citric acid

Three steps

• 5'-deoxyadenosineReach from here →
  1. Citrate Transport, Mitochondrial
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O

  Catalysed by SLC25A1, ME2, ME3, TYW1B and 1 moremitochondrial matrix, cytosol

• L-cysteineReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. transport of chloride and oxalate (cytosol to extracellular)
  3. transport of chloride and cysteine (cytosol to extracellular)

  Catalysed by SLC25A1, SLC26A6, SLC6A14mitochondrial matrix, cytosol, extracellular spaceOne of 3 routes

• indole-3-pyruvateReach from here →
  1. Citrate Transport, Mitochondrial
  2. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)
  3. L-tryptophan + glyoxylate = indole-3-pyruvate + glycine

  Catalysed by SLC25A1, CLYBL, AADATmitochondrial matrix, cytosol

• 3,3'-diiodo-L-thyronine sulfateReach from here →
  1. Citrate Transport, Mitochondrial
  2. transport of malate and sulfate (cytosol to mitochondria)
  3. Steryl-Sulfatase

  Catalysed by SLC25A1, SLC25A10, STSmitochondrial matrix, cytosol, Golgi apparatusOne of 2 routes

• (7Z,10Z,13Z)-hexadecatrienoyl-CoAReach from here →
  1. ATP citrate lyase (citrate)
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. Fatty Acid Beta Oxidation (C18:3->C16:3), Mitochondrial

  Catalysed by ACLY, CS, HADHA, ACADVL and 1 morecytosol, mitochondrial matrix

• thymidineReach from here →
  1. transport of citrate and PEP (cytosol to mitochondria)
  2. pyruvate kinase (dTDP)
  3. dTTP + H2O = thymidine + triphosphate + H(+)

  Catalysed by SLC25A1, PKM, PKLR, SAMHD1mitochondrial matrix, cytosol

• glycine betaineReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. transport of chloride and oxalate (cytosol to extracellular)
  3. transport of betaine and chloride (cytosol to extracellular)

  Catalysed by SLC25A1, SLC26A6, SLC6A12mitochondrial matrix, cytosol, extracellular spaceOne of 3 routes

• 4-methyl-2-oxopentanoateReach from here →
  1. Citrate Transport, Mitochondrial
  2. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)
  3. L-leucine + glyoxylate = 4-methyl-2-oxopentanoate + glycine

  Catalysed by SLC25A1, CLYBL, AADATmitochondrial matrix, cytosol

• CHEBI:17895Reach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. transport of chloride and oxalate (cytosol to extracellular)
  3. Transport of L-Tyrosine by Atb0 Transporter

  Catalysed by SLC25A1, SLC26A6, SLC6A14mitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• CHEBI:17927Reach from here →
  1. ATP citrate lyase (citrate)
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. N1,N8-diacetylspermidine to N1-acetylspermidine conversion

  Catalysed by ACLY, CScytosol, mitochondrial matrix

• 3-phenylpyruvateReach from here →
  1. Citrate Transport, Mitochondrial
  2. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)
  3. glyoxylate + L-phenylalanine = 3-phenylpyruvate + glycine

  Catalysed by SLC25A1, CLYBL, AADATmitochondrial matrix, cytosol

• CHEBI:18019Reach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. transport of chloride and oxalate (cytosol to extracellular)
  3. transport of chloride and lysine (cytosol to extracellular)

  Catalysed by SLC25A1, SLC26A6, SLC6A14mitochondrial matrix, cytosol, extracellular space

• thiocyanateReach from here →
  1. Citrate Transport, Mitochondrial
  2. transport of malate and thiosulfate (cytosol to mitochondria)
  3. thiosulfate:cyanide sulfurtranserase

  Catalysed by SLC25A1, SLC25A10, MPST, TSTmitochondrial matrix, cytosolOne of 2 routes

• 4-fumarylacetoacetateReach from here →
  1. Citrate Transport, Mitochondrial
  2. (S)-malate hydro-lyase (fumarate-forming)
  3. 4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)

  Catalysed by SLC25A1, FH, FAHmitochondrial matrix, cytosol

• triphosphateReach from here →
  1. transport of citrate and PEP (cytosol to mitochondria)
  2. pyruvate kinase (dTDP)
  3. dTTP + H2O = thymidine + triphosphate + H(+)

  Catalysed by SLC25A1, PKM, PKLR, SAMHD1mitochondrial matrix, cytosol

• L-glutamineReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. transport of chloride and oxalate (cytosol to extracellular)
  3. Transport of L-Glutamine by Atb0 Transporter

  Catalysed by SLC25A1, SLC26A6, SLC6A14mitochondrial matrix, cytosol, extracellular spaceOne of 3 routes

• dTDPReach from here →
  1. Citrate Transport, Mitochondrial
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. pyruvate kinase (dTDP)

