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Proteins/UNIPROT:P12955
Dipeptidase that catalyzes the hydrolysis of dipeptides with a prolyl (Xaa-Pro) or hydroxyprolyl residue in the C-terminal position. The preferred dipeptide substrate is Gly-Pro, but other Xaa-Pro dipeptides, such as Ala-Pro, Met-Pro, Phe-Pro, Val-Pro and Leu-Pro, can be cleaved. Plays an important role in collagen metabolism because the high level of iminoacids in collagen..
Function from UniProtKB (P12955), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
249 statements
249 statements · 8 reference databases · Subject: PEPD · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Rhea, UniProt, WikiPathways
3 reactions
water+MAM03896cglycine+CHEBI:17203
Catalysed by PEPD
Reaction pageLeft to rightBalancedEC 3.4.13.9cytosol
Human-GEM MAR07193CC BY 4.0Reference data
water+CHEBI:356660glycine+CHEBI:17203
Catalysed by PEPD
Reaction pageLeft to rightBalancedEC 3.4.13.9cytosol
6 names
Resolves to: PEPD
Xaa-L-Pro dipeptide+wateran L-alpha-amino acid+L-proline
Catalysed by PEPD
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:76407CC BY 4.0Reference data