methylmercury-L-cysteineReach from here →
  1. D-lysine(in) + L-ornithine(out) = D-lysine(out) + L-ornithine(in)
  2. transport of methionine and ornithine (cytosol to extracellular)
  3. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)

  Catalysed by SLC25A2, SLC7A6, SLC7A8inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 6 routes

• 2-aminoisobutanoateReach from here →
  1. D-lysine(in) + L-ornithine(out) = D-lysine(out) + L-ornithine(in)
  2. transport of alanine and ornithine (cytosol to extracellular)
  3. 2-aminoisobutanoate(out) + L-alanine(in) = 2-aminoisobutanoate(in) + L-alanine(out)

  Catalysed by SLC25A2, SLC7A6, SLC7A10inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• biocytinReach from here →
  1. D-lysine(in) + L-ornithine(out) = D-lysine(out) + L-ornithine(in)
  2. L-ornithine(out) + L-lysine(in) = L-ornithine(in) + L-lysine(out)
  3. biocytin + H2O = biotin + L-lysine

  Catalysed by SLC25A2, SLC25A15, BTDinner side of the membrane, outer side of the membrane

• 5-(3,3-dimethylguanidino)-2-oxopentanoateReach from here →
  1. D-lysine(in) + L-ornithine(out) = D-lysine(out) + L-ornithine(in)
  2. N(omega),N(omega)-dimethyl-L-arginine(in) + L-ornithine(out) = N(omega),N(omega)-dimethyl-L-arginine(out) + L-ornithine(in)
  3. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by SLC25A2, AGXT2inner side of the membrane, outer side of the membraneOne of 6 routes

• N(omega),N('omega)-dimethyl-L-arginineReach from here →
  1. D-lysine(in) + L-ornithine(out) = D-lysine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine

  Catalysed by SLC25A2, GATM, AGXT2inner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

• 5,6,7,8-tetrahydrofolic acidReach from here →
  1. D-lysine(in) + L-ornithine(out) = D-lysine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase

  Catalysed by SLC25A2, GATM, SHMT1inner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

• S-disulfanyl-L-cysteineReach from here →
  1. D-lysine(in) + L-ornithine(out) = D-lysine(out) + L-ornithine(in)
  2. transport of cysteine and ornithine (cytosol to extracellular)
  3. S-sulfanyl-L-cysteine + L-cysteine = S-disulfanyl-L-cysteine + L-alanine

  Catalysed by SLC25A2, SLC7A6, CARS2inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• CHEBI:240943Reach from here →
  1. D-lysine(in) + L-ornithine(out) = D-lysine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. glycine N-acyltransferase (2-methylbutyryl-CoA)

  Catalysed by SLC25A2, GATM, GLYAT, GLYATL2 and 1 moreinner side of the membrane, outer side of the membrane, cytosol, mitochondrial matrix

• phenylacetylglycineReach from here →
  1. D-lysine(in) + L-ornithine(out) = D-lysine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. phenylacetyl-CoA:glycine N-phenylacetyltransferase

  Catalysed by SLC25A2, GATM, GLYATinner side of the membrane, outer side of the membrane, cytosolOne of 3 routes

• 5-hydroxytryptophanReach from here →
  1. D-lysine(in) + L-ornithine(out) = D-lysine(out) + L-ornithine(in)
  2. transport of ornithine and tryptophan (cytosol to extracellular)
  3. L-Tryptophan, Tetrahydrobiopterin:Oxygen Oxidoreductase (5-Hydroxylating)

  Catalysed by SLC25A2, SLC7A6, TPH1, TPH2inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• CHEBI:28666Reach from here →
  1. D-lysine(in) + L-ornithine(out) = D-lysine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. LTD4 hydrolysis

  Catalysed by SLC25A2, GATMinner side of the membrane, outer side of the membrane, cytosol

