maleate

Three steps

• formic acidReach from here →
  1. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of chloride and formate (cytosol to extracellular)

  Catalysed by SLC25A14, SLC25A30, SLC26A6, SLC26A4inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• (indol-3-yl)acetateReach from here →
  1. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. (indol-3-yl)acetate(out) + a dicarboxylate(in) = (indol-3-yl)acetate(in) + a dicarboxylate(out)

  Catalysed by SLC25A14, SLC25A30, SLC25A35, SLC25A34 and 2 moreinner side of the membrane, outer side of the membraneOne of 2 routes

• glutarateReach from here →
  1. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)
  2. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)
  3. dehydroepiandrosterone 3-sulfate(out) + glutarate(in) = dehydroepiandrosterone 3-sulfate(in) + glutarate(out)

  Catalysed by SLC25A14, SLC25A30, STS, SLC22A24 and 1 moreinner side of the membrane, outer side of the membraneOne of 4 routes

• 4-hydroxy-2-oxoglutaric acidReach from here →
  1. maleate(in) + citrate(out) = maleate(out) + citrate(in)
  2. ATP citrate lyase (citrate)
  3. D-aspartate:2-oxoglutarate aminotransferase

  Catalysed by SLC25A1, ACLY, GOT2inner side of the membrane, outer side of the membrane, cytosol, mitochondrial matrix

• pentanoateReach from here →
  1. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)
  2. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)
  3. pentanoate(out) + dehydroepiandrosterone 3-sulfate(in) = pentanoate(in) + dehydroepiandrosterone 3-sulfate(out)

  Catalysed by SLC25A14, SLC25A30, STS, SLC22A9inner side of the membrane, outer side of the membraneOne of 4 routes

• N-carbamoyl-L-aspartateReach from here →
  1. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. carbamoyl phosphate + L-aspartate = N-carbamoyl-L-aspartate + phosphate + H(+)

  Catalysed by SLC25A14, SLC25A30, CADinner side of the membrane, outer side of the membrane

• a phenolReach from here →
  1. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)
  2. an aryl sulfate + H2O = a phenol + sulfate + H(+)
  3. an aryl sulfate + H2O = a phenol + sulfate + H(+)

  Catalysed by SLC25A14, SLC25A30, ARSL, ARSF and 4 moreinner side of the membrane, outer side of the membrane

• glyoxylateReach from here →
  1. maleate(in) + citrate(out) = maleate(out) + citrate(in)
  2. Citrate Transport, Mitochondrial
  3. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)

  Catalysed by SLC25A1, CLYBLinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosol

• L-erythro-7,8-dihydrobiopterinReach from here →
  1. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. L-erythro-7,8-dihydrobiopterin(out) + a dicarboxylate(in) = L-erythro-7,8-dihydrobiopterin(in) + a dicarboxylate(out)

  Catalysed by SLC25A14, SLC25A30, SLC25A35, SLC25A34 and 2 moreinner side of the membrane, outer side of the membraneOne of 2 routes

• (5-hydroxyindol-3-yl)acetaldehydeReach from here →
  1. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)
  2. Transport of 5-Hydroxyindoleacetate
  3. (5-hydroxyindol-3-yl)acetaldehyde + NAD(+) + H2O = (5-hydroxyindol-3-yl)acetate + NADH + 2 H(+)

  Catalysed by SLC25A14, SLC25A30, SLC4A1, ALDH9A1inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• taurineReach from here →
  1. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3

  Catalysed by SLC25A14, SLC25A30, SLC26A6, SLC6A6inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• glycineReach from here →
  1. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of chloride and glycine (cytosol to extracellular)

  Catalysed by SLC25A14, SLC25A30, SLC26A6, SLC6A9 and 1 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 3 routes

• (S)-malyl-CoAReach from here →
  1. maleate(in) + citrate(out) = maleate(out) + citrate(in)
  2. Citrate Transport, Mitochondrial
  3. (S)-malate + ATP + CoA = (S)-malyl-CoA + ADP + phosphate

  Catalysed by SLC25A1, SUCLG1, SUCLA2inner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosol

• prostaglandin F2alphaReach from here →
  1. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. prostaglandin F2alpha(out) + a dicarboxylate(in) = prostaglandin F2alpha(in) + a dicarboxylate(out)

  Catalysed by SLC25A14, SLC25A30, SLC25A35, SLC25A34 and 1 moreinner side of the membrane, outer side of the membraneOne of 2 routes