  Catalysed by SLC25A1, ME2, ME3, PKM and 1 moremitochondrial matrix, cytosolOne of 12 routes

• CHEBI:18095Reach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. transport of chloride and oxalate (cytosol to extracellular)
  3. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)

  Catalysed by SLC25A1, SLC26A6, CLTRN, SLC6A20mitochondrial matrix, cytosol, extracellular space

• N-carbamoyl-beta-alanineReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. transport of chloride and oxalate (cytosol to extracellular)
  3. Transport of 3-Ureidopropionate

  Catalysed by SLC25A1, SLC26A6mitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• hydrogen cyanideReach from here →
  1. Citrate Transport, Mitochondrial
  2. transport of malate and sulfite (cytosol to mitochondria)
  3. thiosulfate:cyanide sulfurtranserase

  Catalysed by SLC25A1, SLC25A10, MPST, TSTmitochondrial matrix, cytosolOne of 2 routes

• 5-(3,3'-dimethylguanidino)-2-oxopentanoateReach from here →
  1. Citrate Transport, Mitochondrial
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by SLC25A1, ME2, ME3, AGXT2mitochondrial matrix, cytosolOne of 2 routes

• 5-(3-methylguanidino)-2-oxopentanoateReach from here →
  1. Citrate Transport, Mitochondrial
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. N(omega)-methyl-L-arginine + pyruvate = 5-(3-methylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by SLC25A1, ME2, ME3, AGXT2mitochondrial matrix, cytosolOne of 2 routes

• (5Z)-dodecenoyl-CoAReach from here →
  1. ATP citrate lyase (citrate)
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-7-enoyl-CoA)

  Catalysed by ACLY, CS, HADHA, ACAA2 and 1 morecytosol, mitochondrial matrixOne of 2 routes

• (11Z)-docosenoyl-CoA(4-)Reach from here →
  1. ATP citrate lyase (citrate)
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. long-chain-fatty-acid-CoA ligase (cis-cetoleic acid)

  Catalysed by ACLY, CS, SLC27A2, ACSL4 and 6 morecytosol, mitochondrial matrixOne of 5 routes

• (7Z)-tetradecenoyl-CoAReach from here →
  1. ATP citrate lyase (citrate)
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. long-chain-fatty-acid-CoA ligase ((7Z)-tetradecenoic acid)

  Catalysed by ACLY, CS, SLC27A2, ACSL4 and 6 morecytosol, mitochondrial matrixOne of 8 routes

• (4Z,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →
  1. ATP citrate lyase (citrate)
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. Fatty Acid Beta Oxidation (C18:4->C16:4), Mitochondrial

  Catalysed by ACLY, CS, HADHA, ACADVL and 1 morecytosol, mitochondrial matrixOne of 3 routes

• (7Z,10Z)-hexadecadienoyl-CoAReach from here →
  1. ATP citrate lyase (citrate)
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial

  Catalysed by ACLY, CS, HADHA, ACADVL and 1 morecytosol, mitochondrial matrix

• (4Z,7Z)-decadienoyl-CoAReach from here →
  1. ATP citrate lyase (citrate)
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial

  Catalysed by ACLY, CS, ECHS1, ACAA2 and 1 morecytosol, mitochondrial matrixOne of 2 routes

• (5Z)-octenoyl-CoAReach from here →
  1. ATP citrate lyase (citrate)
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. Fatty Acid Beta Oxidation (C10:2->C8:1), Mitochondrial

  Catalysed by ACLY, CS, ECHS1, ACAA2 and 1 morecytosol, mitochondrial matrixOne of 2 routes

• CHEBI:240943Reach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. transport of chloride and oxalate (cytosol to extracellular)
  3. 2-Methylbutyrylglycine Transport, Extracellular

  Catalysed by SLC25A1, SLC26A6, SLC6A5mitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• dUMPReach from here →
  1. transport of citrate and PEP (cytosol to mitochondria)
  2. dGTP:pyruvate 2-O-phosphotransferase
  3. thymidine kinase (deoxyuridine)

  Catalysed by SLC25A1, PKM, PKLRmitochondrial matrix, cytosolOne of 2 routes

• hypochlorous acidReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. transport of chloride and oxalate (cytosol to extracellular)
  3. Peroxidase

  Catalysed by SLC25A1, SLC26A6, LPOmitochondrial matrix, cytosol, extracellular spaceOne of 4 routes

• potassium atomReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. transport of chloride and oxalate (cytosol to extracellular)
  3. transport of chloride (cytosol to extracellular)

  Catalysed by SLC25A1, SLC26A6, SLC12A2, SLC12A1mitochondrial matrix, cytosol, extracellular spaceOne of 3 routes

• folic acidReach from here →
  1. Citrate Transport, Mitochondrial
  2. transport of malate and sulfate (cytosol to mitochondria)
  3. Folate Transport by Oats