• pyridoxine 5'-phosphateReach from here →
  1. D-lysine(in) + L-ornithine(out) = D-lysine(out) + L-ornithine(in)
  2. transport of alanine and ornithine (cytosol to extracellular)
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by SLC25A2, SLC7A6, SCLYinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• N-acetyl-L-cysteineReach from here →
  1. D-lysine(in) + L-ornithine(out) = D-lysine(out) + L-ornithine(in)
  2. transport of cysteine and ornithine (cytosol to extracellular)
  3. N-acetylglutamate synthase (N-acetyl-L-cysteine)

  Catalysed by SLC25A2, SLC7A6, NAGSinner side of the membrane, outer side of the membrane, extracellular space, cytosol, mitochondrial matrix

• K(+)Reach from here →
  1. D-lysine(in) + L-ornithine(out) = D-lysine(out) + L-ornithine(in)
  2. transport of cysteine and ornithine (cytosol to extracellular)
  3. K(+)(in) + L-cysteine(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-cysteine(in) + 3 Na(+)(in) + H(+)(in)

  Catalysed by SLC25A2, SLC7A6, SLC1A1inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• Cys-tRNA(Cys)Reach from here →
  1. D-lysine(in) + L-ornithine(out) = D-lysine(out) + L-ornithine(in)
  2. transport of cysteine and ornithine (cytosol to extracellular)
  3. L-Cysteine:tRNA(Cys) ligase (AMP-forming)

  Catalysed by SLC25A2, SLC7A6, CARS1inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• Phe-tRNA(Phe)Reach from here →
  1. D-lysine(in) + L-ornithine(out) = D-lysine(out) + L-ornithine(in)
  2. transport of ornithine and phenylalanine (cytosol to extracellular)
  3. L-Phenylalanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by SLC25A2, SLC7A6, FARSB, FARSAinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• Gly-tRNA(Gly)Reach from here →
  1. D-lysine(in) + L-ornithine(out) = D-lysine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. glycine:tRNA(Gly) ligase (AMP-forming)

  Catalysed by SLC25A2, GATM, GARS1inner side of the membrane, outer side of the membrane, cytosol

• Trp-tRNA(Trp)Reach from here →
  1. D-lysine(in) + L-ornithine(out) = D-lysine(out) + L-ornithine(in)
  2. transport of ornithine and tryptophan (cytosol to extracellular)
  3. L-Tryptophan -tRNA(Trp) ligase (AMP-forming)

  Catalysed by SLC25A2, SLC7A6, WARS1inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• Ile-tRNA(Ile)Reach from here →
  1. D-lysine(in) + L-ornithine(out) = D-lysine(out) + L-ornithine(in)
  2. transport of isoleucine and ornithine (cytosol to extracellular)
  3. L-Isoleucine:tRNA(Ile) ligase (AMP-forming)

  Catalysed by SLC25A2, SLC7A6, IARS1inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• Gln-tRNA(Gln)Reach from here →
  1. D-lysine(in) + L-ornithine(out) = D-lysine(out) + L-ornithine(in)
  2. transport of glutamine and ornithine (cytosol to extracellular)
  3. L-Glutamine:tRNA(Gln) ligase (AMP-forming)

  Catalysed by SLC25A2, SLC7A6, QARS1inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• isocyanateReach from here →
  1. D-lysine(in) + L-ornithine(out) = D-lysine(out) + L-ornithine(in)
  2. Amino Acid-Polyamine-Organocation (Apc) Tcdb:2.A.3.8.15
  3. L-citrulline + H(+) = isocyanate + L-ornithine

  Catalysed by SLC25A2, SLC7A9, LACC1inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• Asn-tRNA(Asn)Reach from here →
  1. D-lysine(in) + L-ornithine(out) = D-lysine(out) + L-ornithine(in)
  2. transport of asparagine and ornithine (cytosol to extracellular)
  3. L-Asparagine:tRNA(Asn) ligase (AMP-forming)