• 7,8-dihydrofolateReach from here →
  1. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)
  2. Folate Transport by Oats
  3. dihydrofolate:NAD+ oxidoreductase

  Catalysed by SLC25A14, SLC25A30, SLC22A8, SLC22A7 and 2 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 3 routes

• 2-(N(omega)-L-arginino)succinateReach from here →
  1. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. 2-(Nomega-L-arginino)succinate arginine-lyase (fumarate-forming)

  Catalysed by SLC25A14, SLC25A30, SLC25A10, ASLinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 4 routes

• N(6)-(1,2-dicarboxyethyl)-AMPReach from here →
  1. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming)

  Catalysed by SLC25A14, SLC25A30, SLC25A10, ADSL and 1 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 4 routes

• guanidinoacetateReach from here →
  1. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Transport of Guanidinoacetic Acid

  Catalysed by SLC25A14, SLC25A30, SLC26A6inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• 3',5'-cyclic GMPReach from here →
  1. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. 3',5'-cyclic GMP(out) + a dicarboxylate(in) = 3',5'-cyclic GMP(in) + a dicarboxylate(out)

  Catalysed by SLC25A14, SLC25A30, SLC25A35, SLC25A34 and 1 moreinner side of the membrane, outer side of the membraneOne of 2 routes

• L-methionineReach from here →
  1. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of chloride and methionine (cytosol to extracellular)

  Catalysed by SLC25A14, SLC25A30, SLC26A6, SLC6A14inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 4 routes

• adenosine 5'-phosphoramidateReach from here →
  1. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)
  2. ATP:sulfate adenylyltransferase
  3. adenosine 5'-phosphosulfate + NH4(+) = adenosine 5'-phosphoramidate + sulfate + 2 H(+)

  Catalysed by SLC25A14, SLC25A30, PAPSS1, PAPSS2 and 1 moreinner side of the membrane, outer side of the membrane, cytosol

• L-tryptophanReach from here →
  1. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Transport of L-Tryptophan by Atb0 Transporter

  Catalysed by SLC25A14, SLC25A30, SLC26A6, SLC6A14inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 4 routes

• glutathioneReach from here →
  1. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)
  2. sulfite(in) + sulfate(out) = sulfite(out) + sulfate(in)
  3. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)

  Catalysed by SLC25A14, SLC25A30, TSTD1inner side of the membrane, outer side of the membraneOne of 2 routes

• beta-alanineReach from here →
  1. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of beta-alanine and chloride (cytosol to extracellular)

  Catalysed by SLC25A14, SLC25A30, SLC26A6, SLC6A6 and 1 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 4 routes

• L-alanineReach from here →
  1. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of alanine and chloride (cytosol to extracellular)

  Catalysed by SLC25A14, SLC25A30, SLC26A6, SLC6A14inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 3 routes

• L-asparagineReach from here →
  1. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Transport of L-Asparagine by Atb0 Transporter

  Catalysed by SLC25A14, SLC25A30, SLC26A6, SLC6A14inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 4 routes

• N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagineReach from here →
  1. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O = N-acetyl-beta-D-glucosaminylamine + L-aspartate + H(+)

  Catalysed by SLC25A14, SLC25A30, AGAinner side of the membrane, outer side of the membrane

• L-phenylalanineReach from here →
  1. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Transport of L-Phenylalanine by Atb0 Transporter

  Catalysed by SLC25A14, SLC25A30, SLC26A6, SLC6A14inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 4 routes

• 3',5'-cyclic AMPReach from here →
  1. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. 3',5'-cyclic AMP(out) + a dicarboxylate(in) = 3',5'-cyclic AMP(in) + a dicarboxylate(out)

  Catalysed by SLC25A14, SLC25A30, SLC25A35, SLC25A34 and 1 moreinner side of the membrane, outer side of the membraneOne of 2 routes

• (2R)-2-phosphoglycerateReach from here →
  1. maleate(in) + citrate(out) = maleate(out) + citrate(in)
  2. transport of citrate and PEP (cytosol to mitochondria)
  3. 2-phospho-D-glycerate hydro-lyase (phosphoenolpyruvate-forming)

  Catalysed by SLC25A1, ENO1, ENO2, ENO3inner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 2 routes

• glutathione disulfideReach from here →
  1. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)
  2. thiosulfate(in) + sulfate(out) = thiosulfate(out) + sulfate(in)
  3. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)