  Catalysed by SLC25A1, SLC25A10, SLC22A8, SLC22A7mitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• CHEBI:27540Reach from here →
  1. ATP citrate lyase (citrate)
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. medium-chain acyl-CoA ligase (hexanoic acid)

  Catalysed by ACLY, CS, ACSM4, ACSM1 and 4 morecytosol, mitochondrial matrixOne of 6 routes

• elaidic acidReach from here →
  1. ATP citrate lyase (citrate)
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. long-chain-fatty-acid-CoA ligase (elaidate)

  Catalysed by ACLY, CS, SLC27A2, ACSL4 and 6 morecytosol, mitochondrial matrixOne of 5 routes

• 2-oxopentanoateReach from here →
  1. ATP citrate lyase (citrate)
  2. N(omega),N(omega)-dimethyl-L-arginine + oxaloacetate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-aspartate
  3. 2-oxopentanoate + N(omega),N(omega)-dimethyl-L-arginine = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-2-aminopentanoate

  Catalysed by ACLY, AGXT2cytosol

• CHEBI:28701Reach from here →
  1. ATP citrate lyase (citrate)
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. Propanoyl-CoA:acetyl-CoA C-acyltransferase

  Catalysed by ACLY, CS, ACAA1, SCP2 and 1 morecytosol, mitochondrial matrix, peroxisomeOne of 7 routes

• CHEBI:28862Reach from here →
  1. transport of citrate and PEP (cytosol to mitochondria)
  2. dATP:pyruvate 2-O-phosphotransferase
  3. dADP to dATP conversion

  Catalysed by SLC25A1, PKM, PKLRmitochondrial matrix, cytosolOne of 13 routes

• a dicarboxylateReach from here →
  1. Citrate Transport, Mitochondrial
  2. transport of malate and sulfate (cytosol to mitochondria)
  3. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)

  Catalysed by SLC25A1, SLC25A10, SLC25A35, SLC25A34mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• K(+)Reach from here →
  1. ATP citrate lyase (citrate)
  2. L-Aspartate:2-oxoglutarate aminotransferase
  3. K(+)(in) + L-aspartate(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-aspartate(in) + 3 Na(+)(in) + H(+)(in)

  Catalysed by ACLY, GOT2, SLC1A7, SLC1A3 and 3 morecytosol, mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• Asp-tRNA(Asp)Reach from here →
  1. ATP citrate lyase (citrate)
  2. L-Aspartate:2-oxoglutarate aminotransferase
  3. L-Aspartate:tRNA(Asp) ligase (AMP-forming)

  Catalysed by ACLY, GOT2, DARS1cytosol, mitochondrial matrix

• glycolateReach from here →
  1. Citrate Transport, Mitochondrial
  2. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)
  3. glycolate + NADP(+) = glyoxylate + NADPH + H(+)

  Catalysed by SLC25A1, CLYBL, GRHPRmitochondrial matrix, cytosol

• hydrogen sulfideReach from here →
  1. Citrate Transport, Mitochondrial
  2. transport of malate and thiosulfate (cytosol to mitochondria)
  3. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)

  Catalysed by SLC25A1, SLC25A10mitochondrial matrix, cytosolOne of 2 routes

• D-aspartateReach from here →
  1. Citrate Transport, Mitochondrial
  2. transport of malate and sulfate (cytosol to mitochondria)
  3. D-aspartate(in) + sulfate(out) = D-aspartate(out) + sulfate(in)

  Catalysed by SLC25A1, SLC25A10, SLC25A14, SLC25A30mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• acetateReach from here →
  1. Citrate Transport, Mitochondrial
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. transport of acetate and pyruvate (cytosol to extracellular)

  Catalysed by SLC25A1, ME2, ME3, SLC16A4 and 4 moremitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• oxalateReach from here →
  1. Citrate Transport, Mitochondrial
  2. transport of malate and sulfate (cytosol to mitochondria)
  3. oxalate(in) + sulfate(out) = oxalate(out) + sulfate(in)

  Catalysed by SLC25A1, SLC25A10, SLC25A14, SLC26A2 and 3 moremitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 3 routes

• formic acidReach from here →
  1. Citrate Transport, Mitochondrial
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. transport of formate and pyruvate (cytosol to extracellular)

  Catalysed by SLC25A1, ME2, ME3, SLC16A4 and 4 moremitochondrial matrix, cytosol, extracellular spaceOne of 4 routes

• propionic acidReach from here →
  1. Citrate Transport, Mitochondrial
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. transport of propanoate and pyruvate (cytosol to extracellular)

  Catalysed by SLC25A1, ME2, ME3, SLC16A4 and 5 moremitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• butyric acidReach from here →
  1. Citrate Transport, Mitochondrial
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. transport of butyrate and pyruvate (cytosol to extracellular)

  Catalysed by SLC25A1, ME2, ME3, SLC16A4 and 5 moremitochondrial matrix, cytosol, extracellular spaceOne of 2 routes