  Catalysed by SLC25A2, SLC7A6, NARS1inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• chlorine(.)Reach from here →
  1. D-lysine(in) + L-ornithine(out) = D-lysine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. transport of arginine and chloride (cytosol to extracellular)

  Catalysed by SLC25A2, GATM, SLC6A14inner side of the membrane, outer side of the membrane, cytosol, extracellular spaceOne of 31 routes

• glycocholateReach from here →
  1. D-lysine(in) + L-ornithine(out) = D-lysine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by SLC25A2, GATM, BAATinner side of the membrane, outer side of the membrane, cytosol, peroxisomeOne of 3 routes

• hydrogen sulfideReach from here →
  1. D-lysine(in) + L-ornithine(out) = D-lysine(out) + L-ornithine(in)
  2. transport of cysteine and ornithine (cytosol to extracellular)
  3. L-cysteine hydrogen-sulfide-lyase (deaminating

  Catalysed by SLC25A2, SLC7A6, CTHinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• L-aspartateReach from here →
  1. D-lysine(in) + L-ornithine(out) = D-lysine(out) + L-ornithine(in)
  2. transport of alanine and ornithine (cytosol to extracellular)
  3. oxaloacetate + L-alanine = L-aspartate + pyruvate

  Catalysed by SLC25A2, SLC7A6, AGXT2inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 19 routes

• acetateReach from here →
  1. D-lysine(in) + L-ornithine(out) = D-lysine(out) + L-ornithine(in)
  2. N2-Acetyl-L-ornithine amidohydrolase
  3. N2-Acetyl-L-ornithine amidohydrolase

  Catalysed by SLC25A2, ACY1inner side of the membrane, outer side of the membrane, cytosol

• CHEBI:30249Reach from here →
  1. D-lysine(in) + L-ornithine(out) = D-lysine(out) + L-ornithine(in)
  2. transport of ornithine and tryptophan (cytosol to extracellular)
  3. L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)

  Catalysed by SLC25A2, SLC7A6, IDO1, TDO2 and 1 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• 4-methylthio-2-oxobutanoic acidReach from here →
  1. D-lysine(in) + L-ornithine(out) = D-lysine(out) + L-ornithine(in)
  2. transport of methionine and ornithine (cytosol to extracellular)
  3. L-Methionine:oxygen oxidoreductase (deaminating)

  Catalysed by SLC25A2, SLC7A6, IL4I1inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• di-mu-sulfido-diiron(2+)Reach from here →
  1. D-lysine(in) + L-ornithine(out) = D-lysine(out) + L-ornithine(in)
  2. transport of cysteine and ornithine (cytosol to extracellular)
  3. De novo synthesis of 2Fe2S

  Catalysed by SLC25A2, SLC7A6, NDUFAB1, FDXR and 5 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosol, mitochondrial matrix

• (S)-3-methyl-2-oxopentanoateReach from here →
  1. D-lysine(in) + L-ornithine(out) = D-lysine(out) + L-ornithine(in)
  2. transport of isoleucine and ornithine (cytosol to extracellular)
  3. L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate

  Catalysed by SLC25A2, SLC7A6, BCAT2, BCAT1inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• D-cysteineReach from here →
  1. D-lysine(in) + L-ornithine(out) = D-lysine(out) + L-ornithine(in)
  2. transport of alanine and ornithine (cytosol to extracellular)
  3. D-cysteine(out) + L-alanine(in) = D-cysteine(in) + L-alanine(out)

  Catalysed by SLC25A2, SLC7A6, SLC7A10inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• D-serineReach from here →
  1. D-lysine(in) + L-ornithine(out) = D-lysine(out) + L-ornithine(in)
  2. transport of alanine and ornithine (cytosol to extracellular)
  3. D-serine(out) + L-alanine(in) = D-serine(in) + L-alanine(out)

  Catalysed by SLC25A2, SLC7A6, SLC7A10inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 10 routes

• 5-aminolevulinateReach from here →
  1. D-lysine(in) + L-ornithine(out) = D-lysine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA

