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Proteins/UNIPROT:P11172
Bifunctional enzyme catalyzing the last two steps of de novo pyrimidine biosynthesis, orotate phosphoribosyltransferase (OPRT), which converts orotate to orotidine-5'-monophosphate (OMP), and orotidine-5'-monophosphate decarboxylase (ODC), the terminal enzymatic reaction that decarboxylates OMP to uridine monophosphate (UMP)..
Function from UniProtKB (P11172), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
37 statements
37 statements · 5 reference databases · Subject: UMPS · Sources: Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
4 reactions
proton+CHEBI:15842carbon dioxide+UMP
Catalysed by UMPS
Reaction pageLeft to rightBalancedEC 4.1.1.23cytosol
Human-GEM MAR04036CC BY 4.0Reference data
orotic acid+5-phospho-alpha-D-ribose 1-diphosphateCHEBI:15842+diphosphate(3-)
Catalysed by UMPS
Reaction pageLeft to rightBalancedEC 2.4.2.10cytosol
7 names
Resolves to: UMPS
orotidine 5'-phosphate+diphosphate(3-)orotate+5-phospho-alpha-D-ribose 1-diphosphate
Catalysed by UMPS
Reaction pageRight to leftBalanced
Rhea RHEA:10380CC BY 4.0Reference data
orotidine 5'-phosphate+hydronUMP+carbon dioxide
Catalysed by UMPS
Reaction pageLeft to rightBalanced
Rhea RHEA:11596CC BY 4.0Reference data