CHEBI:28666

Two steps

• CHEBI:18019Reach from here →
  1. membrane dipeptidase (LTD4)
  2. transport of glycine and lysine (cytosol to extracellular)

  Catalysed by DPEP1, DPEP2, SLC7A6extracellular space, cytosolOne of 2 routes

• L-glutamineReach from here →
  1. membrane dipeptidase (LTD4)
  2. transport of glutamine and glycine (cytosol to extracellular)

  Catalysed by DPEP1, DPEP2, SLC7A5extracellular space, cytosolOne of 4 routes

• N(1)-(5-phospho-D-ribosyl)glycinamideReach from here →
  1. membrane dipeptidase (LTD4)
  2. 5-Phospho-D-ribosylamine:glycine ligase (ADP-forming)

  Catalysed by DPEP1, DPEP2, GARTextracellular space, cytosol

• ophthalmateReach from here →
  1. membrane dipeptidase (LTD4)
  2. gamma-L-glutamyl-(2S)-2-aminobutanoate + glycine + ATP = ophthalmate + ADP + phosphate + H(+)

  Catalysed by DPEP1, DPEP2, GSSextracellular space

• N(omega),N('omega)-dimethyl-L-arginineReach from here →
  1. membrane dipeptidase (LTD4)
  2. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine

  Catalysed by DPEP1, DPEP2, AGXT2extracellular space

• 5,6,7,8-tetrahydrofolic acidReach from here →
  1. membrane dipeptidase (LTD4)
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase

  Catalysed by DPEP1, DPEP2, SHMT1extracellular space, cytosolOne of 2 routes

• CHEBI:240943Reach from here →
  1. membrane dipeptidase (LTD4)
  2. glycine N-acyltransferase (2-methylbutyryl-CoA)

  Catalysed by DPEP1, DPEP2, GLYAT, GLYATL2 and 1 moreextracellular space, mitochondrial matrix

• phenylacetylglycineReach from here →
  1. membrane dipeptidase (LTD4)
  2. phenylacetyl-CoA:glycine N-phenylacetyltransferase

  Catalysed by DPEP1, DPEP2, GLYATextracellular space, cytosolOne of 3 routes

• 5(S)-HETEReach from here →
  1. transport of GSH and LTD4 (cytosol to extracellular)
  2. Glutathione: 5-HPETE oxidoreductase

  Catalysed by SLCO2A1, GPX5, GPX1, GPX2 and 6 moreextracellular space, cytosolOne of 2 routes

• Gly-tRNA(Gly)Reach from here →
  1. membrane dipeptidase (LTD4)
  2. glycine:tRNA(Gly) ligase (AMP-forming)

  Catalysed by DPEP1, DPEP2, GARS1extracellular space, cytosol

• chlorine(.)Reach from here →
  1. membrane dipeptidase (LTD4)
  2. transport of chloride and glycine (cytosol to extracellular)

  Catalysed by DPEP1, DPEP2, SLC6A9, SLC6A14extracellular space, cytosolOne of 3 routes

• glycocholateReach from here →
  1. membrane dipeptidase (LTD4)
  2. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by DPEP1, DPEP2, BAATextracellular space, peroxisomeOne of 7 routes

• cholateReach from here →
  1. transport of LTD4 (cytosol to extracellular)
  2. solute carrier organic anion transporter (cholate)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• (5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. transport of LTD4 (cytosol to extracellular)
  2. transport of arachidonate (cytosol to extracellular)

  Catalysed by SLCO1B1extracellular space, cytosolOne of 4 routes

• serotoninReach from here →
  1. transport of LTD4 (cytosol to extracellular)
  2. transport of serotonin (cytosol to extracellular)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• 5-aminolevulinateReach from here →
  1. membrane dipeptidase (LTD4)
  2. succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA

  Catalysed by DPEP1, DPEP2, ALAS1, ALAS2extracellular space

• chenodeoxycholateReach from here →
  1. transport of LTD4 (cytosol to extracellular)
  2. solute carrier organic anion transporter (chenodiol)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 2 routes