  Catalysed by SLC25A2, GATM, ALAS1, ALAS2inner side of the membrane, outer side of the membrane, cytosol

• 3-methyl-2-oxovaleric acidReach from here →
  1. D-lysine(in) + L-ornithine(out) = D-lysine(out) + L-ornithine(in)
  2. transport of isoleucine and ornithine (cytosol to extracellular)
  3. L-Leucine:2-oxoglutarate aminotransferase

  Catalysed by SLC25A2, SLC7A6, BCAT1inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• 3-(4-hydroxyphenyl)pyruvateReach from here →
  1. D-lysine(in) + L-ornithine(out) = D-lysine(out) + L-ornithine(in)
  2. transport of ornithine and tyrosine (cytosol to extracellular)
  3. L-tyrosine:2-oxoglutarate aminotransferase

  Catalysed by SLC25A2, SLC7A6, GOT2, GOT1 and 1 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 3 routes

• glycochenodeoxycholateReach from here →
  1. D-lysine(in) + L-ornithine(out) = D-lysine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. chenodeoxycholoyl-CoA + glycine = glycochenodeoxycholate + CoA + H(+)

  Catalysed by SLC25A2, GATM, BAATinner side of the membrane, outer side of the membrane, cytosol

• glycochenodeoxycholic acidReach from here →
  1. D-lysine(in) + L-ornithine(out) = D-lysine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by SLC25A2, GATM, BAATinner side of the membrane, outer side of the membrane, cytosol, peroxisomeOne of 3 routes

• glyoxylateReach from here →
  1. D-lysine(in) + L-ornithine(out) = D-lysine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. glycine + 2-oxoglutarate = glyoxylate + L-glutamate

  Catalysed by SLC25A2, GATM, AADATinner side of the membrane, outer side of the membrane, cytosolOne of 12 routes

• glycolithocholic acidReach from here →
  1. D-lysine(in) + L-ornithine(out) = D-lysine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. bile acid-CoA:amino acid N-acyltransferase (glycine)

  Catalysed by SLC25A2, GATM, BAATinner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

• L-2-amino-3-oxobutanoic acidReach from here →
  1. D-lysine(in) + L-ornithine(out) = D-lysine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. Acetyl-CoA:glycine C-acetyltransferase

  Catalysed by SLC25A2, GATM, GCATinner side of the membrane, outer side of the membrane, cytosol, mitochondrial matrix

• gamma-Glu-AlaReach from here →
  1. D-lysine(in) + L-ornithine(out) = D-lysine(out) + L-ornithine(in)
  2. transport of alanine and ornithine (cytosol to extracellular)
  3. gamma-glutamyltransferase (alanine)

  Catalysed by SLC25A2, SLC7A6, GGT1, GGT5 and 4 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• S(8)-aminomethyldihydrolipoamideReach from here →
  1. D-lysine(in) + L-ornithine(out) = D-lysine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. dihydrolipoyl dehydrogenase ([protein]-N6-(lipoyl)lysine)

  Catalysed by SLC25A2, GATM, GLDC, GCSHinner side of the membrane, outer side of the membrane, cytosol, mitochondrial matrix

• D-alanineReach from here →
  1. D-lysine(in) + L-ornithine(out) = D-lysine(out) + L-ornithine(in)
  2. transport of alanine and ornithine (cytosol to extracellular)
  3. D-alanine(out) + L-alanine(in) = D-alanine(in) + L-alanine(out)

  Catalysed by SLC25A2, SLC7A6, SLC7A10inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• sarcosineReach from here →
  1. D-lysine(in) + L-ornithine(out) = D-lysine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2

  Catalysed by SLC25A2, GATM, PIPOXinner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

• (6S)-5,6,7,8-tetrahydrofolateReach from here →
  1. D-lysine(in) + L-ornithine(out) = D-lysine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine

  Catalysed by SLC25A2, GATM, SHMT1, SHMT2inner side of the membrane, outer side of the membrane, cytosol