  Catalysed by SLC25A14, SLC25A30, SLC26A1, SLC25A10 and 1 moreinner side of the membrane, outer side of the membrane

• L-tyrosineReach from here →
  1. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. L-tyrosine(out) + L-aspartate(in) = L-tyrosine(in) + L-aspartate(out)

  Catalysed by SLC25A14, SLC25A30, SLC7A13inner side of the membrane, outer side of the membraneOne of 2 routes

• N(omega),N(omega)-dimethyl-L-arginineReach from here →
  1. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. N(omega),N(omega)-dimethyl-L-arginine + oxaloacetate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-aspartate

  Catalysed by SLC25A14, SLC25A30, AGXT2inner side of the membrane, outer side of the membrane

• (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinateReach from here →
  1. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. 1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole AMP-lyase

  Catalysed by SLC25A14, SLC25A30, SLC25A10, ADSLinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 4 routes

• kynurenateReach from here →
  1. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. kynurenate(out) + a dicarboxylate(in) = kynurenate(in) + a dicarboxylate(out)

  Catalysed by SLC25A14, SLC25A30, SLC25A35, SLC25A34 and 1 moreinner side of the membrane, outer side of the membraneOne of 2 routes

• D-glucosamineReach from here →
  1. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)
  2. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate
  3. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate

  Catalysed by SLC25A14, SLC25A30, SGSHinner side of the membrane, outer side of the membrane

• S-sulfanylglutathioneReach from here →
  1. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)
  2. sulfite(in) + sulfate(out) = sulfite(out) + sulfate(in)
  3. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)

  Catalysed by SLC25A14, SLC25A30, ETHE1inner side of the membrane, outer side of the membraneOne of 2 routes

• (6R)-L-erythro-5,6,7,8-tetrahydrobiopterinReach from here →
  1. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(out) + a dicarboxylate(in) = (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(in) + a dicarboxylate(out)

  Catalysed by SLC25A14, SLC25A30, SLC25A35, SLC25A34 and 2 moreinner side of the membrane, outer side of the membraneOne of 2 routes

• 4-aminobutanoateReach from here →
  1. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of 4-aminobutyrate and chloride (cytosol to extracellular)

  Catalysed by SLC25A14, SLC25A30, SLC26A6, SLC6A12inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 4 routes

• prostaglandin E2Reach from here →
  1. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. prostaglandin E2(out) + a dicarboxylate(in) = prostaglandin E2(in) + a dicarboxylate(out)

  Catalysed by SLC25A14, SLC25A30, SLC25A35, SLC25A34 and 1 moreinner side of the membrane, outer side of the membraneOne of 2 routes

• N-benzoylglycineReach from here →
  1. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. N-benzoylglycine(out) + a dicarboxylate(in) = N-benzoylglycine(in) + a dicarboxylate(out)

  Catalysed by SLC25A14, SLC25A30, SLC25A35, SLC25A34 and 2 moreinner side of the membrane, outer side of the membraneOne of 2 routes

• 3-sulfino-L-alanineReach from here →
  1. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)

  Catalysed by SLC25A14, SLC25A30, SLC25A12, SLC25A13inner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 4 routes

• ubiquinol-10Reach from here →
  1. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)
  2. sulfite(in) + sulfate(out) = sulfite(out) + sulfate(in)
  3. ubiquinone-10 + hydrogen sulfide + sulfite + 2 H(+) = ubiquinol-10 + thiosulfate

  Catalysed by SLC25A14, SLC25A30, SQORinner side of the membrane, outer side of the membrane

• 16alpha-hydroxydehydroepiandrosterone 3-sulfateReach from here →
  1. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)
  2. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)
  3. dehydroepiandrosterone 3-sulfate + reduced [NADPH--hemoprotein reductase] + O2 = 16alpha-hydroxydehydroepiandrosterone 3-sulfate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by SLC25A14, SLC25A30, STS, CYP3A7inner side of the membrane, outer side of the membrane

• 3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate 9-phosphateReach from here →
  1. maleate(in) + citrate(out) = maleate(out) + citrate(in)
  2. phosphoenolpyruvate(in) + citrate(out) = phosphoenolpyruvate(out) + citrate(in)
  3. aldehydo-D-mannose 6-phosphate + phosphoenolpyruvate + H2O = 3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate 9-phosphate + phosphate

  Catalysed by SLC25A1, NANSinner side of the membrane, outer side of the membrane