• glycochenodeoxycholateReach from here →
  1. membrane dipeptidase (LTD4)
  2. chenodeoxycholoyl-CoA + glycine = glycochenodeoxycholate + CoA + H(+)

  Catalysed by DPEP1, DPEP2, BAATextracellular space

• taurocholateReach from here →
  1. transport of LTD4 (cytosol to extracellular)
  2. solute carrier organic anion transporter (S-glutathionyl-2-4-dinitrobenzene)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• glycochenodeoxycholic acidReach from here →
  1. membrane dipeptidase (LTD4)
  2. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by DPEP1, DPEP2, BAATextracellular space, peroxisomeOne of 3 routes

• glyoxylateReach from here →
  1. membrane dipeptidase (LTD4)
  2. glycine + 2-oxoglutarate = glyoxylate + L-glutamate

  Catalysed by DPEP1, DPEP2, AADATextracellular spaceOne of 11 routes

• glycolithocholic acidReach from here →
  1. membrane dipeptidase (LTD4)
  2. bile acid-CoA:amino acid N-acyltransferase (glycine)

  Catalysed by DPEP1, DPEP2, BAATextracellular space, cytosolOne of 6 routes

• L-2-amino-3-oxobutanoic acidReach from here →
  1. membrane dipeptidase (LTD4)
  2. Acetyl-CoA:glycine C-acetyltransferase

  Catalysed by DPEP1, DPEP2, GCATextracellular space, mitochondrial matrix

• L-ornithineReach from here →
  1. membrane dipeptidase (LTD4)
  2. L-Arginine:glycine amidinotransferase

  Catalysed by DPEP1, DPEP2, GATMextracellular space, cytosolOne of 5 routes

• gamma-Glu-AlaReach from here →
  1. transport of GSH and LTD4 (cytosol to extracellular)
  2. gamma-glutamyltransferase (alanine)

  Catalysed by SLCO2A1, GGT1, GGT5, GGTLC2 and 3 moreextracellular space, cytosol

• S(8)-aminomethyldihydrolipoamideReach from here →
  1. membrane dipeptidase (LTD4)
  2. dihydrolipoyl dehydrogenase ([protein]-N6-(lipoyl)lysine)

  Catalysed by DPEP1, DPEP2, GLDC, GCSHextracellular space, mitochondrial matrix

• 3,3',5-triiodo-L-thyronineReach from here →
  1. transport of LTD4 (cytosol to extracellular)
  2. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• prostaglandin E1Reach from here →
  1. transport of LTD4 (cytosol to extracellular)
  2. transport of prostaglandin E1 (cytosol to extracellular)

  Catalysed by SLCO1B1extracellular space, cytosolOne of 4 routes

• prostaglandin I2Reach from here →
  1. transport of LTD4 (cytosol to extracellular)
  2. transport of prostaglandin I2 (cytosol to extracellular)

  Catalysed by SLCO1B1extracellular space, cytosolOne of 4 routes

• prostaglandin F2alphaReach from here →
  1. transport of LTD4 (cytosol to extracellular)
  2. transport of prostaglandin F2alpha (cytosol to extracellular)

  Catalysed by SLCO1B1extracellular space, cytosolOne of 4 routes

• prostaglandin H2Reach from here →
  1. transport of LTD4 (cytosol to extracellular)
  2. transport of prostaglandin H2 (cytosol to extracellular)

  Catalysed by SLCO1B1extracellular space, cytosolOne of 4 routes

• prostaglandin D2Reach from here →
  1. transport of LTD4 (cytosol to extracellular)
  2. transport of prostaglandin D2 (cytosol to extracellular)

  Catalysed by SLCO1B1extracellular space, cytosolOne of 4 routes

• (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. transport of GSH and LTD4 (cytosol to extracellular)
  2. Glutathione: 15-HPETE oxidoreductase

  Catalysed by SLCO2A1, GPX5, GPX1, GPX2 and 6 moreextracellular space, cytosol

• sarcosineReach from here →
  1. membrane dipeptidase (LTD4)
  2. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2

