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an N-acyl-aromatic L-alpha-amino acid

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

18 compounds within 3 steps: 2 in 1, 7 in 2, 9 in 3

Does it reach a compound?

One step

a carboxylateReach from here →
1. an N-acyl-aromatic L-alpha-amino acid + H2O = an aromatic L-alpha-amino acid + a carboxylate
Catalysed by PM20D1, ACY3
an aromatic L-alpha-amino acidReach from here →
1. an N-acyl-aromatic L-alpha-amino acid + H2O = an aromatic L-alpha-amino acid + a carboxylate
Catalysed by PM20D1, ACY3

Two steps

an aldehydeReach from here →
1. an N-acyl-aromatic L-alpha-amino acid + H2O = an aromatic L-alpha-amino acid + a carboxylate
2. an aldehyde + O2 + H2O = a carboxylate + H2O2 + H(+)
Catalysed by PM20D1, ACY3, AOX1
orotateReach from here →
1. an N-acyl-aromatic L-alpha-amino acid + H2O = an aromatic L-alpha-amino acid + a carboxylate
2. orotate(out) + a carboxylate(in) = orotate(in) + a carboxylate(out)
Catalysed by PM20D1, ACY3, SLC22A13inner side of the membrane, outer side of the membraneOne of 2 routes

Three steps

a quinoneReach from here →
Catalysed by PM20D1, ACY3, SLC22A13, DHODHinner side of the membrane, outer side of the membrane
cholineReach from here →

a carboxylic ester

Reach from here →

an N-acyl-aromatic L-alpha-amino acid + H2O = an aromatic L-alpha-amino acid + a carboxylate
a carboxylic ester + H2O = an alcohol + a carboxylate + H(+)

Catalysed by PM20D1, ACY3, CES2, CES1 and 3 more

an acylcholineReach from here →

an N-acyl-aromatic L-alpha-amino acid + H2O = an aromatic L-alpha-amino acid + a carboxylate
an acylcholine + H2O = a carboxylate + choline + H(+)

Catalysed by PM20D1, ACY3, BCHE

a thioesterReach from here →

an N-acyl-aromatic L-alpha-amino acid + H2O = an aromatic L-alpha-amino acid + a carboxylate
a thioester + H2O = a thiol + a carboxylate + H(+)

Catalysed by PM20D1, ACY3, PNKD

a 3-acylpyruvateReach from here →

an N-acyl-aromatic L-alpha-amino acid + H2O = an aromatic L-alpha-amino acid + a carboxylate
a 3-acylpyruvate + H2O = a carboxylate + pyruvate + H(+)

Catalysed by PM20D1, ACY3, FAHD1

an N-acyl-L-amino acidReach from here →

an N-acyl-aromatic L-alpha-amino acid + H2O = an aromatic L-alpha-amino acid + a carboxylate
an N-acyl-L-amino acid + H2O = an L-alpha-amino acid + a carboxylate

Catalysed by PM20D1, ACY3, ACY1

Catalysed by PM20D1, ACY3, BCHE

pyruvateReach from here →

an N-acyl-aromatic L-alpha-amino acid + H2O = an aromatic L-alpha-amino acid + a carboxylate
a 3-acylpyruvate + H2O = a carboxylate + pyruvate + H(+)
a 3-acylpyruvate + H2O = a carboxylate + pyruvate + H(+)

Catalysed by PM20D1, ACY3, FAHD1

a thiolReach from here →

an N-acyl-aromatic L-alpha-amino acid + H2O = an aromatic L-alpha-amino acid + a carboxylate
a thioester + H2O = a thiol + a carboxylate + H(+)
a thioester + H2O = a thiol + a carboxylate + H(+)

Catalysed by PM20D1, ACY3, PNKD

(S)-dihydroorotateReach from here →

an N-acyl-aromatic L-alpha-amino acid + H2O = an aromatic L-alpha-amino acid + a carboxylate
orotate(out) + a carboxylate(in) = orotate(in) + a carboxylate(out)
(S)-dihydroorotate + a quinone = orotate + a quinol

Catalysed by PM20D1, ACY3, SLC22A13, DHODHinner side of the membrane, outer side of the membrane

an alcoholReach from here →

an N-acyl-aromatic L-alpha-amino acid + H2O = an aromatic L-alpha-amino acid + a carboxylate
a carboxylic ester + H2O = an alcohol + a carboxylate + H(+)
a carboxylic ester + H2O = an alcohol + a carboxylate + H(+)

Catalysed by PM20D1, ACY3, CES2, CES1 and 3 more

nicotinateReach from here →

an N-acyl-aromatic L-alpha-amino acid + H2O = an aromatic L-alpha-amino acid + a carboxylate
orotate(out) + a carboxylate(in) = orotate(in) + a carboxylate(out)
orotate(out) + nicotinate(in) = orotate(in) + nicotinate(out)

Catalysed by PM20D1, ACY3, SLC22A13, SLC22A12inner side of the membrane, outer side of the membraneOne of 2 routes

orotidine 5'-phosphateReach from here →

an N-acyl-aromatic L-alpha-amino acid + H2O = an aromatic L-alpha-amino acid + a carboxylate
orotate(out) + a carboxylate(in) = orotate(in) + a carboxylate(out)
orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate

Catalysed by PM20D1, ACY3, SLC22A13, UMPSinner side of the membrane, outer side of the membrane

an L-alpha-amino acidReach from here →

an N-acyl-aromatic L-alpha-amino acid + H2O = an aromatic L-alpha-amino acid + a carboxylate
an N-acyl-L-amino acid + H2O = an L-alpha-amino acid + a carboxylate
an N-acyl-L-amino acid + H2O = an L-alpha-amino acid + a carboxylate

Catalysed by PM20D1, ACY3, ACY1