  Catalysed by DPEP1, DPEP2, PIPOXextracellular spaceOne of 2 routes

• (6S)-5,6,7,8-tetrahydrofolateReach from here →
  1. membrane dipeptidase (LTD4)
  2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine

  Catalysed by DPEP1, DPEP2, SHMT1, SHMT2extracellular space

• leukotriene A4Reach from here →
  1. transport of LTD4 (cytosol to extracellular)
  2. transport of leukotriene A4 (cytosol to extracellular)

  Catalysed by SLCO1B1extracellular space, cytosolOne of 5 routes

• (R)-S-lactoylglutathioneReach from here →
  1. transport of GSH and LTD4 (cytosol to extracellular)
  2. (R)-S-Lactoylglutathione methylglyoxal-lyase (isomerizing)

  Catalysed by SLCO2A1, GLO1, GLOD4extracellular space, cytosolOne of 2 routes

• an N-acylglycineReach from here →
  1. membrane dipeptidase (LTD4)
  2. an acyl-CoA + glycine = an N-acylglycine + CoA + H(+)

  Catalysed by DPEP1, DPEP2, GLYATL3, GLYAT and 1 moreextracellular space

• S-formylglutathioneReach from here →
  1. transport of GSH and LTD4 (cytosol to extracellular)
  2. alcohol dehydrogenase (formaldehyde)

  Catalysed by SLCO2A1, ADH1C, ADH1A, ADH5 and 3 moreextracellular space, cytosol

• guanidinoacetateReach from here →
  1. membrane dipeptidase (LTD4)
  2. L-Arginine:glycine amidinotransferase

  Catalysed by DPEP1, DPEP2, GATMextracellular space, cytosolOne of 2 routes

• L-methionineReach from here →
  1. membrane dipeptidase (LTD4)
  2. transport of glycine and methionine (cytosol to extracellular)

  Catalysed by DPEP1, DPEP2, SLC7A5extracellular space, cytosolOne of 5 routes

• dehydroepiandrosterone 3-sulfateReach from here →
  1. transport of LTD4 (cytosol to extracellular)
  2. transport of dehydroepiandrosterone sulfate (cytosol to extracellular)

  Catalysed by SLCO1B1extracellular space, cytosolOne of 2 routes

• L-tryptophanReach from here →
  1. membrane dipeptidase (LTD4)
  2. transport of glycine and tryptophan (cytosol to extracellular)

  Catalysed by DPEP1, DPEP2, SLC7A5extracellular space, cytosolOne of 5 routes

• glutathioneReach from here →
  1. membrane dipeptidase (LTD4)
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)

  Catalysed by DPEP1, DPEP2, GSSextracellular spaceOne of 2 routes

• L-alanineReach from here →
  1. membrane dipeptidase (LTD4)
  2. transport of alanine and glycine (cytosol to extracellular)

  Catalysed by DPEP1, DPEP2, SLC3A2, SLC7A5 and 1 moreextracellular space, cytosolOne of 6 routes

• L-asparagineReach from here →
  1. membrane dipeptidase (LTD4)
  2. transport of asparagine and glycine (cytosol to extracellular)

  Catalysed by DPEP1, DPEP2extracellular space, cytosolOne of 4 routes

• L-phenylalanineReach from here →
  1. membrane dipeptidase (LTD4)
  2. transport of glycine and phenylalanine (cytosol to extracellular)

  Catalysed by DPEP1, DPEP2, SLC7A5extracellular space, cytosolOne of 7 routes

• glutathione disulfideReach from here →
  1. transport of GSH and LTD4 (cytosol to extracellular)
  2. Glutathione: 5-HPETE oxidoreductase

  Catalysed by SLCO2A1, GPX5, GPX1, GPX2 and 6 moreextracellular space, cytosolOne of 13 routes

• taurolithocholate 3-sulfateReach from here →
  1. transport of LTD4 (cytosol to extracellular)
  2. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• L-tyrosineReach from here →
  1. membrane dipeptidase (LTD4)
  2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine

  Catalysed by DPEP1, DPEP2, AADATextracellular space